For the 4th edition of Trauma Biomechanics all existing chapters referring to traffic and sports have been revised and updated. New scientific knowledge and changes in legal defaults (such as norms and standards of crash tests) have been integrated. Additionally one chapter has been added where biomechanical aspects of injuries affected by high energies are communicated in a new way. The mechanical basics for ballistics and explosions are described and the respective impacts on human bodies are discussed. The new edition with the additional chapter therefore is addressed to a broader audience than the previous one.

After 17 years of private practice as a cardiovascular surgeon, my partners qu- tionedtherationalityofmydecisiontoleavetheclinicalpracticebehindandbecome acardiovascular pathologist. Infact,theirdisbeliefofmyintentiontomakethe"leap of faith" was understandable. For a surgeon, the operating room is where the action is. It is as simple as that. And when a cardiac surgeon can hold in his hand a beating heart, now off-bypass and improved by an operation just completed, satisfaction is real and profound. However, life is complex. Throughout my surgical career, questions regarding the pathogenesis of atherosclerotic cardiovascular disease arose; curiosities of va- ous phenotypes of the disease piqued my interest. I became aware of the power of investigative techniques that might address these questions. I then began to realize that my career in the operating room left me little time to address them. I needed to study the disease full time in order to contribute to my understanding of it. Ironically, my ?rst autopsy as a pathology resident was on an individual with a past history of coronary artery bypass surgery. When it came to examining the heart, the dissection, as all pathologists know, was complex. However, I found it to be straightforward and enjoyable. But I subsequently learned that my fellow re- dents and mentors did not share my intrigue and comfort in de?ning the nuances of the operated heart.

Rabies is the deadliest zoonotic disease that threatens humans and animals on all continents except Antarctica. Asia and Africa are worst affected as more than 95 per cent of rabies associated human deaths occur in these regions. India alone bears about 36 per cent of the global human rabies burden. Dogs are the main transmitters of rabies that potentially threaten over 3 billion people in Asia and Africa. Many developed nations have been able to successfully control dog rabies but continue to face the risk from wildlife including bats. Bat rabies is responsible for most human rabies deaths in the United States of America and Canada but has emerged as a public health threat in Australia, Latin America and Western Europe as well. Despite being vaccine preventable, rabies continues to haunt the mankind. Poor resources is a major constraint but the factors like low priority attributed to rabies, misconceptions in the community about the disease and unsystematic approach for its prevention and control are also responsible for the grim situation. Targets have been set for elimination of human and dog rabies in all Latin American countries by 2015 and of human rabies transmitted by dogs in South-East Asia by 2020. However, the myths prevailing among the people together with inadequate knowledge of the health professionals, veterinarians, and the civic body staff about the rabies prevention and control strategies might make the task very difficult. This book comprising eight chapters elaborates the causation of rabies in man and animals, its global epidemiology, risk analysis and effective strategies for the management of exposures. Proven methods of rabies prevention and control have been discussed in length along with the challenges and ways to overcome the constraints through intersectoral coordination. The inclusion of 200 frequently asked questions is a unique feature of the book which may help not only the common people and pet lovers in clearing their doubts about rabies in man and animals also be equally instrumental in updating the knowledge and skills of the public health personnel, veterinarians and other professionals. Apt illustrations and simple language make the contents of the book easily comprehensible and a reading pleasure.

This handbook is unique in its comprehensive coverage of the subject and focus on practical applications in diverse fields. It includes methods for sample preparation, the role of certified reference materials, calibration methods and statistical evaluation of the results. Problems concerning inorganic and bioinorganic speciation analysis, as well as special aspects such as trace analysis of noble metals, radionuclides and volatile organic compounds are also discussed. A significant part of the content presents applications of methods and procedures in medicine (metabolomics and therapeutic drug monitoring); pharmacy (the analysis of contaminants in drugs); studies of environmental samples; food samples and forensic analytics - essential examples that will also facilitate problem solving in related areas.

This book explores the response of forensic psychiatry and psychology to changes over the last several decades. It presents the disciplines themselves as change agents that have shaped forensic work, public policy, and law. Topics include selected developments in forensic practice, the management and treatment of individuals who have had involvement with law enforcement systems, and the application of administrative principles to the management of forensic entities.

