The essential work in HIV for providers and pharmacists, updated for 2021. Includes CME access code for 2021 AAHIVS, AAHIVP, or AAHIVE study materials and accreditation! An end-to-end clinical resource for the treatment of individuals with HIV/AIDS, Fundamentals of HIV Medicine has served as a key resource for clinicians preventing and treating HIV for over a decade. Now updated for 2021, Fundamentals of HIV Medicine 2021 offers state-of-the-art continuing education for physicians, pharmacists, nurse practitioners, nurses, and other professionals working in the care of HIV patients. With this volume, practitioners will have immediate, indexed access to the most updated science, research, and guidelines related to all aspects of HIV care and prevention. This revised edition features key clinical updates across classic domains of HIV medicine along with recent research in HIV medicine including HIV workforce strains and PrEP, newly emerging antiretroviral treatment options, and the evolving effects of COVID-19 on HIV care. Embodying the American Academy of HIV Medicine's commitment to excellence in the care of seropositive patients, Fundamentals of HIV Medicine 2021 is a must-have for health professionals across HIV care, treatment, and prevention. Note: This edition includes a login for online CME questions and accreditation

According to the Centers for Disease Control and Prevention, young people aged 18 to 25 are at a significant risk for acquiring and transmitting HIV (Human Immunodeficiency Virus) and other STIs (sexually transmitted infections). Primary developmental processes that place college students particularly at risk include the experience of intimacy, sexual desires and the centrality of the peer group. During these routine developmental processes, college students experiment with unprotected sex, multiple sex partners and alcohol and illicit drugs, all of which are contributing risk factors for HIV/STI infections.

Early diagnosis, treatment and prevention of HIV and other STIs is germane to promoting the sexual health of college students and reducing high HIV/STI infection rates among young people. This edited volume will provide innovative and cutting-edge approaches to prevention for college students and will have a major impact on advancing the interdisciplinary fields of higher education and public health. It will explore core ideas such as hooking up culture, sexual violence, LGBT and students of color, as well as HIV and STI prevention in community colleges, rural colleges and minority serving institutions."

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Encyclopedic in scope, Reversibility of Chronic Degenerative Disease and Hypersensitivity, Volume 3: Environmental Manifestations of the Neurocardiovascular Systems draws deeply from clinical histories of thousands of patients. It focuses on clinical syndromes within the musculoskeletal, neurological, and cardiovascular systems with a special focus on vascular dysfunction and heart failure treatment. The book explores mechanisms of chemical sensitivity and chronic degenerative disease, their manifestations, diagnosis, and approaches to reverse dysfunction. It covers a wide variety of topics including environmental sensitivity due to external pollutants, environmental control for reducing total body load, pollutant damage to vascular perfusion, altered blood volume, fluctuations of oxygen extraction, effects of endocrine on the vascular system, effects of pollutants on myocardial cells, and mechanisms in vascular damage. The book also discusses in detail a wide variety of clinical manifestations including vasculitis, cardiac arrhythmias, cardiac metabolic syndrome, myocarditis, atherosclerosis, heart failure, urticaria, and anaphylaxis. Treatment for heart failure is also discussed. The third volume of a five-volume set, the book provides an essential resource for health care providers diagnosing and treating chemical sensitivity and chronic degenerative disease.

There are common midlife events that account for the special narcissistic vulnerabilities of this period of life, and Eda Goldstein ably reviews these events and the theoretical perspectives commonly brought to bear on them. In When the Bubble Bursts, however, Goldstein's special concern is those individuals who come to midlife with heightened narcissistic vulnerabilities that make the navigation of this stage of life more difficult still. In understanding the latter such patients and devising a treatment approach appropriate to their "self" issues, Goldstein adopts a broadly self-psychological frame of reference. It is a matter, she finds again and again, of understanding how current stressors frustrate healthy self needs and trigger narcissistic vulnerabilities. Self-psychologically informed treatment, which, in Goldstein's pragmatic purview, embraces modalities that are, to varying degrees, supportive, psychodynamic, and psychoanalytic, reworks and strengthens self structures in helping patients find new ways of affirming their sense of self. Her substantive case studies, which accompany the reader through all the chapters in her study, draw on personal and supervisory experiences to illustrate crucial foci of the treatment process with a range of midlife patients in psychotherapy. Eda Goldstein presents a study that comprises an admirable blend of theoretical astuteness, clinical wisdom, and personal honesty. Her clinical study of midlife narcissistic pathology is bracketed by her balanced discussion of theoretical perspectives on adult development and her concluding consideration of the countertransference issues elicited by midlife patients in midlife therapists. When the Bubble Bursts is an edifying contribution to the literatures of psychodynamic psychotherapy, self psychology, and adult development.

