The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to the different fields of interest representing research in the hypothalamo-neurohypophysial system.

Two neurohypophysial neurohormones, oxytocin and vasopressin, exert a variety of central and peripheral actions and thus involve different scientific domains, which too often, even today, do not always find the appropriate occasion to interact. This volume is composed of chapters dealing with topics varying from basic and clinical neurosciences and neuroendocrinology, to reproductive, renal, cardiovascular physiology and pathology. It encompasses all areas of current neurohypophysial research and should be of vital interest as an integrative reference volume to specialized investigators and as an excellent introductory text to students, scientists and clinicians not yet closely familiar with the field. To ensure novelty and to make sure that all topics of current importance were covered, plenary and symposium speakers as well as poster presentations concentrated on recent advances made in the last few years.

The original Dr. Neal Barnard's Program For Reversing Diabetes is one of Rodale's strongest backlist sellers with nearly two hundred thousand copies sold since 2006 and several hundred copies continuing to be sold per month. By following Dr. Barnard's revolutionary plan, readers have been able to cut back on or eliminate medications and reduce the risk of complications, while experiencing weight loss, increased energy, and a new lease on life. Before Dr. Barnard's scientific breakthrough, most health professionals believed that once you developed diabetes, you were stuck with it - and could anticipate one health issue after another, from worsening eyesight and nerve symptoms to heart and kidney problems. But as Dr. Barnard's groundbreaking work has revealed, this simply is not true. Dr. Barnard has shown that it is often possible to improve insulin sensitivity and tackle type 2 diabetes by following his step-by-step plan, which includes a healthful vegan diet with plenty of recipes to get started, an exercise guide, advice about taking supplements and tracking progress, and troubleshooting tips. The scientifically proven, life-changing program introduces a style of eating that will improve how people with type 2 diabetes respond to insulin, addressing the defining symptom of diabetes and allowing people with diabetes to control blood sugar more effectively than with conventional dietary regimens for people with diabetes.

The Diabetes LIFEMAP changes the way chronic diabetes care is delivered forever. The LIFEMAP raises diabetes care for the primary care and ancillary healthcare provider to the level of world renown diabetes expert, David Bleich, MD. For patients, the LIFEMAP provides real-time diabetes care that changes a "tough-to-manage" disease into a shared, personal, and efficient management experience. The LIFEMAP can be used as a stand-alone diabetes management tool or can be combined with our cloud based LIFEMAP platform through GoMo Health. Now care can be delivered seamlessly at home for both provider and patient. The Diabetes LIFEMAP is the playbook for 21st century diabetes care. It starts with an understanding of the basic principles of insulin secretion and moves to a discussion of how the LIFEMAP evolved and why it is such a powerful management tool. Finally, case studies are provided to reinforce basic concepts of LIFEMAP diabetes care with real world examples. Taken together, The Diabetes LIFEMAP succeeds in helping healthcare providers overcome a difficult to manage disease and provides patients with an optimal diabetes outcome with the least amount of effort necessary to achieve high level results.

Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.

