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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Gastric Cancer In The Precision Medicine Era - Diagnosis and Therapy (Hardcover, 1st ed. 2019)
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Gastric Cancer In The Precision Medicine Era - Diagnosis and Therapy (Hardcover, 1st ed. 2019)
Series: Current Clinical Pathology
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Gastric cancer is one of the most common and potentially lethal
gastrointestinal malignancy, but it is now at the forefront of
modern oncology due to new discoveries. In recent years, the field
of gastric cancer has been transformed by many notable developments
in both the diagnostic area and the therapeutic strategies. The
main aim of the text is to propose a comprehensive, state-of-the
art review of this field, and will serve as a valuable resource for
oncologists, pathologists, surgeons and researchers with an
interest in gastric cancer. The first chapters will review the
interplay between pathogens and especially H. pylori, inflammation,
genomic instability, and tumorigenesis. Secondly, an exhaustive
overview of the diagnosis of gastric cancer from a
clinical/endoscopic and pathologic perspectives will be
illustrated. Two specific chapters will deal with tissue and serum
biomarkers with an important role in diagnosis as well as
prognostic and predictive markers of response to specific therapy.
A central section of the book will focus on treatment options
available today for patients. Surgery is the cornerstone of
treatment for gastric cancer; however, the prognosis of patients
with locally advanced disease is still poor even after curative
resection. Therefore, in order to improve the prognosis of
patients, especially with advanced stage, a multimodal strategy is
advisable and is thoroughly addressed in the appropriate section.
With the advent of next-generation sequencing and new preclinical
model technologies, the genomic landscape of gastric cancer has
been delineated and molecular characterizations finalized to novel
therapeutic targets of each molecular subtype have been identified.
These advances are making it feasible to integrate clinical and
phenotype-based diagnostic and therapeutic methods and are
described in a dedicated section. The text will conclude with
chapters focusing on the future direction of gastric cancer
research in the precision medicine era: an in-depth analysis of
non-coding RNAs and their role in gastric cancer, the impact of
immunomodulation/immunotherapy and the perspectives of
nano-medicine will be finally proposed to the audience. A brief
review of the existing literature addressing the above mentioned
topics will be present in each chapter. This text will serve as a
useful resource for physicians and researchers dealing with, and
interested in, this challenging malignancy. It will provide a
concise yet comprehensive summary of the current status of the
field that will help guide patient management and stimulate
investigative efforts. All chapters will be written by experts in
their fields and will include the most up to date scientific and
clinical information.
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