Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

Bringing together more than a decade of dedicated investigation and clinical work, this unique textbook is a unified, comprehensive source for oncofertility research and medical practice that is both authoritative and up-to-date. It will serve as the primary oncofertility reference for the various medical disciplines that must be coordinated to provide care for young cancer patients. Moreover, it contains case studies that are prismatic for new entrants into the field. The book is organized around the major themes of the discipline and includes current research, clinical practice, emerging technologies and didactic questions and is divided into six thematic sections: Fertility implications in both oncologic and non-oncologic settings Options for fertility preservation, both male and female Care of the oncofertility patient, including contraception and pregnancy considerations Oncofertility in clinical practice, from setting up a new program to genetic counseling and communication Ethical and legal considerations Advances in the basic science of oncofertility In each chapter, bulleted key learning points and review study questions bookend the text. Six additional sections, comprised exclusively of clinical case studies illustrating the management of both oncologic and non-oncologic conditions, add to the pedagogical value of the text. Timely and utilizing the best current evidence, Textbook of Oncofertility Research and Practice: A Multidisciplinary Approach will be an invaluable resource for students, residents, fellows and professionals in reproductive endocrinology, pediatric endocrinology, adult and pediatric oncology, adult and pediatric urology, breast surgery, radiation oncology and allied professions where iatrogenic treatments or genetic conditions result in infertility.

Analyzes various reproductive and gynecological disorders encountered in the care of women who do not wish to conceive, as well as those who have difficulty with conception, early pregnancy, and menopause. Discusses the latest strategies in the treatment of infertility, pelvic pain, ectopic pregnancy, and osteoporosis.

The clinical benefits of hormone replacement therapy in women have to be carefully balanced against the possible risks, and a particular theoretical concern relates to risks associated with various forms of female oncology. Because of conflicting reports, gynecologists and oncologists especially need a single, authoritative resource of up-to-date information. Hormone Replacement Therapy and Cancer, published in association with the International Menopause Society, provides the very consensus statement that clinicians need in this difficult and complex area.

Many of the world's leading specialists have contributed important chapters that provide state-of-the-art knowledge about the effects of hormones on women and possible cancer risks. The introductory section deals with carcinogenesis, and the other main sections cover HRT and breast cancer, endometrial cancer, colon cancer, melanoma and epithelial ovarian cancer. The concluding chapters discuss the benefits and risks of specific therapies. An authoritative clinical reference with extensive bibliographic references and index, Hormone Replacement Therapy and Cancer covers all aspects of HRT and cancer based on the research available up to June 2001.

This monograph summarises the proceedings of the Seventh International Barts Symposium held 20 April 2001 in London, UK. Chapters address new developments in the administration of insulin, including oral preparations and long-acting insulin analogue. Breakthroughs in the understanding of the pathogenesis of type 2 diabetes are also covered, along with the future of the glitazones in management.

Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors

This book is a how-to manual for practicing physicians and health care providers, nurse educators, nutritionists, and physicians in training in the management of persons with diabetes mellitus. Experts with strong clinical and teaching backgrounds provide up-to-date recom-mendations and rationale of the most effective diagnostic and therapeutic approaches to diabetes mellitus and its multiorgan micro- and macrovascular complications for patients of all ages. Gives five practical guidelines for nutrition therapy that supplies realistic recommendations! With contributions from nearly 60 clinicians who reveal a constellation of disorders with different signs, symptoms, clinical characteristics, and therapies, Medical Management of Diabetes Mellitus -reviews the autoimmune process and genetics of type 1 and type 2 diabetes -offers an overview of the medications that impair glucose metabolism causing hypo- or hyperglycemia -covers pathogenesis, clinical presentation, and diagnosis with specialized laboratory tests -surveys therapeutic modalities, their mechanisms of action, and rationale for use -focuses on outcomes and how they are tracked -stresses early detection and therapy of end-organ complications -discusses the effect of intensive diabetes management on reducing retinopathy, nephropathy, and neuropathy -considers incorporating psychiatric techniques into the treatment of diabetes -compares and contrasts diabetes in children, adults, and the elderly -and more! Containing over 850 references, tables, drawings, and photographs, Medical Management of Diabetes Mellitus is a cross-disciplinary reference perfect for family practice physicians, internists, pediatricians, endocrinologists, pharmacologists, nutritionists, physiologists, dietitians, obesity specialists, psychiatrists, and medical school students in these disciplines.

