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Radiocontrast Agents (Paperback, Softcover reprint of the original 1st ed. 1984)
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Radiocontrast Agents (Paperback, Softcover reprint of the original 1st ed. 1984)
Series: Handbook of Experimental Pharmacology, 73
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Contrast media are drugs by default. Had there been no default,
there would be no need for a related pharmacology, and thus no need
for this book. Radiographic contrast media (CM) are substances
whose primary purpose is to enhance diagnostic information of
medical imaging systems. The position of CM in pharmacology is
unique. First, there is the unusual requirement of biological
inertness. An ideal CM should be completely biologically inert,
i.e., stable, not pharmacologically active, and efficiently and
innocuously excretable. Because they fail to meet these
requirements, CM must be considered drugs. The second unusual
aspect of CM is that they are used in large quantities, their
annual production being measured in tens of tons. It is not in
spite of, but because of, the increased use of new radiographic
systems, computed tomography, digital radiography, etc., that
consumption is on the rise. And, it is not likely that the other
emerging imaging modalities - NMR, ultrasonography, etc. - will
displace radiographic CM soon; it is quite probable that these
remarkable compounds will continue to play an active role in
diagnostic imaging in the foreseeable future.
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