Consolidates the information LC-MS bioanalytical scientists need
to analyze small molecules and macromolecules
The field of bioanalysis has advanced rapidly, propelled by new
approaches for developing bioanalytical methods, new liquid
chromatographic (LC) techniques, and new mass spectrometric (MS)
instruments. Moreover, there are a host of guidelines and
regulations designed to ensure the quality of bioanalytical
results.
Presenting the best practices, experimental protocols, and the
latest understanding of regulations, this book offers a
comprehensive review of LC-MS bioanalysis of small molecules and
macromolecules. It not only addresses the needs of bioanalytical
scientists working on routine projects, but also explores advanced
and emerging technologies such as high-resolution mass spectrometry
and dried blood spot microsampling.
"Handbook of LC-MS Bioanalysis" features contributions from an
international team of leading bioanalytical scientists. Their
contributions reflect a review of the latest findings, practices,
and regulations as well as their own firsthand analytical
laboratory experience. The book thoroughly examines: Fundamentals
of LC-MS bioanalysis in drug discovery, drug development, and
therapeutic drug monitoringThe current understanding of regulations
governing LC-MS bioanalysisBest practices and detailed technical
instructions for LC-MS bioanalysis method development, validation,
and stability assessment of analyte(s) of interestExperimental
guidelines and protocols for quantitative LC-MS bioanalysis of
challenging molecules, including pro-drugs, acyl glucuronides,
N-oxides, reactive compounds, and photosensitive and autooxidative
compounds
With its focus on current bioanalytical practice, "Handbook of
LC-MS Bioanalysis" enables bioanalytical scientists to develop and
validate robust LC-MS assay methods, all in compliance with current
regulations and standards.
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