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Books > Medicine > Clinical & internal medicine > Endocrinology

Insulin-like Growth Factor Receptor Signalling (Hardcover, 2003 ed.): Derek Leroith, Walter Zumkeller, Robert C. Baxter Insulin-like Growth Factor Receptor Signalling (Hardcover, 2003 ed.)
Derek Leroith, Walter Zumkeller, Robert C. Baxter
R5,673 Discovery Miles 56 730 Ships in 10 - 15 working days

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets.
This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Post-transcriptional Mechanisms in Endocrine Regulation (Hardcover, 1st ed. 2016): K.M.J. Menon, PhD, Aaron Goldstrohm, PhD Post-transcriptional Mechanisms in Endocrine Regulation (Hardcover, 1st ed. 2016)
K.M.J. Menon, PhD, Aaron Goldstrohm, PhD
R6,080 Discovery Miles 60 800 Ships in 12 - 19 working days

This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.

Hormone Resistance Syndromes (Hardcover, 1999 ed.): J.Larry Jameson Hormone Resistance Syndromes (Hardcover, 1999 ed.)
J.Larry Jameson
R4,601 Discovery Miles 46 010 Ships in 10 - 15 working days

Leading clinicians review in depth the clinical and molecular aspects of the hormone resistance syndromes caused by receptor mutations. These mutations are involved in a large number of disorders, including dwarfism, Laron syndrome, pseudohypoparathyroidism, insulin resistance, resistance to thyroid hormone, glucocorticoid resistance, hereditary resistance to vitamin D, and estrogen resistance. Throughout, the book's distinguished contributors not only summarize the clinical features of these and related disorders, but also illuminate their molecular bases. Hormone Resistance Syndromes provides an authoritative summary and standard reference for all those clinicians and researchers actively studying these mutations today and affords a unique opportunity to understand hormone action in normal physiology.

Insulin pump therapy - Indication - Method - Technology (Hardcover, Dt. Ausg. u.d.T.: Austenat, Elke: Insulinpumpentherapie.... Insulin pump therapy - Indication - Method - Technology (Hardcover, Dt. Ausg. u.d.T.: Austenat, Elke: Insulinpumpentherapie. Reprint 2019)
Elke Austenat, Tilman Stalh
R3,540 Discovery Miles 35 400 Ships in 12 - 19 working days
Choose Your Foods - Food Lists for Diabetes (Paperback): Academy Of Nutrition And Dietetics And American Diabetes Association Choose Your Foods - Food Lists for Diabetes (Paperback)
Academy Of Nutrition And Dietetics And American Diabetes Association
R185 R117 Discovery Miles 1 170 Save R68 (37%) Ships in 12 - 19 working days

For nearly 70 years, this resource has been the standard for diabetes education and meal planning. Based on input from current users, this new edition has been streamlined and redesigned and enhanced with more food images. It also features updated carbohydrate, protein, and fat information for a wide variety of food and beverages that reflect the diverse populations living with diabetes. This edition includes action-oriented eating plan tips throughout, a new section on Snacks and Extras, dedicated pages for notes, and a customizable eating plan.

Dyslipidemias - Pathophysiology, Evaluation and Management (Hardcover, 2015 ed.): Abhimanyu Garg Dyslipidemias - Pathophysiology, Evaluation and Management (Hardcover, 2015 ed.)
Abhimanyu Garg
R5,233 Discovery Miles 52 330 Ships in 10 - 15 working days

Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Program's Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.

