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Immunotherapy of Hepatocellular Carcinoma (Hardcover, 1st ed. 2017)
Loot Price: R5,299
Discovery Miles 52 990
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Immunotherapy of Hepatocellular Carcinoma (Hardcover, 1st ed. 2017)
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In this book we provide insights into liver - cancer and
immunology. Experts in the field provide an overview over
fundamental immunological questions in liver cancer and
tumorimmunology, which form the base for immune based approaches in
HCC, which gain increasing interest in the community due to first
promising results obtained in early clinical trials. Hepatocellular
carcinoma (HCC) is the third most common cause of cancer related
death in the United States. Treatment options are limited. Viral
hepatitis is one of the major risk factors for HCC, which
represents a typical "inflammation-induced" cancer. Immune-based
treatment approaches have revolutionized oncology in recent years.
Various treatment strategies have received FDA approval including
dendritic cell vaccination, for prostate cancer as well as immune
checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in
melanoma, lung, and kidney cancer. Additionally, cell based
therapies (adoptive T cell therapy, CAR T cells and TCR transduced
T cells) have demonstrated significant efficacy in patients with B
cell malignancies and melanoma. Immune checkpoint inhibitors in
particular have generated enormous excitement across the entire
field of oncology, providing a significant benefit to a minority of
patients.
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