Plutarch is one of the most prolific and important writers from antiquity. His Parallel Lives continue to be an invaluable historical source, and the numerous essays in his Moralia, covering everything from marriage to the Delphic Oracle, are crucial evidence for ancient philosophy and cultural history. This volume provides an engaging introduction to all aspects of his work, including his method and purpose in writing the Lives, his attitudes toward daily life and intimate relations, his thoughts on citizenship and government, his relationship to Plato and the second Sophistic, and his conception of foreign or 'other'. Attention is also paid to his style and rhetoric. Plutarch's works have also been important in subsequent periods, and an introduction to their reception history in Byzantium, Italy, England, Spain, and France is provided. A distinguished team of contributors together helps the reader begin to navigate this most varied and fascinating of writers.

Plutarch is one of the most prolific and important writers from antiquity. His Parallel Lives continue to be an invaluable historical source, and the numerous essays in his Moralia, covering everything from marriage to the Delphic Oracle, are crucial evidence for ancient philosophy and cultural history. This volume provides an engaging introduction to all aspects of his work, including his method and purpose in writing the Lives, his attitudes toward daily life and intimate relations, his thoughts on citizenship and government, his relationship to Plato and the second Sophistic, and his conception of foreign or 'other'. Attention is also paid to his style and rhetoric. Plutarch's works have also been important in subsequent periods, and an introduction to their reception history in Byzantium, Italy, England, Spain, and France is provided. A distinguished team of contributors together helps the reader begin to navigate this most varied and fascinating of writers.

The book focuses on original approaches intended to support the development of biologically inspired cognitive architectures. It bridges together different disciplines, from classical artificial intelligence to linguistics, from neuro- and social sciences to design and creativity, among others. The chapters, based on contributions presented at the Eleventh Annual Meeting of the BICA Society, held on November 10-14, 2020, in Natal, Brazil, discuss emerging methods, theories and ideas towards the realization of general-purpose humanlike artificial intelligence or fostering a better understanding of the ways the human mind works. All in all, the book provides engineers, mathematicians, psychologists, computer scientists and other experts with a timely snapshot of recent research and a source of inspiration for future developments in the broadly intended areas of artificial intelligence and biological inspiration.

The book focuses on original approaches intended to support the development of biologically inspired cognitive architectures. It bridges together different disciplines, from classical artificial intelligence to linguistics, from neuro- and social sciences to design and creativity, among others. The chapters, based on contributions presented at the Tenth Annual Meeting of the BICA Society, held in on August 15-18, 2019, in Seattle, WA, USA, discuss emerging methods, theories and ideas towards the realization of general-purpose humanlike artificial intelligence or fostering a better understanding of the ways the human mind works. All in all, the book provides engineers, mathematicians, psychologists, computer scientists and other experts with a timely snapshot of recent research and a source of inspiration for future developments in the broadly intended areas of artificial intelligence and biological inspiration.

The book focuses on original approaches intended to support the development of biologically inspired cognitive architectures. It bridges together different disciplines, from classical artificial intelligence to linguistics, from neuro- and social sciences to design and creativity, among others. The chapters, based on contributions presented at the Ninth Annual Meeting of the BICA Society, held in on August 23-24, 2018, in Prague, Czech Republic, discuss emerging methods, theories and ideas towards the realization of general-purpose humanlike artificial intelligence or fostering a better understanding of the ways the human mind works. All in all, the book provides engineers, mathematicians, psychologists, computer scientists and other experts with a timely snapshot of recent research and a source of inspiration for future developments in the broadly intended areas of artificial intelligence and biological inspiration.

This book presents multiple new and classical methods for studying the vital poly-ADP-ribose (pADPr) pathway. Beginning with techniques for the detection and quantification of the product of poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection of variation in pADPr production during the cell cycle, the volume continues with sections on the identification of pADPr protein acceptors, methods focusing on studying molecular mechanisms of PARP functions in eukaryotic cells, particularly those involved in control of DNA repair and oxidative stress, as well as in expression regulation, approaches to the in vitro reconstitution of PARP-1 interaction with chromatin, the development and testing of small molecule PARP inhibitors, and the functions of understudied members of PARP family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods and Protocols, Second Edition serves as an ideal companion to the first edition for scientists whose investigations involve this important pathway. The chapter 'Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach' is published open access under a CC BY 4.0 license.

