This issue of Endocrinology and Metabolism Clinics, edited by Dr. Alice Levine, is devoted to Adrenal Disease. This issue will be broken down into 3 sections: Overview of Adrenal Cortical Development, Steroidogenesis, Comparative Anatomy and Molecular Pathophysiology; Benign Adrenal Tumors; and Adrenal Cortical Carcinoma. Articles in this issue include: Adrenal Cortical Zonal Development; Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia; Animal Models of Adrenocortical Tumorigenesis; Genetics of Adrenal Cortical Tumors; Adrenal Incidentalomas; Aldosteronomas - Challenges in Diagnosis and Management; Mild Hypercortisolism Due to Adrenal Adenomas - Definitions and Therapeutic Options; Management of Adrenal Tumors in Pregnancy; Pathology of ACC; Diagnosis and Medical Management of ACC; and Surgical Management of ACC.

This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.

"The Protective Arm of the RAS: Functional Aspects and Therapeutic Implications" is the first comprehensive publication to signal the protective role of the renin angiotensin system (RAS) providing readers with early insight into a system which will become of major medical importance. It is extensively demonstrated that the RAS, when over activated, represents a disease-promoting and disease-sustaining system. But recently the protective role of the RAS has emerged supported by a large number of experimental studies. In fact, specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1 7) peptide with its receptor Mas, and the enzyme ACE 2 exert significant beneficial actions by counter-balancing the well-known harmful side of the RAS.
Provides a complete understanding of the protective, beneficial role of the Renin Angiotensin System (RAS).Combines the knowledge of editors who pioneered research on protective renin angiotensin system including Dr. Robson Santos who discovered angiotensins-(1-7) and its receptor Mas; and Dr. U. Muscha Steckelings and Dr. Thomas Unger who made contributions to AT2 receptor research and were the first to use a novel specific AT2-antagonist in preclinical studies.Shows the protective RAS axes are able to ameliorate the course of several cardiovascular, renal and neurological diseases.
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The Year Book of Endocrinology brings you abstracts of the articles that reported the year's breakthrough developments in endocrinology carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Diabetes, Lipoproteins and Ahterosclerosis, Obesity, Thyroid, Calcium and Bone Metabolism, Adrenal Cortex, and Neuroendocrinology are represented highlighting the most current and relevant articles in the field.

This issue of Endocrinology and Metabolism Clinics, edited by Drs. Anat Ben-Shlomo and Maria Fleseriu, is devoted to Pituitary Disorders. Articles in this issue include: Pathogenesis of Pituitary Tumors; Prognostic Clinicopathological Classification of Pituitary Adenomas; Familial Isolated Pituitary Adenomas (FIPA) and Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene; Pitfalls of IGF1 and GH Assays; Acromegaly: Pharmacotherapy; Hypothalamo-pituitary-adrenal Axis Testing; Pharmacotherapy of Cushing Disease: New Targets; Prolactinomas; Non-functioning Pituitary Tumors; Cabergoline Use for Pituitary Tumors and Valvular Disorders; Aggressive Atypical Pituitary Tumors and Carcinoma; Outcomes of Endoscopic Transsphenoidal Pituitary Surgery; Efficacy and Complications of Pituitary Irradiation; Hypopituitarism: GH and ACTH Deficiency; Hypophysitis; Hypopituitarism After Traumatic Brain Injury; Quality of Life in Pituitary Diseases; Pituitary and Bone Disease; Pituitary Tumor Management in Pregnancy; and Pituitary Apoplexy.

This issue of Endocrinology and Metabolism Clinics, devoted to Lipids, is edited by Dr. Donald A. Smith. Articles in this issue include: Advanced Lipoprotein Testing; Improving Cardiovascular Risk Assessment: Coronary calcium scor and CT coronary imaging; Understanding HDL; Statin Strategies for Maximizing Public Health: benefits and harms; Cellular Cholesterol Regulation: SREBP and miRNA; Mediterranean Diet - the best diet for CV protection?; Pediatric Lipidology: An Earlier Approach; Newer LDL-lowering Therapies; and Statin Combination Therapies.

This book offers a complete overview on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history and diagnosis. NCRNNE liver metastases are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.

This important reference, edited by Ronald Ross Watson and Betsy Dokken, collects the research needed to make the distinct connection between pre-diabetes, diabetes, and cardiovascular disease. Glucose Intake and Utilization in Pre-Diabetes and Diabetes: Implications for Cardiovascular Disease explains the mechanisms of progression from pre-diabetes to diabetes to cardiovascular disease. Since pre-diabetes and diabetes are important cardiovascular disease risk factors, and impaired glucose metabolism among cardiac patients is extremely prevalent, the importance of reviewing pre-diabetes and its involvement in CVD complications is vital as one applies food and glycemic control to slow progress to diabetes and heart disease. The book further focuses on glucose intake and utilization in diabetes, including coverage of diabetes in the development and pathology of cardiovascular disease, risks and epidemiology of cardiovascular problems promoted by diabetes, macrovascular effects and their safety in therapy of diabetics, beta cell biology and therapy of diabetes, and nutrition to modulate diabetes.

"Clinical Neuroendocrinology," a volume in the "Handbook of Clinical Neurology Series" gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis, and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines, including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies, are discussed. It is the first textbook in the field to address all these aspects by a range of international experts.

