Inflammation of the brain, usually brought on by a viral infection, encephalitis currently poses a grave threat to patients around the world. With the migration of West Nile virus into North America, there is a greater awareness and corresponding need to understand, diagnose, and manage this illness. In Encephalitis: Diagnosis and Treatment, experts discuss advances in diagnostic tools, as well as therapeutic approaches that allow clinicians to better recognize and treat afflicted patients. Individual chapters address the principal infectious and non-infectious causes of brain inflammation, including paraneoplastic encephalitides-an apparent autoimmune process in patients with malignancies-as well as acute disseminated encephalomyelitis, a post-infectious disorder. The book addresses etiology, epidemiology, and specific issues in diagnosis, pathology, and treatment, including various laboratory methodologies, pathologic changes seen in the different disorders, and diagnosis and management of the seizures that occur quite frequently in these disorders. With contributions from a group of international experts, the book provides a perspective on this disorder that is both broad and in-depth.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

A brand-new edition of the bestselling guide to hematologic malignancies. An international team of contributors come together to present all clinically relevant aspects of leukemias, lymphomas, and myelomas. Using clear terminology, the book discusses salient features, diagnostic procedures, prognosis, and treatments for these cancers. Following on the successful steps of the first edition, this Second Edition covers: various types of leukemias, lymphomas, and myelomas utilizing stem cell transplantation side-effects of various treatments future prospects for leukemia, lymphoma, and myeloma targeted therapies and history of the cancers information and support sources for patients

This book focuses on public health and epidemiologic aspects of cancer, and explores the sources of information concerning the frequency of occurrence of human cancer. It describes statistical methods useful in studying problems arising in the field of cancer and its concurrent development.

Multiple myeloma is the second most prevalent hematological malignancy, with over 55,000 new cases diagnosed each year. This exciting new text, edited by lauded authorities on the topic, stands as the only available reference to assemble, review, and synthesizes the latest studies on translational therapies and clearly explains the impact of molecular pathogenesis, biology, and prognostic factors on the diagnosis, prognosis, and individualization of treatment and the development of novel therapeutic options for patients with myeloma. Moving from the bench to the bedside to the forefront of therapeutic development, this source: helps clinicians and researchers effectively deploy therapeutic strategies into clinical practice reflects trends in the use of agents which target both the tumor cell and its bone marrow microenvironment to overcome resistance to conventional therapies considers the critical role of the bone marrow microenvironment in the regulation of growth, survival, and homing of multiple myeloma discusses novel therapies in phase I and phase II trials, focusing specifically on therapeutic options for patients with newly diagnosed or relapsed/refractory multiple myeloma addresses novel therapies for other plasma cell disorders, and provides the framework for the design of next generation agents and combination therapies covers the entire scope of translational work in multiple myeloma, from advances in molecular pathogenesis, to prognostic factors, immunotherapy, and new options for newly diagnosed and relapsed multiple myeloma patients

With new infectious agents, antibiotics, and instances of antimicrobial resistance constantly on the horizon, this field is an ever growing discipline that requires constant vigilance. This book responds to burgeoning growth in the field and provides a comprehensive and expert armamentarium of guidelines for the treatment and diagnosis of the entire breadth of adult and pediatric anaerobic infections.

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this
source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.

While evolving molecular diagnostic methods are being heralded for the role they will play in improving our ability to cultivate and identify bacteria, fungi, and viruses, the reality is that those new methods are still beyond the technical and financial reach of most clinical laboratories. Most clinical microbiology laboratories still rely upon culture methods for the identification of microorganisms of medical importance. The newest edition of the Handbook of Media for Clinical Microbiology addresses the needs of clinical microbiology laboratories and infectious disease researchers. Authored by Ronald Atlas and James Snyder, who over the years have built solid reputations among researchers for their exceptionally reliable media handbooks, this volume gives microbiologists in clinical and medical laboratories the reference they need to quickly and effectively deal with the modern challenges shaping the field. Organized for a fast-paced environment, this fully updated Second Edition provides clinical diagnostic laboratories with an easy-to-use reference for those routine and specialized media employed in the cultivation of pathogenic bacteria, fungi, and viruses. Almost 1,650 media are described in this edition, among them many newly developed media designed for the rapid detection and identification of disease-causing microorganisms, including those responsible for emerging and re-emerging infectious diseases. Describes media designed to cultivate and identify Escherichia coli O157:H7, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant enterococci Includes chromogenic or fluorogenic substrates that permit the rapid detection of specific pathogens critical to the diagnosis of individuals with specific infectious diseases The Handbook provides a compilation of the formulations, methods of preparation, and applications for media used in the clinical microbiology laboratory. Listings are alphabetical, and each inc