This book includes papers from the second year of the prestigious First International Early Research Career Enhancement School (FIERCES) series: a successful, new format that puts a school in direct connection with a conference and a social program, all dedicated to young scientists. Reflecting the friendly, social atmosphere of excitement and opportunity, the papers represent a good mixture of cutting-edge research focused on advances towards the most inspiring challenges of our time and first ambitious attempts at major challenges by as yet unknown, talented young scientists. In this second year of FIERCES, the BICA Challenge (to replicate all the essential aspects of the human mind in the digital environment) meets the Cybersecurity Challenge (to protect all the essential assets of the human mind in the digital environment), which is equally important in our age. As a result, the book fosters lively discussions on today's hot topics in science and technology, and stimulates the emergence of new cross-disciplinary, cross-generation and cross-cultural collaboration. FIERCES 2017, or the First International Early Research Career Enhancement School on Biologically Inspired Cognitive Architectures and Cybersecurity, was held on August 1-5 at the Baltschug Kempinski in Moscow, Russia.

This book presents multiple new and classical methods for studying the vital poly-ADP-ribose (pADPr) pathway. Beginning with techniques for the detection and quantification of the product of poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection of variation in pADPr production during the cell cycle, the volume continues with sections on the identification of pADPr protein acceptors, methods focusing on studying molecular mechanisms of PARP functions in eukaryotic cells, particularly those involved in control of DNA repair and oxidative stress, as well as in expression regulation, approaches to the in vitro reconstitution of PARP-1 interaction with chromatin, the development and testing of small molecule PARP inhibitors, and the functions of understudied members of PARP family. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods and Protocols, Second Edition serves as an ideal companion to the first edition for scientists whose investigations involve this important pathway. The chapter 'Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach' is published open access under a CC BY 4.0 license.

Poly (ADP-ribose) Polymerases (PARPs) are abundant and ubiquitous proteins that regulate crucial processes of the cell cycle, DNA repair, genomic stability, and transcriptional regulation. Being involved in basic cell functions, PARPs mediate rapid responses to such environmental factors as stress, infection, nutrition and hormonal signals. Whereas PARP inhibitors can suppress tumor growth and proliferation in certain breast, ovarian, and prostate cancers, understanding how PARP controls cellular functions is essential for the development of novel cancer treatments strategies. Divided into three convenient sections, Poly(ADP-Ribose) Polymerase: Methods and Protocols aims to explain how PARP proteins act within the normal development of an organism as well as in pathogenic conditions, seeks to advance the knowledge of developmental pathways regulation, and endeavors to facilitate the development of new therapeutic drugs and methods to target PARP-dependent processes. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Poly(ADP-Ribose) Polymerase: Methods and Protocols serves as an ideal guide to scientists who wish to continue exploring this exciting and progressive research field.

This book presents cutting-edge research focused on current challenges towards the realization of Biologically Inspired intelligent agents, or Cognitive Architectures (BICA). The chapters are written by both world-recognized experts (including Antonio Chella, Olivier Georgeon, Oliver Kutz, Antonio Lieto, David Vernon, Paul Verschure, and others) and young researchers. Together, they constitute a good mixture of new findings with tutorial-based reviews and position papers, all presented at the First International Early Research Career Enhancement School on Biologically Inspired Cognitive Architectures (FIERCES on BICA 2016), held April 21-24 in Moscow, Russia. Most works included here cross boundaries between disciplines: from neuroscience to social science, from cognitive science to robotics, and from bioengineering to artificial intelligence. A special emphasis is given to novel solutions to urgent problems that have been resisting traditional approaches for decades. Intended for providing readers with an update on biologically inspired approaches towards the computational replication of all the essential aspects of the human mind (the BICA Challenge), this book is expected to foster lively discussions on the topic and stimulate cross-disciplinary, cross-generation and cross-cultural collaboration.

Poly (ADP-ribose) Polymerases (PARPs) are abundant and ubiquitous proteins that regulate crucial processes of the cell cycle, DNA repair, genomic stability, and transcriptional regulation. Being involved in basic cell functions, PARPs mediate rapid responses to such environmental factors as stress, infection, nutrition and hormonal signals. Whereas PARP inhibitors can suppress tumor growth and proliferation in certain breast, ovarian, and prostate cancers, understanding how PARP controls cellular functions is essential for the development of novel cancer treatments strategies. Divided into three convenient sections, Poly(ADP-Ribose) Polymerase: Methods and Protocols aims to explain how PARP proteins act within the normal development of an organism as well as in pathogenic conditions, seeks to advance the knowledge of developmental pathways regulation, and endeavors to facilitate the development of new therapeutic drugs and methods to target PARP-dependent processes. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Poly(ADP-Ribose) Polymerase: Methods and Protocols serves as an ideal guide to scientists who wish to continue exploring this exciting and progressive research field.

