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Books > Medicine > Clinical & internal medicine > Endocrinology
Fibroblast Growth Factor 23 describes how FGF23 was initially
identified as a bone-derived factor targeting the kidney. As such,
sections in this comprehensive book cover exciting research that
shows that different FGF23 effects require distinct signaling
receptors and mediators that differ among target tissues, cover
FGF23 initially identified as a bone-derived factor targeting the
kidney, look at FGF23 as a regulator of phosphate metabolism and
beyond, and cover research on novel concepts of FGF receptor
signaling. Additional sections cover biochemistry, pharmacology and
nephrology, making this book an ideal reference source on FGF23.
Guest edited by Dr. Margaret E. Wierman, this issue of
Endocrinology and Metabolism Clinics will cover several key areas
of interest related to Androgens in Women. This issue is one of
four selected each year by our series Consulting Editor, Dr.
Adriana Ioachimescu. Articles in this issue include but are not
limited to: Hyperandrogenic Anovulation: Differential Diagnosis and
Evaluation, Diagnosis of Polycystic Ovary Syndrome, Polycystic
Ovary Syndrome: Ontogeny in Adolescence, Fertility Issues in
Polycystic Ovarian Disease: A Systematic Approach, Management of
Women with PCOS during Pregnancy, Genetics of PCOS, Cardiometabolic
Risk in PCOS: Current Guidelines, Non Classical Congenital Adrenal
Hyperplasia, Post-menopausal Hyperandrogenism: Evaluation and
Treatment Strategies, Sexual Dysfunction in Women, Use of
Testosterone in Postmenopausal women, Risks of Testosterone Therapy
in Women, Non-Classic Congenital Adrenal Hyperplasia, and more.
It is 1919 and Elizabeth Hughes, the eleven-year-old daughter of
America's most-distinguished jurist and politician, Charles Evans
Hughes, has been diagnosed with juvenile diabetes. It is
essentially a death sentence. The only accepted form of treatment -
starvation - whittles her down to forty-five pounds skin and bones.
Miles away, Canadian researchers Frederick Banting and Charles Best
manage to identify and purify insulin from animal pancreases - a
miracle soon marred by scientific jealousy, intense business
competition and fistfights. In a race against time and a ravaging
disease, Elizabeth becomes one of the first diabetics to receive
insulin injections - all while its discoverers and a little known
pharmaceutical company struggle to make it available to the rest of
the world.
Relive the heartwarming true story of the discovery of insulin
as it's never been told before. Written with authentic detail and
suspense, and featuring walk-ons by William Howard Taft, Woodrow
Wilson, and Eli Lilly himself, among many others.
Endocrine Self-Assessment Program (ESAP (TM)), Reference Edition
2018 is a self-study curriculum for physicians and health
professionals wanting a self assessment and a broad review of
endocrinology. It consists of 120 brand-new multiple choice
questions in all areas of endocrinology, diabetes, and metabolism.
There is extensive discussion of each correct answer, a
comprehensive syllabus, and references. ESAP is updated annually
with new questions. Customers are advised that this book is a
reference edition and the questions in it are designed for
self-study and reference. The content is the same as the
non-reference edition, but CME and MOC credits are not available
upon completion of the material. Anyone with questions about CME
and/or MOC credits should consult www.endocrine.org/store for
further information.
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Polycystic Kidney Disease
(Hardcover)
Christian Riella, Peter G Czarnecki, Theodore I Steinman; Series edited by D. Neil Granger, Ph.D., Joey P. Granger, Ph.D.
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R1,472
Discovery Miles 14 720
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Ships in 10 - 15 working days
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This book reviews important aspects of polycystic kidney diseases,
the latest scientific understanding of the diseases and syndromes,
along with the therapies being developed. Cystic kidney diseases
comprise a spectrum of genetic syndromes defined by renal cyst
formation and expansion with variable extrarenal manifestations.
