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Molecular Pathology of Breast Cancer (Hardcover, 1st ed. 2016)
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Molecular Pathology of Breast Cancer (Hardcover, 1st ed. 2016)
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The complex landscape of breast cancer requires distinct strategies
for the management of various molecular subtypes of this disease.
Rapid advances in the field of molecular biology have been
bewildering for those involved in its study and management.
"Molecular Pathology of Breast Cancer" aims to close this knowledge
gap by discussing comprehensively the evolution, biological basis
and clinical applications with a focus on the "what, when, and how"
of the most significant molecular markers known to date. These
markers are evaluated in the context of genomic, transcriptomic and
proteomic profiles, which is integral to the practice of precision
medicine. The application of next generation sequencing (NGS) has
provided new insights in the regulation of genomic and
transcriptomic structure and function. Alterations in DNA such as
mutations and single nucleotide polymorphisms (SNPs) have been
correlated with outcomes and provide for novel therapeutic
approaches. These NGS analyses have also revealed the extensive
contributions of epigenetic mechanisms such as histone
modifications, non-coding RNA and alternative splicing. All of
these changes together contribute to alterations in proteome. Newer
assays that allow greater stability and analytical consistency are
emerging. These alterations in tumor profiles can be also now
detected by imaging techniques. The heterogeneity of both tumor and
tumor microenvironment, an inevitable reality, is discussed in
detail with particular focus on cancer stem cells and immune
signaling. A chapter is dedicated to the emerging technology of
"liquid biopsy", which opens a novel approach for "continuous"
monitoring of cancer that might be superior to conventional
diagnostics, "Molecular Pathology of Breast Cancer" provides a
quick and easy, not to mention essential, tour for clinicians,
pathologists and scientists who are seeking to understand the
integration of molecular biology into the diagnosis, prognosis and
management of breast cancer.
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