This book describes the state of the art and future prospects of the most important bio-medicolegal subdisciplines in the post-genomic framework of personalized medicine. Focusing on the three main themes Innovation, Unitariness and Evidence, the book addresses a wide range of topics, including: Bio-Medicolegal and Criminological Sciences, Forensic Pathology and Anthropology, Clinical and Forensic Medicine in Living Persons (from Interpersonal Violence to Personal Injury and Damage, Malpractice, Personal Identification and Age Estimation), Forensic Genetics and Genomics, and Toxicology and Imaging. The unitariness of the "Bio-Medicolegal Sciences", historically founded on the accuracy and rigor of the methods of ascertainment and criteria of evaluation, should be re-established on the basis of molecular evidence, and used to promote Personalized Justice. Taken together, the book's conclusions and future perspectives outline a vision of transdisciplinary innovation and future evidence in the framework of personalized justice.

This volume aims to provide a range of methods and protocols for studying tumor angiogenesis in vitro and in vivo to reflect advances in the field. The chapters in this book cover topics such as: morphological aspects of tumor angiogenesis, aortic ring assay and its use for the study of tumor angiogenesis, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Tumor Angiogenesis Assays: Methods and Protocols is a valuable resource for anyone interested in tumor angiogenesis assay research.

Causation and Risk in the Law of Torts provides a comparative account of the legal and scientific issues relating to proof of causation in cases of alleged drug-induced injury, principally in Europe and North America.

This text seeks to assess whether, by using probabilistic approaches, the courts may more accurately determine the cause of adverse reactions contentiously associated with drugs. In four case studies (DES, Bondoctin, vaccine damage and "Gulf War Syndrome"), the deficiencies of orthodox approaches to causation are revealed. A sustained argument is presented in favor of applying greater weight to epidemiological statistics, as refined by the application of the Bayes' Theorem.

A valuable feature of this book is the discussion of the role of expert witnesses, including an examination of how the author's proposals could be accommodated with the reformed civil process envisaged by the Woolf Report.

Goldberg also examines the economic implications of these proposals. Causation and Risk in the Law of Torts is a timely contribution to the resolution of the legal problems in this complex area of tort law.

This book challenges the assumptions of modern criminal law that insanity is a natural, legally and medically defined phenomenon (covering a range of medical disorders). By doing so, it paves the way for a new perspective on insanity and can serve as the basis for a new approach to insanity in modern criminal law. The book covers the following aspects: the structure of the principle of fault in modern criminal law, the development of the insanity defense in criminal law, tangential in personam defenses in criminal law and their implications for insanity and the legal mechanism of reproduction of fault. The focus is on the Anglo-American and European-Continental legal systems. Given the attention consistently drawn by international and domestic events in this context, the book will be of interest to a broad and growing international audience.

Dr. Robert Sadoff's The Evolution of Forensic Psychiatry is extraordinarily unique in that it is not intended to be a textbook or a guide to forensic psychiatry. Instead, this book is a fascinating mix of historical beginnings, current developments, representative subspecialties of psychiatry, and several allied disciplines and their impact on forensic psychiatry. Furthermore, it also includes neuroscientific research and how it translates to civic and criminal case work. Judges, attorneys, law professors and a police scientist all weigh in on the influence of the interdisciplinary research these forensic scientists have had on the justice system. Featuring case examples and research conducted by the professionals who have had the greatest influence on the growth of the field of forensic psychiatry, they lead the discussion on the various aspects and issues of the discipline's impact on the criminal justice system.

The relationship of scientific research on human sexuality (sexology) to society's legal, judicial, and law enforcement systems (forensics) is the focus of this encyclopaedic volume. Editors James J. Krivacska and John Money have assembled contributions by leading experts, covering a wide range of legal and medical issues pertaining to the interconnection between law and sexual behaviour. Section one examines the nature of paraphilic behaviour and the social framework within which some of it becomes illegal. The topics discussed include sodomy, paedophilia, incest, sexual abuse, rape, exhibitionism, prostitution, and sexual harassment. Section two looks at current strategies for assessing the problems of sex offenders and victims. Among the areas addressed are 'real' sexual abuse vs. 'manufactured' allegations of abuse memories, allegations of satanism and ritual sexual abuse, and the difficulties of treating sex offenders within a legal framework. The final section argues that sexology has much to contribute to the debate of the appropriate role of government in regulating the private sexual behaviour of the citizenry. Sex education, contraception, abortion, AIDS, pornography, social tolerance vs. criminalisation, and a comparative view of public sex policy in China and Russia are among the subjects reviewed.

When a loved one dies in a mysterious manner, we rely on coroners and medical examiners to tell us what happened. The stakes are high: Coroners seek justice for the dead, exoneration for the wrongfully accused, and closure for the families of victims. They are always on call and work closely with law enforcement.

