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This book presents multiple new and classical methods for studying
the vital poly-ADP-ribose (pADPr) pathway. Beginning with
techniques for the detection and quantification of the product of
poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection
of variation in pADPr production during the cell cycle, the volume
continues with sections on the identification of pADPr protein
acceptors, methods focusing on studying molecular mechanisms of
PARP functions in eukaryotic cells, particularly those involved in
control of DNA repair and oxidative stress, as well as in
expression regulation, approaches to the in vitro reconstitution of
PARP-1 interaction with chromatin, the development and testing of
small molecule PARP inhibitors, and the functions of understudied
members of PARP family. Written for the highly successful Methods
in Molecular Biology series, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods
and Protocols, Second Edition serves as an ideal companion to the
first edition for scientists whose investigations involve this
important pathway. The chapter 'Identifying and Validating
Tankyrase Binders and Substrates: A Candidate Approach' is
published open access under a CC BY 4.0 license.
Poly (ADP-ribose) Polymerases (PARPs) are abundant and ubiquitous
proteins that regulate crucial processes of the cell cycle, DNA
repair, genomic stability, and transcriptional regulation. Being
involved in basic cell functions, PARPs mediate rapid responses to
such environmental factors as stress, infection, nutrition and
hormonal signals. Whereas PARP inhibitors can suppress tumor growth
and proliferation in certain breast, ovarian, and prostate cancers,
understanding how PARP controls cellular functions is essential for
the development of novel cancer treatments strategies. Divided into
three convenient sections, Poly(ADP-Ribose) Polymerase: Methods and
Protocols aims to explain how PARP proteins act within the normal
development of an organism as well as in pathogenic conditions,
seeks to advance the knowledge of developmental pathways
regulation, and endeavors to facilitate the development of new
therapeutic drugs and methods to target PARP-dependent processes.
Written in the highly successful Methods in Molecular Biology (TM)
series format, chapters contain introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and notes
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Poly(ADP-Ribose) Polymerase: Methods and Protocols
serves as an ideal guide to scientists who wish to continue
exploring this exciting and progressive research field.
Rapid development of Earth observation satellite using remote sensing techniques enables observations of the oceanic processes by sea and airborne study to be carried out over vast areas in a short time. This first book written by Russian and Norwegian scientists is an analysis of studies of the Kara Sea and presents a unique catalogue of environmental and pollution data of the joint Norwegian and Russian oceanographic expedition studies of the Kara Sea spanning three decades.
This detailed volume explores poly(ADP-ribose) polymerases (PARPs)
in the biology of eukaryotes and their relevance to human health.
Beginning with a section on the detection and quantification of
poly(ADP-ribose) polymer (pADPr), the book continues by delving
into the identification of protein targets, functional analysis,
the poly(ADP-ribosyl)ating pathway in chromatin and genes
expression, as well as the use of animal models and PARP1 inhibitor
design and testing, and more. Written for the highly successful
Methods in Molecular Biology series, chapters include introductions
to their respective topics, lists of the necessary materials and
reagents, step-by-step and readily reproducible laboratory
protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Poly(ADP-Ribose) Polymerase: Methods
and Protocols, Third Edition presents essential new and classical
methods for studying the pADPr-pathway.
This volume explores the challenges of educating professionals
to succeed in a complex, uncertain and global business world. The
book contains intellectual concepts and practical advice from
leaders in innovative education around the globe. It will help
educators and the educational enterprise become more innovative,
efficient, and effective in addressing the teaching/learning
challenges associated with helping students prepare to face their
own challenges.
Plutarch is one of the most prolific and important writers from
antiquity. His Parallel Lives continue to be an invaluable
historical source, and the numerous essays in his Moralia, covering
everything from marriage to the Delphic Oracle, are crucial
evidence for ancient philosophy and cultural history. This volume
provides an engaging introduction to all aspects of his work,
including his method and purpose in writing the Lives, his
attitudes toward daily life and intimate relations, his thoughts on
citizenship and government, his relationship to Plato and the
second Sophistic, and his conception of foreign or 'other'.