If you had a trillion dollars and a year to spend it for the good of the world and the advancement of science, what would you do? It's an unimaginably large sum, yet it's only around one per cent of world GDP, and about the valuation of Google, Microsoft or Amazon. It's a much smaller sum than the world found to bail out its banks in 2008 or deal with Covid-19. But what could you achieve with $1 trillion? You could solve the problem of the pandemic, for one, and eradicate malaria, and maybe cure all disease. You could end global poverty. You could settle on the Moon and explore the solar system. You could build a massive particle collider to probe the nature of reality like never before. You could build quantum computers, develop artificial intelligence, or increase human lifespan. You could even create a new life form. Or how about transitioning the world to clean energy? Or preserving the rainforests, or saving all endangered species? Maybe you could refreeze the melting Arctic, launch a new sustainable agricultural revolution, and reverse climate change? How to Spend a Trillion Dollars is the ultimate thought experiment but it is also a call to arms: these are all things we could do, if we put our minds to it - and our money.

Experts from The Jackson Laboratory and around the world provide practical advice on everything from how to establish a colony to where to go for specific mutations. Systematic Approach to Evaluation of Mouse Mutations includes information on medical photography, grafting procedures, how to map the genes and evaluate the special biological characteristics of the mice.

Why a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic and clinical questions that need to be addressed. Angiogenesis: From Basic Science to Clinical Applications presents the latest advances in basic science and reviews the status of the clinical applications of angiogenic growth factors and inhibitors. It explores current molecular and genetic findings on the regulation of angiogenesis, discusses the results of clinical trials and identifies the pathological conditions that are most likely to benefit from such treatments. Edited by a leading researcher in the field, the book includes contributions from multiple experts in their respective disciplines, supplemented by illustrations and photographs. A unique combination of information on basic science and clinical trials research, this book is truly a state-of-the-art review of the state of the science.

Green tea is the most studied anti-cancer plant over the past 10 years, as more than 5,000 medical studies have been published on the health benefits of tea, with over 1,000 of those focusing on tea and cancer. The NIH stance on green tea is that research indicates it is possibly effective against several types of cancer, clogged arteries, osteoporosis and Parkinson's disease; likely effective in managing high cholesterol; and safe for adults who drink five cups a day. Maria's goal is simple: easily relate to you what she has learned about and experienced with how tea works to help your body's defences against cancer. Maria is not a medical professional, and no statement in this book should be interpreted as direction or prescription, but through her explanations, she breaks down years of her research - her obsession after her own fight with cancer, how tea fights cancer and how you should be drinking it. While humorous in tone, Maria does not intend to make light of the serious research that forms the basis for the understanding. This book is intended to get you on a powerful five-cup a day tea steeping habit, which she passionately believes is one of the best ways to prevent this terrible disease.

In the U.S. alone, severe food-related allergic reactions account for an estimated 30,000 emergency room visits and 150 deaths per year - unsettling statistics for food product developers and manufacturers who are charged with ensuring food safety and quality throughout the entire farm-to-table production chain. Providing the clear-cut information necessary to conduct an effective allergen risk analysis, Chemical and Biological Properties of Food Allergens comprehensively examines the chemical, analytical, technological, and medical aspects of food allergies and the growing problem of cross-contact contamination during product processing. With contributions from an international team of research specialists, the book explains the basic mechanisms of allergenic reactions in humans, the molecular background of these mechanisms, and the problems of food tolerance and intolerance. It also discusses the issues related to common treatments of food allergies and the narrow groups into which they are categorized. Covering the most important recognized allergens in the U.S. and the EU, this resource also explores cutting-edge technological and biotechnological ways to lower the immuno-reactive and allergenic properties of foods. Chemical and Biological Properties of Food Allergens evaluates the current research literature in a concise format - a must for food product developers and biochemists.

This work includes a foreword by Elizabeth Rogerson. Head of Education and Development, International Virtual Nursing School Head, Distance Learning Centre (Nursing and Palliative Care), University of Dundee. It considers all the patient's symptoms and all the information available to us, then assesses the symptoms, signs and information given, using this to choose the appropriate remedies for the problem, and extra information will be offered where available and appropriate. This easy to use, evidence-based guide offers practical resources for every day use. Well laid out, with a simple alphabetical format, "Care of the Cancer Patient" covers the management of common problems, contains basic explanations of pathophysiology and relevant pharmacology, and includes vital guidance on new treatments and scientific papers. It is ideal for non-specialist doctors, nurses, carers and other health professionals who look after patients with cancer-related symptoms. 'This book recognises the complexity inherent in the cancer journey and places a spotlight on the human face of health care management, specifically on the ability to provide careful, individualised and sensitive management of symptom control that aims to make a difference to the patient's quality of life. It is written in a manner that is acceptable to professionals, patients and carers alike. This book adopts a unique approach to symptom management in palliative care, inviting the practitioner to consider the possible causes of the symptom, and then assess the patient with these in mind. Paying attention to the pathophysiology of the symptom and respecting the individual needs of the patient, one is guided to make a logical choice of treatment by thinking about the pharmacological actions of the available drugs. This is a book to be on the desk ready for quick reference, not stored on a shelf in a library.' - Elizabeth Rogerson, in the Foreword.

Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1) Hepatitis C virus (HCV) Epstein-Barr virus (EBV) Human papilloma virus (HPV) Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV) Human immunodeficiency virus (HIV/AIDS) Oncolytic viruses This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies.

Authored by electron microscopists and leading members of the International Committee on Taxonomy of Viruses (ICTV), the Atlas of Virus Diagrams includes chapters on virus classification. The diagrams, selected for content and historic and aesthetic value, illustrate vertebrate, invertebrate, and plant bacterial viruses taken from English, French, and German language virological literature. The book presents this information in three sections: Overviews, including vertebrate and plant viruses Viruses with cubic and helical symmetry Viruses with binary symmetry (tailed bacteriophages).

The Understanding IBS chart presents an overall view of the symptoms and causes of Irritable Bowel Syndrome. The main image features the large intestine, with cut-away views showing a spasm and inflammation. Heavy cover stock with protective varnish for durability.

Now in its second edition, this bestselling title has been extensively revised and expanded to include new topics on: obesity and breast cancer induction of anti-hormone and anti-growth factor resistance in breast cancer clinical implications of testosterone and breast cancer insulin-like growth factors discussions on the biological, genetic, and molecular pathways linked to the development and progression of breast cancer analyses on the latest therapeutic strategies, prognostic and predictive factors, and prevention strategies Examining new developments, Breast Cancer: Prognosis, Treatment, and Prevention, Second Edition also covers: the mechanism involved in carcinogenesis the relationship among a fetus, pregnancy, and breast cancer recent developments in endocrine treatment the relationship among hormone replacement therapy, cytotoxic therapy, and other non-hormonal approaches for the treatment of metastases management of locally advanced breast cancer, and the importance of BRCA-1 and BRCA-2 in hereditary breast cancer With new topics and updated chapters, this new edition keeps both oncologists and radiologists abreast of the current trends and advancements in the prognosis, treatment, and prevention of breast cancer.

A Silent Fire is a captivating expert account of inflammation's hidden role in many of the diseases of modernity and what we can actually do about it. 'Controlling Inflammation is the key to good health and this beautifully written and researched book is the best way to understand it' TIM SPECTOR, #1 bestselling author of Food for Life 'As gripping as a mystery story and as useful as a self-help book' BEE WILSON, author of First Bite _____ Inflammation is the body's response to injury and foreign microbes. But what if it were also a potential root cause of modern disease? The swelling and soreness of inflammation are caused by the gathering of immune cells to defend and heal our bodies. But as our environments and diets have rapidly changed, new science suggests that our immune systems are increasingly turning against us. Low-level inflammation, simmering quietly and undetected, has recently been identified behind everything from heart disease and cancer to mysterious autoimmune conditions. Hidden inflammation even weakens our immunity and increases the likelihood that our immune system will mount an overwhelming, inappropriate attack against infections. Shilpa Ravella is a specialist doctor at the forefront of this field, working on rare inflammatory disorders, gut transplants, nutrition and the microbiome. In A Silent Fire she interweaves the latest research with unusual case studies from her own practice and the history of immunology to explain what we know about this elusive phenomenon. She also debunks common myths about 'anti-inflammatory' lifestyles and reveals how we can reform our relationships with food and our microbiomes to benefit our own health and the planet's. In the eyes of many experts, inflammation is emerging as a common root of the diseases of modernity. This captivating narrative of scientific discovery explains why - and how we might control it.

Understanding immunology is increasingly important in obstetrics and gynecology. Written primarily to meet the needs of practicing obstetricians and gynecologists, this book explores the role of immunological processes in reproduction. It presents immunologic concepts and illustrates important points with examples familiar to the clinician. The book is organized into four sections that explore the fundamentals of the immune system, the immunological paradox of pregnancy, clinical applications of immunology in obstetric and gynecologic practice, and immunopathology in obstetric and gynecologic practice. Written mainly for practicing obstetricians and gynecologists, the research results cited in the book are based on human experimentation. Fully illustrated with clear schematic drawings that highlight important concepts and processes, The Immunology of Human Reproduction gives readers an essential overview of immunology as it relates to human reproduction.

