Avian Immunology, Third Edition contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers, include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. With contributions from the foremost international experts in the field, Avian Immunology 3rd, provides the most up-to-date crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. Avian Immunology, Third Edition, is a fascinating and growing field and surely provides new and exciting insights for mainstream immunology in the future.

Paratuberculosis, also referred to as Johne's disease, affects principally cattle, goats, sheep, buffalo, deer and other ruminants. It is common worldwide and responsible for significant economic losses in the ruminant livestock industries. A timely follow up to the first book on Paratuberculosis, this new edition is still the only comprehensive text providing both historical context and the latest developments in the field. Examining the epidemiology of paratuberculosis, the organism that causes the disease, and practical aspects of its diagnosis and control, it also addresses the link between paratuberculosis in the food chain and human health implications, including Crohn's disease. This new edition: * Builds on a strong foundation to update, streamline and better structure existing chapters with important new developments from the last decade, such as whole genome sequencing and phage-based assays; * Includes new chapters on the fast-growing field of whole genome based comparative genomics, and the increasing opportunities for disease control in low- and middle-income countries; * Increases inclusivity by bringing on board new rising star authors from diverse backgrounds to provide international perspectives. A truly comprehensive, critical reference resource, this book is an essential reference for large animal veterinarians, livestock industry personnel and those involved in the dairy and meat industries, as well as microbiologists, researchers and students in these fields.

This book presents the facet theoretical framework as a tool for facilitating the conception of complex animal behaviour research and the design of research procedures through employing mapping sentences. Using the facet theoretical framework, this book takes a holistic view of bird behaviour. Components of bird behavior are identified and then reassembled to facilitate an understanding of the behaviour in the context of its natural occurrence. This provides new insight on both the parts of the behaviour and how these interact as a whole. The multi-faceted approach to designing, evaluating and understanding bird behavior presented offers a template that is adaptable for investigating a wide variety of avian species and different forms of behaviour. Behavioural biologists, animal and comparative psychologists, other natural and behavioural scientists, as well as students of these disciplines will find this book to be an interesting and enlightening read.

Infectious Diseases of Wild Mammals and Birds in Europe is a key resource on the diagnosis and treatment of infectious diseases in European wildlife that covers the distinctive nature of diseases as they occur in Europe, including strains, insect vectors, reservoir species, and climate, as well as geographical distribution of the diseases and European regulations for reporting, diagnosis and control. Divided into sections on viral infections, bacterial infections, fungal and yeast infections, and prion infections, this definitive reference provides valuable information on disease classification and properties, causative agents, epidemiology, pathogenesis, and implications for human, domestic and wild animal health.

Key features: - Brings together extensive research from many different disciplines into one integrated and highly useful definitive reference.- Zoonotic risks to human health, as well as risks to pets and livestock are highlighted.- Each disease is covered separately with practical information on the animal species in which the disease has been recorded, clinical signs of the disease, diagnostic methods, and recommended treatments and vaccination.- Wildlife vaccination and disease surveillance techniques are described.- Examines factors important in the spread of disease such as changing climate, the movement of animals through trade, and relaxations in the control of wide animal populations.

Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource.

This issue, guest edited by Kathryn Michel and Amy Farcas, focuses on Small Animal Obesity. Article topics include: Scope of the Problem/Perception by Owners/Vets; Physiology; New Areas of Research; Metabolic Effects of Obesity/Interaction with Endocrine Diseases; Impact on Cardio/Respiratory Disease; Impact on Ortho/Neuro Disease; Nutritional Assessment; Treatment-diet; Treatment- Environment/Behavior Modification; and more!

Gorilla Pathology and Health: With a Catalogue of Preserved Materials consists of two cross-referenced parts. The first, the book itself, is a review of pathological changes and tissue responses in gorillas (Gorilla gorilla and G. beringei), with an emphasis on free-living animals, but also with reference to those in captivity. The comparative aspects are discussed, stressing the relevance of research to both gorillas and humans. What makes the publication truly unique, however, is the second part, a comprehensive descriptive catalogue of the location and nature of gorilla material in museums and scientific institutions throughout the world. This is of great consequence because free-living gorillas are strictly conserved with restricted access, so the location of a wealth of preserved tissues and other material that has been collected over the decades is a great benefit for research and study. This book can, and should, be used to gain cardinal knowledge regarding the biology and pathology of this genus. The combination of book and catalogue in this extensive compilation makes it an invaluable tool for all those concerned with the health, welfare, and conservation of gorillas, one of our nearest living relatives.