Controversies in Thyroid Surgery (Hardcover, 1st ed. 2016): John B. Hanks, William B Inabnet III Controversies in Thyroid Surgery (Hardcover, 1st ed. 2016)
John B. Hanks, William B Inabnet III
R3,065 R2,101 Discovery Miles 21 010 Save R964 (31%) Ships in 12 - 19 working days

This book encompasses many different diagnoses as well as several specialties of practicing surgeons in the United States. Over the last ten years many advances have been made in preoperative assessment including imaging and diagnostic techniques, operative approaches including "minimally invasive" and robotic surgery, and post operative care. Controversies in Thyroid Surgery explores some of the controversies that arise as the result of these new findings and applications. The book is divided into the two categories of benign diagnosis and cancer topics. Both of these areas lend themselves to separate analysis of specific problems in the areas mentioned above. The text reviews recent data about advances in diagnostic techniques as well as outcomes with specific regards to the newer operative techniques. The textbook will serve as a resource for medical and surgical colleagues involved in the treatment of a wide variety of thyroid diseases. Authors that are experts in their field and have published extensively provide balanced and non-biased views of topics that are admittedly controversial. Controversies in Thyroid Surgery will be of great value and utility to practicing endocrinologists, general surgeons and otolaryngologists.

Vitamin D - A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings... Vitamin D - A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28-June 2, 1994 (Hardcover, Reprint 2020)
Anthony W. Norman, Roger Bouillon, Monique Thomasset
R9,874 Discovery Miles 98 740 Ships in 12 - 19 working days
Natriuretic Peptides in Health and Disease (Hardcover): Willis K. Samson, Ellis Levin Natriuretic Peptides in Health and Disease (Hardcover)
Willis K. Samson, Ellis Levin
R5,673 Discovery Miles 56 730 Ships in 10 - 15 working days

A comprehensive, state-of-the-art review of the biochemistry, molecular and cellular biology, pharmacology, physiology, and pathology of natriuretic peptides. Written by the foremost researchers in the field, the reviews range from describing the actions of these peptides on the kidney, adrenal gland, vasculature, and brain, to their effects on immune regulation, reproduction, and cell growth. Special attention is given to the potential involvement of these hormones in clinical pathology and to their possible therapeutic use. Especially enlightening is the first-time review of molecular understanding of key cellular signaling pathways and of the importance of the vascular smooth muscle-endothelial interface.

Impact of Sleep and Sleep Disturbances on Obesity and Cancer (Hardcover, 2014 ed.): Susan Redline, Nathan A. Berger Impact of Sleep and Sleep Disturbances on Obesity and Cancer (Hardcover, 2014 ed.)
Susan Redline, Nathan A. Berger
R4,744 R3,599 Discovery Miles 35 990 Save R1,145 (24%) Ships in 12 - 19 working days

Sleep has recently been recognized as a critical determinant of energy balance regulating, restoration and repair of many of the physiologic and psychologic processes involved in modulating energy intake and utilization. In addition to having an impact on obesity, sleep abnormalities, both quantitative and qualitative, have now been shown to have significant effects on obesity associated comorbidities, including metabolic syndrome, premalignant lesions and cancer. Sleep problems and fatigue also constitute a significant challenge for the ever expanding group of cancer survivors. Moreover, circadian misalignment, such as that experienced by "shift workers" has been shown to be associated with an increased incidence of several malignancies including, breast, colorectal and prostate cancer, consistent with the increasing recognition of the role of clock genes in the metabolic processes. Of increasing concern is the accelerating incidence of sleep disorders in childhood, their association with childhood obesity and associated abnormalities of circulating cytokines, adipokines and metabolic factors, many of which are implicated as etiologic mediators of the connection between obesity and cancer. Extensive studies have now been initiated to investigate the mechanisms by which disturbances in sleep duration, sleep continuity and sleep related breathing affect circadian rhythm, central and peripheral tissue oxygenation and metabolism, quality and quantity of dietary intake and circulating inflammatory cytokines and regulatory hormones. This volume aims to present the latest research on sleep, sleep disturbance and its correlation to obesity and cancer.

