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Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control (Hardcover, 1st ed. 2017)
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Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control (Hardcover, 1st ed. 2017)
Series: Advances in Experimental Medicine and Biology, 1019
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Until about 10 years ago, the general view in the field was that
Mycobacterium tuberculosis, the causative agent of human
tuberculosis was a "clone" with insufficient natural sequence
variation between clinical strains to be considered biologically
and epidemiologically "relevant". This view has now changed quite
dramatically thanks to the -omics revolution, particularly the
advent of next generation DNA sequencing. Large-scale comparative
genomic studies over the last few years have revealed that M.
tuberculosis clinical strains are more genetically diverse than
appreciated previously. Moreover, an increasing number of
experimental and epidemiological studies are showing that this
genetic diversity also translates into important phenotypic
variation. Taken together, these findings have led to a paradigm
shift, such that currently phylogenetic diversity among M.
tuberculosis clinical strains is being considered in the
development of new tools to combat tuberculosis. The purpose of
this book is to bring together a series of contributions from some
of the most influential groups working on various aspects of M.
tuberculosis diversity, and which through their work have
contributed to the this paradigm shift. This includes authors
focusing on the evolution of M. tuberculosis in relation to other
members of the M. tuberculosis complex adapted to animals, the
co-evolution between M. tuberculosis and humans, the phenotypic
consequences of strains diversity both from an experimental and
epidemiological point of view, the ecology and evolution of drug
resistant tuberculosis, the diversity and evolution of the BCG
vaccine strains, and the use of mathematical modelling to study
strain diversity and drug resistance in human tuberculosis. No such
book has ever been published, and given the paradigm shift
described above, this book will be a valuable resource both for
established researchers as well as new scientists, clinicians and
public health officials joining the growing field of tuberculosis
research.
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