An Introduction to Single Molecule Biophysics (Hardcover)

This book gives an accessible, detailed overview on techniques of single molecule biophysics (SMB), showing how they are applied to numerous biological problems associated with understanding the molecular mechanisms of DNA replication, transcription, and translation, as well as functioning of molecular machines. It covers major single molecule imaging and probing techniques, highlighting key strengths and limitations of each method using recent examples. The chapters begin with a discussion of single molecule fluorescence techniques followed by an overview of the atomic force microscope and its use for direct time-lapse visualization of dynamics of molecular complexes at the nanoscale, as well as applications in measurements of interactions between molecules and mechanical properties of isolated molecules and their complexes. The next chapters address magnetic tweezers and optical tweezers, including instrumentation, fundamentals of operation, and applications. A final chapter turns to nanopore transport and nanopore-based DNA sequencing technology that will play a major role in next-generation genomics and healthcare applications.

General

Imprint:	Crc Press
Country of origin:	United States
Series:	Foundations of Biochemistry and Biophysics
Release date:	November 2017
First published:	2018
Editors:	Yuri L. Lyubchenko
Dimensions:	234 x 156 x 19mm (L x W x T)
Format:	Hardcover
Pages:	250
ISBN-13:	978-1-4398-0694-4
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Professional & Technical > Technology: general issues > Nanotechnology Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
LSN:	1-4398-0694-2
Barcode:	9781439806944

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