Biologic Effects of Light 1998 - Proceedings of a Symposium Basel, Switzerland November 1-3, 1998 (Hardcover, 1999 ed.):... Biologic Effects of Light 1998 - Proceedings of a Symposium Basel, Switzerland November 1-3, 1998 (Hardcover, 1999 ed.)
Michael F. Holick, Ernst G. Jung
R8,581 Discovery Miles 85 810 Ships in 10 - 15 working days

It is remarkable how much we take for granted the tremendous energy and vitality that the sun provides earth's inhabitants. As we enter the new millennium, it is worthwhile to review how our ancestors perceived the biologic effects of sunlight, and how science and medicine have advanced our knowledge about the biologic effects of light. At the turn of the century, a multitude of investigators explored the use of sunlight and artificial radiation for treating a multitude of diseases. These explorations gave rise to photodynamic therapy, phototherapy, and chemophototherapy. However, enthusiasm for using sunlight and artificial radiation to treat disease was dampened with the birth of pharmacology. It was the goal of the Fifth International Arnold Rikli Symposium on the Biologic Effects of Light, held in Basel, Switzerland, on November 1-3, 1998, to review the history of phototherapy and have some of the world's leading experts on the biologic effects of light provide new perspectives on the positive and negative effects of light. The general topics included a broad range of biologic effects of sunlight, artificial ultraviolet radiation and electromagnetic radiation. Special sessions on radiation and vitamin D and bone health, photoimmunology, biopositive effects of UV radiation, effects of electromagnetic currents and fields, and ocular and non-ocular regulation of circadian rhythms and melatonin, should be of particular interest to readers of Biologic Effects of Light.

Practical Stress Management - A Comprehensive Workbook (Paperback, 8th edition): John A Romas, Manoj Sharma Practical Stress Management - A Comprehensive Workbook (Paperback, 8th edition)
John A Romas, Manoj Sharma
R2,361 R2,146 Discovery Miles 21 460 Save R215 (9%) Ships in 12 - 19 working days

Practical Stress Management, Eighth Edition emphasizes a positive approach to stress management, covering topics such as relaxation techniques, coping with anxiety, managing anger, communication skills, exercise and nutrition. In this edition, the authors cover the latest advances in stress management, as well as stress related to the use of technology in education. The context of disasters, such as the COVID-19 pandemic, is also incorporated throughout. The workbook describes some of the surreptitious meditation techniques from India not described before in any text. Worksheets and Thoughts for Reflection boxes help users determine their own level of stress to apply effective stress management techniques.

Research Methodologies in Human Diabetes. Part 2 (Hardcover, Reprint 2020): C.E. Mogensen, E. Standl Research Methodologies in Human Diabetes. Part 2 (Hardcover, Reprint 2020)
C.E. Mogensen, E. Standl
R4,526 Discovery Miles 45 260 Ships in 12 - 19 working days
Puberty - Physiology and Abnormalities (Hardcover, 1st ed. 2016): Philip Kumanov, Ashok Agarwal Puberty - Physiology and Abnormalities (Hardcover, 1st ed. 2016)
Philip Kumanov, Ashok Agarwal
R4,309 Discovery Miles 43 090 Ships in 12 - 19 working days

Bringing together the latest knowledge on the growth and development of children and the most important abnormalities of puberty, this comprehensive text presents the current views on the pathogenesis, diagnostic possibilities and therapeutic options of the main deviations from the normal course of puberty (e.g., precocious and delayed puberty). The chain of physical and hormonal changes in the transitional years is carefully followed, including the regulation of the hypothalamic pulse generator as well as the timing of puberty. Further topics include growth disturbances, adolescent varicocele, adolescent gynecomastia, polycystic ovary syndrome, pubertal acne, and the psychosocial development of adolescents with pubertal abnormalities. Written and edited by internationally noted experts, Puberty will be an excellent resource for pediatricians, endocrinologists, gynecologists, andrologists, urologists, family practitioners, child psychologists and public health specialists - all those who will be challenged in their everyday practice with the problems of puberty.