Human Diseases from Wildlife presents information on the most prevalent and serious zoonotic diseases in the US and Canada, some of which have been national headline news like anthrax, influenza, and West Nile virus. Diseases that are caused by pathogens with the ability to infect both humans and animals are known as zoonotic diseases, which literally means "disease from animals." The issue of human-wildlife disease interactions is a growing concern as humans continue to interface with wildlife. People who handle wildlife including field workers, wildlife professionals, trappers, and hunters want to know about potential diseases, risks, and how to protect themselves from disease. This book was written because many people are uninformed about zoonotic diseases. This lack of information causes some people to have a heightened fear of zoonotic diseases, preventing them from enjoying wildlife or spending time outdoors. Other people needlessly expose themselves to disease by neglecting simple precautions. This book includes information on bacterial, spirochetal, rickettsial, and viral diseases as well as macroparasites and emerging zoonotic diseases. More than two dozen diseases are covered including rabies, tularemia, baylisascariasis, salmonellosis, leprosy, Lyme disease, Rocky Mountain spotted fever, and swimmer's itch. Each chapter contains the history of the disease, symptoms in humans, medical treatment, transmission of pathogens to humans, the role of wildlife as vectors, and methods to minimize risk. The diseases people can contract from wild animals can be both threatening and fascinating, and the book includes interesting information to make it more enjoyable to read.

This book covers the complete gamut of neuroradiology cases, including normal anatomy, pitfalls, and artifacts across the brain and spine in a single volume, enriched with high-resolution images that support the interpretation of CT and MRI images of the brain, spine, head, and neck. It includes case studies commonly encountered in clinical practice, in addition to normal anatomy, that prepare the reader for the challenges in the clinical setting. Each case study discusses the clinical history, relevant imaging findings, differential diagnosis, and management, serving as a helpful read for trainee radiologists, neurophysicians, neurosurgeons, and CT/MRI technicians, along with physicians interested in medical imaging. Key Features Provides a succinct overview of normal variants with case studies structured into thematic chapters Serves as a basic accompaniment for radiology residents, fellows, practicing radiologists, neurophysicians, neurosurgeons, emergency medicine practitioners, trainee and practicing radiographers, and those studying for Board exams Highlights the relevance of artificial intelligence in clinical practice

This book presents the latest evidence-based approaches to assessing and managing movement disorders in children. Uniquely, the authors have chosen to examine not just children with developmental coordination disorder, but also children with movement difficulties as a co-occurring secondary characteristic of another development disorder, including Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Specific language Impairment and Dyslexia. Guidelines are underpinned by motor learning theory, empiricism and professional practice. The authors have taken an ecological approach to management and show how professionals and carers working together can make relatively simple changes in a child's life that aggregate to substantial support. The book is rich in case studies to demonstrate the adaptability of these guidelines and show how they may be applied to children of different ages, abilities, and environments. The final chapter is comprised of interviews of thirteen notable clinicians and academics with intervention methodologies from around the world. This book is a valuable guide for anybody working with children with movement difficulties, including clinicians, teachers and parents.

This title includes a number of Open Access chapters. The study of the intestinal ecosystem of bacteria in the human gut-the gut microbiome-is a new field that is rapidly evolving. This book serves as an introduction to some of the new and exciting research that is being done in this field. Included are chapters that examine the following: * Gut microbiome's roles in the pathogenesis of obesity and autoimmune disease * The effect of nutrition on the richness of the microbial community * The stability of the microbiome to various stressors * Emerging ways to diagnose diseases using the microbiome * Exciting prospects for using these microbes to cure disease This easily accessible reference volume offers a comprehensive guide to this relatively new field of study. Edited by a researcher from Yale University, Health and the Gut: The Emerging Role of Intestinal Microbiota in Disease and Therapeutics is an authoritative and easy-to-use reference, ideal for both researchers in the field and those who wish to gain more information about the impact of gut microbiota on human health.

Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer" "is an authoritative and easy-to-use reference.

