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Books > Medicine > Clinical & internal medicine > Endocrinology
This book illustrates the importance and significance of oxidative
stress in the pathophysiology of various human diseases. The book
initially introduces the phenomenon of oxidative stress, basic
chemical characteristics of the species involved and summarizes the
cellular oxidant and anti-oxidant system and the cellular effects
and metabolism of the oxidative stress. In addition, it reviews the
current understanding of the potential impact of oxidative stress
on telomere shortening, aging, and age-related diseases. It also
examines the role of oxidative stress in chronic diseases,
including cancer, diabetes, cardiovascular diseases, and
neurodegenerative disorders. Further, the book presents novel
technologies for the detection of oxidative stress biomarkers using
nanostructure biosensors, as well as in vitro and in vivo models to
monitor oxidative stress. Lastly, the book addresses the drug
delivery carriers that can help in combating oxidative stress.
The world is faced with an epidemic of metabolic diseases such as
obesity and type 2 diabetes. This is due to changes in dietary
habits and the decrease in physical activity. Exercise is usually
part of the prescription, the first line of defense, to prevent or
treat metabolic disorders. However, we are still learning how and
why exercise provides metabolic benefits in human health. This open
access volume focuses on the cellular and molecular pathways that
link exercise, muscle biology, hormones and metabolism. This will
include novel "myokines" that might act as new therapeutic agents
in the future.
Stay current with recent progress in the field of diabetic
retinopathy management with this practical resource by Drs.
Caroline R. Baumal and Jay S. Duker. Concise, highly illustrated
coverage includes summaries of the latest evidence and expert
guidance on the rationale for each therapeutic option. Features a
wealth of information for ophthalmologists, retinal specialists,
and trainees on current management of this increasingly common
condition. Covers how to select the best course of action between
drug, laser, or surgical treatment and how to achieve optimal
results. Includes high-quality images that detail before and after
treatment, including OCT. Consolidates today's available
information and guidance on diabetic retinopathy management into
one convenient resource.
This book provides a pioneering approach to modeling the human
diabetic patient using a software agent. It is based on two MASc
(Master of Applied Science) theses: one looking at the evolution of
the patient agent in time, and another looking the interaction of
the patient agent with the healthcare system. It shows that the
software agent evolves in a manner analogous to the human patient
and exhibits typical attributes of the illness such as reacting to
food consumption, medications, and activity. This agent model can
be used in a number of different ways, including as a prototype for
a specific human patient with the purpose of helping to identify
when that patient's condition deviates from normal variations. The
software agent can also be used to study the interaction between
the human patient and the health care system. This book is of
interest to anyone involved in the management of diabetic patients
or in societal research into the management of diabetes. The
diabetic patient agent was developed using the Ackerman model for
diabetes, but this model can be easily adapted for any other model
subject with the necessary physiological data to support that
model.
Fatigue; weight gain; depression; arthritis; high cholestrol; low sex drive; skin, digestive, and female problems; abnormal blood pressure -- all may be symptoms of low thyroid, one of the most misdiagnosed disorders in America. Thyroid Power can help you determine whether you're one of the millions who suffer from low thyroid. It discusses food, vitamins, and natural remedies that support thyroid health;explains how to avoid environmental and emotional triggers; and offers tips from thyroid support groups. By following this clear 10-step program and working with your health practitioner, you can channel the incredible power of your thyroid into greater health and well-being.
This issue of Endocrinology and Metabolism Clinics, guest edited by
Drs. Richard Auchus, Adina Turcu, Alan D. Waxman, and Barry D.
Pressman, is devoted to Biochemical and Imaging Diagnostics in
Endocrinology. Articles in this issue include Mass spectrometry
applicability in endocrine testing; Point-of-care endocrine
testing; Thyroid, Bone; NET; Predictors of fertility; Thyroid
ultrasound imaging and needle biopsy; Pituitary imaging; Adrenal
imaging; Pancreatic imaging; Diagnosis and management of thyroid
disorders; Neuroendocrine Tumors, and Parathyroid Imaging.
This issue of Endocrinology and Metabolism Clinics, guest edited by
Dr. Constantine A. Stratakis, is devoted to Genetics in Endocrine
Disorders. Articles in this issue include: Genetics of Short
Stature; Genetics of Diabetes Insipidus; Pituitary Hypoplasia;
Pituitary Tumor Genetics and Associated Syndromes; Defects of
Thyroid Hormone Synthesis; Molecular Genetics of Thyroid Cancer;
Genetics of Hyperparathyroidism Including Parathyroid Cancer;
Genetics of Adrenocortical Development and Tumors; Genetics of
Congenital Adrenal Hyperplasia; Genetics of Pheochromocytomas and
Related Conditions; Genetics of Multiple Endocrine Neoplasia Type 1
and Type 2 Syndromes; Genetics of Hypogonadotrophic Hypogonadism
and Kallman Syndrome; Disorders of Sex Development; Genetics of
Lipodystrophy; and PTEN-Spectrum Disorders.
Biomarkers of Inborn Errors in Metabolism: Clinical Aspects and
Laboratory Determination is structured around the new reality that
laboratory testing and biomarkers are an integral part in the
diagnosis and treatment of inherited metabolic diseases. The book
covers currently used biomarkers as well as markers that are in
development. Because biomarkers used in the initial diagnosis of
disease may be different than the follow-up markers, the book also
covers biomarkers used in both the prognosis and treatment of
inherited metabolic disorders. With the introduction of expanded
new-born screening for inborn metabolic diseases, an increasing
numbers of laboratories are involved in follow-up confirmatory
testing. The book provides guidance on laboratory test selection
and interpreting results in patients with suspected inherited
metabolic diseases. The book provides comprehensive guidance on
patient diagnosis and follow-up through its illustrative material
on metabolic pathways, genetics and pathogenesis, treatment and
prognosis of inherited metabolic diseases, along with essential
information on clinical presentation. Each chapter is organized
with a uniform, easy-to-follow format: a brief description of the
disorder and pathway; a description of treatment; biomarkers for
diagnosis; biomarkers followed for treatment efficacy; biomarkers
followed for disease progression; confounding conditions that can
either: affect biomarker expression or mimic IEMs; other
biomarkers: less established, future.
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Thymus
(Hardcover)
Nima Rezaei
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Discovery Miles 33 210
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Ships in 10 - 15 working days
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This issue of Clinics in Podiatric Medicine and Surgery will cover
the diabetic charcot foot and how to manage it with a team
approach. Articles will include: The Diabetic Charcot Foot from
1936 to 2016: Eighty Years Later and Still Growing; Pathogenesis
and Classification Systems for the Diabetic Charcot Foot; An
Overview of Medical Imaging for the Diabetic Charcot Foot;
Pharmacological and Conservative Treatments for the Diabetic
Charcot Foot; An Overview of Internal and External Fixation Methods
for the Diabetic Charcot Foot and Ankle; Surgical Treatment Options
for the Diabetic Charcot Midfoot Deformity; and many more.
This issue of Endocrinology and Metabolism Clinics, guest edited by
Dr. Albert Shieh of UCLA, is devoted to Bone Disorders. Articles in
this outstanding issue include: Role of Osteocyte in Bone and
Non-Bone Disease; Bone-Fat Interaction; Imaging Beyond DXA; Vitamin
D in African-Americans; Pre-Menopausal Osteoporosis; Combined
Pharmacologic Therapy in Osteoporosis; Drug-Related Adverse Events
in Osteoporosis; Novel Therapies for Osteoporosis; Diabetes and
Bone Disease; Bariatric Surgery and Bone Metabolism;
Hyperparathyroidism and Bone Microarchitecture; FGF-23 Mediated
Bone Disease; and Endothelin-Related Bone Disorder.
This astute volume brings together the latest expert research on
adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically
benign but clinically aggressive tumors exhibiting a high
propensity for local invasion into the hypothalamus, optic and
vascular structures. These tumors, as well as the current
treatments, may result in pan-hypopituitarism, diabetes insipidus,
morbid obesity followed by type II diabetes mellitus, blindness, as
well as serious behavioral and psychosocial impairments. Exploring
in detail advances in both the understanding of tumor biology as
well as clinical advances in patient management are explored in
detail, this book will also look towards potential new treatment
approaches. Basic Research and Clinical Aspects of Adamantinomatous
Craniopharyngioma is the first book compiling all current research
on ACPs. Mouse and human studies have unequivocally demonstrated
that mutations in CTNNB1 encoding -catenin underlie the etiology of
the majority, if not all ACP tumors. Genetic studies in mice have
shown that ACPs are tumors of the pituitary gland and not of the
hypothalamus as previously thought, and are derived from Rathke's
pouch precursors. In addition, a role for tissue-specific adult
pituitary stem cells has been revealed as causative of ACP.
Together, these studies have provided novel insights into the
molecular and cellular etiology as well as the pathogenesis of
human ACP. Finally, this volume covers new treatment approaches
that have been shown to be effective both in reducing ACP burden as
well as reducing the morbidity associated with therapy.
This issue of Endocrinology and Metabolism Clinics, guest edited by
Dr. Sethu K. Reddy, is devoted to Diabetes. Articles in this issue
include: Approach to Multicultural Issues in Diabetes; Clinical
Utility of Genetic Testing in T2DM; Utility of CGM - Type 1 and
Type 2 Diabetes Mellitus; Islet Cell Transplantation; Use of
Telemedicine; Nonalcoholic Steatohepatitis; Microbiome: Role in
Type 1 and Type 2 Diabetes Mellitus; Population Management and
Diabetes; Pre-diabetes; Metformin: What do we know?; Insulin:
Making Sense of Current Options; Nutrition in Diabetes; Bariatric
Surgery: Pathophysiology and Outcomes; Future Therapies in
Diabetes; Lipodystrophic Syndromes; and In-patient Diabetes
Management in the 21st Century.
This book reviews the growing literature that is consistent with
the hypothesis that hormones can regulate auditory physiology and
perception across a broad range of animal taxa, including humans.
Understanding how hormones modulate auditory function has far
reaching implications for advancing our knowledge in the basic
biomedical sciences and in understanding the evolution of acoustic
communication systems. A fundamental goal of neuroscience is to
understand how hormones modulate neural circuits and behavior. For
example, steroids such as estrogens and androgens are well-known
regulators of vocal motor behaviors used during social acoustic
communication. Recent studies have shown that these same hormones
can also greatly influence the reception of social acoustic
signals, leading to the more efficient exchange of acoustic
information.
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