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research.

This book provides comprehensive knowledge on diseases in livestock that are caused by viruses, parasites and bacteria. Emerging and re-emerging pathogens are presented in detail for various animal groups and in-depth insights into pathogenesis and epidemiology will be provided for each of them. In addition, state-of-the-art treatment possibilities, control measures as well as vaccination strategies are discussed. The recent years have witnessed a sharp increase in the number of emerging and re-emerging infectious diseases of livestock and many of these, including Influenza, Corona and Hanta are of public health importance. The reasons for this development are manifold:changes in the climate, life cycle of vectors and increased global travel. Also, due to extensive deforestation, livestock are increasingly coming in direct contact with wild animals that are reservoirs of many emerging pathogens. Recent progress in diagnosis and management of emerging infectious diseases are also topic of this book.

Manual of Techniques in Invertebrate Pathology, Second Edition, describes a wide range of techniques used in the identification, isolation, propagation/cultivation, bioassay, quantification, preservation, and storage of the major groups of entomopathogens, including entomophthorales, entomopathogenic fungi, entomopathogenic bacteria of the Bacilli, Nematode parasites, and pathogens and parasites of terrestrial molluscs. The book presents the perspectives of an international group of experts in the fields of invertebrate pathology, including microbiology, mycology, virology, nematology, biological control, and integrated pest management. Organized into 15 chapters, the book covers methods for the study of virtually every major group of entomopathogen, as well as methods for discovery and diagnosis of entomopathogens and the use of complementary methods for microscopy. It discusses the use of molecular techniques for identifying and determining phylogeny, factors that contribute to resistance to entomopathogens, and several other aspects of the science of invertebrate pathology. It also explains initial handling and diagnosis of diseased invertebrates, basic techniques in insect virology, and bioassay of bacterial entomopathogens against insect larvae. In addition, the reader is introduced to the use of bacteria against soil-inhabiting insects and preservation of entomopathogenic fungal cultures. The remaining chapters focus on research methods for entomopathogenic microsporidia and other protists, how the pathogenicity and infectivity of entomopathogens to mammals are tested, and preparations of entomopathogens and diseased specimens for more detailed study using microscopy. Experienced insect pathologists, biologists, entomologists, students, biotechnology personnel, technicians, those working in the biopesticide industry, and government regulators will find this manual extremely helpful.

Global problems require global information, which satellites can now provide. With ever more sophisticated control methods being developed for infectious diseases, our ability to map spatial and temporal variation in risk is more important than ever. Only then may we plan control campaigns and deliver novel interventions and remedies where the need is greatest, and sustainable success is most likely. This book presents a comprehensive guide to using the very latest methods of surveillance from satellites, including analysing spatial data within geographical information systems, interpreting complex biological patterns, and predicting risk both today and as it may change in the future. Of all infectious disease systems, those that involve free-living invertebrate vectors or intermediate hosts are most susceptible to changing environmental conditions, and have hitherto received most attention from the marriage of analytical biology with this new space technology. Accordingly, this volume presents detailed case studies on malaria, African trypanosomiasis (sleeping sickness), tick-borne infections and helminths (worms). For those who are unfamiliar with this science, and unsure how to start, the book ends with a chapter of practical advice on where to seek hands-on instruction. The lessons to be learned from these studies are applicable to many other epidemiological and ecological problems that face us today, most significantly the preservation of the world's biodiversity.
Key Features
* Only book to provide a synthesis of complex biology, quantitative analysis, space technology and practical applications, focused on solving real epidemiological problems on a global scale
* Broad scope, with methods relevant to subjects ranging from biodiversity to public health
* Practical advice on relevant courses
* 24 pages of colour plates

