This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.

Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original text and artwork.

Methadone and buprenorphine are the only two opioids that are indicated for the management of both pain and opioid-related drug addiction. Both present unique challenges to the general practitioner and pain specialist, requiring a separate analysis from the rest of the drugs in the same family. Handbook of Methadone Prescribing and Buprenorphine Therapy is an invaluable guide to the safe use of these opioids. Authored by clinical and academic leaders from a variety of settings and backgrounds, this book includes chapters on pharmacology, adverse effects, safe rotation from other opioids, cardiac toxicity, prescribing, pharmacokinetics, equianalgesic dose and replacement therapy. This comprehensive text provides clinicians, researchers, policy-makers and academicians a resource for all the relevant points in methadone prescribing and buprenorphine therapy.

Written by a professional musician who is also a certified occupational therapist, Teaching Healthy Musicianship both helps music educators avoid common injuries that they themselves encounter and equips them with the tools they need to instill healthy musicianship practices in their students. Author Nancy Taylor combines her two unique skill sets to provide a model for injury prevention that is equally cognizant of the needs of music educators and their students. Through practical explanation of body mechanics, ergonomics, and the performance-related health problems and risk factors unique to musicianship, Taylor gives music educators the tools they need to first practice healthy posture, body mechanics, environmental safety, and ergonomics, and then to introduce these same practices to their students. Taylor also provides practical guidance for healthy musicianship practices in the wrists and shoulders, the most common site of music-related injuries. The final sections address issues of vocal and hearing health, both of which are at high risk in music classroom environments. Working from the dual observations that busy music teachers sometimes overlook taking care of themselves, and that music teachers are not always able to guide students through instrument-related stresses, Taylor provides here a book that addresses injury prevention for the music student and the music educator alike. Thoroughly illustrated with 125 photographs, Teaching Healthy Musicianship is a key resource for preservice and inservice teachers of middle school and high school band, orchestra, choir and general music.

This text contains the edited presentations of the 39th Annual Postgraduate Course in Anaesthesiology, February 1994. The chapters reflect new data concepts within the general framework of pain research and basic science, and clinical topics in pain management. The purpose of the textbook is to serve as a vehicle to bring many of the latest concepts in anaesthesiology to those who did not attend the conference, within a short time of the formal presentation. Each chapter is a brief by sharply focused glimpse of the current interests in anaesthesia. This volume, as well as past and future volumes, reflects the rapid and continuing evolution of anaesthestiology in the late-20th century.

For many of the millions of people who undergo anaesthesia each year, it is the source of great fear and fascination. In Counting Backwards, anaesthetist Henry Jay Przybylo has written an unforgettable account of the routine procedure's daily dramas and fundamental mysteries. Przybylo has administered anaesthesia more than 30,000 times on newborn babies, screaming toddlers and sullen teenagers, his own son and even a gorilla. With compassion and candour, he weaves his experiences into stories that explore the nature of consciousness, the politics of pain relief and the wonder of modern medicine. Through its intense and humane tales of mistakes, near-disasters, life-saving successes and moments of grace, Counting Backwards shines a light on a fascinating but unexplored corner of the medical world.

"Anaesthesia and the Lung 1992" presents recent advances in the diagnosis, pre-, intra-, and postoperative anaesthetic management of patients with lung disease, presenting for pulmonary and non-pulmonary surgery. It also deals with ventilation - perfusion issues, the lung as a metabolic organ, the effects of anaesthesia on pulmonary mechanics and pulmonary blood flow. In addition, there are chapters that focus on hypoxia; regional differences in the lung; pulmonary surfactant; recent advances in the understanding of pulmonary edema; high altitude disease; anaesthesia and the control of breathing; recent development in oximetry; instrumentation designed to measure pulmonary oxygen tension, pO2 and pCO2 transcutaneously; differential lung ventilation; reactive airways; septic shock; the adult respiratory distress syndrome and numerous aspects of ventilatory support.

