Chronic Hope is a long drink of cool water for the parent thirsting for practical wisdom in navigating the emotional stress of raising their chronically ill child. Leaning on Bonnie O'Neil's personal experience as a caregiver Chronic Hope delivers practical insight and solutions while avoiding the tone of a typical self-help book. Instead, it reads like a conversation with a friend, where one parent's stories give the other parent permission to feel the full range of their emotions and encourages them to discover hope in the long journey. Readers witness Bonnie's mistakes and missteps, glean from her revelations, and find inspiration in the principles and attitudes she begins to apply to everyday situations. Through story and reflection, Bonnie gently shares a vision of navigating chronic disease with strength, resilience and loving self-sacrifice. Chronic Hope leverages one family's journey raising a child with chronic illness and provides readers the tools necessary to process their own emotional responses to the unexpected path ahead of them. Thematically, Chronic Hope begins deep within the heart of the caregiver and gradually works itself outward into each relationship within the family, and eventually into the wider world. Chronic Hope offers a fresh vision of hope in the darkest valleys of illness, suffering, and broken dreams.

Endocrinology, and diabetes care in particular, is a dynamic field where clinicians must translate new evidence into clinical practice at a rapid pace. Designed in an engaging, case-based format, Endocrinology and Diabetes: A Problem Oriented Approach offers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Further, by providing a list of specific clinical problems, this format offers the reader a more convenient and pointed way to solve precise clinical problems in a timely manner. Developed by a renowned, international group of experts, this comprehensive title covers the most common clinical problems in endocrinology and diabetes and should be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents.

In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient's condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification of vitamin D, and its sunlight driven production in skin, paved the way to the elimination of rickets as a major medical problem. Twenty years or so later, Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.

Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin.
Presents an overview of Diabetes MellitusIncludes a discussion of various strategies and techniques adopted for oral delivery of insulinPresents an update of research in the field

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

Adrenal disorders are often difficult to diagnose due to common symptoms, and challenging to treat due to common comorbidities. Adrenal Disorders: 100 Cases from the Adrenal Clinic provides a comprehensive, case-based approach to the evaluation and treatment of both common and uncommon adrenal disorders, offering practical, real-world guidance highlighted by ultrasound scans, biopsy images, and tables. Features 100 two-page cases covering a wide range of common and uncommon adrenal disorders. Includes case report, investigations, treatment, and outcome for each case, plus a case overview with expert advice, take-home points, and references. Organizes comprehensive content by type of disorder, including adrenal masses (benign and malignant), primary aldosteronism, ACTH-independent Cushing syndrome, ACTH-dependent Cushing syndrome, adrenal carcinoma, pheochromocytoma, adrenal and ovarian hyperandrogenism, and adrenal disorders in pregnancy. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Proceedings of the 2nd World Conference Hormonal and Genetic Basis of Sexual Differentiation Disorders and Hot Topics in Endocrinology. The meeting took place at The Eden Roc Hotel in Miami Beach, Florida, 1/15/10 1/17-10. Endocrinology and more specifically, the area of sexual differentiation disorders is an evolving field of medicine. The diagnosis and treatment of Disorders of Sex Development (DSD) is multi-faceted.

Key Features Explains normal physiology of pregnancy in addition to the physiology, evaluation, and management of endocrine diseases in pregnancy, and in the pre- and post-partum periods. Explores from a clinical standpoint with practical applications, useful for students, residents, fellows, mid-level providers, and practicing physicians. Discusses special considerations and emerging topics including pregnancy in transgender men, obesity and metabolism, and endocrine emergencies.