*All contributors are recognized experts in the different fields of clinical neuroendocrinology *The book provides expanded coverage on hypothalamic mechanisms in human pathophysiology *The book includes current perspectives, diagnosis and treatment of pituitary diseases

This book provides case studies accompanied by questions and commentaries for the specialist registrar in diabetes and endocrinology, to assist with problem-based learning during their training. The case studies range from the everyday to the rare and complicated, presenting a strong foundation for the specialist trainee to prepare them for their qualifying exams and, more importantly, for their future clinical consultations.

Diabetes can limit blood supply to the feet resulting in loss of feeling, which means foot injuries do not heal well and may go unnoticed. People with diabetes are 15 times more likely to have a limb amputated due to gangrene (NHS Choices). Presented as case studies, this book is a practical guide to the diabetic foot, with a focus on the different types and stages of diabetic foot disease and clinical management. Divided into nine sections, the book begins with in depth coverage of diagnostic tools. Each of the following sections discusses the treatment of different diabetic foot disorders, from simple cures to more aggressive and advanced modalities to avoid amputations.

The third edition of The Parathyroids, led by a new stellar editorial team, has been thoroughly updated to reflect the considerable advances in just about every aspect of PTH biology over the past decade. It continues to be the authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium. This translational resource is invaluable to graduate students, fellows, researchers, and research clinicians in the fields of endocrinology, bone biology, osteology, and rheumatology.

This issue of Thoracic Surgery Clinics is devoted to "Clinical Management of Neuroendocrine Tumors of the Lung" and is edited by Dr. Pier Luigi Filosso. Articles in this outstanding issue include: Pathology of neuroendocrine tumors, Clinical and radiological presentation of neuroendocrine tumors of the lung, Neuroendocrine tumors and endocrine syndromes, The significance of histology: typical and atypical bronchial carcinoids, Surgical management of well-differentiated lung neuroendocrine tumors, Surgical management of large cell neuroendocrine carcinoma (LCNC) of the lung, The role of surgery in small cell carcinoma, Management of thymic neuroendocrine tumors, Medical treatment of advanced thoracic neuroendocrine tumors, Radiometabolic treatment of advanced neuroendocrine tumors, Biological and clinical prognostic factors in thoracic neuroendocrine tumors, and more!

This Otolaryngologic Clinics' publication's intent is to provide standard and state of the art clinician performed thyroid ultrasound and ultrasound guided FNA technique. The subject area is evolving rapidly with new technologies being incorporated. This title integrates thyroid cytology, FNA and Ultrasound Guided FNA with inclusion of diagnostic molecular testing. Clinical Thyroid Molecular Testing has ushered in a new era to the diagnosis, management and prognostication of thyroid nodules. The discussion of this highly clinically applicable subject is described in terms of diagnostic process. This is a thyroid neoplasm clinical "game changer? for the General Otolaryngologist, Head and Neck Surgeon, General Surgeon, Endocrinologist, Pathologist, and Radiologist. This testing maximizes the number of patients who have cancer to receive the correct therapeutic surgery appropriately and minimizes the number of patients who do not need surgery (and avoid the potential complications and surgery) because they do not have cancer. Surgical management and prognostication have far reaching implications with fine needle aspiration driven molecular markers. Some topics include: Clinical evaluation of the thyroid nodule; Thyroid cytology; Clinician performed thyroid ultrasound; Clinician performed thyroid ultrasound guided FNA; Thyroid cancer molecular laterations - what the surgeon should know; Thyroid cancer multi-gene expression - what the surgeon needs to know; Incorporating molecular testing into your thyroid practice - five experts discuss; and others.

Managing and treating patients with thyroid issues accounts for about 30% of an endocrinologist's practice. The issue will be divided into two parts: thyroid cancer and other major disorders. Articles will cover new information on TSH and radioiodine therapy to treat thyroid cancer, as well as best practices for managing hypothyroidism, Graves disease and thyroiditis.

Editor Peter Mazzaglia and authors review the current management and procedures in endocrine surgery. Articles will cover: central compartment lymph node dissection for papillary thyroid cancer; evaluation of thyroid incidentaloma; the role of genetic markers in the evaluation and management of thyroid nodules; medical therapy for advanced forms of thyroid cancer; follicular lesions of the thyroid; controversy over radio-iodine ablation: who benefits?; minimizing cost while maximizing success in the pre-operative localization strategy for primary hyperparathyroidism; operative treatment for primary hyperparathyroidism; evaluation of adrenal incidentalomas: biochemical and radiographic characterization; hyperaldosteronism: diagnosis, lateralization, and treatment; subclinical Cushing's syndrome; adrenocortical cancer update; and pancreatic neuroendocrine tumors.

The second edition of this atlas is a complete guide to the diagnosis and management of endocrine disorders, including diabetes. Presented as a collection of clinical cases, the book has been fully revised to provide trainees with the most up to date information and latest advances in the field. Divided into seven sections, topics cover thyroid, diabetes, the adrenal and pituitary glands, bone, reproductive issues, and a selection of growth and other metabolic disorders. Cases are presented in a step by step approach explaining pathology, history, symptoms, imaging, diagnosis, and treatment. Each section features multiple choice questions to test understanding, numerous images and illustrations, and suggestions for further reading. Key points Complete guide to diagnosis and management of endocrine disorders including diabetes Fully revised, new edition detailing latest advances in the field Presented as clinical cases with multiple choice questions Previous edition (9789351528579) published in 2016

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Key Features
* First published in 1943, Vitamins and Hormones is AP's longest running serial
* Each volume contains cutting edge reviews by leading contributors