Treating Endocrine and Metabolic Disorders With Herbal Medicines (Hardcover): Arif Hussain, Shalini Behl Treating Endocrine and Metabolic Disorders With Herbal Medicines (Hardcover)
Arif Hussain, Shalini Behl
R8,802 Discovery Miles 88 020 Ships in 10 - 15 working days

The utilization of herbal medicine to treat endocrine and metabolic disorders has garnered much attention within the past few decades. Specifically, the popularity of using dietary supplements for the management of chronic disorders has drastically increased, with a wide variety of these products available over the counter. They represent an attractive adjuvant to traditional therapy for their lower toxicity and their easy accessibility. The identification of such dietary compounds has prompted researchers to explore the vast array of their beneficial effects. However, despite their widespread use, there is still limited data on the safety and efficacy of the products currently on the market. Current research on the side effects and safe usage of herbal medicines is necessary for providing optimal care and counseling for patients. Treating Endocrine and Metabolic Disorders With Herbal Medicines is a comprehensive reference book focused on spreading awareness on the safety, potential harmful effects, and rational use of herbal medicines. The chapters within explore and provide insight on the effectiveness, versatility, and side effects of various herbal medicines across a range of different diseases and conditions. While highlighting herbal medicine in areas such as diabetes, cancer, infertility, and endocrine disorders, this publication is ideally intended for clinical practitioners, pharmaceutical scientists, doctors, practitioners, stakeholders, researchers, academicians, and students interested in enhancing their knowledge and awareness in the field of complementary medicine.

Pharmacotherapy of Diabetes: New Developments - Improving Life and Prognosis for Diabetic Patients (Hardcover, 2007 ed.): Carl... Pharmacotherapy of Diabetes: New Developments - Improving Life and Prognosis for Diabetic Patients (Hardcover, 2007 ed.)
Carl Erik Mogensen
R2,938 Discovery Miles 29 380 Ships in 10 - 15 working days

In the United States, 20.8 million children and adults, 7% of the population, have diabetes. While an estimated 14.6 million have been diagnosed, 6.2 million have yet to be diagnosed. Worldwide diabetes afflicts 150 million people. The World Health Organization estimates that by 2025 that figure will double. Diabetes is responsible for more deaths than AIDS and breast cancer, combined. It is a leading cause of blindness, kidney failure, amputations, heart complications and stroke. Treatment of Type 1 and Type diabetes has changed radically over the past few years. There are new opportunities for treating the key abnormality in diabetes, increased blood glucose, by effective agents such as new insulin preparations and oral agents. Increasing so-called non-glycemic intervention is of prime importance. Blood pressure lowering therapies, anti-cholesterol strategies, and specific treatment related to complications is becoming increasingly important. Pharmacotherapy of Diabetes is a unique, invaluable guide to all aspects of the pharmacological treatment of diabetes, covering basic concepts and an in-depth review of current and future therapies. This work provides an overview for the new changes in therapies that can be implemented in clinical practice and treatment of the diabetic patient.

Precision Medicine in Neurodegenerative Disorders, Volume 193 - Part II (Hardcover): Alberto J. Espay Precision Medicine in Neurodegenerative Disorders, Volume 193 - Part II (Hardcover)
Alberto J. Espay
R5,767 Discovery Miles 57 670 Ships in 12 - 19 working days

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 deals with the "How" in the reconfiguration of our approach to slow the progression of those suffering from diseases of accelerated brain aging. This second Handbook of Clinical Neurology volume offers a rethinking of the animal models on which therapies are tested; outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology; and the growing role of microbiome in shaping disease and as a future target of therapeutic efforts. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision medicine -matching the biology of those affected with the mechanism of the intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes.

