This volume discusses the many ways to prevent, identify and control hypertension in African Americans, a common and potent risk factor for virtually all forms of cardiovascular-renal diseases. Comprehensive chapters address modifiable risk factors, such as lifestyle changes, especially sodium restriction, and appropriate combination pharmacotherapy. Emerging devices and evidence-based approaches that may also enhance effective blood pressure control and decrease the disparate cardiovascular disease risks, including MI, stroke, HF, and cardiorenal metabolic syndrome and diabetes are also discussed in detail. Written by a wide-range of experts in the field, Hypertension in High Risk African Americans: Current Concepts, Evidence-based Therapeutics and Future Considerations is a valuable resource for clinicians, researchers, health administrators and public health policy leaders to better understand the best practices and unique aspects of risk assessment and treatment of hypertension and co-morbid conditions in African Americans.

This work is based on the proceedings of the seventh conference of the Society for Menstrual Cycle Research held at the University of Michigan in Arbor in June 1987. It discusses such topics as the experience of menstruation, perimenstrual symptoms and premenstrual syndrome and menopause.

Nutrition plays a key role in prevention of cardiovascular disease, the leading cause of death worldwide. Diet influences a broad spectrum of cardiometabolic risk factors, notably a cluster including excess adiposity, dyslipidemia, impaired glucose metabolism and high blood pressure. In the face of the rapidly increasing incidence of obesity and diabetes, maintaining cardiometabolic health through adoption of a healthy lifestyle is a top public health priority. In this book, Nutrition and Cardiometabolic Health, international experts present state-of-the-art scholarly reviews of dietary and lifestyle effects on metabolic systems associated with cardiovascular health and disease. It covers a broad range of topics including biological and behavioral processes regulating food intake; lifestyle and surgical approaches to weight loss; nutritional considerations for optimal cardiometabolic health across the lifespan; the relationship of macronutrients, whole foods and dietary patterns to diabetes and cardiovascular disease; and diet as a modulator of gene expression, epigenetics and the gut microbiome and the relationship of these traits to disorders of metabolism. This book provides its readers with an authoritative view of the present state of knowledge of dietary effects on cardiometabolic health and will be of interest to nutrition and healthcare professionals alike.

The Sunday Times Bestseller 'The cookbook every diabetic needs.' - Dr Aseem Malhotra From the bestselling authors of The Diabetes Weight-loss Cookbook Being diagnosed with prediabetes or type 2 diabetes can be a real shock. How do you try to lose weight and eat healthily when you also have so little time to cook and shop? Giancarlo Caldesi has successfully lost 4 stone and kept his diabetes in remission for over 8 years. He and his wife, Katie, share their knowledge and experience alongside 100 mouthwatering low-carb recipes that can be made in just 30 minutes or less to help you eat well every day. Suitable for the whole family, there are weekday suppers, no-cook meals to throw together in minutes, feasts to feed friends and celebrate special occasions and even scrumptious desserts. With the unique combination of two chefs, pioneering GP and diabetes specialist Dr David Unwin (@lowcarbgp) and highly respected nutritionist Jenny Phillips, this essential book provides a complete plan for beating diabetes for good.

The increasing prevalence of diabetes mellitus world-wide is an issue of major socio-economic concern. Scientific interest in plant-derived medicine is steadily rising, yet there is often a wide disparity in the caliber of information available. A detailed compilation of scientific information from across the globe, Traditional Medicines for Modern Times: Antidiabetic Plants highlights the potential role of dietary and medicinal plant materials in the prevention, treatment, and control of diabetes and its complications. The book not only describes plants traditionally used to treat diabetes, but evaluates the scientific studies on these plants and describes in vitro, in vivo, and clinical methods for their investigation. It examines the theory that changes in dietary patterns from traditional plant foodstuffs containing beneficial components, to richer, more processed "junk" food is responsible for the increased prevalence of diabetes worldwide.The book begins with an introduction to the disease diabetes mellitus written by a consultant physician and an up-to-date, detailed summary table and discussion of scientifically screened antidiabetic plants compiled by authors from the Jodrell Laboratories, Royal Botanic Gardens, Kew, UK. The next chapters provide an outline of clinical, in vivo, and in vitro methods for assessing antidiabetic activity of plant materials, followed by descriptions of traditional plant remedies used in Asia, the Americas, Africa, Europe, and Australia written by an international group of authors active in antidiabetic plant research. The final chapters emphasize the role of particular phytochemical groups in the treatment or prevention of diabetes. By documenting both traditional and scientifically derived knowledge, Traditional Medicines for Modern Times: Antidiabetic Plants brings us closer to the translation of traditional knowledge into new methods for treatment of this important disease.

