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This is an in-depth look at 50 different spices and their curative
qualities. It offers spice 'prescriptions' to match the right spice
to a specific ailment. It is written by the world's foremost expert
of the therapeutic use of culinary spices. Breakthrough scientific
research is finding that spices, even more than herbs, fruits and
vegetables, are loaded with antioxidants and other unique
health-enhancing compounds. Studies of dietary patterns around the
world confirm that spice-consuming populations have the lowest
incidence of such life-threatening illnesses as heart disease,
cancer, diabetes and Alzheimer's. Bharat B. Aggarwal, the world's
foremost expert on the therapeutic use of culinary spices, taken an
in-depth look at 50 different spices and their curative qualities
and also offers spice 'prescriptions', categorised by health
condition, to match the right spice to a specific ailment.
Most therapeutics available today are highly toxic, very expensive
and exhibit minimum efficacy. The issue of toxicity is even more
critical for prevention than for therapy because the former
involves normal subjects. Thus, therapeutics that are safe and
affordable are needed for both prevention and therapy. Spices of
Southeast Asian origin, once employed for taste, appearance and
preservation of food, now appear to have therapeutic value for
humans. What the active principles in these spices are and how they
mediate their effect against various diseases are beginning to
emerge from extensive research carried out within the last
half-century. The current monograph is an attempt to address the
active constituents, their molecular targets and the therapeutic
uses of these spices.
This comprehensive volume focuses on anti-inflammatory
nutraceuticals and their role in various chronic diseases. Food and
Drug Administration (FDA) approved drugs such as steroids,
non-steroidal anti-inflammatory drugs (NSAIDS), statins and
metformin have been shown to modulate inflammatory pathways, but
their long-term intake has been associated with numerous side
effects. This means that there is enormous potential for dietary
agents that can modulate inflammatory pathways in humans. Leading
experts describe the latest research on the role of
anti-inflammatory nutraceuticals in preventing and treating chronic
diseases.
Second comprehensive volume focuses on anti-inflammatory
nutraceuticals and their role in prevention and therapy of various
chronic diseases. Food and drug administration (FDA) approved drugs
such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS),
statins and metformin have been shown to modulate inflammatory
pathways, but their long-term intake has been associated with
numerous side effects. Thus dietary agents which can modulate
inflammatory pathways in humans, are likely to exhibit enormous
potential. Leading experts describe the latest results of
anti-inflammatory nutraceuticals and their role in prevention and
therapy of various chronic diseases.
Second comprehensive volume focuses on anti-inflammatory
nutraceuticals and their role in prevention and therapy of various
chronic diseases. Food and drug administration (FDA) approved drugs
such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS),
statins and metformin have been shown to modulate inflammatory
pathways, but their long-term intake has been associated with
numerous side effects. Thus dietary agents which can modulate
inflammatory pathways in humans, are likely to exhibit enormous
potential. Leading experts describe the latest results of
anti-inflammatory nutraceuticals and their role in prevention and
therapy of various chronic diseases.
In this book, clinicians and basic scientists from USA, India, and
other countries discuss the rationales and clinical experiences
with targeted approaches to treat, prevent, or manage cancer.
Cancer is a hyperproliferative disorder that is regulated by
multiple genes and multiple cell signaling pathways. Genomics,
proteomics, and metabolomics have revealed that dysregulation of
dozens of genes and their products occur in any given cell type
that ultimately leads to cancer. These discoveries are providing
unprecedented opportunities to tackle cancer by multi-faceted
approaches that target these underpinnings. This book emphasizes a
multi-targeted approach to treating cancer, the focus of the 5th
International Conference on Translational Cancer Research that was
held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.
This comprehensive volume focuses on anti-inflammatory
nutraceuticals and their role in various chronic diseases. Food and
Drug Administration (FDA) approved drugs such as steroids,
non-steroidal anti-inflammatory drugs (NSAIDS), statins and
metformin have been shown to modulate inflammatory pathways, but
their long-term intake has been associated with numerous side
effects. This means that there is enormous potential for dietary
agents that can modulate inflammatory pathways in humans. Leading
experts describe the latest research on the role of
anti-inflammatory nutraceuticals in preventing and treating chronic
diseases.
In this book, clinicians and basic scientists from USA, India, and
other countries discuss the rationales and clinical experiences
with targeted approaches to treat, prevent, or manage cancer.
Cancer is a hyperproliferative disorder that is regulated by
multiple genes and multiple cell signaling pathways. Genomics,
proteomics, and metabolomics have revealed that dysregulation of
dozens of genes and their products occur in any given cell type
that ultimately leads to cancer. These discoveries are providing
unprecedented opportunities to tackle cancer by multi-faceted
approaches that target these underpinnings. This book emphasizes a
multi-targeted approach to treating cancer, the focus of the 5th
International Conference on Translational Cancer Research that was
held in Vigyan Bhawan, Delhi (India) from Feb 6-9, 2014.
This volume examines in detail the role of chronic inflammatory
processes in the development of several types of cancer. Leading
experts describe the latest results of molecular and cellular
research on infection, cancer-related inflammation and
tumorigenesis. Further, the clinical significance of these findings
in preventing cancer progression and approaches to treating the
diseases are discussed. Individual chapters cover cancer of the
lung, colon, breast, brain, head and neck, pancreas, prostate,
bladder, kidney, liver, cervix and skin as well as gastric cancer,
sarcoma, lymphoma, leukemia and multiple myeloma.
