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Chronic Psychological Stress and AIDS (Paperback)
Loot Price: R1,290
Discovery Miles 12 900
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Chronic Psychological Stress and AIDS (Paperback)
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Total price: R1,310
Discovery Miles: 13 100
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Chronic Psychological stress has several adverse effects both on
HIV- people and on HIV+ patient. When the HIV- people are
concerned, stress makes them more susceptible to HIV infection.
T-cells have CXCR4 receptor and Macrophage have CCR5 receptor which
can bind with both glucocorticoid and catecholamine hormone. HIV
has GP120 protein which has to bind with both CD4 and CXCR4/CCR5
receptor for its entry into the host cells. Mental stress increases
glucocorticoid and catecholamine concentration in blood. When these
stress hormones, glucocorticoid and catecholamine, bind with the
CXCR4/CCR5 receptors, cAMP signaling pathway gets activated. This
signal transduction pathway leads to the synthesis of more CXCR4
and CCR5 receptors by those cells, which in turn become more
susceptible to HIV infection. Stress inhibits Th2 when the cell
produces INF- as a response to viral attacks. So that other cells
remain vulnerable to viral infection. When T-cell count is
decreased in the blood, the body cannot protect itself from other
opportunistic infectious pathogens. As a result progression of AIDS
is increased."
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