The most prevalent disorder is the autosomal dominant polycystic
kidney disease (ADPKD). It is the most common monogenetic disorder
in humans and accounts for 4.4% of end-stage renal disease (ESRD)
cases in the U.S. Patients inevitably progress to ESRD and require
renal replacement therapy in the form of dialysis or
transplantation. Through advancements in genomics and proteomics
approaches, novel genes responsible for cystic diseases have been
identified, further expanding our understanding of basic mechanisms
of disease pathogenesis. The hallmark among all cystic genetic
syndromes is the formation and growth of fluid-filled cysts, which
originate from tubular epithelia of nephron segments. Cysts are the
disease, and treatment strategies are being developed to target
prevention or delay of cyst formation and expansion at an early
stage, however no such therapy is currently approved.
Diabetes Mellitus: Impact on Bone, Dental and Musculoskeletal
Health focuses on the under recognized and managed conditions
associated with diabetes, including impacts on bone health, dental
health, hand, and foot disorders, wounds, infections, and
musculoskeletal disorders. A full understanding of the relationship
of diabetes to skeletal disorders remains elusive and many
physicians who deal with such issues are unclear about causes and
management. While the macro- and microvascular complications
associated with diabetes mellitus are well known, complications
associated with bone, dental and musculoskeletal health are not.
Endocrinologists, primary care physicians, geriatricians,
podiatrists, dentists, and researchers interested in diabetes
mellitus associated bone, dental and musculoskeletal disorders will
find this to be a comprehensive tome on the topic.
Great-Tasting Food for People with Diabetes and their Families
Revised and updated to reflect the latest recommendations from The
American Diabetes Association and The American Dietetic
Association, "The New Family Cookbook for People with Diabetes
"remains the most authoritative and comprehensive resource
available for people with diabetes and their families.
With more than 370 healthful and flavorful recipes accompanied by
complete nutritional analysis, this book makes it easy to prepare
satisfying and delicious meals that the whole family will enjoy.
RECIPES INCLUDE:
Whole Wheat Blueberry Rice Pancakes - Baked Orange French
Toast
Black Bean and Cilantro Spread - Honey-Mustard Chicken Wings
Curried Chicken Salad - Marinated Skirt Steak with Vegetable
Chutney
Lamb Over Minted Couscous - Italian Turkey Sausage with Peppers
and Onions
Baked Salmon with Horseradish Mayonnaise - Sugar Snap Peas with
Basil and Lemon
Baked Potato Skins - Rum Baked Black Beans - Apple Raspberry
Crisp
Port-Poached Pears - New York Cheesecake - Raisin Rice Pudding
Wound Healing, Tissue Repair and Regeneration in Diabetes explores
a wide range of topics related to wound healing, tissue repair and
regeneration, putting a special focus on diabetes and obesity. The
book addresses the molecular and cellular pathways involved in the
process of wound repair and regeneration. Other sections explore a
wide spectrum of nutritional supplements and novel therapeutic
approaches, provide a comprehensive overview, present various types
of clinical aspects related to diabetic wounds, including
infection, neuropathy, and vasculopathy, provide an exhaustive
review of various foods, minerals, supplements and phytochemicals
that have been proven beneficial, and assess future directions.
This book is sure to be a welcome resource for nutritionists,
practitioners, surgeons, nurses, wound researchers and other health
professionals.
Metabolic syndrome is a set of risk factors that includes:
abdominal obesity, a decreased ability to process glucose (insulin
resistance), dyslipidemia (unhealthy lipid levels), and
hypertension. Patients who have this syndrome have been shown to be
at an increased risk of developing cardiovascular disease and/or
type 2 diabetes. Metabolic syndrome is a common condition that goes
by many names (dysmetabolic syndrome, syndrome X, insulin
resistance syndrome, obesity syndrome, and Reaven's syndrome).
This is the first book to fully explain the relationships between
psychiatric illness, Metabolic Syndrome, diet, sleep, exercise,
medications, and lifestyle choices. Metabolic Syndrome is a major
risk factor in Major Depression, Alzheimer's Disease, Sleep
Disorders, Sexual Dysfunction, Fibromyalgia, and several other
illnesses of psychiatric significance. Conversely, some psychiatric
illnesses tend to predispose patients to Metabolic Syndrome. Of
further interest is the fact that some of the medications used in
the treatment of psychiatric illnesses have been found to cause or
exacerbate Metabolic Syndrome.