With globalisation taking centre stage in the business world and multiculturalism affecting markets and societies, there is a need to understand the ways that customers respond to the changing marketplace from international and multicultural perspectives. This book is timely in addressing important themes raised in the most recent marketing literature, such as: global consumer culture, and the impact of Western culture on consumer behaviour in other countries; consumer acculturation processes, and the impact on identity conflicts and the strategies people use to manage them; globalisation vs. localised strategies, and the interaction of local and global influences on customer behaviour; climate change and global warming, the impact on consumer behaviour, and the implications for social responsibility; and cross-cultural customer research, including important methodological questions around the application of sociological, group-level measures to psychological, individual-level phenomenon in marketing contexts. The papers in this edition address those themes, reporting on studies from a range of countries, including Germany, Greece, China, and Austria, and a number of cultural groups in the UK. These papers draw on quantitative and qualitative methodologies, reflecting the full range of methods employed in contemporary consumer research.

This book was originally published as a special issue of the Journal of Marketing Management.

This contemporary book covers significant new knowledge that has emerged during the last two decades and, thus, provides novel antibody phylogenetic perspectives relevant to development of new antibody-based therapeutics and vaccines. It fills a much-needed niche in the area of immunoglobulin genetics across species from a comparative perspective. New insights and perspectives from immunoglobulin genetics from species such as sea lamprey, cattle, marsupial, bat, rat, rabbit, and swine other species than the traditional subjects of mice and humans are relevant to antibody design and engineering. These new perspectives find direct application in the cutting-edge areas of antibody design, engineering and therapeutics, antibody-drug conjugates, and novel antibody-based vaccines. This book fills the need to provide updated knowledge of this newly exploded area that is finding applications in new drug development. No other competing books on the topic are available in the market. The book will be of great interest to immunologists, immunology researchers, immunogeneticists, researchers in pharmaceutical science, those involved in the infectious disease and antibody therapeutics areas, and many others."

Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E has been fully updated and revised. The clinical diagnostic approach to common infectious disease problems in the CCU is the underlying theme in the book. Emphasized throughout is the importance of formulating an accurate early presumptive clinical syndromic diagnosis which is the basis for selecting optimal initial antimicrobial therapy in the CCU. Without an accurate presumptive clinical diagnosis, effective therapy is unlikely at best. Based on the most probable clinical diagnosis, optimal antibiotic empiric therapy, based on antimicrobial stewardship principles, minimizes resistance and antibiotic complications in the CCU. This new edition features chapters that explain the tenets of differential diagnostic reasoning, differential diagnostic characteristics of fever patterns in the CCU. The proper interpretation of rapid diagnostic tests, in the appropriate clinical context, is included. The diagnostic importance of cardinal clinical findings, particularly when combined, in the appropriate clinical context is emphasized and remains the basis for clinical problem solving in the CCU. Uniquely, critical diagnostic physical findings in the CCU, including color atlas of diagnostic eye findings, are included as important diagnostic determinants in the CCU. Written by infectious disease clinicians for CCU consultants, Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E remains a useful evidence based and experience tempered key clinical resource for infectious disease problems in the CCU. Key Features Essentials of the tenets of clinical diagnostic reasoning is explained as it relates to formulating a rapid and accurate clinical syndromic diagnosis in the CCU The diagnostic significance of fever patterns and their relationship to the pulse rate in the proper clinical context is explained in depth as related to the CCU setting Formulating an accurate early clinical syndromic diagnosis is presented as essential since it is the basis of effective empiric antibiotic therapy in the CCU How to combine key non-specific laboratory and imaging findings to increase diagnostic specificity and diagnostic probability in the CCU is presented Clinical perspective on the proper interpretation of the clinical significance of rapid diagnostic test results in the CCU is included A clinical approach to apparent "antibiotic failure" in the CCU is presented either due to actual antibiotic failure or seeming but unrelated non-antibiotic failure Section focuses on the practical aspects of antimicrobial stewardship particularly as related to optimizing dosing effectiveness while minimizing resistance and adverse effects in the CCU

