The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library!

The Artificial Pancreas: Current Situation and Future Directions presents research on the top issues relating to the artificial pancreas (AP) and its application to diabetes. AP is a newer form of treatment to accurately and efficiently inject insulin, thereby significantly improving the patient's quality of life. By connecting a continuous glucose monitor (CGM) to a continuous subcutaneous insulin infusion using a control algorithm, AP delivers and regulates the most accurate amount of insulin to maintain normal glycemic values. Featured chapters in this book are written by world leaders in AP research, thus providing readers with the latest studies and results.

Scientists now know that diet and lifestyle can have a positive effect on type 2 diabetes! Dr. Tom Barnard and Brenda Davis, RD, (the author of several books on diet and health) offer real hope by showing how your health can be vastly improved or, in some cases, completely restored by making lifestyle changes.

This book offers the practical steps you need to take to construct a diet and lifestyle that really works.

The diet that works best to defeat diabetes is based on simple, whole foods. Included are meal menus using whole grains and legumes, nutrition content of selected foods, long with basic shopping list sa and over 50 delicious recipes to get you started.

Also includes a daily self-care checklist that addresses the essentials of living well: physical fitness, sleep, sexual fitness, and emotional health.

This issue of Endocrinology and Metabolism Clinics provides essential updates across the spectrum of pediatric endocrinology. Topics covered include Prevention of type 1 and type 2 diabetes mellitus; genetics of growth; diagnosis in prepubescent girls; Turner and Noonan Syndromes; thyroid function in Down Syndrome; chronic disease; effects of ADHD treatment on growth; Vitamin D and bone health; use of statins; and obesity prevention.

This issue of Endocrinology Clinics covers essential updates in a range of common endocrine disorders that are of special concern during pregnancy, as well as endocrine problems that can arise due to pregnancy.? A variety of thyroid, pituitary, adrenal, and hypertensive disorders are covered, as well as calcium and bone metabolism disorders during pregnancy and lactation.? Diagnosis and treatment of gestational diabetes, and pregestational diabetes are addressed.? Iodine disorders in pregnancy and lactation are covered.? Hyperprolactinemia and infertility are also addressed.? Special concerns of obesity in women with reproductive dysfunction are considered.? An in-depth guide to achieving a successful pregnancy with PCOS is provided

This issue of Endocrinology Clinics brings the reader up to date on the latest information about hormones and cancer of the breast and prostate.? The first section focuses on the breast, and topics covered include the following.? The role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; hormonal mechanisms underlying the relationship between obesity and breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; aromatase inhibitors, anti-estrogen and SERMS in the treatment of breast cancer; and androgens in breast cancer in men and women.? The second section is devoted to the prostate, and topics covered include the following.? Overview of prostate anatomy, histology, and pathology; the critical role of sex steroids in normal prostate development; estrogens and androgens in prostate cancer development and the rationale for hormonal chemopreventive therapies; weighing the clinical evidence regarding the timing and extent of androgen ablative therapy for prostate cancer treatment; new hormonal therapies for castration-resistant prostate cancer; and the management of the side effects of castration therapy.

This important issue of Endocrinology Clinics is devoted to the unique topic of endocrine-adrenal and steroid hypertension. The following topics are covered. An overview of endocrine systems and hypertension; accuracy and cost effectiveness of screening for adrenal-endocrine hypertension; pheochromocytoma and related chromaffin cell tumors in adreno-medullary disease; variants, detection, and treatment of Cushing's Syndrome; how glucocorticoids cause hypertension and cardiovascular disease; primary aldosteronism, Conn's diagnosis and management; familial or genetic primary aldosteronism in Gordon's Sydrome; Liddle's Syndrome, Bartter, Gitelman, and related disorders of high and low pressure and pregnancy-related hypertension due to MR mutation; glucocorticoid remediable hypertension; low rennin hypertension in childhood; ovarian hypertension and PCOS; and oral contraceptives and hypertension.

This two-part issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with comprehensive essential updates about tumors of the gastroenteropancreatic system. Topics covered include the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders; new and emerging syndromes related to gastrointestinal (GI) hormones; an update on incretins; prospects for ghrelin in the clinic, obesity/appetite and hedonism; GI motility disorders; gastric bypass and GI hormones; pancreatic exocrine function and GI hormones; harnessing the pancreatic stem cell; how to diagnose NETs before there are METs; NETs in kids: combining the SEER data for children and adults with site differences; novel biomarkers for NETs; standard imaging techniques for NETs; novel peptide imaging: glucagon receptor; signaling mechanism in NETs as targets for therapy; update on clinical trials; nutrition and the GEP; peptide radiotherapy; in vitro analysis of NETs: the role of angiogenesis; modern lab evaluation of peptide and amines: a continuing role for radioimmunoassay?; surgery/surgical management of NETs; and evaluation and quality of life in NETs patients.

Cardiovascular Endocrinology and Metabolism: Theory and Practice of Cardiometabolic Medicine discusses the close intersection between metabolic disorders and cardiovascular disease, covering the basic science and pathophysiology of disease and the latest research in pharmacological approaches and translational therapeutic options. This book is a valuable resource for the vascular and endocrinology clinical and research communities in need of knowledge and potential outcomes. The global increase in the prevalence of cardiometabolic disorders, and the introduction of therapeutic options for treating metabolic disease that also lower cardiovascular risk, is bringing endocrinologists and cardiologists together in a shared clinical experience.

This book is written as a comprehensive and practical guide for General Practitioners who often manage patients with diabetic foot complications. Topics covered include Types of Diabetic Foot Complications, Basic Science involved, Examining a Diabetic Foot, Doing Investigations and Treating a Diabetic Foot, Endocrine Control, Nutritional Support, Choice of Wound Dressing and Choice of the appropriate Antibiotic. An important chapter, especially useful to the GPs is a practical guide on when to treat the patients in their clinics and when to send them to hospitals for management by Diabetic Foot Specialists. A special emphasis has also been given to guide GPs how to educate their patients on Care of Diabetes itself, Care of the Foot and Choice of Footwear. In addition, this Companion Book to GPs will also be useful to Nurses and Podiatrists who also provide care to Diabetic Foot patients. For the latter, a Supplement has been added. Relevant topics include Team Approach, Nursing a Diabetic Foot, Nutrition, Wound Dressings, Negative Pressure Wound Therapy, Maggot Debridement Therapy, Off-loading & Shoes, Hyperbaric Oxygen Therapy, Charcot Joint Disease and Rehabilitation.

2020 Endocrine Case Management: Meet the Professor, Reference Edition is your source for the latest updates in the diagnosis and management of a wide range of endocrine disorders. This valuable resource allows you to evaluate your endocrine knowledge and gain insight into the strategies used by clinical experts. Endocrine Case Management is updated annually with new cases. Features include: Significance of the Clinical Problem. Key Learning Objectives. Strategies for Diagnosis and Management. Clinical Pearls and Pertinent References. Cases and Questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.

This issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with essential updates on treatment of type 1 diabetes, with an eye toward future trends and developments.? The Guest Editors brought together a remarkable group of notable authors, such as Paul Robertson, President of the National Diabetes Association.? Topics covered include epidemiology; economics; contemporary management; inpatient management; update on insulin pumps and continuous glucose monitoring systems; update on studies aimed at interdicting and preventing type 1 diabetes; advances in the prediction, natural history, and mechanisms leading to type 1 diabetes; complications; hypoglycemia in type 1 diabetes; new lessons from animal models; the role of the gut in the genesis of type 1 diabetes and other autoimmune diseases; and an update on transplantation for reversing type 1 diabetes.

Why can two people use a drug and one person becomes addicted while the other does not? Determinants of Addiction: Neurobiological, Behavioral, Cognitive, and Sociocultural Factors unravels the complexities underlying addiction to understand how individual factors at the genetic, cellular, anatomical, cognitive-behavioral, and sociocultural level can influence susceptibility to substance use disorders. The first section reviews the neurobiological determinants of addiction and examines how drugs hijack the reward pathway and alter numerous neurotransmitter systems such as dopamine. The second section covers the behavioral-cognitive determinants of addiction such a conditioning, memory processes, and decision-making. The final section examines individual differences in addiction vulnerability, with a focus on personality factors, sociocultural factors, sex/gender, and stress. The book references commonly used drugs such as nicotine, ethanol (alcohol), opioids, and cocaine.

Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

Type 2 diabetes mellitus is a chronic progressive disease characterised by hyperglycaemia. It affects many people around the world and creates burden for the individual as well as the economy. Chinese medicine can be used to support the management of Type 2 diabetes mellitus symptoms. Chapter 1 of the book summarises the conventional understanding of Type 2 diabetes mellitus, including aetiology, diagnosis and current available treatments.This book uses the 'whole evidence' approach to give an overview of the available evidence for Chinese medicine treatment for Type 2 diabetes mellitus, from classical literature to clinical evidence. Evidence from clinical studies are evaluated using high-quality and rigorous scientific methodology. Clinical trial literature of Chinese medicine treatments for Type 2 diabetes mellitus are described, with treatment modalities including Chinese herbal medicine, acupuncture and other Chinese medicine therapies. The findings are analysed and potential implications for clinical practice and research are explored. Experimental studies that describe the potential mechanisms of action of key herbs are summarised. Current evidence of Chinese medicine for Type 2 diabetes mellitus is synthesised in the final chapter, and suggestions for contemporary clinical practice and future research are also offered.Targeted at clinicians and students of Chinese and integrative medicine, this book is a convenient reference that provides comprehensive synthesis of both classical and contemporary knowledge, which can support and be incorporated into their clinical practice.

Endocrine Self-Assessment Program (ESAP (TM)), Reference Edition 2020 is a self-study curriculum for physicians and health professionals wanting a self assessment and a broad review of endocrinology. It consists of 120 brand-new multiple choice questions in all areas of endocrinology, diabetes, and metabolism. There is extensive discussion of each correct answer, a comprehensive syllabus, and references. ESAP is updated annually with new questions. Customers are advised that this book is a reference edition and the questions in it are designed for self-study and reference. The content is the same as the non-reference edition, but CME and MOC credits are not available upon completion of the material. Anyone with questions about CME and/or MOC credits should consult www.endocrine.org/store for further information.