Furunculosis: Multidisciplinary Fish Disease Research presents a fascinating insight into the opinions and the controversies which have led to current knowledge of this disease. It is the first book to cover one single fish disease by presenting not just the reviews, but also critical examination of the progress made by various disciplines. The multidisciplinary approach of the book makes it a valuable guide for veterinarians, fisheries biologists, and fish farm managers, as well as an excellent instructional text for students. The volume explores current research strategies and projects what developments can be expected in each field.
Key Features
* Considers the whole disease and not just the pathogen, "Aeromonas salmonicida"
* Analyzes the state of modern knowledge on the disease
* Suggests topics for future research and uses furunculosis as a model for other diseases
* Highlights and summarizes each section's themes and concepts
* Presents a unique compendium of research information for all professionals working on furunculosis

Blackwell s Five-Minute Veterinary Consult: Avian presents complete information on diseases and conditions seen in birds in a quick-reference format ideal for clinical practice. Offers fast access to essential information on 128 avian diseases and syndromes Written by leading experts in avian medicine Uses the trusted Five-Minute Veterinary Consult format Focuses on practical clinical knowledge Includes access to a companion website offering algorithms, procedure guides, and client education handouts to download, edit, and use in practice

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.

Agriculture is often under the threat of invasive species of animal pests and pathogens that do harm to crops. It is essential to have the best methods and tools available to prevent this harm. Biosecurity is a mixture of institutions, policies, and science applications that attempts to prevent the spread of unhealthy pests. Tactical Sciences for Biosecurity in Animal and Plant Systems focuses on the tactical sciences needed to succeed in the biosecurity objectives of preventing plant and animal pathogens from entering or leaving the United States. This book explores a divergence of tactics between plant and animal exotic disease response. Covering topics such as animal pests and pathogens, tactical management, and early detection, this book is an essential resource for researchers, academicians, university faculty, government biosecurity practitioners, customs officers, clinical scientists, and students.

The study of proteomics provides researchers with a better understanding of disease and physiological processes in animals. Methods in Animal Proteomics will provide animal scientists and veterinarians currently researching these topics in domestic animals a firm foundation in the basics of proteomics methodology, while also reviewing important advances that will be of interest to established researchers in the field. Chapters will provide practical information on a range of topics including protein identification and separation, bioinformatics, and applications to disease and reproduction research. This text will be written by leading international proteomics experts and essential for researchers in the fields of animal biology and veterinary medicine.

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book's content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.

Pathology of Wildlife and Zoo Animals is a comprehensive resource that covers the pathology of wildlife and zoo species, including a wide scope of animals, disease types and geographic regions. It is the definitive book for students, biologists, scientists, physicians, veterinary clinicians and pathologists working with non-domestic species in a variety of settings. General chapters include information on performing necropsies, proper techniques to meet the specialized needs of forensic cases, laboratory diagnostics, and an introduction into basic principles of comparative clinical pathology. The taxon-based chapters provide information about disease in related groups of animals and include descriptions of gross and histologic lesions, pathogenesis and diagnostics. For each group of animals, notable, unique gross and microscopic anatomical features are provided to further assist the reader in deciding whether differences from the domestic animal paradigm are "normal." Additional online content, which includes text, images, and whole scanned glass slides of selected conditions, expands the published material resulting in a comprehensive approach to the topic.

Records of parasitism in crocodilians date back to the early 1800s, distributed among various types of published and unpublished materials. Analyzing parasite-host specificity, geographic distribution, and taxonomy can provide otherwise cryptic details about crocodilian ecology and evolution, as well as their local food web dynamics. This information is critical for improved conservation tactics for both crocodilians and their habitat. As climate change, anthropogenic conflict, and environmental pollution endanger crocodilian ecosystems, there is a need for organized information on crocodile, alligator, caiman, and gharial infectious diseases. This volume meets this need by delivering the first checklist of crocodilians and their parasites for researchers and scholars in biology, herpetology, and ecology in order to further the knowledge and study of crocodilian-parasite dynamics and improve our understanding of human impacts on ecosystems.

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Zoonotic diseases constitute a public health problem throughout the world. Addressing a little studied area of veterinary and medical science, this book covers the viruses, bacteria and protozoan and helminth parasites that are transmitted between man and dogs, discussing population management, control disease agents and human-dog relationships. Fully updated throughout, this new edition also includes two new chapters on benefits of the human-dog relationship and non-infectious disease issues with dogs. It is a valuable resource for researchers and students of veterinary and human medicine, microbiology, parasitology and public health.

Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.