Current knowledge concerning both morphological and functional cryptorchid-related alterations in the various testicular compartments is summarized in this valuable new publication. Damage to the germinal epithelium and resulting infertility in both humans and experimental animals as well as the degree of damage to the different stages of germ cell development is discussed. In addition, information concerning hormonal therapy and orchidopexy to reverse cryptorchid-related damage is provided. Morphological alterations in Sertoli and Leydig cells is discussed in terms of cellular hypertrophy and hyperplasia, alterations in organelle number and characteristics as well as changes in cell-cell junctional complexes. Changes in Sertoli cell and Leydig cell function, including gonadotropin binding, steroidogenesis and other metabolic alterations is also outlined, as well as the influence of altered testicular function on subsequent hypothalamic-pituitary changes. Vascular disruption, the potential role of paracrine substances and direct thermal damage, all of which may be responsible for the resulting detrimental changes in one or more testicular compartments, are considered.

This book addresses all aspects of white coat hypertension the phenomenon of raised blood pressure in a medical setting yet not elsewhere from its history to its pathophysiology, diagnosis and treatment. White coat hypertension is a common condition, accounting for 30 40% of the overall hypertensive population. While many studies have addressed this condition, controversy still exists over whether it causes an increased risk to sufferers and should be treated.

In the volume neurogenic and non-neurogenic mechanisms are discussed and the significance of various predictive factors, evaluated. The association of white coat hypertension with dysmetabolic risk factors, new-onset diabetes and other conditions is carefully reviewed. Further chapters consider the occurrence of asymptomatic organ damage and cardiovascular outcomes in affected patients and helpful guidance is also provided on the controversial issue of when to treat and when not to treat. "White Coat Hypertension" is based largely on work done during the past 30 years by renowned researchers working in Milan, who have made key contributions in improving knowledge of the condition and whose work is well known across the world."

Endocrinology is a complex specialty that spans a wide range of diseases, disorders, and conditions. The field is now moving toward an increasingly personalized approach to patient management, with a greater focus on mechanisms of disease and biomarkers. Written by internationally renowned specialists, the second edition of Endocrinology in Clinical Practice provides a cutting-edge, problem-orientated approach to the management of clinical problems in endocrinology. Highlights of the new edition include: An overview of neuroendocrine disease Strides made by the identification of aryl hydrocarbon receptor-interacting protein mutations in patients with familial isolated pituitary adenomas The diverse roles of IGF-I Changes in diagnostic imaging and the increasing use of positron emission tomography The rapidly increasing incidence of neuroendocrine tumors and their management Hereditary primary hyperparathyroidism and multiple endocrine neoplasia Mechanistic and genomic advances related to disorders of calcium regulation and infertility The endocrinology of aging Protocols for pituitary function testing With complete updates to existing chapters, the second edition also presents new research data, diagnostic techniques, treatment options, and safety concerns related to existing therapies. This edition offers current guidance and scientifically focused information relevant to a range of clinical problems, making it an essential reference for practicing endocrinologists and specialist clinicians.

The incidence and severity of diabetes mellitus is increasing worldwide, presenting a significant burden to society both in economic terms and overall well-being. Fortunately, time-tested anti-diabetes mellitus plant foods exist that are safe and could be effective in addressing this condition when consumed judiciously with a concomitant change in lifestyle. Plants with Anti-Diabetes Mellitus Properties presents an exhaustive compilation of the anti-diabetes mellitus activities of more than 1000 plants occurring worldwide. The author provides a brief botanical description, distribution, pharmacological properties, and phytochemicals, where appropriate. A list of traditional medicinal plants used to treat diabetes, but not tested for anti-diabetic activity, is also given. This unique reference highlights anti-diabetes mellitus plant foods along with a list of the edible parts of plants with anti-diabetes mellitus properties. Anti-diabetes mellitus nutraceuticals are described with guidelines for the development of food supplements and formulations of diets appropriate for diabetic patients. This is a valuable source of information for researchers, students, doctors, diabetic patients, and other individuals wanting to learn more about plant-based treatments for diabetes mellitus.