Contents:
1. What do gap junctions do anyway? 2. Cardiovascular gap junctions: Functional Diversity, complementation and specialization of connexins 3. Endothelium and smooth muscle pathways for conduction along resistance microvessels 4. Membrane potential and calcium responses evoked by acetylcholine in submucosal arterioles of the guinea-pig small intestine 5. The effects of ouabain, 18a-glycyrrhetinic acid and connexin-mimetic peptides on intercellular communication in cells expressing a Cx43-GFP chimeric protein 6. Role of gap junctions in endothelium-dependent hyperpolarizations 7. Heterogeneity of EDHF-type relaxations of rabbit and rat arteries analysed with peptides homologous to the extracelluar loops of connexins 37, 40 and 43 8. Myoendothelial and circumferential spread of endothelium-dependent hyperpolarization in coronary arteries 9. Direct myoendothelial contact in human pulmonary microvessels 10. Role of gap junctional communication in EDHF-mediated responses and mechanisms of K-induced dilatations 11. Comparison of alpha and beta isoforms of glycyrrhetinic acid and carbenoxolone as inhibitors of EDHF-type relaxation 12. Inhibitory effect of 18-beta-glycyrrhetinic acid on the relaxation induced by acetylcholine in the rat aorta 13. A central role for endothelial cell potassium channels in EDHF-mediated responses 14. Could the EDHF be K in porcine coronary arteries? 15. Nitro-L-arginine/indomethacin-resistant relaxations to acetylcholine in small gastric arteries of the rat: Effect of ouabain plus Ba2+ and relation to potassium ions 16. Effects of barium, ouabain and K+ on the resting membrane potential and endothelium-dependent responses in rat arteries 17. EDHF and potassium: Blockade of chloride channels reveals relaxations of rat mesenteric artery to potassium 18. Cytochrome P450 2C is a source of EDHF and reactive oxygen species in the porcine coronary artery 19. Cortisol increases EDHF-mediated relaxations in porcine coronary artery 19. Cortisol increases EDHF-mediated relaxations in porcine coronary arteries and up-regulates the expression of cytochrome P450 2C9 20. An arachidonic acid metabolite(s) produced by the endothelial cytochrome P450 isoform, CYP3A4, relaxes the lingual artery of the monkey via K+ channel opening 21. EDHF-mediated responses induced by bradykinin in the porcine coronary artery 22. Epoxyeicosatrienoic acid release mediates nitric oxide-independent dilatation of rat mesenteric vessels 23. Epoxyeicosatrienoic acid and endothelium-dependent hyperpolarization in porcine coronary arteries 24. Lipoxygenase-derived metabolites of arachidonic acid are not involved in the endothelium-dependent hyperpolarization to acetylcholine in the carotid artery of the guinea-pig 25. Cytochrome P450 isoforms in the brain encode cell specific hyperpolarizing factors with a common mechanism of action 26. Expression of recombinant cytochrome P450 epoxygenase in rat brain 27. Identification of 11, 12, 15-trihydroxyeicosatrienoic acid as the mediator of acetylcholine- and arachidonic acid-induced relaxations in the rabbit aorta 28. Identification of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in mice 29. Components of the potassium currents underlying the actions of endothelium- derived hyperpolarizing factor in arterioles 30. Evidence for relaxation to endothelium-derived hyperpolarizing factor (EDHF) in isolated small mesenteric arteries of the mouse 31. Pharmacological characterization of potassium channels in intact mesenteric arteries and single smooth muscle cells from eNOS-/- and +/+ mice 32. EDHF, which is not NO, is a major endothelium-dependent vasodilator in mice 33. Prostacyclin and iloprost in the isolated carotid artery of the guinea pig 34. Role of charybdotoxin/apamin sensitive K+ Ca channels in pulsatile perfusion- mediated coronary vasodilatation in vivo 35. Essential role of estrogen in the EDHF-mediated responses of mesenteric arteries from middle-aged female rats: Possible contribution of gap junctional protein connexin 43 36. Endothelium-derived hyperpolarizing factor (EDHF) and utero-feto-placental circulation in the rat 37. Endothelium-derived hyperpolarizing factor maintains a normal relaxation to bradykinin despite impairment of the nitric oxide pathway in porcine coronary arteries with regenerated endothelium 38. Mechanisms underlying the vasodilatation caused by bradykinin in essential hypertensive patients 39. Influence of diabetes on endothelium-dependent responses in mesenteric and femoral arteries of rats 40. Folate restores the NO synthase- and cyclooxygenase-resistant renal vasodilator response to acetylcholine in diabetes 41. Resistance of EDHF-mediated relaxations to oxidative stress in human radial arteries 42. Critical limb ischemia results in different types of endothelial dysfunction depending on the vascular bed studied 43. Potentiated EDHF-mediated dilatations in the rat middle cerebral artery following ischemia/reperfusion 44. The EDHF-dependent but not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aorta is resistant to ionized radiation 45. Inhibition of converting enzyme prevents the age-related decline in endothelium-dependent hyperpolarization 46. Effects of a converting enzyme inhibitor, an AT1-receptor antagonist and their combination on endothelial dysfunction in hypertension 47. EDHF: Gap junction or chemical? And many other questions

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts

Coronary heart disease is the single most common cause of death in the UK. Much of the ensuing morbidity and premature morbidity is preventable and the Government is addressing this with the National Service Framework (NSF) initiative. This is a practical text that can be used by an individual practice team or by a group of practices working together. It gives examples of personal development plans and a practice learning plan showing how the information can be applied by a GP health professional or practice team. Topics such as heart failure smoking cessation and primary and secondary prevention of coronary heart disease are included as well as appendices providing NSF standards and goals Read codes and further useful information. It is relevant for all members of the primary healthcare team and also for public health physicians nurses and clinical governance leads responsible for implementing the NSF for coronary heart disease in their local area.

