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Growth Factors and their Receptors in Cancer Metastasis (Hardcover, 2001 ed.)
Loot Price: R6,268
Discovery Miles 62 680
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Growth Factors and their Receptors in Cancer Metastasis (Hardcover, 2001 ed.)
Series: Cancer Metastasis - Biology and Treatment, 2
Expected to ship within 12 - 17 working days
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about the involvement of signaling Transforming growth factor in
tumor development and metastasis. plays a central role in the
signaling network that controls morphogenesis, 2. THE BASICS OF
growth and cell differentiation in SIGNALING multicellular
organisms. The different members of this pleiotropic family of 2.
1. receptor signaling growth and differentiation factors seem to
The family of growth factors regulate many processes in human
disease consists of more than thirty members in and, in particular,
tumor development. humans alone (15, 16). They cluster in Our
understanding of how two major groups, the group composed of
initiated signals are mediated has both the bone morphogenetic
proteins increased dramatically in the last fifteen (BMP) and
growth and differentiation years. Firstly, the prototype of factors
(GDFs), and the group formed by this still constantly growing
family, was the Activins, and Nodals. The two identified and cloned
(1). Secondly, the groups differ in their use of receptors for
family receptors were transmembrane receptors and the identified by
expression cloning from subsequent activation of the mammalian
tissue culture (2-7). Thirdly, transcriptional mediators (for
recent genetic screens in Drosophila reviews see (13, 14, 17)).
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