The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, "from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease" (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

A clear explanation of the cause, diagnosis, and treatment of diabetes Written for a broad range of readers, including students, researchers, policymakers, health care providers, and diabetes patients and caregivers, this book explains the underlying biochemistry and physiology of diabetes mellitus. Each chapter contains a glossary that defines key terms, a summary that highlights essential concepts discussed in each section of the chapter, as well as a set of simple problems to help readers gain a richer and deeper understanding of diabetes, from its history to treatment options. Understanding Diabetes begins with an overview of the disease, its worldwide prevalence and cost, and its connection to the global obesity epidemic. The author then explores the history of diabetes, including the first documented description of the disease dating back to 3400 BCE in Ancient Egypt. The next chapter, A Glucose Metabolism Primer, sets forth the pathways for the metabolism of glucose. Next, the book covers: * Regulation of glucose metabolism and glucose metabolism gone wrong * Diabetes classification system * Diagnosis, including current laboratory tests * Complications, such as retinopathy, neuropathy, and cardiovascular disease * Hereditary transmission * Prevention and treatment, including emerging research Although a cure has still not been found, this book demonstrates that researchers are continuing to make major breakthroughs on all fronts in the fight against diabetes, including a better understanding of its causes and an improved ability to diagnose and treat the disease.

Research into metabolic bone disease has made remarkable progress over the last 20 years, with the identification of numerous new molecules and pathways regulating bone cells as well as their plasma milieu. Their activities are largely regulated by the physiological status of the body incorporating the biochemical, physical and mechanical functions of bone, kidney and intestinal tissues. The Physiological Basis of Metabolic Bone Disease integrates the knowledge derived from molecular techniques with the fundamental principles of the physiology of these organs.
The book places particular emphasis on bone cell activities and the regulation of plasma calcium, phosphate homeostasis, and whole body nutrition. It reviews the nutritional requirements for calcium and vitamin D for the prevention of osteoporosis. It covers vitamin D, calcium and phosphate absorption; calcium sensing receptors; the role of parathyroid hormone; physiological actions of calcitonin; and the diagnosis and significance of osteoporosis. Reviewing the physiological significance of advances in the molecular biology of metabolic bone disease, this book provides a valuable reference for researchers as well as practicing clinicians.

Sometimes living with a condition like type 1 diabetes can be a mammoth task. How to Manage a Mammoth is a book for children and families living with type 1 diabetes. Join Jake, his Mum and Mel the diabetes mammoth as they join forces with their friends to become a super-team and work out how to shrink Mel to a manageable size. This fun and imaginative story helps children to understand the challenges they face living with diabetes and assists them in communicating with their carers about their feelings. Featuring a list of tasks and activities that children and parents can do to help manage the psychological challenges of living with diabetes. An ideal resource for parents and carers supporting a child with type 1 diabetes, as well as the wider diabetes healthcare team, including clinical psychologists, specialist nurses, endocrinologists and general practitioners.

This is a must read book created with the idea of what is important for the physicians who take care of patients with diabetes. It is a practical and comprehensive manual without unnecessary research details. Each chapter is comprehensively written by authorities from across the world with extensive clinical experience. Pictures, tables, flow diagrams and bullet points make its reading simple and direct.

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. Thisis the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.
Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases.

Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles "

Congenital Adrenal Hyperplasia: A Comprehensive Guide addresses how hydrocortisone works, what can go wrong, and how to correct it, also explaining why the timing of doses and measurement of cortisol from a dose is extremely important. The book provides an in-depth analysis of this disorder for pediatric endocrinologists and primary care providers, allowing them to help patients with an updated model of care and appropriate treatment. Patients and family members will benefit from the trend-forward information that will empower them to approach their healthcare providers with the expectation of receiving individualized care and treatment for this disorder.

Highly Commended, BMA Medical Book Awards 2013 Sarcoidosis represents a major challenge for physicians-not just in respiratory medicine, but across a range of specialties. This book, with a multidisciplinary authorship of the highest standard, presents the most up-to-date thinking on all aspects of the condition, from epidemiology to clinical manifestations and treatment options. Full coverage is given to both respiratory and non-respiratory aspects. The basic science that underlies the disease and its progression is evaluated in detail, and placed into its correct clinical context. Possible future advances are covered in a concluding section. The editors-all leading figures in the field with international reputations-have compiled the definitive work on the subject in a single volume. The book is fully comprehensive and evidence based and will be an essential addition to the bookshelves of all whose practice involves the care and treatment of patients with sarcoidosis.

Part of the Paediatric Psychology series Children and young people are increasingly among those being diagnosed with diabetes. However in the UK only 1 in 6 children succeed in controlling their diabetes successfully, despite support from parents and professionals. This enlightening new book is a comprehensive account of diabetes and the complex medical and psychosocial factors that influence metabolic control in children and young people. It presents a series of evidence-based and accessible educational, psychological and social approaches to increase specialist knowledge, promote positive attitudes, enhance patient care and create appropriate healthcare environments. The book offers an easy-to-comprehend approach to clinical care and includes practical tools for assessment for all healthcare professionals throughout the text. Featuring contributions from a number of international experts in the field, this thorough and wide-ranging guide is informative reading for all students, academics and professionals with an interest in paediatric psychology and health.

