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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitatsforschung - Volume 62 (Paperback, Softcover reprint of the original 1st ed. 1973)
Loot Price: R2,902
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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitatsforschung - Volume 62 (Paperback, Softcover reprint of the original 1st ed. 1973)
Series: Current Topics in Microbiology and Immunology, 62
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General aspects of nucleic acid uptake by mammalian cells have been
the subject of several reviews during the last few years (PAGANO,
1970; BHARGAVA and SHANMUGAM, 1971; DUBES, 1971; RYSER, 1967).
These reviews covered methods used for the infection of cells by
viral nucleic acids as well as interaction of mammalian cells with
non-viral nucleic acids. This article is restricted to a discussion
of experiments with poliovirus RNA and focuses special attention on
the steps following the uptake of RNA into a cell, aspects that
were not discussed in earlier review articles. The fate of input
RNA once inside the cell is determined by the host cell but
experimental conditions can be chosen to favor the survival of
input RNA and the induction of a virus growth cycle by interfering
with host-cell meta bolism through events that, in the case of
infection with intact virus, might be controlled by viral
proteins."
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