Introducing the basic concepts of clinical forensic medicine and death investigation, this book covers the main areas of forensic investigation . It provides an introduction to forensic science and coverage of injury patterns, natural disease, accidental trauma, child injury and fatalities, and domestic violence. Anyone who has direct contact with death, crime, and the medicolegal system, including nurses, physicians, attorneys, death investigators, forensic pathologists, and police detectives, will find this an invaluable reference.

As globalization causes profound changes in business, industry, and trade,it can also have significant effects on populations, environments, and individuals.These effects may be harmful, resulting in injury or illness, prompting the critical question: How best to correct wrongs caused to individuals, communities, and/or the environment of one country by the actions of individuals or corporations of another? Possible answers lie in an emerging discipline. Forensic Epidemiology in the Global Context opens meaningful windows onto the processes of forensic epidemiology, the roles of the epidemiologist in civil disputes, and the potential contribution of the field to legal and justice efforts worldwide. Case examples from the U.K., Nigeria, Ecuador, Romania, and Australia illustrate commonly used methodologies and the challenges involved in their use in U.S. and international courts of law. A chapter on expert testimony takes readers through qualification and admissibility issues, report requirements, and working with attorneys. Included in the coverage: Forensic epidemiology in the international legal arena. The epidemiologist as an expert in litigation. Epidemiological evidence in tort law: dispatches from the U.K. Liability for occupational exposure: the role of epidemiology. Forensic epidemiology and environmental justice. Forensic epidemiology, pathology, ethnics, and human rights. By emphasizing both the scientific and legal components of the equation, Forensic Epidemiology in the Global Context gives researchers and graduate students in epidemiology a unique and timely guide to the present and future of an increasingly salient field.

Multiauthored book dealing comprehensively with the various aspects of imaging of pediatric musculoskeletal trauma. The work is subdivided in three main sections: Overview of lesions; Imaging of traumatic injuries according to body region; typical traumatic injuries of early infancy. The third section includes also legal aspects of child abuse (battered child) and will indicate current international medical-legal guidelines. The didactical approach and the wide-ranging account of the subject makes the book particularly valuable to practitioners from various disciplines, involved in diagnosis and management of trauma of pediatric bone and joint

Essentials of Autopsy Practice: Innovations, Updates and Advances in Practice is the fifth volume in the Essentials in Autopsy Practice series, covering topics of current and future interest. Designed to keep all involved in the investigation of death abreast of changes within the field, this volume covers a wide range of topical areas which can be encountered around the world. Essentials of Autopsy Practice: Innovations, Updates and Advances in Practice covers death by drowning; deaths from extreme temperature; the radioactive autopsy; chemical contamination and the autopsy; blast injuries; forensic odontology identification; and determination of the force used to cause an injury. Useful to both trainees and consultants in all specialty areas within pathology, including forensic pathology, Essentials of Autopsy Practice: Innovations, Updates and Advances in Practice also serves as a guide to all those involved in death investigation, i.e. nurses, lawyers, paramedics and police officers.

In this revised and expanded edition, leading forensic scientist John Trestrail offers a pioneering survey of all that is known about the use of poison as a weapon in murder. Topics range from the use of poisons in history and literature to convicting the poisoner in court, and include a review of the different types of poisons, techniques for crime scene investigation, and the critical essentials of the forensic autopsy. The author updates what is currently known about poisoners in general and their victims. The Appendix has been updated to include the more commonly used poisons, as well as the use of antifreeze as a poison.

The human foot is a complex body part composed of fifty-two bones, which is twenty-five percent of all the bones in the body. Nonetheless, the foot is often viewed by the public and doctors as a "minor" body part. Similarly, the importance of pedal evidence in crime investigation has also long been undervalued, but as footwear evidence has become more commonly used in forensic situations, so has pedal evidence, which is why this seminal work is so important: it is the first textbook ever dedicated to forensic podiatry. Forensic Podiatry is an international compilation of current practices authored by the pioneers in the field. Part I discusses general forensic concerns, including those at the crime scene, from an informative perspective. It covers tasks performed by the crime laboratory, forensic podiatry principles, and various aspects of human identification. Part II deals with specific forensic podiatric concerns such as photographic techniques, bare footprint identification, and footwear examination and analysis. It also discusses forensic gate and analysis as well as the identification of pedal remains from podiatry records, which is important for mass disaster scenes. Part III presents actual forensic podiatry case studies from the United Kingdom and the United States, and Part IV focuses on podiatry practice standards, which in many instances parallel expert witness responsibilities. Groundbreaking and essential, this book is useful for medical and criminal justice students as well as podiatrists, criminalists, footwear examiners, forensic anthropologists, attorneys and investigators.