Key Features: 1. Builds on its strength of having excellent content on long-term management of hyperglycemia by including pancreas and islet transplantation. 2. Contains invaluable information on glucose monitoring for healthcare professionals interested in diabetes.

It is possible to manage and even reverse diabetes through natural means, and in "Reversing Diabetes," Dr. Colbert shows you how. Most people view diabetes as a dead-end street. Once you receive a diabetes diagnosis, your only option is to manage the symptoms with a restricted diet, close monitoring of blood sugar, and expensive medications. Dr. Colbert shows that diabetes can be treated instead through safe, natural means, like healthy food and vitamins rather than strictly relying on prescription drugs. He shows you how to manage your weight and your glucose intake with a whole-body approach, using nutritional supplements along with dietary and lifestyle changes to lose weight, repair cell damage, improve insulin function, and reduce the side effects from prescription drugs, many of which rob nutrients from the body and cause additional symptoms.
Based on the same life-changing principles of the low-glycemic, high-fiber eating plan provided in Dr. Colbert's "New York Times "best-selling book, "Dr. Colbert's "I Can Do This" Diet," this book adapts that plan in a way that makes it ideal for diabetics who need to manage their glucose levels and their weight. "Siloam, an imprint of Charisma House Book Group, is the leader in the Christian health and fitness genre, with several best-sellers...including Don Colbert's The Bible Cure series." --"Christian Retailing" "Physician Don Colbert Preaches The Gospel Of Good Nutrition, Advising His Patients To Follow In The Footsteps Of One Of History's Better-known Role Models." --"Orlando Sentinel"

An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.

Despite being regarded as the most common toxicological target in the endocrine system, the adrenal gland has often been neglected in regulatory testing. Adrenal Toxicology addresses the increased interest in adrenocortical toxicology and the need for a resource that makes techniques available to examine adrenal endocrine disruption. Examining current techniques and the latest advancements, Adrenal Toxicology reviews the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. This text provides information on the range of drugs and chemicals that affect adrenocortical function and suggests standardized approaches for in vivo and in vitro assessment. This volume also presents recent developments in the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species. Adrenal Toxicology: reflects the major developments made over the past decade focuses on the latest research techniques, including their uses and limitations provides an integrated strategy for adrenal toxicology evaluation identifies knowledge and data gaps, providing impetus for regulatory consideration

Organised into Breakfasts, Light Bites, Soup & Lunch, Main Meals, Sweet Things & Drinks and Sides & Dressings, the recipes are accompanied by nutritional analysis and at-a-glance traffic light labelling, as well as being arranged into Menu Plans. They include delicious dishes such as Squash, Feta & Hazelnut Salad and Roast Butterfly Chicken with Pomegranate, Lemon, Garlic & Mint, and cakes and desserts such as Banana Pinenut Cake and Easy Chocolate Mousse. With advice on achieving (and maintaining) a healthy weight, practical tips on eating less refined carbohydrates, smaller portions, and nutrient dense ingredients, Phil makes eating sensibly easier and more appealing than ever.

Estrogens are key modulators of brain regions that mediate learning and memory formation. This regulation has significant translational implications, as estrogens contribute to age-related memory decline and dementia, emotional disorders, addiction, and recovery from brain injury. Although the importance of estrogens for memory formation has been well accepted within the behavioral neuroendocrinology community, it has yet to be fully appreciated by neuroscientists outside of the discipline. Recent National Institutes of Health policies on the inclusion of sex as a biological variable in grant applications will force thousands of researchers to consider hormonal regulation of memory for the first time. However, the majority of these researchers are not trained endocrinologists, and no previous monograph comprehensively encompasses the breadth of basic and clinical research on this subject. Thus, this book provides a vital resource for non-endocrinologists and endocrinologists alike. Estrogens and Memory: Basic Research and Clinical Implications provides a compendium of cutting-edge basic and clinical research describing the ways in which estrogens regulate memory in a variety of species. Chapters are written by leading experts whose work is on the forefront of this exciting field. Three fundamental discussions focus on: effects of estrogens on the hippocampus and other brain regions central to memory, effects of estrogens on memory and related cognitive processes throughout the lifespan, and translational implications of estrogenic regulation of memory for aging and disease.

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.