In this groundbreaking collection, Ruth DyckFehderau and twenty-seven storytellers offer a rich and timely accounting of contemporary life in Eeyou Istchee, the territory of the James Bay Cree of Northern Quebec. The stories are connected by diabetes, but they are not records of illness as much as they are deeply personal accounts of life in the North: the fine, swayingbalances of living both in town and on the land, of family and work and studies, of healing from relocations and residential school histories while building communities of safety and challenge and joy, of hunting and hockey, and much more.Sweet Bloods is essential reading for anyone who knows anyone with diabetes, and for anyone interested in a contemporary rendering of one of Canada's vibrant, thriving, and highly adaptive Indigenous communities.

This book is a how-to manual for practicing physicians and health care providers, nurse educators, nutritionists, and physicians in training in the management of persons with diabetes mellitus. Experts with strong clinical and teaching backgrounds provide up-to-date recom-mendations and rationale of the most effective diagnostic and therapeutic approaches to diabetes mellitus and its multiorgan micro- and macrovascular complications for patients of all ages. Gives five practical guidelines for nutrition therapy that supplies realistic recommendations! With contributions from nearly 60 clinicians who reveal a constellation of disorders with different signs, symptoms, clinical characteristics, and therapies, Medical Management of Diabetes Mellitus -reviews the autoimmune process and genetics of type 1 and type 2 diabetes -offers an overview of the medications that impair glucose metabolism causing hypo- or hyperglycemia -covers pathogenesis, clinical presentation, and diagnosis with specialized laboratory tests -surveys therapeutic modalities, their mechanisms of action, and rationale for use -focuses on outcomes and how they are tracked -stresses early detection and therapy of end-organ complications -discusses the effect of intensive diabetes management on reducing retinopathy, nephropathy, and neuropathy -considers incorporating psychiatric techniques into the treatment of diabetes -compares and contrasts diabetes in children, adults, and the elderly -and more! Containing over 850 references, tables, drawings, and photographs, Medical Management of Diabetes Mellitus is a cross-disciplinary reference perfect for family practice physicians, internists, pediatricians, endocrinologists, pharmacologists, nutritionists, physiologists, dietitians, obesity specialists, psychiatrists, and medical school students in these disciplines.

Skin lesions are often the first sign for an endocrine disease. Their description is thus of relevance for early diagnosis and treatment of endocrine disease for specialists in endocrinology as well as in dermatology.

Lavishly illustrated, this book describes the clinical and histological features of skin lesions observed in endocrine diseases. All features are reader-friendly structured and written in the language of dermatologists in order to enable a simple association between the features observed and the endocrine etiology.

Metabolism, behaviour, sleep, mood swings, the immune system, fighting, fleeing, puberty and sex: these are just a few of the things our bodies control with hormones. Armed with a healthy dose of wit and curiosity, medical journalist Randi Hutter Epstein takes us on a journey through the unusual history of these potent chemicals from a basement filled with jarred nineteenth-century brains to a twenty-first-century hormone clinic in Los Angeles. Brimming with fascinating anecdotes, illuminating new medical research and humorous details, Aroused introduces the leading scientists who made life-changing discoveries about the hormone imbalances that ail us, as well as the charlatans who used those discoveries to peddle false remedies.

Female Puberty: A Comprehensive Guide for Clinicians is a practical reference, covering the full range of issues related to pubertal development. Developed to answer pointed clinical questions and to provide a thorough review of the literature, the book covers both the basics and the complexities of puberty, encompassing psychosocial development to pubertal nuances in highly specialized populations. Comprehensive in scope, this title offers concepts that are concisely conveyed and chapters that complement each other well. Complex subjects such as details of the hypothalamic-pituitary-ovarian axis are covered in a readily understandable manner and bullet points throughout the text serve as helpful reminders to the reader. An invaluable contribution to the literature, Female Puberty: A Comprehensive Guide for Clinicians will be of great interest to all health providers concerned with female reproductive health - including obstetrician gynecologists, reproductive endocrine specialists, pediatricians, pediatric specialists, family practitioners and allied health professionals.

Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice -analyzes structural requirements for GH secretagogue efficacy -demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secretion from the pituitary -reports on the development of a simple screening system based on polyclonal antibodies -discusses laboratory synthesis of agonistic analogs intended for human and veterinary use -proposes applications in managing conditions such as Turner's syndrome, acromegaly, diabetic retinopathy, glomerulosclerosis, tumors, and cancer -provides physiological evidence for the effects of GHRP on behavior with a series of trials involving voluntary and forced exercise -describes a new diagnostic test for evaluating pituitary function in slowly growing children and aging adults -explores the interactions of GH secretagogues with other hormones and endogenous substances from sex steroids to interferons -and much more!

Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions -discusses the genetic determinants of mucociliary system structure and function -explains ciliary wave activity in cell-cell communication -elucidates many of the key physiological processes in ciliary regulation -reveals possible means of treating irregularities in mucus secretion and clearance -improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia -approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques -and much more! Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

Contents:
Evolution of the endocrine system and mechanisms of hormone action; control of the endocrine system and the anterior pituitary gland; the posterior pituitary gland; the thyroid gland; the parathyroid gland and calcium homeostasis; the hormonal control of the gastrointestinal tract; the endocrine pancreas and the hormonal control of carbohydrate metabolism; the adrenal medulla; the adrenal cortex; the testes and the male reproductive system; the ovaries and the female reproductive system; the hormonal control of growth and development; answers to revision questions.

This volume in the Human Molecular Genetics series is an invaluable text for endocrinologists wishing to update their knowledge. It also provides an excellent grounding in the basic genetics of molecular endocrinology and relevant analytical techniques fo

This brand new title in the "Lecture Notes" series covers a core element of the medical school curriculum.

It presents the basic science needed to understand mechanisms of disease and describes the clinical presentations of the disorders associated with different glands, concluding with the relevant investigations and management.

Focusing on conditions commonly encountered on the wards and in exams, with key points to aid revision and recall, this new title is perfect as a course companion and is the ideal revision tool for medical students, specialist nurses, and doctors working on endocrinology rotations. "Lecture Notes: Endocrinology and Diabetes" is also essential for endocrinology trainees approaching the new Knowledge Based Assessment (KBA).

Over 100 delicious recipes suitable for people with diabetes -- and those without! A healthy diet should be an important feature of our daily life and include a variety of foods from all food groups -- plenty of vegetables and fruits, breads and cereals, some dairy foods, lean meat and/or meat alternatives, and a small amount of polyunsaturated and monounsaturated fats. All recipes in this book satisfy the nutritional guidelines suitable for diabetes and overall healthy eating. Unless otherwise stated, the recipes use wholegrain cereal products, low-fat dairy products, minimal sugar and polyunsaturated and monounsaturated fats. In the interests of health and diabetes management, each recipe provides a nutritional analysis per recipe and serve for: Kilojoules; total fat; saturated fat; fibre; carbohydrates; sodium; protein.

The study of Burkitt's lymphoma is now in its 6 decade beginning with its discovery by Dr. Dennis Burkitt in equatorial Africa in the mid to late 1950's. A large body of information is available which provides a current understanding of the underlying molecular changes that are linked to the initiation and development of Burkitt's lymphoma. This proposed volume will provide a comprehensive view of Burkitt's Lymphoma from the diagnosis to potential animal models for this disease and include a view from physicians who have a up close view of the patients in populations where the disease is rampant. We expect that this will be an excellent resource for Medical students and faculty as well as educated laypersons who have a person interest in the disease.