This groundbreaking analysis moves our knowledge of pain and its effects from the biomedical model to one accounting for its complex psychosocial dimensions. Starting with its facial and physical display, pain is shown in its manifold social contexts-in the lifespan, in a family unit, expressed by a member of a gender and/or race-and as observed by others. These observations by caregivers and family are shown as vital to the social dynamic of pain-as observers react to sufferers' pain, and as these reactions affect those suffering. The book's findings should enhance practitioners' understanding of pain to develop more effective individualized treatments for clients' pain experience, and inspire researchers as well. Among the topics covered: Why do we care? Evolutionary mechanisms in the social dimension of pain. When, how, and why do we express pain? On the overlap between physical and social pain. Facing others in pain: why context matters. Caregiving impact upon sufferers' cognitive functioning. Targeting individual and interpersonal processes in therapeutic interventions for chronic pain. Social and Interpersonal Dynamics in Pain will be a valuable resource for clinicians who deal in pain practice and management, as well as for students and researchers interested in the social, interpersonal, and emotional variables that contribute to pain, the processes with which pain is associated, and the psychology of pain in general.

Peter J. Jannetta, the neurosurgeon/neuroscientist who has contributed so much to the evaluation and treatment of trigeminal neuralgia and other cranial nerve disorders brings together the most distinguished contributors in Trigeminal Neuralgia.
This seminal work collates and categorizes in one succinct volume what we understand about the various forms of face pain syndromes. By providing information on former beliefs, as well as current understanding, this book provides multiple options regarding diagnosis, medical treatment and operative intervention which will help decision making, develop knowledge and improve care of patients.
Trigeminal Neuralgia begins with an Introduction explaining where we were and what role those ideas have played in current thinking, all with the goal of giving the reader a basis for future thought. With each subsequent chapter - written by basic scientists and astute clinicians working in the area of facial pain - enigmas are clarified, solutions of apparently untreatable problems are presented, and a better understanding of how diagnoses and pathophysiology are evolving are presented.
This is a must read for all who would learn about neurogenic facial pain.

This book is of great significance for final year MBBS and postgraduate students of general surgery, orthopedics and anesthesia. It provides the basic knowledge needed to answer questions that are routinely asked in practical table viva examinations. It includes simple, comprehensive, condensed and pointwise information with illustrative diagrams wherever required. A comprehensive description of the instruments used in general surgery, orthopedics and anesthesia along with their photographs is a prominent feature of this book. Important major and minor general surgical procedures and commonly performed bedside procedures are described in a step-by-step approach. Some of the neglected, but important commonly-asked topics such as different types of surgical suture materials, surgical needles, perurethral, catheters, tubes, drains, intravenous fluids and intravenous cannulas are also covered in this book. The second edition also includes chapters on recent advances in general surgery such as laparoscopic surgery and robotic surgery. Common surgical emergencies presenting to the emergency room are also discussed in the second edition. The book covers all aspects of practical examination for undergraduates. Also helpful to the postgraduate students of general surgery, orthopedics and anesthesia. Identification points of the instruments and their uses are mentioned in each section. Discusses all surgical instruments used in general surgery and super specialty surgeries such as neurosurgery, urosurgery and plastic surgery along with illustrative photographs. Orthopedic implants used in different fractures are also discussed along with their photographs. Different sterilization procedures of every instrument are discussed in detail. Anesthesia section includes equipments for general as well as regional anesthesia. Commonly used drugs in anesthesia and emergency drugs are also described. Major and minor operative and bedside procedures in general surgery which are commonly asked in examinations are described in a step-by-step approach. Preoperative preparation of the patient prior to surgical procedures is described in detail. Different types of surgical suture materials, needles and the basic surgeries are discussed in the section of suture materials. Different types of perurethral catheter, tubes and drains used in general surgery are described. It covers the basic knowledge of different intravenous fluids and intravenous cannulas used in clinical practice. Includes chapters on recent advances in robotic surgery, instruments used for laparoscopic surgical procedures and a brief description of the energy sources in surgery. A chapter on approach to diagnose common surgical emergencies presenting at the emergency room and its subsequent management has been added.

Decision making regarding fluid volume loading, fluid restriction, or administration of vasoactive drugs may vary among physicians, depending solely upon their clinical experience in the absence of evidence-based measurement. The initial distribution volume of glucose (IDVG) is believed to be clinically relevant as a marker of cardiovascular and fluid management in critically ill patients without a significant modification of glucose metabolism. This book covers all aspects of IDVG measurement, including the basic concept, its relationship with other fluid volumes, and the clinical application of this technique in the intensive care unit based on both the authors studies and their clinical experience with more than 4000 IDVG determinations. When the concept of IDVG is properly understood and its measurement is then performed routinely, daily fluid and cardiovascular management in critically ill patients can be improved based on evidence-based measurement."

