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Resistance to therapies, both targeted and systemic, and metastases
to distant organs are the underlying causes of breast
cancer-associated mortality. The second edition of Breast Cancer
Metastasis and Drug Resistance brings together some of the leading
experts to comprehensively understand breast cancer: the factors
that make it lethal, and current research and clinical progress.
This volume covers the following core topics: basic understanding
of breast cancer (statistics, epidemiology, racial disparity and
heterogeneity), metastasis and drug resistance (bone metastasis,
trastuzumab resistance, tamoxifen resistance and novel therapeutic
targets, including non-coding RNAs, inflammatory cytokines, cancer
stem cells, ubiquitin ligases, tumor microenvironment and signaling
pathways such as TRAIL, JAK-STAT and mTOR) and recent developments
in the field (epigenetic regulation, microRNAs-mediated regulation,
novel therapies and the clinically relevant 3D models). Experts
also discuss the advances in laboratory research along with their
translational and clinical implications with an overarching goal to
improve the diagnosis and prognosis, particularly that of breast
cancer patients with advanced disease.
This, the first of two volumes on personalized medicine in lung
cancer, touches on the core issues related to the understanding of
lung cancer-statistics and epidemiology of lung cancer-along with
the incidence of lung cancer in non-smokers. A major focus of this
volume is the state of current therapies against lung
cancer-immune, targeted therapies against EGFR TKIs, KRAS, ALK,
angiogenesis; the associated challenges, especially resistance
mechanisms; and recent progress in targeted drug development based
on metal chemistry. Chapters are written by some of the leading
experts in the field, who provide a better understanding of lung
cancer, the factors that make it lethal, and current research
focused on developing personalized treatment plans. With a unique
mix of topics, this volume summarizes the current
state-of-knowledge on lung cancer and the available therapies.
The book is a collection of high-quality, peer-reviewed innovative
research papers from the International Conference on Signals,
Machines and Automation (SIGMA 2018) held at Netaji Subhas
Institute of Technology (NSIT), Delhi, India. The conference
offered researchers from academic and industry the opportunity to
present their original work and exchange ideas, information,
techniques and applications in the field of computational
intelligence, artificial intelligence and machine intelligence. The
book is divided into two volumes discussing a wide variety of
industrial, engineering and scientific applications of the emerging
techniques.
The book is a collection of high-quality, peer-reviewed innovative
research papers from the International Conference on Signals,
Machines and Automation (SIGMA 2018) held at Netaji Subhas
Institute of Technology (NSIT), Delhi, India. The conference
offered researchers from academic and industry the opportunity to
present their original work and exchange ideas, information,
techniques and applications in the field of computational
intelligence, artificial intelligence and machine intelligence. The
book is divided into two volumes discussing a wide variety of
industrial, engineering and scientific applications of the emerging
techniques.
This, the second of two volumes on personalized medicine in lung
cancer, touches upon the recent progress in targeted drug
development based on genomics; emerging biomarkers and therapeutic
targets such as EMT, cancer stem cells, and the tumor
microenvironment; current personalized clinical management and
radiation therapy for lung cancers; and the promise of epigenetics
and next-generation sequencing for the advancements towards
personalized therapy of lung cancer patients. With chapters on
state-of-the-art therapies and technologies written by leading
experts working to develop novel companion diagnosis tools for the
personalized treatment of lung cancer patients, this volume brings
readers up-to-date by presenting the current knowledge on the
efforts to make personalized management of lung cancer patients a
reality.
This book focuses on the prophylactic potential of diet-derived
factors in primary prevention of cancer. It is written by a group
of highly reputed experts in the area of dietary agents and cancer
chemoprevention. The translational potential of dietary factors
from epidemiological, laboratory and clinical studies as prevention
strategy in normal and risk populations is highlighted. The work
presents options of routine inclusion of specific dietary regimens
for prevention as well as therapeutic strategy for better
management through adjuvant interventions in cancer treatment.
This, the second of two volumes on personalized medicine in lung
cancer, touches upon the recent progress in targeted drug
development based on genomics; emerging biomarkers and therapeutic
targets such as EMT, cancer stem cells, and the tumor
microenvironment; current personalized clinical management and
radiation therapy for lung cancers; and the promise of epigenetics
and next-generation sequencing for the advancements towards
personalized therapy of lung cancer patients. With chapters on
state-of-the-art therapies and technologies written by leading
experts working to develop novel companion diagnosis tools for the
personalized treatment of lung cancer patients, this volume brings
readers up-to-date by presenting the current knowledge on the
efforts to make personalized management of lung cancer patients a
reality.