The increasing prevalence of diabetes mellitus world-wide is an issue of major socio-economic concern. Scientific interest in plant-derived medicine is steadily rising, yet there is often a wide disparity in the caliber of information available. A detailed compilation of scientific information from across the globe, Traditional Medicines for Modern Times: Antidiabetic Plants highlights the potential role of dietary and medicinal plant materials in the prevention, treatment, and control of diabetes and its complications. The book not only describes plants traditionally used to treat diabetes, but evaluates the scientific studies on these plants and describes in vitro, in vivo, and clinical methods for their investigation. It examines the theory that changes in dietary patterns from traditional plant foodstuffs containing beneficial components, to richer, more processed "junk" food is responsible for the increased prevalence of diabetes worldwide.The book begins with an introduction to the disease diabetes mellitus written by a consultant physician and an up-to-date, detailed summary table and discussion of scientifically screened antidiabetic plants compiled by authors from the Jodrell Laboratories, Royal Botanic Gardens, Kew, UK. The next chapters provide an outline of clinical, in vivo, and in vitro methods for assessing antidiabetic activity of plant materials, followed by descriptions of traditional plant remedies used in Asia, the Americas, Africa, Europe, and Australia written by an international group of authors active in antidiabetic plant research. The final chapters emphasize the role of particular phytochemical groups in the treatment or prevention of diabetes. By documenting both traditional and scientifically derived knowledge, Traditional Medicines for Modern Times: Antidiabetic Plants brings us closer to the translation of traditional knowledge into new methods for treatment of this important disease.

Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain.
This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans. Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed. The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions.

This volume discusses the many ways to prevent, identify and control hypertension in African Americans, a common and potent risk factor for virtually all forms of cardiovascular-renal diseases. Comprehensive chapters address modifiable risk factors, such as lifestyle changes, especially sodium restriction, and appropriate combination pharmacotherapy. Emerging devices and evidence-based approaches that may also enhance effective blood pressure control and decrease the disparate cardiovascular disease risks, including MI, stroke, HF, and cardiorenal metabolic syndrome and diabetes are also discussed in detail. Written by a wide-range of experts in the field, Hypertension in High Risk African Americans: Current Concepts, Evidence-based Therapeutics and Future Considerations is a valuable resource for clinicians, researchers, health administrators and public health policy leaders to better understand the best practices and unique aspects of risk assessment and treatment of hypertension and co-morbid conditions in African Americans.

Prevention and Recovery from Eating Disorders in Type 1 Diabetes: Injecting Hope sheds light on an often overlooked and misunderstood issue: the problem of eating disorders in women with type 1 diabetes - referred to by lay people and the media as "diabulimia" and characterized by insulin restriction as a means of calorie purging for weight loss. Drawing on a series of recent interviews and over 16 years of research and clinical experience with this unique phenomenon, author Dr. Ann Goebel-Fabbri provides groundbreaking insight into the lives of women who have recovered from eating disorders in type 1 diabetes. She explores the condition's origins, its effects on the lives of those affected, and possible paths to recovery. Also included are suggestions for prevention and treatment, as well as practical and inspirational advice from now-recovered women. Prevention and Recovery from Eating Disorders in Type 1 Diabetes is a valuable guide for patients and loved ones, diabetes treatment teams, and eating disorder clinicians.

This work is based on the proceedings of the seventh conference of the Society for Menstrual Cycle Research held at the University of Michigan in Arbor in June 1987. It discusses such topics as the experience of menstruation, perimenstrual symptoms and premenstrual syndrome and menopause.

This book addresses all aspects of white coat hypertension the phenomenon of raised blood pressure in a medical setting yet not elsewhere from its history to its pathophysiology, diagnosis and treatment. White coat hypertension is a common condition, accounting for 30 40% of the overall hypertensive population. While many studies have addressed this condition, controversy still exists over whether it causes an increased risk to sufferers and should be treated.

In the volume neurogenic and non-neurogenic mechanisms are discussed and the significance of various predictive factors, evaluated. The association of white coat hypertension with dysmetabolic risk factors, new-onset diabetes and other conditions is carefully reviewed. Further chapters consider the occurrence of asymptomatic organ damage and cardiovascular outcomes in affected patients and helpful guidance is also provided on the controversial issue of when to treat and when not to treat. "White Coat Hypertension" is based largely on work done during the past 30 years by renowned researchers working in Milan, who have made key contributions in improving knowledge of the condition and whose work is well known across the world."