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Signposts to Chiral Drugs - Organic Synthesis in Action (Paperback, 2011 ed.)
Loot Price: R4,471
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Signposts to Chiral Drugs - Organic Synthesis in Action (Paperback, 2011 ed.)
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Highlighting 15 selected chiral structures, which represent
candidate or marketed drugs, and their chemical syntheses, the
authors acquaint the reader with the fascinating achievements of
synthetic and medicinal chemistry. The book starts with an
introduction treating the discovery and development of a new drug
entity. Each of the 15 subsequent chapters presents one of the
target structures and begins with a description of its biological
profile as well as any known molecular mechanisms of action,
underlining the importance of its structural and stereochemical
features. This section is followed by detailed discussions of
synthetic approaches to the chiral target structure, highlighting
creative ideas, the scaling-up of laboratory methods and their
replacement by efficient modern technologies for large-scale
production. Nearly 60 synthetic reactions, most of them
stereoselective, catalytic or biocatalytic, as well as chiral
separating methodologies are included in the book. Vitomir Sunjic
and Michael J. Parnham provide an invaluable source of information
for scientists in academia and the pharmaceutical industry who are
actively engaged in the interdisciplinary development of new drugs,
as well as for advanced students in chemistry and related fields.
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