Author Robert S. West, who served as a physician-coroner in rural Kootenai County, Idaho, from 1970 to 2011, delves into the challenges he faced on the job. While he often lacked resources, he always did the best he could to serve his community, solving numerous mysteries using the tactics of forensic medicine.

Dr. West also explores the shortcomings of the coroner/medical examiner system and how it can be improved. Widely varying educational requirements and unrealistic expectations need to be balanced in order to fill the shortage of forensic pathologists while enhancing the training of current coroners.

Join a coroner from rural northern Idaho as he looks back at his career's most challenging cases and explains how to reform the system in It Can (and Does) Happen Here

This book presents recent applications and approaches as well as challenges in digital forensic science. One of the evolving challenges that is covered in the book is the cloud forensic analysis which applies the digital forensic science over the cloud computing paradigm for conducting either live or static investigations within the cloud environment. The book also covers the theme of multimedia forensics and watermarking in the area of information security. That includes highlights on intelligence techniques designed for detecting significant changes in image and video sequences. Moreover, the theme proposes recent robust and computationally efficient digital watermarking techniques. The last part of the book provides several digital forensics related applications, including areas such as evidence acquisition enhancement, evidence evaluation, cryptography, and finally, live investigation through the importance of reconstructing the botnet attack scenario to show the malicious activities and files as evidences to be presented in a court.

Computational Intelligence techniques have been widely explored in various domains including forensics. Analysis in forensic encompasses the study of pattern analysis that answer the question of interest in security, medical, legal, genetic studies and etc. However, forensic analysis is usually performed through experiments in lab which is expensive both in cost and time. Therefore, this book seeks to explore the progress and advancement of computational intelligence technique in different focus areas of forensic studies. This aims to build stronger connection between computer scientists and forensic field experts.

This book, "Computational Intelligence in" "Digital Forensics: Forensic Investigation and Applications," is the first volume in the Intelligent Systems Reference Library series. The book presents original research results and innovative applications of computational intelligence in digital forensics. This edited volume contains seventeen chapters and presents the latest state-of-the-art advancement of Computational Intelligence in Digital Forensics; in both theoretical and application papers related to novel discovery in intelligent forensics. The chapters are further organized into three sections: (1) Introduction, (2) Forensic Discovery and Investigation, which discusses the computational intelligence technologies employed in Digital Forensic, and (3) Intelligent Forensic Science Applications, which encompasses the applications of computational intelligence in Digital Forensic, such as human anthropology, human biometrics, human by products, drugs, and electronic devices.

This volume will describe both growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine, on their own or in combination, in cancer. It will coherently review the pathophysiological aspects of the mucin glycoproteins in malignancies and provide an updated account of the status of bromelain and N-acetylcysteine in cancer therapy. The volume will develop the idea of using these two drugs as a combination formulation for mucin-depleting effects.

A broad understanding of bone and tooth microstructure is necessary for constructing the biological profile of an individual or individuals within a population. Bone Histology: An Anthropological Perspective brings together authors with extensive experience and expertise in various aspects of hard tissue histology to provide a comprehensive discussion of the application of methods, current theories, and future directions in hard tissue research related to anthropological questions.

Topics discussed include:

• The biology underlying skeletal growth and development leading to adult skeletal morphology
• Current research in understanding in bone modeling
• Histological features of dental hard tissues and their utility in biological anthropology
• Histological analysis as a means to differentiate human from nonhuman bone and for the purpose of age estimation
• The biomechanics of cortical bone
• Histotaphonomy and how postmortem microstructural change can be used for taphonomic inquiry
• The application of light microscopy in paleopathology to classify pathological conditions
• The histological study of bone tissue of archaeological origin
• Researchers' access to collections of bone samples with known demographic information
• Technological aspects of hard tissue histology, including laboratory requirements and high-resolution imaging

In most cases, the physical remains of humans available to bioarchaeologists, paleopathologists, and paleontologists are limited to skeletal material. Fortunately, these hard tissues are a storehouse of information about biological processes experienced during the life of an individual. This volume provides an overview of the current state of research and potential applications in anthropology and other fields that employ a histological approach to the study of hard tissues.

Geriatric Forensic Psychiatry: Principles and Practice is one of the first texts to provide a comprehensive review of important topics in the intersection of geriatric psychiatry, medicine, clinical neuroscience, forensic psychiatry, and law. It will speak to a broad audience among varied fields, including clinical and forensic psychiatry and mental health professionals, geriatricians and internists, attorneys and courts, regulators, and other professionals working with the older population. Topics addressed in this text, applied to the geriatric population, include clinical forensic evaluation, regulations and laws, civil commitment, different forms of capacity, guardianship, patient rights, medical-legal issues related to treatment, long term care and telemedicine, risk management, patient safety and error reduction, elder driving, sociopathy and aggression, offenders and the adjudication process, criminal evaluations, corrections, ethics, culture, cognitive impairment, substance abuse, trauma, older professionals, high risk behavior, and forensic mental health training and research. Understanding the relationship between clinical issues, laws and regulations, and managing risk and improving safety, will help to serve the growing older population.

