Molecular chaperones are a fundamental group of proteins that
have been identified only relatively recently. They are key
components of a protein quality machinery in the cell which insures
that the folding process of any newly-synthesized polypeptide chain
results in the formation of a properly folded protein and that the
folded protein is maintained in an active conformation throughout
its functional lifetime. Molecular chaperones have been shown to
play essential roles in cell viability under both normal and stress
conditions. Chaperones can also assist in the unfolding and
degradation of misfolded proteins and in disaggregating preformed
protein aggregates. Chaperones are also involved in other cellular
functions including protein translocation across membranes, vesicle
fusion events, and protein secretion.
In recent years, tremendous advances have been made in our
understanding of the biology, biochemistry, and biophysics of
function of molecular chaperones. In addition, recent technical
developments in the fields of proteomics and genomics allowed us to
obtain a global view of chaperone interaction networks. Finally,
there is now a growing interest in the role of molecular chaperones
in diseases.
This bookwill providea comprehensive analysis of the structure
and function of the diverse systems of molecular chaperones and
their role in cell stress responses and in diseases from a global
network perspective. "
General
Imprint: |
Springer-Verlag New York
|
Country of origin: |
United States |
Series: |
Interactomics and Systems Biology, 1 |
Release date: |
September 2014 |
First published: |
2014 |
Editors: |
Walid A Houry
|
Dimensions: |
235 x 155 x 27mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
485 |
Edition: |
2014 ed. |
ISBN-13: |
978-1-4939-1129-5 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Biochemistry >
Proteins
|
LSN: |
1-4939-1129-5 |
Barcode: |
9781493911295 |
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