Summarizes signaling pathways regulated by redox reactions Reveals how redox pathways affect cancer and tumor cell metastasis Chapters by an internationals team of leading researchers Chapters describe redox regulation influences developmental processes and these processes originated even before there was much oxygen in the atmosphere

This book focuses on hormones, and on how they are produced in very diverse regions of the body in humans and animals. But hormones can be found not only in vertebrates, but also in insects, shellfish, spiders, mollusks, even at the origin of metazoan diversification and exhibit the same pathways of synthesis. The book addresses the different classes of hormones: protein/peptides hormones, steroids and juvenile hormones and hormones like catecholamines, thyroid hormones and melatonin. It also discusses the types of hormone receptors, the majority of which are heptahelical G-protein coupled receptors or nuclear receptors. Particular attention is paid to the organs where hormones are created, with specifics on hormonal production and release, while a dedicated chapter details hormonal regulation from very simple to highly complex schemes. The remarkable kinetics of hormones production are also shown, before the book is rounded out by chapters on evolution in the endocrine system, the genetics of endocrine diseases and doping.

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

The World Health Organization estimates that there are 2.1 billion individuals with obesity globally. Nearly three quarters of adults in the United States are overweight or obese. The average individual with obesity cuts ten years off their life expectancy, yet less than 40% of physicians routinely counsel individuals concerning the adverse health consequences of obesity. Obesity Prevention and Treatment: A Practical Guide equips healthcare practitioners to include effective weight management counselling in the daily practice of medicine. Written by lifestyle medicine pioneer and cardiologist, Dr. James Rippe and obesity expert Dr. John Foreyt, this book provides evidence-based discussions of obesity and its metabolic consequences. A volume in the Lifestyle Medicine Series, it provides evidence-based information about the prevention and treatment of obesity through lifestyle measures, such as regular physical activity and sound nutrition, as well as the use of new medications or bariatric surgery available to assist in weight management. Provides a framework and practical strategies to assist practitioners in safe and effective treatments of obesity. Contains information explaining the relationship between obesity and increased risk of heart disease, diabetes, cancer, osteoarthritis, and other chronic conditions. Chapters begin with bulleted key points and conclude with a list of Clinical Applications. Written for practitioners at all levels, this user-friendly, evidence-based book on obesity prevention and treatment will be valuable to practitioners in general medicine or subspecialty practices.

Providing a comprehensive review of the most up-to-date evidence, this book presents the latest biology, diagnosis and management for pheochromocytomas, paragangliomas and related disorders of the sympathoadrenal system. Many new areas, including genetic syndromes, have evolved, and these are insufficiently appreciated among practitioners. A discussion of the basics of catecholamine biology sets the stage for presentations of the pathology, clinical features, and diagnosis of these tumors, including localization and imaging. Medical, anesthetic and surgical management of pheochromocytomas and paragangliomas follow, including case material. Additional chapters discuss pheochromocytoma in pediatrics and in pregnancy, both pure and hypoglycemia-associated autonomic failure, and the role of the sympathetic nervous system in hypertension. These diseases are relatively rare, but many, if not most, go undiagnosed during life: If promptly diagnosed and appropriately treated, they are usually completely curable; if undiagnosed or mistreated, they are typically terminal. Bringing the most current knowledge to bear, Pheochromocytomas, Paragangliomas and Disorders of the Sympathoadrenal System will be a valuable resource for practicing endocrinologists, endocrine surgeons, internists and endocrine fellows faced with diagnosing and managing these conditions.

This book on the metabolic aspects of polycystic ovary syndrome (PCOS) reviews the scientific evidence for the key etiological role of insulin resistance in the pathogenesis of PCOS. It also presents a new clinical and diagnostic approach and clearly explains the value of insulin-sensitizing agents, or "insulin sensitizers," in reducing hyperandrogenism and improving fertility outcome. Detailed information is provided on the use of insulin sensitizers such as metformin and inositol and suitable therapeutic protocols are described. All too often, PCOS is treated by gynecologists only as an endocrine disorder, without recognition of the very important part that insulin plays in the syndrome. Practitioners will find this book to be a valuable source of information on PCOS as a metabolic syndrome and a comprehensive guide to achieving good treatment results.

