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miRNAs and Target Genes in Breast Cancer Metastasis (Paperback, 2014 ed.)
Loot Price: R1,807
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miRNAs and Target Genes in Breast Cancer Metastasis (Paperback, 2014 ed.)
Series: SpringerBriefs in Cancer Research
Expected to ship within 10 - 15 working days
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This SpringerBrief gives the latest research on the role of miRNAs
in breast cancer metastasis. MicroRNAs (miRNAs) are recently
described small endogenous noncoding RNAs implicated in the
posttranscriptional control of gene expression. These tiny
molecules are involved in developmental, physiologic phenomenon as
well as pathologic processes including cancers. In fact, miRNAs
have emerged as critical regulators of cancer progression, invasion
and metastasis. This is mainly because a single miRNA can affect
several downstream genes and signaling pathways with oncogenic or
tumor suppressor actions depending on the target genes affected.
Due to this multimodal downstream signaling effects, these small
endogenous molecules hold great promise in metastasis prevention
and treatment. Modulating the activity of miRNAs can provide
opportunities for novel cancer interventions. Targeting miRNAs
could become a novel prognostic and therapeutic strategy to prevent
the future development of metastasis. Thus, miRNAs could also serve
as a potential targets for anti-metastatic therapy. The book
explores how the expression of miRNAs in the primary tumor could be
silenced using antagomirs (chemically modified anti-miRNA
oligonucleotides), which could prevent the development of
metastasis; whereas once metastasis develops then it could be
treated with miRNA mimics for inducing its expression for the
treatment. Therefore, development of miRNA-based prophylactic
therapies could serve as precision and personalized medicine
against future development of metastasis of breast and other
cancers."
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