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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Sendai Virus Vector - Advantages and Applications (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R3,122
Discovery Miles 31 220
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Sendai Virus Vector - Advantages and Applications (Paperback, Softcover reprint of the original 1st ed. 2013)
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Sendai virus (SeV) is not just a mouse pathogen but is evolving
into a cutting-edge component of biotechnology. SeV reverse
genetics originating from a pure academic need to settle long-held
questions in the biology and pathogenicity of nonsegmented negative
strand RNA viruses (Mononegavirales) is about to bear the
impressive fruit of multipurpose cytoplasmic (non-integrating) RNA
vectors. This book brings together in one source the SeV biology
revealed by conventional approaches and reverse genetics, the
methods to construct the first-generation SeV vector and to
generate safer versions, and the applications in medical settings
that have left or are about to leave the laboratory bench. The
applications, which already are diverse and have high medical
impact, include use as vaccine vectors against AIDS and respiratory
virus infections, creation of BioKnife to resect malignant tumors,
induction of "footprint (transgene) free" pluripotent stem cells,
and gene therapy for peripheral arterial disease. These
achievements-which are just a few of many examples-were attainable
only after rigorously incorporating the rich knowledge of SeV
biology that has accumulated during the several decades since the
discovery of the virus. Application of SeV vector is certain to
expand greatly because of its extremely high performance in
transgene expression and its remarkable target cell breadth.
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