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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Rodent Models of Stroke (Hardcover, 2010 ed.)
Loot Price: R3,264
Discovery Miles 32 640
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Rodent Models of Stroke (Hardcover, 2010 ed.)
Series: Neuromethods, 47
Expected to ship within 10 - 15 working days
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In view of the numerous failures of clinical trials aimed at
improving stroke therapy, the role and potential benefit of
experimentally modeling focal cerebral ischemia in rodents has been
debated. When methods of systematic review and metaanalyis are
applied, however, it turns out that experimental models actually
faithfully predicted the negative outcomes of clinical trials. In
addition, thrombolysis and neuroprotection by hypothermia, first
described in animal models, are key examples of treatment
modalities that have made it successfully into clinical practice.
In Rodent Models of Stroke, an international consortium of authors
aims at critically addressing the issues on a very practical level,
from choosing the model and outcome measures, designing the
experiment, conducting and analyzing it, to reporting it in a
scientific publication. The structure and content of the book
reflect both the authors' longstanding expertise in experimental
and clinical stroke research and their roles in training the
scientific community in the tools of the trade. As a volume in the
successful Neuromethods series, the chapters provide authoritative
reviews of the most commonly used, well-honed approaches in the
field today. Stimulating and easy-to-use, Rodent Models of Stroke
will help its readers understand the limitations and the
opportunities of modeling stroke in rodents and enable them to
conduct experiments which will not only improve our understanding
of the pathophysiology of this devastating disorder but also serve
as the basis for developing new highly effective treatments.
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