Indispensable for both the trainee and experienced professional, this is the only truly comprehensive account of the major role of the neurosurgeon in the diagnosis and treatment of chronic pain. The elite panel of contributors were chosen due to their expertise and international reputations. The result of their achievement covers the whole spectrum from criteria for patient selection and the details of operative techniques, to the risks, complications, and expected outcomes for a wide variety of anatomic, ablative, and augmentative neurosurgical procedures in treating chronic, intractable pain. The neurosurgeon will find here chapters on the latest neuroaugmentative advances utilizing electrical stimulation and implantable drug infusion systems as well as a useful section providing algorithms and guidelines for the evaluation and treatment of specific pain syndromes. Over 100 photographs and exquisite line drawings - many specifically commissioned for this book - enhance the text. Invaluable for acquiring the critical judgement and clinical skills necessary to apply the procedures involved.

Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences between sleep and anesthesia? To answer these questions, we may take a look at the neural origin of both effects and the involved physiological pathways. In which way do they resemble? Moreover, we ask what are the detailed features of normal sleep and general anesthesia as applied during surgery and which features exist in both phenomena? If yes in which way?

To receive answers to these questions, it is necessary to consider several experimental techniques that reveal underlying neural mechanisms of sleep and anesthesia. Moreover, theoretical models of neural activity may model both phenomena and comes up with predictions or even theories on the underlying mechanisms. Such models may attack several different description levels, from the microscopic level of single neurons to the macroscopic level of neural populations. Such models may give deeper insight into the phenomena if their assumptions are based on experimental findings and their predictions can be compared to experimental results. This comparison step is essential for valuable theoretical models.

The book is motivated by two successful workshops on anesthesia and sleep organized

during the Computational Neuroscience Conferences in Toronto in 2007 and in Berlin 2009. It aims to cover all the previous aspects with a focus on the link to experimental findings. It elucidates important issues in theoretical models that at the same time reflect some current major research interests. Moreover it considers some diverse issues which are very important to get an overview of the fields. For instance, the book discusses not only neural activity in the brain but also the effects of general anesthesia on the cardio-vascular system and the spinal cord in the context of analgesia. In addition, it considers different experimental techniques on various spatial scales, such as fMRI and EEG-experiments on the macroscopic scale and single neuron and LFP-measurements on the microscopic scale.

In total all book chapters reveal aspects of the neural correlates of sleep and anesthesia motivated by experimental data. This focus on the neural mechanism in the light of experimental data is the common feature of the topics and the chapters. In addition, the book aims to clarify the shared physiological mechanisms of both phenomena, but also reveal their physiological differences.

This important book fills a need in the developing area of Pain Medicine. It provides physicians with an up-to-date resource that details the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain. It summarizes the clinical evidence both for efficacy and safety, and finishes with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.

Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.

"Perioperative Addiction" addresses an issue that every anesthesiologist will encounter many times during the course of his or her career: the patient who arrives for operative care under the influence of legal or illegal drugs. The editors and contributors provide expert guidance on how to identify and manage the addicted patient, approaching the subject from the vantage points of the specific drug and of special patient populations.

Features:

Guidance for spotting and managing addicted patients

All common and important drugs of addiction, from opioids, cocaine, club drugs, and alcohol, to tobacco, marijuana, nitrous oxide, inhalants, and propofol

Special populations, including pregnant women, pain patients, adolescents, older patients, and healthcare professionals

Fascinating overview of the long history of addiction

Genetic basis of addiction, and the range of pharmacological treatments for addiction

Chronic pain is a silent epidemic, with one in five people suffering in their day-to-day life. An indispensible guide to understanding why your pain persists, what is going on inside your body and the symptoms that pain triggers, Manage Your Pain presents possible medical treatments and guides you through practical exercises for daily life. Dr Nicholas and Dr Molloy's strategies make it possible to set short and long term goals that will minimise the impact of pain on both work and leisure. In short, this book offers clarity and control. - Draws on the authors' extensive experience and the latest research - Clearly explains the causes of pain - Offers positive and practical ways to minimise the impact of pain - Revised and updated - Includes a chapter on pain management for older people Highly qualified and experienced medical professionals who specialise in pain management, the authors of this book offer complementary specialisms, ensuring that the widest range of treatments are covered.

This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.

