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Mechanisms of Lymphocyte Activation and Immune Regulation VII - Molecular Determinants of Microbial Immunity (Paperback, Softcover reprint of the original 1st ed. 1998)
Loot Price: R1,591
Discovery Miles 15 910
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Mechanisms of Lymphocyte Activation and Immune Regulation VII - Molecular Determinants of Microbial Immunity (Paperback, Softcover reprint of the original 1st ed. 1998)
Series: Advances in Experimental Medicine and Biology, 452
Expected to ship within 10 - 15 working days
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During the last decade, rapid progress has been made in the area of
microbial immu- nity. New conceptual frameworks have emerged with
regard to the processing and presen- tation of peptides and
nonpeptide antigens from microbes, especially bacteria, to T cells
in the context of classical MHC class I and nonconventional MHC I
molecules. Experimen- tal models have been instrumental in defining
some of these pathways for generating pro- tective immune responses
against microbes, which form the basis for the design of new
vaccines. New evidence has stressed the importance of innate
immunity in microbial in- fections. The concept of dichotomy within
T helper cells has revealed the role of these cell types in
resistance and susceptibility to microbial-mediated pathology.
These latest devel- opments in microbial immunity are discussed in
this volume. Natural killer cell development is known to be
regulated by the presence of MHC class I antigens. Receptors for
MHC class I molecules on NK cells have been discovered. Interaction
of these receptors with their specific ligands leads to inhibition
of cytotoxicity. Vinay Kumar and colleagues review NK cell
differentiation and ontogeny, and functions of NK cells in
experimental animals. Lewis Lanier discusses the role of a newly
discov- ered molecule, DAP 12, in KIR and other receptor-mediated
signal transduction in NK cells. Eric Long describes the regulation
of immune response by inhibitory receptors.
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