p53 Suppressor Gene (Paperback, Softcover reprint of the original 1st ed. 1995)

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene can suppress the growth of cancer cells and the transformation process by oncogenes. The p53 protein is a transcription factor that can repress or activate promoters containing one of three p53 DNA-binding motifs. The activity of p53 is regulated by phosphorylation and other transcription factors. Replacement of the p53 function or restoration of the p53 biochemical pathway is a focus of gene therapy.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Molecular Biology Intelligence Unit
Release date:	April 2014
First published:	1995
Authors:	Tapas Mukhopadhyay • Steven A Maxwell • Jack A. Roth
Dimensions:	279 x 210 x 8mm (L x W x T)
Format:	Paperback
Pages:	132
Edition:	Softcover reprint of the original 1st ed. 1995
ISBN-13:	978-3-662-22277-5
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-662-22277-9
Barcode:	9783662222775

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