The interaction of immune function and nutrition underlies the
low-grade chronic inflammation involved in the etiology of many
common obesity-associated and age-related chronic disease
conditions. This close interaction is the genesis of the term
immunonutrition, which represents a new interdisciplinary field of
nutritional and medical research. Immunonutrition: Interactions of
Diet, Genetics, and Inflammation introduces the breadth of this
field, which implicates nutrition in both immune function and in
the etiology, prevention, and treatment of common diseases
influenced by inflammation and immune imbalance, including obesity,
diabetes, heart disease, asthma, autoimmune diseases, and common
forms of cancer. The book begins by reviewing the basic mechanisms
of immunity and cellular mechanisms of cytokine activation. It
discusses the effects of dietary fat intake and changes in Western
diet and lifestyle linked to inflammation. It also describes the
interaction of genetics and environment in the modulation of immune
function and inflammation, and addresses exercise and skeletal
muscle as an endocrine and immune organ. The book reviews the
entire spectrum of inflammation and cancer from causation to its
role in tumor therapy. It examines abdominal obesity and metabolic
diseases, interactions between nutrition and autoimmunity in
systemic lupus erythematosus and rheumatoid arthritis, and
inflammation associated with type 2 diabetes, heart disease, kidney
disease, Alzheimer's disease, and asthma. Considering potential
nutrition-based treatments, the book explores approaches for
reducing abdominal obesity, anti-inflammatory effects of
phytochemicals, practical strategies for increasing fruit and
vegetable intake, and anti-inflammatory properties of spice
phytonutrients. In addition, it explores how uninformed food
choices related to fats and oils create a balance of
tissue-selective signals that produce harmful health outcomes and
how to restore a healthy balance.
Oxidative stress and inflammation are among the most important
factors of disease. Chronic infections, obesity, alcohol and
tobacco usage, radiation, environmental pollutants, and
high-calorie diets have been recognized as major risk factors for a
variety of chronic diseases from cancer to metabolic diseases. All
these risk factors are linked to chronic diseases through
inflammation. While short-term, acute inflammation generated by the
immune system serves a therapeutic role, chronic low-level
inflammation that may persist "silently" for decades is responsible
for chronic diseases. Inflammation, Lifestyle, and Chronic
Diseases: The Silent Link describes the role of dysregulated
inflammation in persistent and recurring diseases. It investigates
links to lifestyle and presents research on how the suppression of
proinflammatory pathways may provide opportunities for both
prevention and treatment of chronic diseases. The book covers
neurodegenerative diseases, pulmonary diseases, asthma, rheumatic
and arthritic diseases, skin disease, heart disease, chronic
wounds, infectious disease, neuropsychiatric disorders such as
depression, gastrointestinal diseases, insulin resistance, and
cancer, many of which are also diseases of old age. For each
chronic disease, contributors review the clinical and scientific
literature and examine current and potential therapies, including
conventional pharmacotherapies as well as natural products. Noting
that the long-term use of steroids and nonsteroidal
anti-inflammatory drugs (NSAIDs) can cause adverse side effects,
many of the chapters address the role of dietary agents such as
fruits, vegetables, legumes, pulses, nuts, and spices as ideal
anti-inflammatory agents that can be consumed regularly. The book
also suggests directions for further research. Clinical and science
researchers, students, and health professionals interested in the
link between inflammation, lifestyle, and chronic diseases will
find this an informative resource.
The medicinal uses of Curcumin (also called turmeric) have been
known and described for more than 5000 years. A large body of
recent research suggests that curcumin is potentially useful in the
treatment of inflammatory diseases, through modulation of numerous
molecular targets. This is the first monograph to focus on the
potential use of curcumin in the treatment of cancer, diabetes,
cardiovascular diseases, arthritis, Alzheimer s, psoriasis and
more.
Turmeric belongs to the family Zingiberaceae and is a yellow spice
of high economic importance due to its medicinal value. Cultivated
in tropical and sub-tropical regions around the world, it is used
extensively as a colouring, flavouring and preserving agent. In
recent years, several drugs derived from natural products have been
developed and current drug research is actively investigating the
possible therapeutic roles of many Ayurvedic medicines, most
notable among those being examined is turmeric. The wide range of
pharmacological activities attributed to turmeric come mainly from
curcuminoids and two related compounds, demethoxycurcumin and
bisdemethoxycurcumin. This comprehensive book brings together the
research carried out on constituents obtained from turmeric and
highlights their chemical and biological activities. Comprising 17
chapters, each written by experts in their respective field and
curated by authorities, it will be invaluable to all those who are
involved in the production, processing, marketing, and the use of
turmeric. Appealing to researchers and professionals in natural
products, nutraceuticals and food chemists, this book is exposing
some of the myths and showing areas for possible future use.
Recent advances in cytotoxins and immunotoxins are accelerating our
understanding of cancer and leading to more effective therapeutic
treatments. Although a large number of articles have been published
on these cytotoxins and immunotoxins, this important information
has yet to be compiled into one comprehensive resource. For the
first time, Cytotoxins and Immunotoxins for Cancer Therapy:
Clinical Applications presents state-of-the-art information on
various cytotoxins and immunotoxins in a single, highly anticipated
publication. The editors bring together leading researchers to
summarize their work and discuss clinical trial data concerning
some of the most widely studied tumors. The book describes
Pseudomonas exotoxin (PE)-based immunotoxins and presents the
latest results from clinical trials for the treatment of recurrent
glioblastoma and other human cancers. It reviews the role of
ricin-based immunotoxins for the treatment of lymphoma, explores
several DT-based immunotoxins, and details the preclinical and
clinical development of the first FDA-approved cytotoxin. With a
focus on clinical developmental approaches to the use of cytotoxins
and immunotoxins, this book discusses exciting possibilities for
cancer therapy. It is a valuable resource for scientists,
researchers, and clinicians involved in the development of new
treatments that can help keep cancer under control, and may
ultimately lead to a cure.
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