Diabetic Renal-Retinal Syndrome - 21st Century Management Now (Hardcover, 1998 ed.): E.A. Friedman, Francis A. L'Esperance... Diabetic Renal-Retinal Syndrome - 21st Century Management Now (Hardcover, 1998 ed.)
E.A. Friedman, Francis A. L'Esperance Jr
R4,521 Discovery Miles 45 210 Ships in 10 - 15 working days

After a decade or longer, approximately one-third of individuals with either type 1 or type 2 diabetes commence a downhill course in which decreasing renal function and failing vision define a Renal-Retinal Syndrome, dominating all aspects of life and presaging early death. Only a generation ago, survival after onset of end-stage renal disease (ESRD) in diabetes was limited because rehabilitation was preempted by blindness, limb amputation, stroke, and heart disease. By 1998, however, team management has improved the outlook, with preserved sight and return to work and home responsibilities, usually for a decade or longer, following kidney transplantation and laser photocoagulation. Recognition of the critical requirement for blood pressure regulation and metabolic control are central themes in management. In this unique book, the accomplishments of ophthalmologists, nephrologists, diabetologists, transplant surgeons, and basic scientists are blended into a strategic approach that may be readily applied by all those caring for diabetic patients. Each of twenty-one presentations suitable for primary care physicians, as well as for subspecialists concerned with macrovascular and microvascular complications of diabetes, is placed in perspective by an introductory editorial analysis. Promising near-term innovative therapies, including insertion of genetically engineered beta cells or polymer-coated islets of Langerhans, interdiction of kinins that promote retinal angiogenesis, and prevention of synthesis of advanced glycosylated endproducts (AGEs), are presented in detail. While comprehensive care of diabetic patients reflects multiple incremental advances that in sum afford major benefit, this text envisions further remarkable changes likely to suppress and possibly entirely prevent the Diabetic Renal-Retinal Syndrome.

Chromogranins - Functional and Clinical Aspects (Hardcover, 2000 ed.): Karen B. Helle, Dominique Aunis Chromogranins - Functional and Clinical Aspects (Hardcover, 2000 ed.)
Karen B. Helle, Dominique Aunis
R4,711 Discovery Miles 47 110 Ships in 10 - 15 working days

Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With. This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.

Molecular Dermatology - Methods and Protocols (Hardcover, 2013 ed.): Cristina Has, Cassian Sitaru Molecular Dermatology - Methods and Protocols (Hardcover, 2013 ed.)
Cristina Has, Cassian Sitaru
R2,995 Discovery Miles 29 950 Ships in 10 - 15 working days

The sustained skin research efforts over the past decades has led to the accumulation of a significant collection of information on skin structure and physiology as well as on the pathogenesis of cutaneous diseases. In Molecular Dermatology: Methods and Protocols, leading experts in the field provide a collection of state-of-the-art reliable protocols covering a wide spectrum of techniques and experimental models, specific molecular assays and disease models, as well as overviews of diagnostic and research areas relevant to molecular dermatology. As a volume in the highly successful Methods in Molecular Biology (TM) series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Molecular Dermatology: Methods and Protocols emphasizes the vital importance of skin research and collects the methodologies necessary to aid scientists in moving forward in this valuable field.

Secondary Hypertension - Clinical Presentation, Diagnosis, and Treatment (Hardcover, 2004 ed.): George A. Mansoor Secondary Hypertension - Clinical Presentation, Diagnosis, and Treatment (Hardcover, 2004 ed.)
George A. Mansoor
R4,560 Discovery Miles 45 600 Ships in 10 - 15 working days

Secondary forms of hypertension are not uncommon in clinical prac tice, but they are often overlooked or forgotten by clinicians in many fields of medicine. Dr. George Mansoor' s volume on Secondary Hyper tension is an important contribution to the field of clinical hypertension and vascular diseases, since it brings up to date the numerous diagnostic and therapeutic advances in the evaluation for secondary types of hyper tension. In the past, textbooks usually stated that an etiology could be determined in less than 5% of patients presenting with newly diagnosed hypertension. We now know this is far too low a proportion (e.g., pri mary hyperaldosteronism alone may account for hypertension in 5% of patients presenting with chronic elevations in blood pressure). Secondary Hypertension has been thoughtfully organized into chap ters evaluating screening and diagnosis, as well as medical and/or sur gical intervention of the well-known etiologies of secondary hypertension in adults and children. Additional coverage is given to such exogenous or lesser appreciated causes of secondary hypertension as obstructive sleep apnea and drugs. These sections make this book novel because in the past little attention has been paid to the effects of noncar diac drugs that interfere with antihypertensive therapy or to exogenous substances that might induce refractory hypertension."