Forensic Entomology deals with the use of insects and other arthropods in medico legal investigations. We are sure that many people know this or a similar definition, maybe even already read a scientific or popular book dealing with this topic. So, do we really need another book on Forensic Entomology? The answer is 13, 29, 31, 38, and 61. These are not some golden bingo numbers, but an excerpt of the increasing amount of annual publications in the current decade dealing with Forensic Entomology. Comparing them with 89 articles which were published d- ing the 1990s it illustrates the growing interest in this very special intersection of Forensic Science and Entomology and clearly underlines the statement: Yes, we need this book because Forensic Entomology is on the move with so many new things happening every year. One of the most attractive features of Forensic Entomology is that it is multid- ciplinary. There is almost no branch in natural science which cannot find its field of activity here. The chapters included in this book highlight this variety of researches and would like to give the impetus for future work, improving the dev- opment of Forensic Entomology, which is clearly needed by the scientific com- nity. On its way to the courtrooms of the world this discipline needs a sound and serious scientific background to receive the acceptance it deserves.

This volume centers on the application of social theory to commingled remains with special focus on the cultural processes that create the assemblages as a way to better understand issues of meaning, social structure and interaction, and lived experience in the past. The importance of the application of theoretical frameworks to bioarchaeology in general has been recognized, but commingled and fragmentary assemblages require an increased theoretical focus. Too often these assemblages are still relegated to appendices; they are analytical puzzles that need the interpretive power offered by social theory. Theoretical Approaches to Analysis and Interpretation of Commingled Human Remains provides case studies that illustrate how an appropriate theoretical model can be used with commingled and fragmentary remains to add to overall site and population level interpretations of past and present peoples. Specifically, the contributions show a blending and melding of different social theories, highlighting the broad interpretive power of social theory. Contributors are drawn from both the Old and New World. Temporally, time periods from the Neolithic to historic periods are present, further widening the audience for the volume.

The human foot is a complex body part composed of fifty-two bones, which is twenty-five percent of all the bones in the body. Nonetheless, the foot is often viewed by the public and doctors as a "minor" body part. Similarly, the importance of pedal evidence in crime investigation has also long been undervalued, but as footwear evidence has become more commonly used in forensic situations, so has pedal evidence, which is why this seminal work is so important: it is the first textbook ever dedicated to forensic podiatry. Forensic Podiatry is an international compilation of current practices authored by the pioneers in the field. Part I discusses general forensic concerns, including those at the crime scene, from an informative perspective. It covers tasks performed by the crime laboratory, forensic podiatry principles, and various aspects of human identification. Part II deals with specific forensic podiatric concerns such as photographic techniques, bare footprint identification, and footwear examination and analysis. It also discusses forensic gate and analysis as well as the identification of pedal remains from podiatry records, which is important for mass disaster scenes. Part III presents actual forensic podiatry case studies from the United Kingdom and the United States, and Part IV focuses on podiatry practice standards, which in many instances parallel expert witness responsibilities. Groundbreaking and essential, this book is useful for medical and criminal justice students as well as podiatrists, criminalists, footwear examiners, forensic anthropologists, attorneys and investigators.

This volume explores various approaches for enrichment, detection, isolation, and molecular profiling of circulating tumor cells (CTCs). Each chapter provides comprehensive descriptions and guidelines on how to perform innovative experiments in CTC research. Included are protocols for capture of CTCs via filtration and density gradient centrifugation; microfluidic and immunomagnetic separation of CTCs; detection of CTCs by immunocytochemistry, fluorescence in situ hybridization, and flow cytometry; assays designed for genomic characterization and functional analyses of CTCs, and many more. Written in the highly successful Methods in Molecular Biology series format, the chapters in this book include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Circula ting Tumor Cells: Methods and Protocols is a valuable resource for laboratory researchers and clinicians who are interested in furthering their studies on CTCs.

Epidemiology has often been defined as the study of the distribution of disease, together with the distribution of factors that may modify that risk of disease. As such, epidemiology has often been reduced to a methodology only, providing a mechanism for the study of disease that is somehow removed, separate and apart from the populations that serve as its focus. Epidemiology, however, is much more than that. The discipline p- vides a way of perceiving and knowing the world, and of relating to the c- munities whose health and disease patterns we are trying to understand. As such, its usefulness extends past the construction of questionnaires, the detective work inherent in tracing the source of an infection or the analysis of data. Rather, epidemiology serves as a point of reference and a linkage between various domains of reality: in the courtroom, between a com- nity's injuries and those alleged to be responsible for those violations; between the community striving to effectuate changes to improve its health and environment and the lawmakers and policymakers whose actions may dictate or control the likelihood of that change; and between "mainstream" populations and those who become or remain marginalized and stigmatized due to disease or perceived disease.