NEW YORK TIMES BESTSELLER 'A beautiful book' - Jo Good, BBC Radio London 'When Harry Met Minnie made me cry and made me dance with joy. It's an exquisite tale about heartbreak and healing, critters and humans, and the little miracles life hands us when we need them the most' - Jeannette Walls, New York Times bestselling author of The Glass Castle and Half Broke Horses 'Teichner's main themes are sure to warm readers in this cold coronavirus winter: the steadfast devotion between dogs and their owners, and the essential role friendship plays in sustaining both humans and their beloved pets ... Teichner has learned that we all have the capacity to create and build new friendships and attachments at whatever age or stage of life. That such rewards are possible is the inspirational lesson for all the characters in - and readers of - this touching saga' - The Washington Post 'When Harry Met Minnie is a tour-de-force of storytelling. Martha Teichner not only charts the course of two remarkable friendships, between two people and two dogs, she invites us to consider our own relationships. The stars that had to align to put someone special in our life. This is a love story, masterful, warm and funny, heartfelt and heartbreaking. I absolutely loved this book' - Louise Penny, New York Times bestselling author of All the Devils Are Here 'When Harry Met Minnie is a story of laughter and tears, of friendship and dogs. It shows us the loyalty and resilience of Bull Terriers?and of two women who love them. A book of generosity and hope for an era badly in need of both' - Jennifer Finney Boylan, author of GOOD BOY: My Life in Seven Dogs 'When Harry Met Minnie belongs on the shelf next to Travels with Charley and Marley and Me. But the unforgettable dogs we meet in these pages don't just help the people in their lives, they save each other. Martha Teichner has written an extraordinary story filled with love and humor about the transformative power of friendship, among dogs and people, in the thick of life and at its end. I fell in love with Harry, Minnie, their humans, and this marvel of a book' - Will Schwalbe, New York Times bestselling author of The End of Your Life Book Club and Books for Living 'I decided to write this book, because I didn't want to stop living the story of what happened when Harry met Minnie. I didn't want to forget any of it, even the sad parts. This story of unexpected friendship, of love, was a wonderful gift, and in the end, it made me and Minnie happy' - Martha Teichner There are true fairy tales. Stories that exist because impossible-to-explain coincidences change everything. Except in real life, not all of them have conventional, happily-ever-after endings... Carol, who is dying of cancer caused by the toxic pollution in New York in the aftermath of 9/11, needs someone to take care of Harry, who is a 'great listener but does have a problem with large dogs. He is great with smaller dogs. If he sees a hose he will destroy it to protect you. He will figure out ways to let you know exactly how he feels'. When Martha has a chance encounter with Carol's friend, he can't help but notice Minnie, 'oh those chunky little legs', and so the matchmaking begins. After a disastrous first meeting, when Minnie doesn't appear to think much of Harry (who is super keen), things improve and soon they are inseparable. As Carol's illness progresses, so a new friendship and community blossoms, Carol's Club. The bonds that grew changed Martha's life, Carol's life, Minnie's life and Harry's life. And they changed Carol's death as well. In this rich and touching narrative, Martha considers the ways our stories are shaped by the people we meet, and the profound love we can find by opening our hearts to unexpected encounters.

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been-when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time. In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment-and will lead to multiple COVID-19 vaccines. Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won't be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans. As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.

Written by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.

Intraperitoneal Cancer Therapy: Principles and Practice is one of the first books to combine the latest clinical developments in the treatment of patients with peritoneal surface disease and the scientific principles that underlie the concept of intraperitoneal cancer therapy. The book covers basic concepts such as anatomy, physiology, pharmacology, and mathematical models of drug transport as well as practical clinical applications, highlighted with results from clinical trials and promising novel preclinical developments. The book is a state-of-the-art reference for surgical and medical oncologists interested in the treatment of carcinomatosis. It also establishes and promotes basic and translational research interest in the field of intraperitoneal drug delivery, which has the potential to improve the outcome for this dreaded condition. Edited by two renowned surgical oncologists, it represents the definitive reference in the field of intraperitoneal cancer therapy.

Using a multidisciplinary approach, Human Respiratory Viral Infections is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic sciences of epidemiology, virology, molecular biology, and immunology to cover clinical diagnosis, mechanism of pathogenesis, manifestations of disease, impact, treatment, and management strategies. Provides a comprehensive review of all the major human respiratory viral infections Supplies a detailed description of the anatomy of the respiratory system Discusses the salient features of specific viruses Examines the latest diagnostic tools Covers risk factors associated with incidence of respiratory viral infections in children and adults in different occupational and environmental settings Presenting the latest knowledge in human respiratory viral infections, this text will be immensely valuable for pulmonologists, biomedical scientists, research scholars, virologists, vaccinologists, immunologists, clinicians, pharmacologists, and public health specialists.

Neurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: RNA Viruses and Retroviruses presents an up-to-date overview of the general principles of infections and major neuroviral infections caused by RNA viruses and retroviruses. It is designed for virologists, specialists in infectious diseases, teachers of virology, and postgraduate students of medicine, virology, neurosciences, and immunology.

First published in 1998, this book covers a variety of health issues in the contemporary Middle east. Its thirteen chapters, contributed by a total of 23 authors and co-authors, reflect several different disciplines relevant for health studies, including epidemiology, economics and anthropology. In the field of reproductive health, there are chapters on maternal health indicators, fertility, infertility and the utilization of family planning services. In the field of infectious disease there are chapters on schistosomiasis, HIV/AIDS, hepatitis C, and Rift Valley Fever. Several different parts of the Middle East and North Africa are covered, including Tunisia, Egypt, Israel, Palestine and Lebanon. Problems of reproductive health and infectious disease in the region are seen to be more serious than generally recognised. There are significant cultural and political obstacles in both areas. A particular need is for greater empowerment of women as both clients and providers within the health care systems.