An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models.
Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

This is a comprehensive, up-to-date, authoritative research text and clinical reference work the menopause. It contains over 90 contributions covering every conceivable topic in the management of the menopause in women and related issues in the aging male. The book contains many illustrations and a wealth of references.

Despite the gains of the women s movement, women are still judged by what they look like--and men, by what they do. Fat--A Fate Worse Than Death? offers hardy resistance to the narrow, random, and irrational appearance standards set for American women through an approach that is personal, eclectic, courageous, and funny. If you are interested in giving up your diet, throwing out your scales, and concentrating on who you are on a deeper level, this book will show you how to accept, appreciate, and even love your body Using statistics, research, anecdotes, and personal experiences, Fat--A Fate Worse Than Death? explores how appearance standards have built a prison for women. With the book s helpful advice, reading suggestions, and list of more than 100 ways to fight looksism, sexism, ageism, and racism, you will learn to express your rights and needs, regardless of your shape or size, and tear down those prison walls. Designed to transcend the boundaries between the personal and the political, Fat--A Fate Worse Than Death? discusses: examples of how weight and size constitute the last socially accepted prejudice the national "War on Fat" counteracting societal influences that support weight preoccupation connection between appearance standards for older women and large women nurturing your body resisting male-defined standards of beauty for women the myth of diets and dieting how the body resists weight loss how women are disempowered by concentration on weight and appearance how concentrating on appearance leaves real-life issues unaddressed how feeling bad about yourself can turn you into a willing consumerFeminists, faculty and students of women s studies programs, aging women, women of radical politics, and other concerned women and men will find that Fat--A Fate Worse Than Death? states explicitly how women are kept powerless by subscribing to cultural and social edicts on physical appearance. Don t live silently in a society that degrades and discounts women because of their physical stature and don t let obsession with thinness keep you passive, docile, and unable to give your energy to things that really need your passion and intelligence. Read this book and learn to not only value yourself for who you are, but also to counteract American culture s equality-denying prejudices and practices."

The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective - addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 deals with the "How" in the reconfiguration of our approach to slow the progression of those suffering from diseases of accelerated brain aging. This second Handbook of Clinical Neurology volume offers a rethinking of the animal models on which therapies are tested; outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology; and the growing role of microbiome in shaping disease and as a future target of therapeutic efforts. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision medicine -matching the biology of those affected with the mechanism of the intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes.

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more.

Accessible information on the causes, health risks, and treatment of prediabetes

If you or someone you love has been diagnosed with prediabetes - a heightened level of glucose, and/or impaired glucose tolerance - the time to act is now. "Prediabetes For Dummies" examines the signs and symptoms of this potential precursor to diabetes and offers up-to-date information about treatment. It provides clear, practical advice on steps you can take to minimize the risk of serious health consequences.

This plain-English guide shows you how to stop prediabetes in its tracks and prevent it from progressing to diabetes. You'll learn how to recognize the symptoms of this often-undiagnosed condition, and what to do if you think you may be prediabetic. You'll also discover how simple lifestyle changes, such as changes in your diet and moderate exercise, can put the brakes on prediabetes and even reverse the condition.Offers clear explanations of prediabetes causes, health risks, and treatmentIncludes the latest advances in the use of diabetes medications to treat prediabetesProvides diet suggestions, meal plans, and exercise tipsContains helpful suggestions for friends and family members who want to support a loved one with prediabetes

While there is no cure for diabetes, it can be prevented if prediabetes is diagnosed and treated early. Packed with valuable information for patients of all ages, "Prediabetes For Dummies" is an important resource for taking control of this dangerous condition.

This Handbook fulfils a pressing need within the area of psychological measurement in diabetes research and practice by providing access to material which has either been widely dispersed through the psychological and medical literature or has not previously been published.
Journal articles describing the psychometric development of scales have rarely included the scales themselves but this book includes copies of scales and a wealth of additional information from unpublished theses, reports and recent manuscripts.
You will find information about the reliability, validity, scoring, norms, and use of the measures in previous research presented in one volume.
The Handbook is designed to help researchers and clinicians:
. To select scales suitable for their purposes
. To administer and score the scales correctly
. To interpret the results appropriately.
Dr. Clare Bradley is Reader in Health Psychology and Director of the Diabetes Research Group at Royal Holloway, University of London.
Dr. Bradley and her research group have designed, developed and used a wide variety of measures of psychological processes and outcomes. Many of these measures have been designed and developed specifically for people with diabetes. Together with diabetes-specific psychological measures developed by other researchers internationally, these instruments have played an important part in facilitating patient-centred approaches to diabetes research and clinical practice.

Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications provides a thorough review of recent advances in major areas of melatonin research. The book is arranged in a logical sequence, beginning with the history of melatonin and then proceeding to cover its biochemistry and secretion, physiological effects, and clinical significance. New findings and current concepts are emphasized, and a significant amount of previously unpublished data are included. The book will be an important reference for neurobiologists, cell biologists, ophthalmologists, endocrinologists, neuroendocrinologists, reproductive biologists, psychiatrists, and other researchers and clinicians interested in melatonin.

Diabetes and Wellbeing presents a range of effective psychological principles proven to positively impact the emotional wellbeing of individuals with type 1 and 2 diabetes. The guide takes an explicitly CBT approach to motivate sufferers in essential self-care tasks. * Written in a practical style, for those newly diagnosed with diabetes, individuals managing its challenges for many years, and healthcare professionals * Reveals how the stress of daily diabetes management can affect an individual s ability to stay motivated and engaged in essential self-care tasks that are vital for good health * Presents proven techniques for improving emotional wellbeing * First book to take an explicitly CBT approach to diabetes, simultaneously drawing on solution-focused behavioural therapy and mindfulness approaches * Fills the gap information of this kind among healthcare professionals and individuals with diabetes

Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects.
The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined.
* Provides an expert review of the phenomenon of insulin resistance
* Brings together a host of recent research for the first time
* Written by leading experts in biological and clinical research

ABC of Diabetes provides primary care practitioners with a practical guide to all aspects of diabetes including the aetiology, diagnosis and management of Types 1 and 2 diabetes, detection and prevention, and the organization of care and support. Advances in diabetes care take place at a rapid rate and this new edition is updated throughout to cover the latest evidence-based information for contemporary practice. A new chapter describes the management of severe and complex obesity complicated by diabetes and the management of patients through bariatric surgery. It also covers the growing number of devices and digital technology, including health informatics, that can assist in diabetes care and provides evidence of their benefit. With more links to useful websites and resources online, it is now easier than ever to keep up-to-date with changes. Drawing on the professional and teaching experience of an expert author team, ABC of Diabetes is an essential guide for general practice, primary care practitioners, diabetes specialist nurses, as well as for medical students and those training in diabetes as a specialty.

Hormones and Synapse, Volume 114 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including how growth hormone promotes synaptogenesis, sex hormones and proteins involved in brain plasticity, corticotropin releasing factor modulates excitatory synaptic transmission, bisphenol a and memory: a role for dendritic spines, brain insulin resistance impairs hippocampal synaptic plasticity, estradiol induces synaptic rearrangements, stress and remodeling of hippocampal spine synapses, neurotrophin-3 modulates synaptic transmission, nongenomic neurosteroid modulation of hippocampal dendritic spines, neural sex steroids and hippocampal synaptic plasticity, origin of chemical synapses, neural sex steroids and hippocampal synaptic plasticity, and much more.

Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat. This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas.

A diabetes cookbook for every day from a registered dietitian and certified diabetes educator. A new edition of the cookbook companion to Karen Graham’s The Complete Diabetes Guide, with updated recipes based on new research and best practices. One in ten people over 40 now has diabetes. Research by Diabetes UK suggests that by 2030, around 5.5 million people in the UK will be suffering from the condition, which is fuelled by obesity. In this book, Karen Graham explains that carefully planned, nutritious meals and sensible portion sizes are an essential part of diabetes management, and then gives step-by-step instructions for putting this advice into action. This is a simple and straightforward meal planning guide with recipes from Registered Dietitian Karen Graham and Certified Diabetes Educator Dr. Mansur Shomali, which includes balanced options for every meal of the day along with pairing advice and nutritional analysis. While one might assume that a meal supporting diabetes management might not be very tasty, Karen Graham shows you that this is far from the truth. Some of the 100 delicious recipe options here include Poppy Seed Spinach Salad, Roti with Curried Filling, Thai Chicken and Grilled Tomato, and Mandarins and Cottage Cheese. Karen Graham’s Diabetes series is market-leading and has sold 250,000 copies across all titles and editions. She has an easy-tounderstand approach and has devoted her career to helping those with diabetes improve their lives.

Key features include: Details the role of plants for the treatment and management of cancer and diabetes Discusses the role of phytocompounds as ligands for cancer and diabetic targets Reviews plants and the potential of phytochemicals as antidiabetic and anticancer drugs Explores the green biosynthesis of nanoparticles and their treatment efficiency