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Bladder Tumors: - Molecular Aspects and Clinical Management (Paperback, 2011 ed.)
Loot Price: R5,483
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Bladder Tumors: - Molecular Aspects and Clinical Management (Paperback, 2011 ed.)
Series: Cancer Drug Discovery and Development
Expected to ship within 10 - 15 working days
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Bladder cancer is a common cancer of the urinary tract. It is the
fourth leading cause of cancer-related death among men and the
seventh among women. Clinical management of bladder cancer is
challenging because of the heterogeneity among bladder tumors with
respect to invasion and metastasis, frequent occurrence of new
tumors in the bladder among patients treated with bladder
preservation treatments and poor prognosis of patients with tumors
that invade the bladder muscle and beyond. Due to these factors it
has been said that the cost per patient of bladder cancer, from
diagnosis to death is the highest of all cancers. In addition to it
being a significant health problem, bladder cancer is an
interesting cancer to study in many ways than one. For example,
Environmental factors such as cigarette smoking and other
carcinogens play a major role in the development of transitional
carcinoma of the bladder, whereas, schitosomasis, a protozoan
infection results in squamous cell carcinoma of the bladder.
Different molecular pathways with distinct molecular signatures
appear to be involved in the development of low-grade versus
high-grade bladder tumors. Currently being monitored by an invasive
endoscopic procedure, cystectomy, with urine cytology as an
adjunct, bladder cancer is at the forefront of developing cancer
biomarkers for non-invasive detection. Due to the differences in
the invasive and metastatic potential of bladder tumors, treatment
options differ depending upon tumor grade and stage. New advances
are being made in treatment options to improve the outcome and
quality of life for patients with bladder cancer. Similarly, new
molecular nomograms are being discovered to predict treatment
outcome so that individualized treatment options can be offered to
patients.
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