The advancements of medical technology, improvements in medical care, and increased patients' life span make pain research and related drug development high priorities for both the research community and pharmaceutical companies. Rapid development of basic science research tools, such as techniques of flurometric labeling, genomic and proteomic high throughput screening, and genetically modified animals, promotes the swift acceleration of pain research to a stage allowing integrated investigations of pain processing mechanisms at the single cell and/or molecule level, and in a spatially and temporally controlled manner. Using multidisciplinary approaches, we can dissect the complicity of the sensory circuits connecting peripheral stimulation to maladaptive changes in the sensory pathways as well as pain perceptions at the central nervous system. Pain Research: Methods and Protocols, Second Edition provides advanced techniques and animal models that are critical for integrated pain research. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Pain Research: Methods and Protocols, Second Edition serves as an ideal guide to novice pain researchers who may not have extensive experiences in the field, or to experienced pain researchers who would like to expand their research in new directions and/or to new mechanisms in different models.

-- Are patients aware of the fact that pharmacological therapies stress the brain in ways which may prevent or postpone symptomatic and functional recovery ? ==================================================== Rethinking Psychiatric Drugs: A Guide for Informed Consent is a critical appraisal of the medications which an estimated 20% of Americans consume on a regular (and sometimes involuntary) basis. It is the philosophically, epidemiologically, and scientifically supported revelation of how and why psychiatry's drug therapies have contributed to a standard of care which frequently does more to harm than to cure. Extensively researched and documented, the book addresses: -- the process by which psychiatric drugs reach the market -- the history and philosophy of Evidence Based Medicine -- the common flaws in research methodologies which negate the validity of the psychiatric RCT (Randomized Controlled Trial) -- the problem of allostatic load (how drugs stress the body) -- the history, long term effects, and utility of the drugs used to suppress symptoms of depression, psychosis, inattention and hyperactivity -- the effectiveness of alternatives to medication Rethinking Psychiatric Drugs: A Guide for Informed Consent exposes the current crisis in medical ethics and epistemology, and attempts to restore to psychiatry an authentically informed consent to care.

Immune Mechanisms of Pain and Analgesia is the first volume to discuss a new concept of immune-neural interplays leading to pain or analgesia. It argues the classical view that pain and its control are restricted to the nervous system, offering a comprehensive overview of the emerging area of immune mechanisms in pain and its control. It challenges the traditional view that pain sensation or suppression is attributed exclusively to the nervous system and presents a critical analysis of this new concept. The book is written by an internationally recognized group of researchers and discusses complex and controversial issues such as cytokines and their pain-exacerbating but also analgesic effects, the production of opioids by immune cells, peripheral analgesic and anti-inflammatory actions of opioids, immunomodulatory effects of opiates, and immunosuppressive effects of pain.

This book is an extension of my 1992 book entitled The Social Context of Chronic Pain Sufferers. Many ideas nominally explored there are elaborated in this volume, which is an attempt to fill a major gap in the chronic pain literature. Although there has been a virtual flood of new works on the medical and psychological aspects of chronic pain, such enthusiasm is somewhat muted in relation to the social environment of the patient. Although there is universal recognitionamongpain expertsthat biological, psychological, and socialfactors influence the experience ofpain, the social component (forreasons that are - clear) has failed to attract much attention. Theneed forabook focusedonsocialrelationsisobvious.Thepatientisnot merelyacarrierof symptoms.Thereis alargesocialrealityinthe background of each patient; that reality can have multidimensional consequences, from the way pain is perceivedto seriousfinancialhardshipand other sourcesof stress, c- plicating treatment, management, and, ultimately, the prognosis. Clinicians rec- nize the value of incorporating the social dimension in the overall evaluation and treatment of the patient. This book attempts to accomplish that task. In order to achieve that objective, this volume addresses many important e- ments inthepatient'ssocial environment-the mostsignificantbeingthefamily. Beyond the family, for a vast majority of patients, work represents a major source of economic security and self-esteem. Job loss, common in this population and a major cause of much personal and family distress, needs critical examination.

This comprehensive book deals with the fundamental principles of each component of anesthetic machines which every practicing anesthesiologist must know and remember. The relevant applied physics is discussed and explained with clear illustrations, figures and examples. Commonly-used monitors are discussed in detail but in a very simple easy-to-understand manner. The illustrations and figures presented in every chapter are very simple and easy-to-follow. The differences between the older anesthetic machines and the newer workstations are clearly defined. Safety features and precautions related to every equipment are presented in details with their practical significance.