The Heart in Diabetes (Hardcover, 1996 ed.): J. C. Chatham, C. Forder, John H. McNeill The Heart in Diabetes (Hardcover, 1996 ed.)
J. C. Chatham, C. Forder, John H. McNeill
R4,509 Discovery Miles 45 090 Ships in 10 - 15 working days

Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life. In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.

Thyroid Cancer - From Emergent Biotechnologies to Clinical Practice Guidelines (Hardcover): Angelo Carpi, Jeffrey I. Mechanick Thyroid Cancer - From Emergent Biotechnologies to Clinical Practice Guidelines (Hardcover)
Angelo Carpi, Jeffrey I. Mechanick
R3,810 R3,605 Discovery Miles 36 050 Save R205 (5%) Ships in 12 - 19 working days

The current age of clinical medicine is witnessing biotechnological innovation at an unprecedented pace. As a result, the recently popularized clinical practice guidelines (CPG), as a tool to assist clinical decision-making, have been struggling to keep up. Thyroid Cancer: From Emergent Biotechnology to Clinical Practice Guidelines rides the wave of medical innovation, analyzing current and future CPG, and providing an up-to-date and comprehensive treatise on thyroid cancer, its diagnosis, and treatment.

A synthesis of ideas by prominent world experts in the field of thyroid cancer research and clinical practice, Thyroid Cancer covers:

  • Technologically-advanced diagnostic procedures and therapeutic interventions
  • Diagnostic techniques employed in the detection and follow-up of thyroid cancer including ultrasound, needle aspiration techniques, CT, PET, PET-CT, and MRI
  • Basic principles of systems biology, molecular and translational medicine, CPG development, and risk stratification for thyroid cancer
  • How CPG contain knowledge gaps and produce uncertainty
  • Advances in the field, including new surgical techniques, molecular targeted therapies, external beam radiation therapy, and chemotherapy

A comprehensive, scientific description of current and future diagnostic and therapeutic modalities for the management of thyroid cancer, this treatise is an indispensible reference for both the specialist and referring physician.

Transgenic Models in Endocrinology (Hardcover, 2001 ed.): Maria G. Castro Transgenic Models in Endocrinology (Hardcover, 2001 ed.)
Maria G. Castro
R4,385 Discovery Miles 43 850 Ships in 10 - 15 working days

The dramatic recent expansion in genomic information has motivated the development of new approaches to characterize gene expression and function. A critical issue for both basic and clinical endocrinologists is the physiological role of genes involved in regulating endocrine functions. Transgenic technologies allow the translation of genotypic information into specific phenotypes by using gene overexpression or loss of specific gene functions. Murine functional genomics is thus of central importance in modem biomedical endocrine research. Although mice are at present, the preferred mammalian species for genetic manipulations because of the availability of pluripotent embryonic. stem cells and inbred strains and the relatively low breeding and maintenance costs, transgenic rats have also been generated and used to study endocrine physiology. The two basic techniques used in the creation of transgenic animal models are integration of foreign DNA into a fertilized oocyte by random chromosomal insertion and homologous recombination in embryonic stem cells that are then introduced into zygotes. Transgenic mice and rats serve as sophisticted tools to probe protein function, as models of human disease, and as hosts for the testing of gene replacement and other therapies. Embryonic stem cell libraries for mouse gene deletion are being developed, which will make it possible to generate knockout mice rapidly and without the need to analyze gene structure, construct targeting vectors, and screen embryonic stem cell clones. A novel approach to transgenesis for the expression of DNA within adult differentiated neuroendocrine cells in vivo is using viral vectors.

Type 1 Diabetes (Hardcover): Alan Escher, Alice Long Type 1 Diabetes (Hardcover)
Alan Escher, Alice Long
R4,513 Discovery Miles 45 130 Ships in 10 - 15 working days
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