This book summarizes the state-of-the art in the development of
T cell-based "in vitro" assays, which offer useful tools for hazard
identification, risk assessment and improvement of diagnostics. It
will be of interest to scientists, the chemical and pharmaceutical
industry, and regulators involved in the replacement of animal
testing methods.
The identification of hazardous chemicals and drugs is essential
to ensuring human health. The ban on animal testing for the
cosmetics industry since 2009 and international efforts to reduce
and replace animal testing in research and immunotoxicology call
for alternative "in vitro" methods. The most specific immune
response to chemicals and drugs that cause allergic contact
dermatitis, respiratory disease and adverse drug reactions is the
highly antigen-specific T lymphocyte response. Therefore the use of
T cells as tools for identifying contact allergens and drugs that
may cause health problems is of great interest.
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