Adopting an anthrozoological perspective to study the participation of non-human animals in regimes of care, this book examines the use of canine scent detection to alert 'hypo-unaware' individuals to symptoms of human chronic illness. Based on ethnographic research and interviews, it focuses on the manner in which trained assistance dogs are able to use their sense of smell to alert human companions with Type 1 diabetes to imminent hypoglycaemic episodes, thus reducing the risk of collapse into unconsciousness, coma or, at worst, death. Through analyses of participant narrations of the everyday complexities of 'doing' diabetes with the assistance of medical alert dogs, the author sheds light on the way in which each human-canine dyad becomes acknowledged as a team of 'one' in society. Based on the concept of dogs as friends and work colleagues, as animate instruments and biomedical resources, the book raises conceptual questions surrounding the acceptable use of animals and their role within society. As such, this volume will appeal to scholars across the social sciences with interests in human-animal interactions and intersections. It may also appeal to healthcare practitioners and individuals interested in innovative multispecies methods of managing chronic illness.

Diabetes and Wellbeing presents a range of effective psychological principles proven to positively impact the emotional wellbeing of individuals with type 1 and 2 diabetes. The guide takes an explicitly CBT approach to motivate sufferers in essential self-care tasks. * Written in a practical style, for those newly diagnosed with diabetes, individuals managing its challenges for many years, and healthcare professionals * Reveals how the stress of daily diabetes management can affect an individual s ability to stay motivated and engaged in essential self-care tasks that are vital for good health * Presents proven techniques for improving emotional wellbeing * First book to take an explicitly CBT approach to diabetes, simultaneously drawing on solution-focused behavioural therapy and mindfulness approaches * Fills the gap information of this kind among healthcare professionals and individuals with diabetes

The World Health Organization estimates that there are 2.1 billion individuals with obesity globally. Nearly three quarters of adults in the United States are overweight or obese. The average individual with obesity cuts ten years off their life expectancy, yet less than 40% of physicians routinely counsel individuals concerning the adverse health consequences of obesity. Obesity Prevention and Treatment: A Practical Guide equips healthcare practitioners to include effective weight management counselling in the daily practice of medicine. Written by lifestyle medicine pioneer and cardiologist, Dr. James Rippe and obesity expert Dr. John Foreyt, this book provides evidence-based discussions of obesity and its metabolic consequences. A volume in the Lifestyle Medicine Series, it provides evidence-based information about the prevention and treatment of obesity through lifestyle measures, such as regular physical activity and sound nutrition, as well as the use of new medications or bariatric surgery available to assist in weight management. Provides a framework and practical strategies to assist practitioners in safe and effective treatments of obesity. Contains information explaining the relationship between obesity and increased risk of heart disease, diabetes, cancer, osteoarthritis, and other chronic conditions. Chapters begin with bulleted key points and conclude with a list of Clinical Applications. Written for practitioners at all levels, this user-friendly, evidence-based book on obesity prevention and treatment will be valuable to practitioners in general medicine or subspecialty practices.

This book offers a step-by-step guide to mental health assessment for bariatric surgery patients. A general introduction explains the concepts of bariatric psychology and psychiatry, their relevance in contemporary bariatric surgery, and reasons to include psychologists and psychiatrists in multidisciplinary teams taking care of bariatric patients. The following four chapters address the aspects of mental health that are investigated by bariatric psychology. The psychological processes analyzed here play a major role in influencing patients' perception of the outcomes of bariatric surgery and in determining their commitment to lifestyle changes and follow-up programs. The second part of the book includes nine chapters addressing the clinical conditions relevant to bariatric psychiatry. For each condition, the major focus is on the impact of psychopathology on bariatric surgery outcomes (weight loss, weight regain, quality of life) and the impact of surgery on its course (remission, worsening, de novo onset). Each chapter in this part includes a discussion of the diagnostic instruments (i.e., structured interviews, clinician-rated tests, and patient-rated tests) that should be used to obtain a valid assessment of the patient's mental status. Separate chapters focus on psychiatric complications (e.g., suicide and addiction transfer) and psychological problems related to quality of life (e.g., body image dissatisfaction) that may emerge postoperatively. Data on these postsurgery conditions has been reported only recently and, therefore, no published book deals with them. The final chapter offers an overview of unsolved issues in bariatric psychology and psychiatry and reviews emerging research findings that are likely to change assessment and care of bariatric patients' mental health in the near future. Given its scope-and its wealth of tables, diagrams, mnemonics, and key fact boxes-the book will be an invaluable reference tool for clinicians.

