Books > Science & Mathematics > Biology, life sciences > Biochemistry > Toxicology (non-medical)
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Toxicology of Glutathione Transferases (Hardcover)
Loot Price: R5,216
Discovery Miles 52 160
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Toxicology of Glutathione Transferases (Hardcover)
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Since the discovery of Glutathione S-Transferase (GST) or
Glutathione transferase, studies have probed important questions
about its pharmacological and physiological significance.
Toxicology of Glutathione Transferases is the only text that
details the methods used in GST research. With chapters written by
experts who have been involved in all areas of GST research and
have actively contributed to the progress of this field, the book
describes the role of GSTs in toxicology, focusing on their
pharmacologic and physiologic roles and their relevance to
biological toxicology. The book provides current information on
gene families, structure and regulation of gene expression,
reaction mechanisms and substrates, three-dimensional structures of
GSTs, design of proteins with GST activity, and various approaches
to developing inhibitors that overcome drug resistance. It also
covers the physiological significance and the mechanisms of
activation of microsomal GSTs. carcinogens and possible
implications of GST polymorphism in human health and disease, make
the volume useful to researchers in the field of pharmacology and
toxicology. Chapters cover the possible and exciting role of GSTs
in defense mechanisms against chronic oxidative stress-linked
disorders such as atherosclerosis and the newly emerging area of
GST-mediated modulation of stress-signaling through its catalytic
as well as binding activities. They explore an intriguing
hypothesis that strongly suggests an important role of the factors
that modulate the GSH-electrophile conjugate (GS-E) homeostasis in
the regulation of cellular processes. Chapters on known and
potential endogenous electrophilic substrates and a major role of
GSTs in suppressing stress-induced lipid peroxidation reinforce
this newly emerging role of GSTs. These are just a few of the
features that make the book helpful to clinicians involved in basic
as well as translational research, particularly those studying
oxidative stress-related degenerative diseases.
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