Rab GTPases now comprise a family of >63 members. They are
emerging as the key hub element controlling the membrane
architecture of eukaryotic cells. They are intimately involved in
vesicle targeting and fusion in both the endocytic and exocytic
pathways and direct the assembly and disassembly of protein
complexes that include regulators (GEFs and GAPs), effectors
(tethers/motors) and fusion components (SNAREs) that control
membrane targeting and fusion. During the last 3 years the field
has virtually exploded with the identification and characterization
of many new Rab proteins and their effectors.
Our understanding of how Rab GTPases control membrane function
remains at its infancy. This volume of MIE provides a wealth of new
concepts, approaches and tools to study Rab proteins in the test
tube and in living cells that will be of strong benefit to both
established laboratories and new investigators in the field to
elucidate Rab GTPase function in cellular development,
differentiation and proliferation.
* Comprehensive overview of Rab GTPase phylogeny and systems
biology
* Identification and characterization of Rab GEFs, GAPs and
effectors
* General methodologies to study Rab GTPase function in vitro and
in vivo using biochemical, molecular and microscopy approaches
General
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