The publication of this third edition of the definitive text on clinical forensic medicine comes at an exciting time for a subject now gaining recognition as a speciality in the medical establishment. This growing acknowledgement reflects the fact that increasing numbers of health professionals are becoming engaged in general forensic services. Nurses and paramedics are more involved than ever in custody care, while nurses themselves are conducting more examinations in cases involving alleged sexual offences. Thus it is vital that those caring for this vulnerable group of patients (whether detainees or complainants) have the tools to master this specialist set of skills. All the chapters in this new edition have been fully updated, with some undergoing extensive revision. Recent developments in child protection protocols have prompted a major rewrite of the chapter on non-accidental injury, and the text now includes a specific chapter on the use of the TASER. Other aspects of restraint are now dealt with separately. The material on care of detainees and fitness for interview has been split into individual chapters to allow a more comprehensive discussion of the issues. In addition, new authors have joined the team of contributors, facilitating a wider range of international perspectives. From its chapters on the history and core principles of clinical forensic medicine, right up to the text's discussion of substance misuse and deaths in custody, this volume remains the gold standard source for health professionals whose working lives bring them into contact with those in the law enforcement arena.

This book examines ways in which cancer health disparities exist due to class and context inequities even in the most advanced society of the world. This volume, while articulating health disparities in the St. Louis, Missouri metropolitan area, including East St. Louis, Illinois, seeks to move beyond deficit models to focus on health equity. As cancer disparities continue to persist for low-income and women of color, the promotion and attainment of health equity becomes a matter of paramount importance. The volume demonstrates the importance of place and the historical inequity in socio-environmental settings that have contributed to marked health disparities. Through original research, this volume demonstrates that addressing the causes and contributors to women's health disparities is a complex process that requires intervention from a socio-ecological framework, at micro-, meso-, and macro-levels of influence. The book highlights critical aspects of a practical multidimensional model of community engagement with important influences of the various levels of research, policy and practice. More pointedly, the authors support a new model of community engagement that focuses on individuals in their broader ecological context. In so doing, they seek to advance the art and science of community engagement and collaboration, while disavowing the 'parachute' model of research, policy and practice that reinforces and sustains the problems associated with the status quo. The book concludes with broader national policy considerations in the face of the erosion of the social safety net for America's citizenry.

The police composite sketch, one of the most crucial investigative tools in law enforcement, is developed during a composite session-an intense display of communication and art in which the words of a witness are transformed into the features of a suspect. Despite the incredible technological leaps made in investigative work, the forensic science of composite sketching still relies on the basic elements of drawing skill, interpretive ability and the spoken word. The Police Composite Sketch is a comprehensive manual on how to conduct a complete composite session. Through an array of case studies, it details several disciplines that comprise this specialized forensic art, including composite sketching, image modification, age progression, facial comparison analysis, demonstrative evidence and postmortem/skull reconstruction. It also explores how to intuit insights that are often inadvertently revealed by witnesses, victims and perpetrators during the composite session. In addition, this book discusses other relevant topics, such as the three-stage drawing technique, witness and victim types, descriptive terminologies, managing composite sessions. Complete with numerous illustrations and drawing tips, this seminal work offers a general composite session philosophy and specific session strategies to both experienced and aspiring forensic artists as well as any lay reader intrigued by this fascinating skill.

When the SARS virus broke out in China in January 2003, Karl Taro Greenfeld was the editor of Time Asia in Hong Kong, just a few miles from the epicenter of the outbreak. After vague, initial reports of terrified Chinese boiling vinegar to "purify" the air, Greenfeld and his staff soon found themselves immersed in the story of a lifetime.

Deftly tracking a mysterious viral killer from the bedside of one of the first victims to China's overwhelmed hospital wards--from cutting-edge labs where researchers struggle to identify the virus to the war rooms at the World Health Organization headquarters in Geneva--"China Syndrome" takes readers on a gripping ride that blows through the Chinese government's effort to cover up the disease . . . and sounds a clarion call warning of a catastrophe to come: a great viral storm potentially more deadly than any respiratory disease since the influenza of 1918.

