Multi-Paradigm Modelling for Cyber-Physical Systems explores modeling and analysis as crucial activities in the development of Cyber-Physical Systems, which are inherently cross-disciplinary in nature and require distinct modeling techniques related to different disciplines, as well as a common background knowledge. This book will serve as a reference for anyone starting in the field of CPS who needs a solid foundation of modeling, including a comprehensive introduction to existing techniques and a clear explanation of their advantages and limitations. This book is aimed at both researchers and practitioners who are interested in various modeling paradigms across computer science and engineering.

The Feature-Driven Method for Structural Optimization details a novel structural optimization method within a CAD framework, integrating structural optimization and feature-based design. The book presents cutting-edge research on advanced structures and introduces the feature-driven structural optimization method by regarding engineering features as basic design primitives. Consequently, it presents a method that allows structural optimization and feature design to be done simultaneously so that feature attributes are preserved throughout the design process. The book illustrates and supports the effectiveness of the method described, showing potential applications through numerical modeling techniques and programming. This volume presents a high-performance optimization method adapted to engineering structures-a novel perspective that will help engineers in the computation, modeling and design of advanced structures.

In the digital economy, a new type of business activity, digital entrepreneurship, has developed rapidly and required breakthrough technologies such as blockchain, big data, cloud technologies, and more. There is a need for a comprehensive resource that provides all-encompassing insight into the essence, special aspects, models, and international best practices of e-business based on various digital technologies in various high-tech markets. Digital Technologies for Entrepreneurship in Industry 4.0 provides theoretical frameworks and recent results of research in this sphere. It substantiates digital entrepreneurship, discusses the practical experience of its implementation, and develops the scientific and methodological recommendations for the development of its infrastructural provision and regulation of provision of its competitiveness. Covering topics such as investment attractiveness, corporate reporting modernization, and public-private partnership mechanisms, this premier reference source is an excellent resource for entrepreneurs, business executives and managers, investors, IT managers, students and faculty of higher education, researchers, and academicians.

Clinical Engineering: A Handbook for Clinical and Biomedical Engineers, Second Edition, helps professionals and students in clinical engineering successfully deploy medical technologies. The book provides a broad reference to the core elements of the subject, drawing from a range of experienced authors. In addition to engineering skills, clinical engineers must be able to work with both patients and a range of professional staff, including technicians, clinicians and equipment manufacturers. This book will not only help users keep up-to-date on the fast-moving scientific and medical research in the field, but also help them develop laboratory, design, workshop and management skills. The updated edition features the latest fundamentals of medical technology integration, patient safety, risk assessment and assistive technology.

Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal presents in-depth content written by international experts in the study of resistance to anti-CD20 antibodies and approaches for their reversal. Anti-CD20 antibodies are used to achieve B cell depletion and are developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. In the past two decades, anti-CD20 antibodies have revolutionized the treatment of all B cell malignancies, however, there are patients that fail to respond to initial therapy or relapse sooner. This book explores new and existing avenues surrounding Anti-CD20 antibodies. In recent years, several next-generation anti-CD20 therapies have been developed but predicting and reversing resistance is still a challenging task. These areas are being actively studied as they represent a potential to improve anti-CD20 therapies and are discussed thoroughly in the book. It is a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about resistance to anti-CD20 antibodies and their reversal.

Throughout the world, artificial intelligence is reshaping businesses, trade interfaces, economic activities, and society as a whole. In recent years, scholarly research on artificial intelligence has emerged from a variety of empirical and applied domains of knowledge. Computer scientists have developed advanced deep learning algorithms to leverage its utility in a variety of fields such as medicine, energy, travel, education, banking, and business management. Although a growing body of literature is shedding light on artificial intelligence-enabled difficulties, there is still much to be gained by applying fresh theory-driven techniques to this vital topic. Revolutionizing Business Practices Through Artificial Intelligence and Data-Rich Environments provides a comprehensive understanding of the business systems, platforms, procedures, and mechanisms that underpin different stakeholders' experiences with reality-enhancing technologies and their transformative application in management. The book also identifies areas in various business processes where artificial intelligence intervention would not only transform the business but would also make the business more sustainable. Covering key topics such as blockchain, business automation, and manufacturing, this reference work is ideal for computer scientists, business owners, managers, industry professionals, researchers, academicians, scholars, practitioners, instructors, and students.

FOCAPD-19/Proceedings of the 9th International Conference on Foundations of Computer-Aided Process Design, July 14 - 18, 2019, compiles the presentations given at the Ninth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2019. It highlights the meetings held at this event that brings together researchers, educators and practitioners to identify new challenges and opportunities for process and product design.

Geoinformatics for Geosciences: Advanced Geospatial Analysis using RS, GIS and Soft Computing is a comprehensive guide to the methodologies and techniques that can be used in Earth observation data assessments, geospatial analysis, and soft computing in the geosciences. The book covers a variety of spatiotemporal problems and topics in the areas of the environment, geohazards, urban analysis, health, pollution, climate change, resources and geomorphology, among others. Sections cover environmental and climate issues, analysis of geomorphological data, hazard and disaster impacts, natural and human resources, the influence of environmental conditions, geohazards, climate change, geomorphological changes, etc., and socioeconomic challenges. Detailing up-to-date techniques in geoinformatics, this book offers in-depth, up-to-date methodologies for researchers and academics to understand how contemporary data can be combined with innovative techniques and tools in order to address challenges in the geosciences.

Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research and computational approaches for drug discovery and repurposing for cancer therapy. The book provides detailed descriptions about target molecules and pathways and their inhibitors for easy understanding and applicability. Users will find discussions on tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers and transcriptome which are discussed in the context of different cancer types, such as colon, glioblastoma, endometrial and retinoblastoma, amongst others. This book will be a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor treatments for cancer patients.

Biostatistics Manual for Health Research: A Practical Guide to Data Analysis is a guide for researchers on how to apply biostatistics on different types of data. The book approaches biostatistics and its application from medical and health researcher's point-of-view and has real and mostly published data for practice and understanding. The interpretation and meaning of the statistical results, reporting guidelines and mistakes are taught with real world examples. This is a valuable resource for biostaticians, students and researchers from medical and biomedical fields who need to learn how to apply statistical approaches to improve their research.