Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal presents in-depth content written by international experts in the study of resistance to anti-CD20 antibodies and approaches for their reversal. Anti-CD20 antibodies are used to achieve B cell depletion and are developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. In the past two decades, anti-CD20 antibodies have revolutionized the treatment of all B cell malignancies, however, there are patients that fail to respond to initial therapy or relapse sooner. This book explores new and existing avenues surrounding Anti-CD20 antibodies. In recent years, several next-generation anti-CD20 therapies have been developed but predicting and reversing resistance is still a challenging task. These areas are being actively studied as they represent a potential to improve anti-CD20 therapies and are discussed thoroughly in the book. It is a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about resistance to anti-CD20 antibodies and their reversal.

FOCAPD-19/Proceedings of the 9th International Conference on Foundations of Computer-Aided Process Design, July 14 - 18, 2019, compiles the presentations given at the Ninth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2019. It highlights the meetings held at this event that brings together researchers, educators and practitioners to identify new challenges and opportunities for process and product design.

Geoinformatics for Geosciences: Advanced Geospatial Analysis using RS, GIS and Soft Computing is a comprehensive guide to the methodologies and techniques that can be used in Earth observation data assessments, geospatial analysis, and soft computing in the geosciences. The book covers a variety of spatiotemporal problems and topics in the areas of the environment, geohazards, urban analysis, health, pollution, climate change, resources and geomorphology, among others. Sections cover environmental and climate issues, analysis of geomorphological data, hazard and disaster impacts, natural and human resources, the influence of environmental conditions, geohazards, climate change, geomorphological changes, etc., and socioeconomic challenges. Detailing up-to-date techniques in geoinformatics, this book offers in-depth, up-to-date methodologies for researchers and academics to understand how contemporary data can be combined with innovative techniques and tools in order to address challenges in the geosciences.

In the digital economy, a new type of business activity, digital entrepreneurship, has developed rapidly and required breakthrough technologies such as blockchain, big data, cloud technologies, and more. There is a need for a comprehensive resource that provides all-encompassing insight into the essence, special aspects, models, and international best practices of e-business based on various digital technologies in various high-tech markets. Digital Technologies for Entrepreneurship in Industry 4.0 provides theoretical frameworks and recent results of research in this sphere. It substantiates digital entrepreneurship, discusses the practical experience of its implementation, and develops the scientific and methodological recommendations for the development of its infrastructural provision and regulation of provision of its competitiveness. Covering topics such as investment attractiveness, corporate reporting modernization, and public-private partnership mechanisms, this premier reference source is an excellent resource for entrepreneurs, business executives and managers, investors, IT managers, students and faculty of higher education, researchers, and academicians.

Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research and computational approaches for drug discovery and repurposing for cancer therapy. The book provides detailed descriptions about target molecules and pathways and their inhibitors for easy understanding and applicability. Users will find discussions on tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers and transcriptome which are discussed in the context of different cancer types, such as colon, glioblastoma, endometrial and retinoblastoma, amongst others. This book will be a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor treatments for cancer patients.

Aircraft maintenance, repair and overhaul (MRO) requires unique information technology to meet the challenges set by today's aviation industry. How do IT services relate to aircraft MRO, and how may IT be leveraged in the future? Leveraging Information Technology for Optimal Aircraft Maintenance, Repair and Overhaul (MRO) responds to these questions, and describes the background of current trends in the industry, where airlines are tending to retain aircraft longer on the one hand, and rapidly introducing new genres of aircraft such as the A380 and B787, on the other. This book provides industry professionals and students of aviation MRO with the necessary principles, approaches and tools to respond effectively and efficiently to the constant development of new technologies, both in general and within the aviation MRO profession. This book is designed as a primer on IT services for aircraft engineering professionals and a handbook for IT professionals servicing this niche industry, highlighting the unique information requirements for aviation MRO and delving into detailed aspects of information needs from within the industry.

Biostatistics Manual for Health Research: A Practical Guide to Data Analysis is a guide for researchers on how to apply biostatistics on different types of data. The book approaches biostatistics and its application from medical and health researcher's point-of-view and has real and mostly published data for practice and understanding. The interpretation and meaning of the statistical results, reporting guidelines and mistakes are taught with real world examples. This is a valuable resource for biostaticians, students and researchers from medical and biomedical fields who need to learn how to apply statistical approaches to improve their research.