Attention is also paid to his style and rhetoric. Plutarch's works
have also been important in subsequent periods, and an introduction
to their reception history in Byzantium, Italy, England, Spain, and
France is provided. A distinguished team of contributors together
helps the reader begin to navigate this most varied and fascinating
of writers.
Plutarch is one of the most prolific and important writers from
antiquity. His Parallel Lives continue to be an invaluable
historical source, and the numerous essays in his Moralia, covering
everything from marriage to the Delphic Oracle, are crucial
evidence for ancient philosophy and cultural history. This volume
provides an engaging introduction to all aspects of his work,
including his method and purpose in writing the Lives, his
attitudes toward daily life and intimate relations, his thoughts on
citizenship and government, his relationship to Plato and the
second Sophistic, and his conception of foreign or 'other'.
Attention is also paid to his style and rhetoric. Plutarch's works
have also been important in subsequent periods, and an introduction
to their reception history in Byzantium, Italy, England, Spain, and
France is provided. A distinguished team of contributors together
helps the reader begin to navigate this most varied and fascinating
of writers.
The book focuses on original approaches intended to support the
development of biologically inspired cognitive architectures. It
bridges together different disciplines, from classical artificial
intelligence to linguistics, from neuro- and social sciences to
design and creativity, among others. The chapters, based on
contributions presented at the Eleventh Annual Meeting of the BICA
Society, held on November 10-14, 2020, in Natal, Brazil, discuss
emerging methods, theories and ideas towards the realization of
general-purpose humanlike artificial intelligence or fostering a
better understanding of the ways the human mind works. All in all,
the book provides engineers, mathematicians, psychologists,
computer scientists and other experts with a timely snapshot of
recent research and a source of inspiration for future developments
in the broadly intended areas of artificial intelligence and
biological inspiration.
The book focuses on original approaches intended to support the
development of biologically inspired cognitive architectures. It
bridges together different disciplines, from classical artificial
intelligence to linguistics, from neuro- and social sciences to
design and creativity, among others. The chapters, based on
contributions presented at the Tenth Annual Meeting of the BICA
Society, held in on August 15-18, 2019, in Seattle, WA, USA,
discuss emerging methods, theories and ideas towards the
realization of general-purpose humanlike artificial intelligence or
fostering a better understanding of the ways the human mind works.
All in all, the book provides engineers, mathematicians,
psychologists, computer scientists and other experts with a timely
snapshot of recent research and a source of inspiration for future
developments in the broadly intended areas of artificial
intelligence and biological inspiration.
The book focuses on original approaches intended to support the
development of biologically inspired cognitive architectures. It
bridges together different disciplines, from classical artificial
intelligence to linguistics, from neuro- and social sciences to
design and creativity, among others. The chapters, based on
contributions presented at the Ninth Annual Meeting of the BICA
Society, held in on August 23-24, 2018, in Prague, Czech Republic,
discuss emerging methods, theories and ideas towards the
realization of general-purpose humanlike artificial intelligence or
fostering a better understanding of the ways the human mind works.
All in all, the book provides engineers, mathematicians,
psychologists, computer scientists and other experts with a timely
snapshot of recent research and a source of inspiration for future
developments in the broadly intended areas of artificial
intelligence and biological inspiration.
