Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the "setpoint" andcorresponds to values between 0.3-3M. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

The (ISC)(2) (R) Systems Security Certified Practitioner (SSCP (R)) certification is one of the most important credentials an information security practitioner can have. Having helped thousands of people around the world obtain this distinguished certification, the bestselling Official (ISC)2 Guide to the SSCP CBK (R) has quickly become the book that many of today's security practitioners depend on to attain and maintain the required competence in the seven domains of the (ISC)(2) CBK. Picking up where the popular first edition left off, the Official (ISC)2 Guide to the SSCP CBK, Second Edition brings together leading IT security tacticians from around the world to discuss the critical role that policy, procedures, standards, and guidelines play within the overall information security management infrastructure. Offering step-by-step guidance through the seven domains of the SSCP CBK, the text: Presents widely recognized best practices and techniques used by the world's most experienced administrators Uses accessible language, bulleted lists, tables, charts, and diagrams to facilitate a clear understanding Prepares you to join the thousands of practitioners worldwide who have obtained (ISC)(2) certification Through clear descriptions accompanied by easy-to-follow instructions and self-assessment questions, this book will help you establish the product-independent understanding of information security fundamentals required to attain SSCP certification. Following certification it will be a valuable guide to addressing real-world security implementation challenges.

Considered the gold-standard reference on information security, the Information Security Management Handbook provides an authoritative compilation of the fundamental knowledge, skills, techniques, and tools required of today's IT security professional. Now in its sixth edition, this 3200 page, 4 volume stand-alone reference is organized under the CISSP Common Body of Knowledge domains and has been updated yearly. Each annual update, the latest is Volume 6, reflects the changes to the CBK in response to new laws and evolving technology.

The shifting balance of economic power away from Western Europe and the United States and towards East and Southeast Asia - firstly Japan, then the small 'Tiger' economies, and now the larger nations of Southeast Asia and China, the potential 'Dragons' - has provoked anger, dismay and a search for the 'secrets' of growth and for 'lessons' to be learned. The Rise of Asia brings together recent scholarship analysing the process of economic, social and political development in East and Southeast Asia from the mid-nineteenth century to the present day.

Updated annually, the Information Security Management Handbook, Sixth Edition, Volume 6 is the most comprehensive and up-to-date reference available on information security and assurance. Bringing together the knowledge, skills, techniques, and tools required of IT security professionals, it facilitates the up-to-date understanding required to stay one step ahead of evolving threats, standards, and regulations. Reporting on the latest developments in information security and recent changes to the (ISC)2 (R) CISSP Common Body of Knowledge (CBK (R)), this volume features new information on advanced persistent threats, HIPAA requirements, social networks, virtualization, and SOA. Its comprehensive coverage touches on all the key areas IT security professionals need to know, including: Access Control: Technologies and administration including the requirements of current laws Telecommunications and Network Security: Addressing the Internet, intranet, and extranet Information Security and Risk Management: Organizational culture, preparing for a security audit, and the risks of social media Application Security: Ever-present malware threats and building security into the development process Security Architecture and Design: Principles of design including zones of trust Cryptography: Elliptic curve cryptosystems, format-preserving encryption Operations Security: Event analysis Business Continuity and Disaster Recovery Planning: Business continuity in the cloud Legal, Regulations, Compliance, and Investigation: Persistent threats and incident response in the virtual realm Physical Security: Essential aspects of physical security The ubiquitous nature of computers and networks will always provide the opportunity and means to do harm. This edition updates its popular predecessors with the information you need to address the vulnerabilities created by recent innovations such as cloud computing, mobile banking, digital wallets, and near-field communications. This handbook is also available on CD.

Updated annually, the Information Security Management Handbook, Sixth Edition, Volume 6 is the most comprehensive and up-to-date reference available on information security and assurance. Bringing together the knowledge, skills, techniques, and tools required of IT security professionals, it facilitates the up-to-date understanding required to stay one step ahead of evolving threats, standards, and regulations. Reporting on the latest developments in information security and recent changes to the (ISC)2 (R) CISSP Common Body of Knowledge (CBK (R)), this volume features new information on advanced persistent threats, HIPAA requirements, social networks, virtualization, and SOA. Its comprehensive coverage touches on all the key areas IT security professionals need to know, including: Access Control: Technologies and administration including the requirements of current laws Telecommunications and Network Security: Addressing the Internet, intranet, and extranet Information Security and Risk Management: Organizational culture, preparing for a security audit, and the risks of social media Application Security: Ever-present malware threats and building security into the development process Security Architecture and Design: Principles of design including zones of trust Cryptography: Elliptic curve cryptosystems, format-preserving encryption Operations Security: Event analysis Business Continuity and Disaster Recovery Planning: Business continuity in the cloud Legal, Regulations, Compliance, and Investigation: Persistent threats and incident response in the virtual realm Physical Security: Essential aspects of physical security The ubiquitous nature of computers and networks will always provide the opportunity and means to do harm. This edition updates its popular predecessors with the information you need to address the vulnerabilities created by recent innovations such as cloud computing, mobile banking, digital wallets, and near-field communications. This handbook is also available on CD.