Forensic Entomology deals with the use of insects and other arthropods in medico legal investigations. We are sure that many people know this or a similar definition, maybe even already read a scientific or popular book dealing with this topic. So, do we really need another book on Forensic Entomology? The answer is 13, 29, 31, 38, and 61. These are not some golden bingo numbers, but an excerpt of the increasing amount of annual publications in the current decade dealing with Forensic Entomology. Comparing them with 89 articles which were published d- ing the 1990s it illustrates the growing interest in this very special intersection of Forensic Science and Entomology and clearly underlines the statement: Yes, we need this book because Forensic Entomology is on the move with so many new things happening every year. One of the most attractive features of Forensic Entomology is that it is multid- ciplinary. There is almost no branch in natural science which cannot find its field of activity here. The chapters included in this book highlight this variety of researches and would like to give the impetus for future work, improving the dev- opment of Forensic Entomology, which is clearly needed by the scientific com- nity. On its way to the courtrooms of the world this discipline needs a sound and serious scientific background to receive the acceptance it deserves.

Forensic Pathology for Police, Death Investigators, Attorneys, and Forensic Scientists is a forensic pathology book specifically written for professionals who interact with forensic pathologists. The book includes sections that address various general topics which are not normally present in the typical forensic pathology text, such as descriptions of medical, pathology and forensic pathology training, basic anatomy and physiology, an overview of other forensic science disciplines, and autopsy performance. Forensic Pathology for Police, Death Investigators, Attorneys, and Forensic Scientists also covers classic topics in forensic pathology, including death investigation, death certification, postmortem changes, and the entire range of case types, ranging from natural deaths to drug-related deaths to various types of violent death. The text is written in easy-to-understand language, and is complemented by hundreds of high-quality photographs.

A majority of the Fortune 500 Companies implement some practice of workplace drug testing in their company policies. This practice was first initiated by President Ronald Reagan when he ordered federal agencies to drug test federal employees involved in sensitive positions as well as positions involving public safety. As a practicing toxicologist, Dr. Amitava Dasgupta is involved with the pre-employment drug testing at his own hospital and aptly shares his expertise in Beating Drug Tests and Defending Positive Results: A Toxicologist's Perspective, which covers all major issues concerning how people try to beat drug tests and defend positive test results. In each chapter, extensive references are cited so that readers can access more information on a particular topic that may interest them. The book will undoubtedly prove helpful to toxicologists, medical technologists, pathologists, human resources professionals and anyone interested in workplace drug testing.

Our understanding of the humoral (B-cell) immune system has increased dramatically in recent years. IVIG Therapy Today highlights new third generation IgG products for intravenous use. Commercial gammaglobulin preparations first appeared in the early 1980s, and, since that time, therapeutic applications of intravenous immune serum globulin, or IVIG, have been developed at a rapid pace. Uses include replacement therapy in patients with antibody deficiencies and immunoregulatory/immunomodulatory agents in treatment of the autoimmune diseases. In two major parts, IVIG Therapy Today first presents reviews of primary and acquired humoral/B-cell immune deficiencies, featuring IVIG as replacement therapy, then explores the immunomodulatory effects of IVIG in autoimmune disorders.Chapters cover a wealth of timely background information and clinical applications, including: IVIG replacement therapy in primary immune deficiency syndrome * IVIG in prevention and treatment of neonatal bacterial infections * potential use of monoclonal antibodies in neonatal infections * immune deficiencies in chronic lymphocytic leukemia and multiple myeloma * IVIG in treatment of children with idiopathic thrombocytopenic purpura and autoimmune cytopenias * IVIG therapy in neonatal isoimmune thrombocytopenic purpura and alloimmunization thrombocytopenias * IVIG in Kawasaki disease and other autoimmune diseases * use of intravenous serum globulin in patients with antiphospholipid antibodies and recurrent pregnancy losses * IVIG in neurologic diseases * IVIG in asthma management. Dr. Ballow has assembled an outstanding collection of state-of-the-art information, making IVIG Therapy Today an essential guide for specialists in clinical and experimental immunotherapy.

