Type I Interferon in Autoimmune Diseases & its Clinical Applications (Hardcover)

Auto-immune diseases such as systemic lupus erythematosus (SLE), Sjoegren's syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors. Type I interferons (IFNs), especially IFN- / , have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in auto-immunity and cancer. Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some auto-immune and inflammatory diseases. This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signalling pathway, the interplay between components that regulate this pathway, its involvement in auto-immunity, and a detailed review of the roles of type I IFNs in a series of well characterised inflammatory and auto-immune diseases.

General

Imprint:	nova science publishers
Country of origin:	United States
Release date:	June 2013
Editors:	Yihong Yao
Dimensions:	260 x 180 x 22mm (L x W x T)
Format:	Hardcover
Pages:	349
ISBN-13:	978-1-62417-379-0
Categories:	Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General Promotions
LSN:	1-62417-379-9
Barcode:	9781624173790

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