As part of the mucosal immune system, the intestine plays a paramount role in the immune response in all vertebrates. The mucosal immunity includes inductive and effector tissues, as well as effector cells and molecules, all of which are part of both innate and adaptive immunity and their connections. The digestive tract is the target organ of many parasites. In ectotherms, intestinal parasites include mainly flagellates, apicomplexans, myxozoans and helminths. The gut mucosal epithelium acts as a protective barrier against pathogens. This book presents and discusses current research in the study of mucosal intestinal immunity and response to parasite infections in ectothermic vertebrates.

This unique volume of thirty essays, by fifty-three internationally known scholars, honours C.S. (Rufus) Churcher, the distinguished Canadian palaeontologist. The papers focus on late Cenozoic mammals in North America and Africa and provide both site-specific descriptions of faunas and their associated geological contexts, and more general syntheses of regional palaeoenvironments and biogeography. The volume provides a much-needed overview of current research. The stature of the researchers who have contributed to the volume, and the breadth of the material presented, is a reflection of Churcher’s diverse research interests. The first section contains eleven papers on the palaeoenvironment and palaeoecology of Quaternary mammals in North America; the second section has 9 contributions describing faunas and morphological analyses of North American Quaternary mammals; and the final section contains nine papers on the palaeoecology and palaeoenvironments of late Cenozoic mammals of Africa. In this final section, Alan Gentry pays tribute to Churcher by naming a species after him: Budorcas churcheri. The volume contains individual discussions of North American fossil prairie dogs, mastodons, zebras, short-faced bears, sabre cats, lions, giant armadillos, elk-moose, caribou and muskrats, as well as African hyaenas, zebras, hipparion horses, antelopes, rodents, and giraffes.

New epidemics such as AIDS and `mad cow' disease have dramatized the need to explore the factors underlying rapid viral evolution and emerging viruses. Now available in paperback, this comprehensive book is the first to describe this multifaceted new field. The book places viral evolution and emergence in a historical context, describes the interaction of viruses with hosts, and details the advances in molecular biology and epidemiology that have provided the tools necessary to track developing viral epidemics and to detect new viruses far more successfully than could be done in the recent past. Case histories and practical suggestions for the prevention of future epidemics are given.

From reviews of the hardback: "excellent examples of emerging virus diseases...an excellent training resource, and should be required reading for all infectious disease and public health professionals." Trends in Microbiology

"a fine reference point for readers who wish to become familiar with the issue of emerging viruses" The Quarterly Review of Biology

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Most human diseases come from nature, from pathogens that live and breed in non-human animals and are "accidentally" transmitted to us. Human illness is only the culmination of a complex series of interactions among species in their natural habitats. To avoid exposure to these pathogens, we must understand which species are involved, what regulates their abundance, and how they interact. Lyme disease affects the lives of millions of people in the US, Europe, and Asia. It is the most frequently reported vector-borne disease in the United States; About 20,000 cases have been reported each year over the past five years, and tens of thousands more go unrecognized and unreported. Despite the epidemiological importance of understanding variable LD risk, such pursuit has been slow, indirect, and only partially successful, due in part to an overemphasis on identifying the small subset of 'key players' that contribute to Lyme disease risk, as well as a general misunderstanding of effective treatment options. This controversial book is a comprehensive, synthetic review of research on the ecology of Lyme disease in North America. It describes how humans get sick, why some years and places are so risky and others not. It challenges dogma - for instance, that risk is closely tied to the abundance of deer - and replaces it with a new understanding that embraces the complexity of species and their interactions. It describes why the place where Lyme disease emerged - coastal New England - set researchers on mistaken pathways. It shows how tiny acorns have enormous impacts on our probability of getting sick, why biodiversity is good for our health, why living next to a small woodlot is dangerous, and why Lyme disease is an excellent model system for understanding many other human and animal diseases. Intended for an audience of professional and student ecologists, epidemiologists, and other health scientists, it is written in an informal style accessible also to non-scientists interested in human health and conservation.

Humans have lived in close proximity to other animals for thousands of years. Recent scientific studies have even shown that the presence of animals has a positive effect on our physical and mental health. People with pets typically have lower blood pressure, show fewer symptoms of depression, and tend to get more exercise.
But there is a darker side to the relationship between animals and humans. Animals are carriers of harmful infectious agents and the source of a myriad of human diseases. In recent years, the emergence of high-profile illnesses such as AIDS, SARS, West Nile virus, and bird flu has drawn much public attention, but as E. Fuller Torrey and Robert H. Yolken reveal, the transfer of deadly microbes from animals to humans is neither a new nor an easily avoided problem.
Beginning with the domestication of farm animals nearly 10,000 years ago, Beasts of the Earth traces the ways that human-animal contact has evolved over time. Today, shared living quarters, overlapping ecosystems, and experimental surgical practices where organs or tissues are transplanted from non-humans into humans continue to open new avenues for the transmission of infectious agents. Other changes in human behavior like increased air travel, automated food processing, and threats of bioterrorism are increasing the contagion factor by transporting microbes further distances and to larger populations in virtually no time at all.
While the authors urge that a better understanding of past diseases may help us lessen the severity of some illnesses, they also warn that, given our increasingly crowded planet, it is not a question of if but when and how often animal-transmitted diseases will pose serious challenges to human health in the future.

Bach Flower Remedies for Animals is a complete and authoritative guide to using the Bach Flower Remedies as an alternative treatment for pets and other animals. Written by experts, it includes the history behind Dr Bach's internationally acclaimed remedies and explains how the remedies are suitable for animals. According to an animal's temperament, a particular remedy or combination of remedies will prove the most beneficial for it. There is guidance on using the remedies and on reading animal behaviour, drawing on insights from professional animal behaviourists. There is also detailed information on treating animals in the home, horses, and animals on the farm or in the wild. Packed full of helpful advice, there are intriguing case studies throughout.

This ground-breaking work is the first book to present a Darwinian perspective on infectious disease. It views disease-producing bacteria and viruses as parasites and explains the history of disease as a host-parasite relationship, one which can evolve in many different ways and with radically different effects on the host population. The author's evolutionary approach is interdisciplinary, drawing on theory and example from the fields of epidemiology, molecular genetics, biochemistry, physiology, evolutionary ecology, and the ecology of populations and communities.