Updated annually to keep up with the increasingly fast pace of change in the field, the Information Security Management Handbook is the single most comprehensive and up-to-date resource on information security (IS) and assurance. Facilitating the up-to-date understanding required of all IS professionals, the Information Security Management Handbook, Sixth Edition, Volume 5 reflects the latest issues in information security and the CISSP (R) Common Body of Knowledge (CBK (R)). This edition updates the benchmark Volume 1 with a wealth of new information to help IS professionals address the challenges created by complex technologies and escalating threats to information security. Topics covered include chapters related to access control, physical security, cryptography, application security, operations security, and business continuity and disaster recovery planning. The updated edition of this bestselling reference provides cutting-edge reporting on mobile device security, adaptive threat defense, Web 2.0, virtualization, data leakage, governance, and compliance. Also available in a fully searchable CD-ROM format, it supplies you with the tools and understanding to stay one step ahead of evolving threats and ever-changing standards and regulations.

Every year, in response to new technologies and new laws in different countries and regions, there are changes to the fundamental knowledge, skills, techniques, and tools required by all IT security professionals. In step with the lightning-quick, increasingly fast pace of change in the technology field, the Information Security Management Handbook, updated yearly, has become the standard on which all IT security programs and certifications are based. It reflects new updates to the Common Body of Knowledge (CBK) that IT security professionals all over the globe need to know.

Captures the crucial elements of the CBK

Exploring the ten domains of the CBK, the book explores access control, telecommunications and network security, information security and risk management, application security, and cryptography. In addition, the expert contributors address security architecture and design, operations security, business continuity planning and disaster recovery planning. The book also covers legal regulations, compliance, investigation, and physical security. In this anthology of treatises dealing with the management and technical facets of information security, the contributors examine varied topics such as anywhere computing, virtualization, podslurping, quantum computing, mashups, blue snarfing, mobile device theft, social computing, voting machine insecurity, and format string vulnerabilities.

Also available on CD-ROM

Safeguarding information continues to be a crucial concern of all IT professionals. As new risks threaten the security of our systems, it is imperative that those charged with protecting that information continually update their armor of knowledge to guard against tomorrow's hackers and software vulnerabilities. This comprehensive Handbook, also available in fully searchable CD-ROM format keeps IT professionals abreast of new developments on the security horizon and reinforces timeless concepts, providing them with the best information, guidance, and counsel they can obtain.

A compilation of the fundamental knowledge, skills, techniques, and tools require by all security professionals, Information Security Handbook, Sixth Edition sets the standard on which all IT security programs and certifications are based. Considered the gold-standard reference of Information Security, Volume 2 includes coverage of each domain of the Common Body of Knowledge, the standard of knowledge required by IT security professionals worldwide. In step with the lightening-quick, increasingly fast pace of change in the technology field, this book is updated annually, keeping IT professionals updated and current in their field and on the job.

Every year, in response to advancements in technology and new laws in different countries and regions, there are many changes and updates to the body of knowledge required of IT security professionals. Updated annually to keep up with the increasingly fast pace of change in the field, the Information Security Management Handbook is the single most comprehensive and up-to-date resource on information security and assurance.

Providing an up-to-date compilation of the fundamental skills, techniques, tools, and understanding required of IT security professionals, the Information Security Management Handbook, Sixth Edition, Volume 4 reflects the latest changes to information security and the CISSP(r) Common Body of Knowledge (CBK(r)). This edition updates the benchmark Volume 1 with a wealth of new information on mobile device security, adaptive threat defense, Web 2.0, virtualization, data leakage, and governance. New material also addresses risk management, business continuity planning, disaster recovery planning, and cryptography.

As the risks that threaten the security of our systems continue to evolve, it is imperative that those charged with protecting that information stay ahead of the curve. Also available in a fully searchable CD-ROM format, this comprehensive resource provides the up-to-date understanding required to keep you abreast of the latest developments, new vulnerabilities, and possible threats.

A compilation of the fundamental knowledge, skills, techniques, and tools require by all security professionals, Information Security Handbook, Sixth Edition sets the standard on which all IT security programs and certifications are based. Considered the gold-standard reference of Information Security, Volume 2 includes coverage of each domain of the Common Body of Knowledge, the standard of knowledge required by IT security professionals worldwide. In step with the lightening-quick, increasingly fast pace of change in the technology field, this book is updated annually, keeping IT professionals updated and current in their field and on the job.

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the "setpoint" andcorresponds to values between 0.3-3M. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Every year, in response to advancements in technology and new laws in different countries and regions, there are many changes and updates to the body of knowledge required of IT security professionals. Updated annually to keep up with the increasingly fast pace of change in the field, the Information Security Management Handbook is the single most comprehensive and up-to-date resource on information security and assurance. Providing an up-to-date compilation of the fundamental skills, techniques, tools, and understanding required of IT security professionals, the Information Security Management Handbook, Sixth Edition, Volume 4 reflects the latest changes to information security and the CISSP (R) Common Body of Knowledge (CBK (R)). This edition updates the benchmark Volume 1 with a wealth of new information on mobile device security, adaptive threat defense, Web 2.0, virtualization, data leakage, and governance. New material also addresses risk management, business continuity planning, disaster recovery planning, and cryptography. As the risks that threaten the security of our systems continue to evolve, it is imperative that those charged with protecting that information stay ahead of the curve. Also available in a fully searchable CD-ROM format, this comprehensive resource provides the up-to-date understanding required to keep you abreast of the latest developments, new vulnerabilities, and possible threats.