In 1981, David Jenkins, Thomas Wolever, and colleagues introduced the concept of the glycemic index (GI) to differentiate carbohydrates based on the rate of blood glucose rise following their consumption. Although GI was first used in diet therapy for diabetes, research evidence has accumulated since then to thousands of publications from all over the world with applications for prevention and/or management of many diseases, as well as effects on physiological states and exercise. The Glycemic Index: Applications in Practice has gathered together, in an unbiased and critical way, all the evidence and research on GI, including diabetes, cardiovascular disease, cancer, obesity, polycystic ovary syndrome, pregnancy outcomes, sports performance, eye health, and cognitive functioning. It provides a detailed explanation on how to correctly measure a food's GI, how the GI of food products can be altered, as well as the use and misuse of GI labelling around the globe. The contributors are either pioneers or experts in the area of GI from all around the globe, including Australia, Canada, Europe, and the United States. The book is a valuable source of information for healthcare professionals of various disciplines, nutritionists, dietitians, food scientists, medical doctors, sports scientists, psychologists, public health (nutrition) policy makers, and students in these fields, as well as an important addition to university libraries.

Recent research suggests that adult growth hormone (GH) deficiency, whether of pathological or physiological origin, is associated with a dis tinct syndrome that includes alterations in body composition, endocrine metabolic function, immune competence, and physical and psychosocial well-being. Not surprisingly, substantial investigative effort is currently focused on validating the above hypothesis and on determining whether restoration of a normal GH-IGF-I axis in various states of adult GH deficiency is clinically useful, safe, and cost-beneficial. This book contains the proceedings from the Symposium on GHRH, GH, and IGF-I: Basic and Clinical Advances, held December 9 to 12, 1993, in San Diego, California, and sponsored by Serono Symposia USA, Inc. The conference was meant to highlight selected novel and exciting clinical research developments related to possible therapeutic uses of recombinant human GH and IGF-I, GHRH, GH releasing peptides, and related GH secretagogues. This meeting occurred only one year after a similar Serono symposium that was somewhat more oriented to novel basic science discoveries, thus attesting to the current scientific and clinical interest in this area."

This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis is maintained by balanced food intake and energy expenditure, both of which are under the control of brain neurons. In the recent years, significant progress has been made in identifying specific neurons, neural pathways, and non-neuron cells in feeding regulation, as well as in delineating autonomic nervous systems targeting peripheral metabolic tissues in the regulation of energy expenditure and metabolism. This book reviews recent progress on important neuron signaling for body weight and metabolic regulation and the state-of-the-art methods that has been applied in this field, ranging from animal models with neuron-specific manipulations, pharmacology, optogenetics, in vivo Ca2+ imaging, and viral tracing. Readers will be exposed to latest research frontiers on neuron regulation of metabolism. Key Features Explores the role signaling between neurons plays with respect to metabolism Documents how neurotransmitters affect the regulation of feeding Describes various methods and technologies used to study the neuronal control of metabolism Includes contributions from an international team of leading researchers. Related Titles Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Feltz, A. Physiology of Neurons (ISBN 978-0-8153-4600-5) Zempleni, J. & K. Dakshinamurti, eds. Nutrients and Cell Signaling (ISBN 978-0367-39307-6)