This book presents multiple new and classical methods for studying
the vital poly-ADP-ribose (pADPr) pathway. Beginning with
techniques for the detection and quantification of the product of
poly(ADP-ribose) polymerase (PARP) enzymatic activity and detection
of variation in pADPr production during the cell cycle, the volume
continues with sections on the identification of pADPr protein
acceptors, methods focusing on studying molecular mechanisms of
PARP functions in eukaryotic cells, particularly those involved in
control of DNA repair and oxidative stress, as well as in
expression regulation, approaches to the in vitro reconstitution of
PARP-1 interaction with chromatin, the development and testing of
small molecule PARP inhibitors, and the functions of understudied
members of PARP family. Written for the highly successful Methods
in Molecular Biology series, chapters include introductions to
their respective topics, lists of the necessary materials and
reagents, step-by-step, readily reproducible laboratory protocols,
and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Poly(ADP-Ribose) Polymerase: Methods
and Protocols, Second Edition serves as an ideal companion to the
first edition for scientists whose investigations involve this
important pathway. The chapter 'Identifying and Validating
Tankyrase Binders and Substrates: A Candidate Approach' is
published open access under a CC BY 4.0 license.
This book includes papers from the second year of the prestigious
First International Early Research Career Enhancement School
(FIERCES) series: a successful, new format that puts a school in
direct connection with a conference and a social program, all
dedicated to young scientists. Reflecting the friendly, social
atmosphere of excitement and opportunity, the papers represent a
good mixture of cutting-edge research focused on advances towards
the most inspiring challenges of our time and first ambitious
attempts at major challenges by as yet unknown, talented young
scientists. In this second year of FIERCES, the BICA Challenge (to
replicate all the essential aspects of the human mind in the
digital environment) meets the Cybersecurity Challenge (to protect
all the essential assets of the human mind in the digital
environment), which is equally important in our age. As a result,
the book fosters lively discussions on today's hot topics in
science and technology, and stimulates the emergence of new
cross-disciplinary, cross-generation and cross-cultural
collaboration. FIERCES 2017, or the First International Early
Research Career Enhancement School on Biologically Inspired
Cognitive Architectures and Cybersecurity, was held on August 1-5
at the Baltschug Kempinski in Moscow, Russia.
Poly (ADP-ribose) Polymerases (PARPs) are abundant and ubiquitous
proteins that regulate crucial processes of the cell cycle, DNA
repair, genomic stability, and transcriptional regulation. Being
involved in basic cell functions, PARPs mediate rapid responses to
such environmental factors as stress, infection, nutrition and
hormonal signals. Whereas PARP inhibitors can suppress tumor growth
and proliferation in certain breast, ovarian, and prostate cancers,
understanding how PARP controls cellular functions is essential for
the development of novel cancer treatments strategies. Divided into
three convenient sections, Poly(ADP-Ribose) Polymerase: Methods and
Protocols aims to explain how PARP proteins act within the normal
development of an organism as well as in pathogenic conditions,
seeks to advance the knowledge of developmental pathways
regulation, and endeavors to facilitate the development of new
therapeutic drugs and methods to target PARP-dependent processes.
Written in the highly successful Methods in Molecular Biology (TM)
series format, chapters contain introductions to their respective
topics, lists of the necessary materials and reagents,
step-by-step, readily reproducible laboratory protocols, and notes
on troubleshooting and avoiding known pitfalls. Authoritative and
accessible, Poly(ADP-Ribose) Polymerase: Methods and Protocols
serves as an ideal guide to scientists who wish to continue
exploring this exciting and progressive research field.
This book presents cutting-edge research focused on current
challenges towards the realization of Biologically Inspired
intelligent agents, or Cognitive Architectures (BICA). The chapters
are written by both world-recognized experts (including Antonio
Chella, Olivier Georgeon, Oliver Kutz, Antonio Lieto, David Vernon,
Paul Verschure, and others) and young researchers. Together, they
constitute a good mixture of new findings with tutorial-based
reviews and position papers, all presented at the First
International Early Research Career Enhancement School on
Biologically Inspired Cognitive Architectures (FIERCES on BICA
2016), held April 21-24 in Moscow, Russia. Most works included here
cross boundaries between disciplines: from neuroscience to social
science, from cognitive science to robotics, and from
bioengineering to artificial intelligence. A special emphasis is
given to novel solutions to urgent problems that have been
resisting traditional approaches for decades. Intended for
providing readers with an update on biologically inspired
approaches towards the computational replication of all the
essential aspects of the human mind (the BICA Challenge), this book
is expected to foster lively discussions on the topic and stimulate
cross-disciplinary, cross-generation and cross-cultural
collaboration.