This volume is a summary of a 1S-year effort to determine the effects of prison crowding and their relationship to the broader realm of crowding phenomena and theories. Although the writing of this volume was for the most part a solitary effort, the data and ideas it is based on were mostly the result of a collaborative effort with Verne Cox and Garvin McCain. Their schedules limited their ability to contribute to this volume, but they provided much constructive feedback and assistance. Cox also wrote a preliminary draft of Chapter 3, and both McCain and Cox made major contributions to Chapter S and assisted with several other chapters. I am greatly indebted to these two fine scholars for their efforts and support over the course of our joint research endeavors. In recognition of this fact, the pronoun "we" is used throughout this volume. This research would not have been possible without the cooperation and support of thousands of inmates and hundreds of prison officials. The un conditional support throughout the project from Director Norman Carlson and former regional research director Jerome Mabli, both of the Federal Bureau of Prisons, is also greatly appreciated. Thanks are due to the National Institute of Justice for financial support during various phases of this project. The support of John Spevacek of the Institute was indispens able. Funds were also provided by the Hogg Foundation, U. S. Department of Justice-Civil Rights Division, and the University of Texas at Arlington."

Here, experts contribute general examination techniques followed by more specific application models. Beginning with reviews of the principles of chemistry, the chapters also serve as introductions to the tasks and tools of examiners, and illustrate clandestine laboratory operations.

Margaret Stark and a team of authoritative experts offer a timely survey of the fundamental principles and latest developments in clinical forensic medicine. Topics range from sexual assault examination to injury interpretation, from nonaccidental injury in children, to crowd control agents. Also included are extensive discussions of the care of detainees, the management of substance abuse detainees in custody, the causes and prevention of deaths in custody, and the fundamentals of traffic medicine. In the absence of international standards of training, the authors also address the basic issues of consent, confidentiality, note-keeping, court reporting, and attendance in court. Comprehensive and authoritative, A Physicians Guide to Clinical Forensic Medicine offers forensic specialists and allied professionals a reliable, up-to-date guide to proven practices and procedures for a every variety of police inquiry requiring clinical forensic investigation.

A wide variety of professionals find themselves intimately involved in the criminal justice system; firefighters, emergency medical providers, nurses, physicians, public health personnel, environmental professionals, public works personnel, and many others. No previous work has attempted to address the criminal justice system in terms relevant to these professionals. Interface: A Guide for Professionals Supporting the Criminal Justice System explains the system, provides the reader with guidance to documenting incidents so that the data is both of value to the professional in the future and for use by the other components of the system. Further, this volume presents evidence from the aspect of these professionals, their needs in handling evidence, and basics of collection and preservation for those instances where it falls to them to do so. Professionals, not familiar with safety issues outside of their fields of expertise, have been injured or died as a result of exposure to hazards; it also educates them to considerations for their safety when out of their area of comfort. In addition, this book considers the role of the professional as interviewer, and provides basic guidance to this often valuable skill. Finally, Interface attempts to make the professional knowledgeable and comfortable in the courts, especially on the stand, where the professional may appear as a witness or even as an expert.

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology.They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number of these novel gents are already in clinical test.

For more than 35 years the Swiss Society of Neuropathology has organiseditstraditionalInternationalWinterMeeting.Themainaimofthis venue is to bring together neuropathologists and clinicians as well as neuroscientistsinterestedindiseasemechanisms.TheXVIIIthInternational WinterMeeting washeld inMarch 2000 in St. Moritz, Switzerland. The topicofthe2000Meetingwas"NeuropathologyandGeneticsofDementia." Aprogrammeofinvitedplenarylecturesofhigheducationalvalueaswellas platform andposterpresentations given by manyparticipantscoveredthe broadspectrumofdementingdisorders.Encouragedbythehighstandardof the meeting, and probably also influenced by the advent of a new Millenniumwedecided, togetherwithKluwerAcademiclPlenumPublishers, topublishtheProceedingsofthe2000Meetinginthepresentbook. The increaseofthe agedpopulation challenges social and health care systemsinindustrializedsocieties.Maintenanceofhealthandautonomyinto oldage isakeyfactor, andtheautonomyandindependenceofoldpersons crucially depend on mental health. However, neurodegenerative disorders accompanied bydementiaaffect 5-10%ofindividualsoverthe ageof65, and for the age group between 65 and 95 the prevalence of cognitive dysfunction doubles every 5 years. With this challenge in mind, Rossor discusses the clinical syndrome of dementia which encompasses an enormousvarietyofunderlyingdisorders. Over the last few years it has become apparent that many neurodegenerative disorders are characterised by protein misfolding and aberrant polymerization and may therefore be viewed as "aggregation proteopathies." Among them a substantial subsetofdementing disorders, either with or without motor dysfunction, are characterised by abundant v VI Preface neuronaland/orglialaccumulationofhyperphosphorylatedtauprotein.The molecular parametersofthese "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits, isalmost taupathology, inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies." Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.