Cancer and Creativity is a dialogue between accounts by cancer patients and survivors and a more clinical consideration and theoretical discussion from a psychoanalytic point of view of using creativity in coping with serious illness. The contributions featured demonstrate the power of creative expression as a tool for dealing with somatic, chronic and potentially life-threatening illnesses, giving patients a way of expressing and managing their individual cancer journeys and its attendant emotional sequelae. Ten artist-patients and survivors, who were involved in several long-term art therapy groups, give accounts of their experiences with cancer and with their support group, where they create paintings, embroidery, digital photography, comic books, maps and other works to express their experiences of being diagnosed and treated for cancer. The contributors describe their symptoms and their relationships to physicians and family members in words and visual representations. The book also addresses the experience of the public when they are confronted with art by cancer patients. Dreifuss-Kattan's own work as a psychoanalyst and art therapist informs her approach to the art space as what Winnicott calls a "transitional space," influenced by both the personal psychological experience and the physical environment. Dreifuss-Kattan closes her discussion with a reflection on terminal cancer care and the complex transferential and countertransferential relationship between patient and therapist. The book ends with a practical guide for both therapy groups, as well as individuals at home, to creatively address their experiences with cancer and its treatments. Cancer and Creativity will be of great interest to psychoanalysts, psychoanalytic psychotherapists, psychooncologists and art therapists, as well as health professionals working in oncology and in palliative care.

The Japanese Ministry of Health, Labor and Welfare, officially recognizing that various risk factors for disease are present in our environment, has proposed the concept of lifestyle-related diseases. These include those diseases that are tied to such lifestyle choices as excessive alcohol consumption, cigarette smoking, exposure to stress, and poor diet. Ongoing attention to this issue led to an International Symposium on Free Radicals and Health: Molecular Interventions and Protection of Lifestyle-Related Diseases bringing together the top experts in that area. With the belief that the recognition of the occurrence of risk factors and their identification are important to overcoming lifestyle-related diseases, three of those experts invited prominent participants at the symposium to contribute to a book. Molecular Interventions in Lifestyle-Related Diseases is the result of that effort. This book is divided into three main sections: Free Radicals, Lifestyle-Related Diseases, and Their Protection Free Radicals, Brain Diseases, and Their Protection Nutraceuticals, Functional Foods, Micronutrients, and Pharmacological Interventions When bad lifestyle choices cause oxidants and free radicals to have a negative influence on cell signaling and gene expression, lifestyle-related diseases are set into motion, which in turn lead to further oxidative stress. Molecular Interventions in Lifestyle-Related Diseases addresses the molecular basis of free radicals and lifestyle-related diseases and preventive/therapeutic approaches including the use of nutraceuticals, functional foods, and pharmacological interventions. Each section contains several chapters addressing critical molecular mechanisms, therapeutic interventions, and other issues of relevance to human health that will be of interest to students and researchers in the health professions including nutritional and environmental scientists, molecular and cell biologi

Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer prevention and control. This expertly-written reference thoroughly analyzes the scientific principles and methodologies behind the most recent translational therapies and provides the necessary context, data, and studies for practitioners to select appropriate candidates for treatment and effectively apply new therapies in clinical practice.

Emphasizing new and emerging therapies in each chapter, this reference provides essential information for clinicians to provide accurate diagnoses and select the most appropriate treatment regimens for patients with primary and metastatic brain tumors and neurological complications of cancer. Edited by a leading cast of authorities on the topic-including the Chief and Associate Editors of the Journal of Neuro-oncology-this easily-accessible guide reviews the epidemiology, identification, and management of brain tumors while exploring the latest advances in this increasingly diverse field.

This book provides an engaging, jargon-free introduction to the threat of global pandemics, offering an overview of the many origins and triggers of pandemic events. It covers the impacts generated by novel infectious disease outbreaks across various dimensions - from social and ethical to medical and political, from media to economic and legal implications. The author discusses the preparedness strategies developed globally, the lessons learned from various outbreaks and the mitigation measures deployed - from quarantine and social distancing to data sharing and surveillance systems - including their unintended impacts. While the risk of global pandemics is certainly intensely debated by the scientific community, and increasingly by policy makers at various levels, the threat is hardly discussed in the public domain. It only permeates the media during crisis events, such as during the SARS outbreak in 2003, the West African Ebola outbreak in 2014-15, and most notably the ongoing COVID-19 global pandemic crisis. This book is thus highly timely and topical. It has a global scope, whilst at times zooming in on the implications of pandemic risk and mitigation for the Global North or the Global South. Given the interdisciplinarity of the topic, this book will be of great interest to a wider non-academic audience, as well as students from a range of subjects including politics, sociology, geography, anthropology, and international development, along with entry-level medical students keen to widen their appreciation of the social dimensions of the medical work they set out to conduct.