This volume explores the challenges of educating professionals
to succeed in a complex, uncertain and global business world. The
book contains intellectual concepts and practical advice from
leaders in innovative education around the globe. It will help
educators and the educational enterprise become more innovative,
efficient, and effective in addressing the teaching/learning
challenges associated with helping students prepare to face their
own challenges.
This is a monograph on the fluctuational theory of
superconductivity. The theory was originally developed by M. A.
Savchenko in 1964 in response to the work of B. T. Matthias, the
discoverer of superconductive compounds. Further development of the
theory led to the prediction of the existence of high-temperature
superconductors among magnetic and nonmagnetic compounds of
rare-earth metals, ceramics, and polymers. In 1987 this prediction
was experimentally verified by the discovery of high-Tc
superconducting rare-earth metal oxides by I. Bednorz and K.
Muller. To date, this is the only account that explains
consistently all the available data. The theory of high-temperature
superconductivity is based on the concept of an enhanced
electron-phonon interaction which leads to an attraction between
electrons forming superconducting pairs. This interaction is due to
the exchange spin fluctu ations (exchange enhancement effect). In
compounds in which there is no magnetic ordering except at very low
temperatures, such as in rare-earth metal oxides, the
electron-phonon interaction is strengthened due to fluctuations in
the spins of the conducting electrons. If there is magnetic
ordering in a superconductor at a tempera ture higher than or of
the same order as the critical superconducting temperature Tc, then
the attraction in the electron pairs will be further increased
because the Coulomb repulsion is overwhelmed by fluctuations in the
spins forming the long-range anti fer romagnetic order.
Protein Physics is a lively presentation of the most general
problems of protein structure, folding and function from the
physics and chemistry perspective, based on lectures given by the
authors. It deals with fibrous, membrane and, most of all, with the
best studied water-soluble globular proteins, in both their native
and denatured states. The major aspects of protein physics are
covered systematically, physico-chemical properties of polypeptide
chains; their secondary structures; tertiary structures of proteins
and their classification; conformational transitions in protein
molecules and their folding; intermediates of protein folding;
folding nuclei; physical backgrounds of coding the protein
structures by their amino acid sequences and protein functions in
relation to the protein structure. The book will be of interest to
undergraduate and graduate level students and researchers of
biophysics, biochemistry, biology and material science.
* Designed for a wide audience of undergraduate and graduate
students, as well as being a reference for researchers in academia
and industry
* Covers the most general problems of protein structure, folding,
and function and introduces the key concepts and theories
* Deals with fibrous, membrane and especially water-soluble
globular proteins, in both their native and denatured states
* Summarizes and presents in a systematic form the results of
several decades of world wide fundamental research on protein
physics, structure and folding
* Examines experimental data on protein structure in the
post-genome era
Protein Physics: A Course of Lectures covers the most general
problems of protein structure, folding and function. It describes
key experimental facts and introduces concepts and theories,
dealing with fibrous, membrane, and water-soluble globular
proteins, in both their native and denatured states. The book
systematically summarizes and presents the results of several
decades of worldwide fundamental research on protein physics,
structure, and folding, describing many physical models that help
readers make estimates and predictions of physical processes that
occur in proteins. New to this revised edition is the inclusion of
novel information on amyloid aggregation, natively disordered
proteins, protein folding in vivo, protein motors, misfolding,
chameleon proteins, advances in protein engineering & design,
and advances in the modeling of protein folding. Further, the book
provides problems with solutions, many new and updated references,
and physical and mathematical appendices. In addition, new figures
(including stereo drawings, with a special appendix showing how to
use them) are added, making this an ideal resource for graduate and
advanced undergraduate students and researchers in academia in the
fields of biophysics, physics, biochemistry, biologists,
biotechnology, and chemistry.
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