This, the first of two volumes on personalized medicine in lung
cancer, touches on the core issues related to the understanding of
lung cancer-statistics and epidemiology of lung cancer-along with
the incidence of lung cancer in non-smokers. A major focus of this
volume is the state of current therapies against lung
cancer-immune, targeted therapies against EGFR TKIs, KRAS, ALK,
angiogenesis; the associated challenges, especially resistance
mechanisms; and recent progress in targeted drug development based
on metal chemistry. Chapters are written by some of the leading
experts in the field, who provide a better understanding of lung
cancer, the factors that make it lethal, and current research
focused on developing personalized treatment plans. With a unique
mix of topics, this volume summarizes the current
state-of-knowledge on lung cancer and the available therapies.
This book focuses on the prophylactic potential of diet-derived
factors in primary prevention of cancer. It is written by a group
of highly reputed experts in the area of dietary agents and cancer
chemoprevention. The translational potential of dietary factors
from epidemiological, laboratory and clinical studies as prevention
strategy in normal and risk populations is highlighted. The work
presents options of routine inclusion of specific dietary regimens
for prevention as well as therapeutic strategy for better
management through adjuvant interventions in cancer treatment.
Resistance to therapies, both targeted and systemic, and metastases
to distant organs are the underlying causes of breast
cancer-associated mortality. The second edition of Breast Cancer
Metastasis and Drug Resistance brings together some of the leading
experts to comprehensively understand breast cancer: the factors
that make it lethal, and current research and clinical progress.
This volume covers the following core topics: basic understanding
of breast cancer (statistics, epidemiology, racial disparity and
heterogeneity), metastasis and drug resistance (bone metastasis,
trastuzumab resistance, tamoxifen resistance and novel therapeutic
targets, including non-coding RNAs, inflammatory cytokines, cancer
stem cells, ubiquitin ligases, tumor microenvironment and signaling
pathways such as TRAIL, JAK-STAT and mTOR) and recent developments
in the field (epigenetic regulation, microRNAs-mediated regulation,
novel therapies and the clinically relevant 3D models). Experts
also discuss the advances in laboratory research along with their
translational and clinical implications with an overarching goal to
improve the diagnosis and prognosis, particularly that of breast
cancer patients with advanced disease.
Introduction to Cancer Metastasis provides, in one place, an
overview of organ-specific cancer metastasis and the most common
sites of cancer metastasis. Through specific chapters on individual
primary cancers, their metastasis, and chapters on common
metastatic sites, this volume comprehensively informs readers about
the broader knowledge base in cancer metastasis. The process of
metastasis is particularly responsible for making cancer so lethal.
This volume explores both metastasis from sites of origin and
common metastatic sites, thus increasing understanding of both
perspectives.
This volume comprehensively covers recent prrogress in breast
cancer research. In an effort to successfully treat breast cancer,
it is imperative to a) fully understand the disease with all its
heterogeneity, b) understand the factors that influence the
metastasis of breast cancer to distant organs making it lethal and
c) understand the underlying processes that lead to the phenomenon
of drug-resistance making the disease particularly incurable. The
book explores all of these issues, including the phenomenon of
epithelial-mesenchymal-transition, cancer stem cells as well as
microRNAs in an attempt to better understand the disease in
connection to its heterogeneity/metastasis/drug-resistance as well
as to propose novel signaling pathways for therapeutic
intervention. The profiling of tumors to molecularly classify
breast cancers is also investigated so that customized targeted
therapies can be developed.
This book is a collection of articles detailing the very diverse
roles of soy-derived compounds. Many cultures around the world have
realised the importance of soy in diet. Through a total of 20
chapters, this book showcases the very diverse chemistry, biology
and functions of soy. In view of the many reported effects of
soy-derived compounds against diverse human cancers, this book
concludes with few chapters on the anticancer activity of
soy-derived compounds. Thus, through a collection of articles
authored by renowned experts from across the globe, this book is an
attempt to touch upon and highlight the importance of soy in diet
with emphasis on its various health beneficial effects.
This volume comprehensively covers recent prrogress in breast
cancer research. In an effort to successfully treat breast cancer,
it is imperative to a) fully understand the disease with all its
heterogeneity, b) understand the factors that influence the
metastasis of breast cancer to distant organs making it lethal and
c) understand the underlying processes that lead to the phenomenon
of drug-resistance making the disease particularly incurable. The
book explores all of these issues, including the phenomenon of
epithelial-mesenchymal-transition, cancer stem cells as well as
microRNAs in an attempt to better understand the disease in
connection to its heterogeneity/metastasis/drug-resistance as well
as to propose novel signaling pathways for therapeutic
intervention. The profiling of tumors to molecularly classify
breast cancers is also investigated so that customized targeted
therapies can be developed.
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