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Somatic Genome Manipulation - Advances, Methods, and Applications (Hardcover, 2015 ed.)
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Somatic Genome Manipulation - Advances, Methods, and Applications (Hardcover, 2015 ed.)
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Somatic genome manipulation is required when a sexual crossing
approach cannot be used in breeding or genetic treatment of an
individual organism. Examples can include gene- or cell-therapy of
a person to correct disease, genetic improvement of vegetatively
propagated plants, and genetic replacement of cytoplasm without
significantly modifying the nuclear genome. The advantage of
somatic genome manipulation is maintenance of the general genotype
while correcting one or more traits. Somatic genome manipulation is
also an option for genetic improvement of sexually propagated
plants in polyploidy breeding or in overcoming issues of sexual
incompatibility. Recent novel technologies in somatic genome
manipulation are developing quickly but much of this literature is
fragmented and difficult or inconvenient to access. This book
represents the first attempt to assemble updated reviews, detailed
protocols, and their applications in all fields in which somatic
genome manipulation has thrived. This is a truely one-of-a-kind
work that brings together the most important and relevant advances
in somatic genome manipulation in plants, algae, microorganisms,
humans and animals, and demonstrates where the science interacts
and where it diverges. The chapters are written by experts on the
topic with ready-to-use protocols that were originally developed or
adapted from the literature in their laboratories. We expect that
this book will be useful for students, researchers, and teachers in
both plant and animal research as a resource for the latest
information on somatic genome manipulation and for its useful
laboratory methods.
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