Read an exclusive interview with Dr. Jerry Battista here. A critical element of radiation treatment planning for cancer is the accurate prediction and delivery of a tailored radiation dose distribution inside the patient. Megavoltage x-ray beams are aimed at the tumour, while collateral damage to nearby healthy tissue and organs is minimized. The key to optimal treatment therefore lies in adopting a trustworthy three-dimensional (3D) dose computation algorithm, which simulates the passage of both primary and secondary radiation throughout the exposed tissue. Edited by an award-winning university educator and pioneer in the field of voxel-based radiation dose computation, this book explores the physics and mathematics that underlie algorithms encountered in contemporary radiation oncology. It is an invaluable reference for clinical physicists who commission, develop, or test treatment planning software. This book also covers a core topic in the syllabus for educating graduate students and residents entering the field of clinical physics. This book starts with a historical perspective gradually building up to the three most important algorithms used for today's clinical applications. These algorithms can solve the same general radiation transport problem from three vantages: firstly, applying convolution-superposition principles (i.e. Green's method); secondly, the stochastic simulation of radiation particle interactions with tissue atoms (i.e. the Monte Carlo method); and thirdly, the deterministic solution of the fundamental equations for radiation fields of x-rays and their secondary particles (i.e. the Boltzmann method). It contains clear, original illustrations of key concepts and quantities thoughout, supplemented by metaphors and analogies to facilitate comprehension and retention of knowledge. Features: Edited by an authority in the field, enhanced with chapter contributions from physicists with clinical experience in the fields of computational dosimetry and dose optimization Contains examples of test phantom results and clinical cases, illustrating pitfalls to avoid in clinical applications to radiation oncology Introduces four-dimensional (4D) dose computation, on-line dose reconstruction, and dose accumulation that accounts for tissue displacements and motion throughout a course of radiation therapy

This book addresses a wide range of topics, from the principles of evidence-based practice to the process and dissemination of research to unique considerations such as clinical trials, patenting, and health services research. The case for evidence-based practice and a collaborative research culture is made first, followed by a series of chapters walking the reader through the research process by way of the scientific method. One of the more unique aspects of the scope of this book is the inclusion of chapters relating to the dissemination of knowledge, manuscript publication, and how to build an academic research program. Each chapter focuses on introducing the reader to foundational principles, methodology, and terminology, and highlight case studies of radiation therapist research or experience that is relevant to provide contextual examples and inspiration to the reader.

While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure-function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines.Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"

Microbiota are a promising and fascinating subject in biology because they integrate the microbial communities in humans, animals, plants, and the environment. In humans, microbiota are associated with the gut, skin, and genital, oral, and respiratory organs. The plant microbial community is referred to as "holobiont," and it is influential in the maintenance and health of plants, which themselves play a role in animal health and the environment. The contents of Microbiome-Host Interactions cover all areas as well as new research trends in the fields of plant, animal, human, and environmental microbiome interactions. The book covers microbiota in polar soil environments, in health and disease, in Caenorhabditis elegans, and in agroecosystems, as well as in rice root and actinorhizal root nodules, speleothems, and marine shallow-water hydrothermal vents. Moreover, this book provides comprehensive accounts of advanced next-generation DNA sequencing, metagenomic techniques, high-throughput 16S rRNA sequencing, and understanding nucleic acid sequence data from fungal, algal, viral, bacterial, cyanobacterial, actinobacterial, and archaeal communities using QIIME software (Quantitative Insights into Microbial Ecology). FEATURES Summarizes recent insight in microbiota and host interactions in distinct habitats, including Antarctic, hydrothermal vents, speleothems, oral, skin, gut, feces, reproductive tract, soil, root, root nodules, forests, and mangroves Illustrates the high-throughput amplicon sequencing, computational techniques involved in the microbiota analysis, downstream analysis and visualization, and multivariate analysis commonly used for microbiome analysis Describes probiotics and prebiotics in the composition of the gut microbiota, skin microbiome impact in dermatologic disease prevention, and microbial communities in the reproductive tract of humans and animals Presents information in a reachable way for students, teachers, researchers, microbiologists, computational biologists, and other professionals who are interested in strengthening or enlarging their knowledge about microbiome analysis with next-generation DNA sequencing in the different branches of the sciences