The author here provides basic information about what genetic
predispositions, medical conditions, and lifestyle choices make
Metabolic Syndrome more likely to occur. Among the contributing
factors that are discussed are genetics, habitual intake of high
glycemic index carbohydrates, fructose, saturated fats, trans fatty
acids, vitamins, micronutrients, obesity, smoking, and lack of
exercise.
The author describes the actual mechanisms by which Metabolic
Syndrome progresses and causes damage in the body, including the
action of insulin and the pathophysiology of insulin resistance.
Details are provided on what occurs in the liver, pancreas, muscle,
fat cells, and immune system as Metabolic Syndrome progresses. New
findings are presented on fat cells, including the fact that they
are beginning to be considered as endocrine cells. There is a
substantive discussion of leptin, which is one of the important
adipocytokines. Also carbohydrate, 'bad fats', inflammation,
oxidative damage, over-stimulation of the 'fight or flight' system,
and high levels of the stress hormone cortisol can actually cause
the manifestations of Metabolic Syndrome. These explanations set
the stage for an explanation of the inter-relationships between
Metabolic Syndrome, psychiatric illness, dementia and effects of
not only diet and life choices, but also the effects of psychiatric
medications.
Finally, there is an important and unique section on the
relationship between Metabolic Syndrome and various psychiatric
illnesses, and how they exacerbate each other. The significance of
Metabolic Syndrome in Major Depression, Bipolar Affective Disorder,
Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast
and it is important to realise the effects of psychiatric
medications on Metabolic Syndrome. The author discusses
antidepressants, mood stabilizers and the new atypical
antipsychotics. There are dramatic differences among medications in
the way they affect Metabolic Syndrome and pharmaceutical companies
will want to promote patient awareness with this book.
* Provides an understanding of Metabolic Syndrome and how this
syndrome is a major risk factor in depression, Alzheimer's Disease,
Sleep Disorders, Sexual Dysfunction, and other illnesses of
psychiatric significance.
* Places specific emphasis on the connection of Metabolic Syndrome
with Psychiatric illnesses, and how these conditions exacerbate
each other.
* Discusses the actual mechanisms by which Metabolic Syndrome
progresses and causes damage to the body.
* Explores the relationship between Major Depression, Heart Disease
and Metabolic Syndrome.
* Includes supplementary section which discusses and critiques many
current dietary supplements that are thought to be helpful for
Metabolic Syndrome.
* Discusses the roles of diet, genetics and supplements in managing
Metabolic Syndrome.
100 years of Human Chorionic Gonadotropin: Reviews and New
Perspectives is a collection of articles written by some of the
world's leading experts on the pregnancy hormone and cancer marker
hCG. In 2019 it is difficult to ignore the effect that our
understanding of hCG has had on the lives of millions of people
worldwide. The hCG immunoassay, in one form or another, is now one
of the most common medical tests conducted and is often the first
indication that a mother-to-be is pregnant. Not only a marker of
pregnancy, hCG is utilized in the diagnosis and monitoring in
oncology and presents a potential target for novel cancer
therapeutics. 100 years ago, in 1919, Hirose was demonstrating
gonadotropic functions which resulted from a chorionic factor. Over
the last century this factor has become defined as hCG and more
recently explored as not one molecule but a group of molecules with
variable structure and variable functions in both pregnancy and
cancer. hCG is a multi-faceted molecule that has clinical and
therapeutic implications but can be a challenging topic for
researchers and physicians alike. This text covers the different
structures and functions of hCG exploring the genes and evolution
of the molecule, the different protein and glycosylation structures
which can exist and their effect on structure, detection and
quantification. 100 Years of hCG is not an attempt to recount the
history of every publication on hCG, but rather a collection of
reviews and new perspectives by "hCG-ologists", the term used by
Hussa to describe biochemists working on HCG in the first book
written on the topic over 30 years ago. Some of the authors have
been around a while, some not so long, but others are just
beginning their journey with a most beguiling molecule.
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