This volume explores the challenges of educating professionals to succeed in a complex, uncertain and global business world. The book contains intellectual concepts and practical advice from leaders in innovative education around the globe. It will help educators and the educational enterprise become more innovative, efficient, and effective in addressing the teaching/learning challenges associated with helping students prepare to face their own challenges.

This volume explores the challenges of educating professionals to succeed in a complex, uncertain and global business world. The book contains intellectual concepts and practical advice from leaders in innovative education around the globe. It will help educators and the educational enterprise become more innovative, efficient, and effective in addressing the teaching/learning challenges associated with helping students prepare to face their own challenges.

Rapid development of Earth observation satellite using remote sensing techniques enables observations of the oceanic processes by sea and airborne study to be carried out over vast areas in a short time. This first book written by Russian and Norwegian scientists is an analysis of studies of the Kara Sea and presents a unique catalogue of environmental and pollution data of the joint Norwegian and Russian oceanographic expedition studies of the Kara Sea spanning three decades.

This is a monograph on the fluctuational theory of superconductivity. The theory was originally developed by M. A. Savchenko in 1964 in response to the work of B. T. Matthias, the discoverer of superconductive compounds. Further development of the theory led to the prediction of the existence of high-temperature superconductors among magnetic and nonmagnetic compounds of rare-earth metals, ceramics, and polymers. In 1987 this prediction was experimentally verified by the discovery of high-Tc superconducting rare-earth metal oxides by I. Bednorz and K. Muller. To date, this is the only account that explains consistently all the available data. The theory of high-temperature superconductivity is based on the concept of an enhanced electron-phonon interaction which leads to an attraction between electrons forming superconducting pairs. This interaction is due to the exchange spin fluctu ations (exchange enhancement effect). In compounds in which there is no magnetic ordering except at very low temperatures, such as in rare-earth metal oxides, the electron-phonon interaction is strengthened due to fluctuations in the spins of the conducting electrons. If there is magnetic ordering in a superconductor at a tempera ture higher than or of the same order as the critical superconducting temperature Tc, then the attraction in the electron pairs will be further increased because the Coulomb repulsion is overwhelmed by fluctuations in the spins forming the long-range anti fer romagnetic order.

This detailed volume explores poly(ADP-ribose) polymerases (PARPs) in the biology of eukaryotes and their relevance to human health. Beginning with a section on the detection and quantification of poly(ADP-ribose) polymer (pADPr), the book continues by delving into the identification of protein targets, functional analysis, the poly(ADP-ribosyl)ating pathway in chromatin and genes expression, as well as the use of animal models and PARP1 inhibitor design and testing, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Poly(ADP-Ribose) Polymerase: Methods and Protocols, Third Edition presents essential new and classical methods for studying the pADPr-pathway.

Protein Physics is a lively presentation of the most general problems of protein structure, folding and function from the physics and chemistry perspective, based on lectures given by the authors. It deals with fibrous, membrane and, most of all, with the best studied water-soluble globular proteins, in both their native and denatured states. The major aspects of protein physics are covered systematically, physico-chemical properties of polypeptide chains; their secondary structures; tertiary structures of proteins and their classification; conformational transitions in protein molecules and their folding; intermediates of protein folding; folding nuclei; physical backgrounds of coding the protein structures by their amino acid sequences and protein functions in relation to the protein structure. The book will be of interest to undergraduate and graduate level students and researchers of biophysics, biochemistry, biology and material science.
* Designed for a wide audience of undergraduate and graduate students, as well as being a reference for researchers in academia and industry
* Covers the most general problems of protein structure, folding, and function and introduces the key concepts and theories
* Deals with fibrous, membrane and especially water-soluble globular proteins, in both their native and denatured states
* Summarizes and presents in a systematic form the results of several decades of world wide fundamental research on protein physics, structure and folding
* Examines experimental data on protein structure in the post-genome era

Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry.