This issue of Endocrinology and Metabolism Clinics, edited by Drs. Nanette Santoro and Lubna Pal, is devoted to Postmenopausal Endocrinology. Articles in this issue include: Endocrinology of Menopause; Menopausal Symptoms; Bone Health and Osteoporosis; Surgical Menopause; Premature Menopause; Cardiovascular Changes; MHT: Current Considerations; Breast Cancer and Hormones; Other Cancers and Menopause; CAM for Menopausal Symptoms; Menopause and Sexuality; and Menopause and Metabolism.

The Guest Editors have compiled a comprehensive issue that includes both disorders of endocrinology as well as diabetes. Authors have addressed the following clinical topics: disorders of menstruation, thyroid function; gender dysphoria; hypoglycemia in the nondiabetic child; preventing DKA; short- and long-term outcomes in diabetes, and whole genome sequencing in endocrinology. These topics represent the current knowedge in the field, and pediatricians will have the most updated clinical information as they evaluate and treat children with diabetes or endocrinology disorders.

This issue will focus on the most common reproductive endocrine conditions encountered by healthcare providers. This series is timely and will be of interest to readers as there are many recent updates to the recommendations for appropriate evaluation and treatment of several reproductive conditions. Each chapter will address specific anatomic and hormonal conditions and will examine reproductive function from puberty to menopause. A thorough summary of abnormal uterine bleeding including recent 2012 updates for evaluation and management will be emphasized. Individual chapters on anatomic causes of bleeding, such as uterine fibroids and endometriosis, will be included with a focus on new treatment options. Polycystic ovarian syndrome (PCOS), a common hormonal cause of irregular bleeding and infertility, will also be reviewed. Recent studies provide insight into new fertility treatments for patients with PCOS including the use of aromatase inhibitors for ovulation induction. Other fertility related chapters include the evaluation of the infertile woman, ovulation induction, recurrent pregnancy loss, and age-related infertility. Finally, a transition to premature ovarian insufficiency and menopause will be provided. The Women's Health Initiative publication in 2002 reported an association between hormone replacement therapy and breast cancer. There are several updates since this controversial publication and recent literature will be summarized. Attention will focus on appropriate evaluation and management of these common reproductive endocrine topics reviewing recent recommendations on best practices for clinicians.

This issue of Clinics in Chest Medicine focuses on Sarciodosis. Drs. Baughman and Culver have put together a, expert roster of authors for articles concerning: Etiology of sarcoidosis, Immunology of sarcoidosis, Genetics of Sarcoidosis, Diagnosis of sarcoidosis, Chest imaging, Biomarkers and genetic profiles, Pulmonary Sarcoidosis, Neurosarcoidosis, Cardiac Sarcoidosis, Ocular Sarcoidosis, Quality of life assessments, and more!

This issue of Endocrinology and Metabolism Clinics of North America is devoted to Reproductive Endocrinology. Guest Editors Peter Lee, MD and Christopher P. Houk, MD have assembled a group of expert authors to review the following topics: Fertility Among Females and Males with Congenital Adrenal Hyperplasia (21-Hydroxylase Deficiency); Reproductive Issues for Turner Syndrome; Fertility and Reproduction Among Childhood Cancer Survivors; Fertility After Crypotochidism; Male Obesity and Fertility; Fertility Issues among Transgender Individuals; Fertility Preservation in Pediatrics; Polycystic Ovary Syndrome (PCOS); Fertility Issues for Patients With Delayed Puberty (Constitutional Delay, Functional Delay, and Hypogonadotropism); Varicocele; Testis Development and Reproduction in Klinefelters Syndrome; and Fertility Issues Among Those With Disorders of Sex Development.

This issue of Endocrinology and Metabolism Clinics, edited by Dr. Alice Levine, is devoted to Adrenal Disease. This issue will be broken down into 3 sections: Overview of Adrenal Cortical Development, Steroidogenesis, Comparative Anatomy and Molecular Pathophysiology; Benign Adrenal Tumors; and Adrenal Cortical Carcinoma. Articles in this issue include: Adrenal Cortical Zonal Development; Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia; Animal Models of Adrenocortical Tumorigenesis; Genetics of Adrenal Cortical Tumors; Adrenal Incidentalomas; Aldosteronomas - Challenges in Diagnosis and Management; Mild Hypercortisolism Due to Adrenal Adenomas - Definitions and Therapeutic Options; Management of Adrenal Tumors in Pregnancy; Pathology of ACC; Diagnosis and Medical Management of ACC; and Surgical Management of ACC.

'A life-changing diet... in 8 weeks you can halt the progress of pre-diabetes and even reverse type 2 diabetes returning blood sugar levels to normal.' - Daily Mail **AS SEEN ON CHANNEL 4** Dr Michael Mosley, author of the bestselling 5:2 Fast Diet, reveals a game-changing approach to one of the greatest silent epidemics of our time - raised blood sugar levels. The food we eat today, high in sugar and easily digestible carbohydrates, is not only making us fat, but is putting us at risk of type 2 diabetes, strokes, dementia, cancer and a lifetime on medication. More than a third of adults in the UK now have raised blood sugar levels and most don't know it. In this timely book, Dr Mosley explains why we pile on dangerous abdominal fat and shows us how to shed it, fast. He demolishes common myths, such as the claim that steady weight loss is always better than rapid weight loss and that those who lose weight rapidly will inevitably put it back on. This is a book not just for those at highest risk but for anyone who has struggled with their weight and wants to regain control of their health.

"The Protective Arm of the RAS: Functional Aspects and Therapeutic Implications" is the first comprehensive publication to signal the protective role of the renin angiotensin system (RAS) providing readers with early insight into a system which will become of major medical importance. It is extensively demonstrated that the RAS, when over activated, represents a disease-promoting and disease-sustaining system. But recently the protective role of the RAS has emerged supported by a large number of experimental studies. In fact, specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1 7) peptide with its receptor Mas, and the enzyme ACE 2 exert significant beneficial actions by counter-balancing the well-known harmful side of the RAS.
Provides a complete understanding of the protective, beneficial role of the Renin Angiotensin System (RAS).Combines the knowledge of editors who pioneered research on protective renin angiotensin system including Dr. Robson Santos who discovered angiotensins-(1-7) and its receptor Mas; and Dr. U. Muscha Steckelings and Dr. Thomas Unger who made contributions to AT2 receptor research and were the first to use a novel specific AT2-antagonist in preclinical studies.Shows the protective RAS axes are able to ameliorate the course of several cardiovascular, renal and neurological diseases.
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The Year Book of Endocrinology brings you abstracts of the articles that reported the year's breakthrough developments in endocrinology carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Diabetes, Lipoproteins and Ahterosclerosis, Obesity, Thyroid, Calcium and Bone Metabolism, Adrenal Cortex, and Neuroendocrinology are represented highlighting the most current and relevant articles in the field.

This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.

This issue of Endocrinology and Metabolism Clinics, devoted to Lipids, is edited by Dr. Donald A. Smith. Articles in this issue include: Advanced Lipoprotein Testing; Improving Cardiovascular Risk Assessment: Coronary calcium scor and CT coronary imaging; Understanding HDL; Statin Strategies for Maximizing Public Health: benefits and harms; Cellular Cholesterol Regulation: SREBP and miRNA; Mediterranean Diet - the best diet for CV protection?; Pediatric Lipidology: An Earlier Approach; Newer LDL-lowering Therapies; and Statin Combination Therapies.

This book offers a complete overview on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history and diagnosis. NCRNNE liver metastases are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.

This issue of Endocrinology and Metabolism Clinics, edited by Drs. Anat Ben-Shlomo and Maria Fleseriu, is devoted to Pituitary Disorders. Articles in this issue include: Pathogenesis of Pituitary Tumors; Prognostic Clinicopathological Classification of Pituitary Adenomas; Familial Isolated Pituitary Adenomas (FIPA) and Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene; Pitfalls of IGF1 and GH Assays; Acromegaly: Pharmacotherapy; Hypothalamo-pituitary-adrenal Axis Testing; Pharmacotherapy of Cushing Disease: New Targets; Prolactinomas; Non-functioning Pituitary Tumors; Cabergoline Use for Pituitary Tumors and Valvular Disorders; Aggressive Atypical Pituitary Tumors and Carcinoma; Outcomes of Endoscopic Transsphenoidal Pituitary Surgery; Efficacy and Complications of Pituitary Irradiation; Hypopituitarism: GH and ACTH Deficiency; Hypophysitis; Hypopituitarism After Traumatic Brain Injury; Quality of Life in Pituitary Diseases; Pituitary and Bone Disease; Pituitary Tumor Management in Pregnancy; and Pituitary Apoplexy.

"Clinical Neuroendocrinology," a volume in the "Handbook of Clinical Neurology Series" gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis, and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines, including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies, are discussed. It is the first textbook in the field to address all these aspects by a range of international experts.

*All contributors are recognized experts in the different fields of clinical neuroendocrinology *The book provides expanded coverage on hypothalamic mechanisms in human pathophysiology *The book includes current perspectives, diagnosis and treatment of pituitary diseases

This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and its involvement in CVD complications is vital as one applies food and glycemic control to slow progress to diabetes and heart disease. The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and nutrition to modulate diabetes.

Richard B. Welbourn, a retired endocrine surgeon who has written two books on the subject, has compiled the definitive history of the new and advancing discipline of endocrine surgery. The book traces the history of endocrine surgery from its origins to the 1980s, detailing the stories behind the surgery of each gland. A valuable biographical index containing basic information as well as the ideas and achievements of great names in the field will prove an invaluable resource.

Topics include: Evolution of Endocrine Surgery; The Pituitary; The Thyroid; Thyroid Cancer; The Adrenal Glands; The Parathyroid Glands; The Endocrine Gut and Pancreas; Islet Cell Transplantation; Multiple Endocrine Adenopathy and Paraendocrine Syndromes; Cancer of the Breast and Prostate; Essential and Renal Hypertension; Surgical Stress. The book also includes more than 80 photos and diagrams. A chronological table shows the main events described in the text in their temporal context via milestones in general medicine, surgery and science, and selected major events in political and social history.

The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology.

Editor Peter Mazzaglia and authors review the current management and procedures in endocrine surgery. Articles will cover: central compartment lymph node dissection for papillary thyroid cancer; evaluation of thyroid incidentaloma; the role of genetic markers in the evaluation and management of thyroid nodules; medical therapy for advanced forms of thyroid cancer; follicular lesions of the thyroid; controversy over radio-iodine ablation: who benefits?; minimizing cost while maximizing success in the pre-operative localization strategy for primary hyperparathyroidism; operative treatment for primary hyperparathyroidism; evaluation of adrenal incidentalomas: biochemical and radiographic characterization; hyperaldosteronism: diagnosis, lateralization, and treatment; subclinical Cushing's syndrome; adrenocortical cancer update; and pancreatic neuroendocrine tumors.