Homicidal insanity has remained a vexation to both the psychiatric and legal professions despite the panorama of scientific and social change during the past 200 years. The predominant opinion today among psychiatrists is that no correlation exists between dangerousness and specific mental disorders. But for generation after generation, psychiatrists have reported cases of insane homicide that were clinically similar. Although psychiatric theory changed and psychiatric nosology was inconsistent, the mental phenomena psychiatrists identified in such cases remained the same. The central thesis of "Homicidal Insanity" is that as psychiatric theory changed, psychiatrists regarded these phenomena variously as symptoms of mental disease or the disease in itself. It is possible to trace these phenomena throughout the history of Anglo-American psychiatric theory and practice. A secondary thesis of the book is that psychiatrists have used these phenomena as predictors and markers in the practical matters of preventing insane homicide and of testifying in the courts to defend the irresponsible and expose the culpable.For 200 years, scientific and philosophical disagreement raised controversy and brought the issues to public attention. Still, to this day no rational method exists to discriminate the dangerous from the harmless in matters of involuntary commitment, nor insanity from crime in the courts.

As DNA forensic profiling and databasing become established as key technologies in the toolbox of the forensic sciences, their expanding use raises important issues that promise to touch everyone's lives. In an authoritative global investigation of a diverse range of countries, including those at the forefront of these technologies' development and use, this book identifies and provides critical reflection upon the many issues of privacy; distributive justice; DNA information system ownership; biosurveillance; function creep; the reliability of collection, storage and analysis of DNA profiles; the possibility of transferring medical DNA information to forensics databases; and democratic involvement and transparency in governance, an emergent key theme. This book is timely and significant in providing the essential background and discussion of the ethical, legal and societal dimensions for academics, practitioners, public interest and criminal justice organisations, and students of the life sciences, law, politics, and sociology.

Die Vermeidung von Behandlungsfehlern und der Umgang mit haftungsrechtlichen Konsequenzen sind fur jeden Chirurgen ein Thema von wachsender Bedeutung.

Eine umfassende und prazise Darstellung fur die Viszeralchirurgie finden Sie in diesem Buch. Im Allgemeinen Teil sind rechtliche Grundlagen, allgemeine Verhaltensregeln und Verfahren der rechtlichen Klarung zusammengefasst. Im Speziellen Teil sind von renommierten Klinikern zu allen relevanten Indikationen systematisch die moglichen Behandlungsfehler beschrieben, Hinweise zu ihrer Vermeidung gegeben und die haftungsrechtlichen Konsequenzen aufgezeigt. Sowohl konventionelle Operationsverfahren als auch die Verfahren der Minimal Invasiven Chirurgie sind berucksichtigt."

Psychopathie ist eine Persoenlichkeitsstoerung, die durch eine ausgepr- te Kombination von Verhaltensweisen und daraus gefolgerten Charakter- genschaften definiert wird. Die meisten dieser Eigenschaften werden von der Gesellschaft als negativ angesehen; daher ist es keine Bagatelle, jem- den als Psychopathen zu diagnostizieren. Wie bei jeder psychiatrischen S- rung basiert die Diagnose auf zusammengetragenen Indizien dafur, dass eine Person zumindest die Minimalkriterien der Persoenlichkeitsstoerung - fullt. Bei Fallen aus meinen eigenen Akten sind die jeweiligen Personen sorgfaltig auf der Basis umfangreicher Informationen aus Interviews und den Akten diagnostiziert worden. Allerdings habe ich diese Personen durch die Veranderung von Einzelheiten und das Entfernen von Identifikatio- merkmalen unkenntlich gemacht, ohne jedoch die zu treffende Aussage zu verfalschen. Wenn auch das Thema dieses Buches Psychopathie ist, so sind doch nicht alle hier beschriebenen Personen Psychopathen. Viele der verwendeten Beispiele stammen aus oeffentlich zuganglichen Berichten, den Nachricht- medien und persoenlichen Gesprachen, und ich kann nicht sicher sein, dass die jeweils in Frage stehenden Personen Psychopathen sind, selbst wenn sie von anderen so bezeichnet worden sind. In jedem Falle stehen aber die belegten Aussagen uber einen Verhaltensaspekt der jeweiligen Person mit dem Konzept der Psychopathie in Einklang, oder sie illustrieren einen fur die Persoenlichkeitsstoerung zentralen Charakterzug oder ein typisches V- halten. Solche Personen koennten Psychopathen sein oder auch nicht. Aber die Berichte uber ihr Verhalten sind ein nutzliches Vehikel, um die v- schiedenen Eigenschaften und Verhaltensweisen zu eroertern, die Psycho- thie definieren.

'Absolutely gripping. Impeccably researched and written with the pace and narrative drive of a thriller, but attentive too to the dignity of the victims.' - Daragh Carville, creator of ITV's The BayThe true story of the shocking 1930s murder case, and the revolutionary investigation that changed forensics forever. Lancaster, 1935. In a jealous rage, Dr Buck Ruxton kills his wife, Isabella, and their children's nanny, Mary, before dismembering the bodies in the bathtub. When walkers discover the remains scattered in a ravine in the Scottish Borders, police are confronted with a gruesome jigsaw puzzle that they must piece together - not only to give the women their names back, but also to catch their killer. Using new research, Jeremy Craddock tells the full story of this landmark case in British criminal history. The Jigsaw Murders brings to life Dr Ruxton, the investigators, the legal figures, and silent witnesses Isabella and Mary, recreating the dramatic scenes that shook the world.

When a bone of unknown origin is found at a location, forensic implications arise immediately. Is this bone human, and if so, is it evidence of a murder? Human and Non-Human Bone Identification: A Color Atlas presents a comprehensive handbook of photographs and other information essential for law enforcement and forensic anthropologists when examining skeletal remains and determining species and body parts. Presenting over 3000 color photographs, this atlas is a practical comparative guide to the differences among species for nearly all bones in the body. Useful in either the laboratory or the field, it features images of the types of bones that are most commonly discovered, and provides annotations pointing out salient features. The book begins with a section on general osteology and explains the major anatomical differences between humans and other animals. It compares human and non-human bones, categorized by type of bone, and includes most of the major bones in humans and non-humans. The third section discusses non-human skeletal elements, categorized by species, and explores numerous skeletal elements within those species. This book is also available on a fully searchable DVD: Catalog no. 62964 Includes Bones from the Following Species! Moose Elk Deer Bison Cow Antelope Mountain Sheep Domestic Sheep Llama Horse Bear Wolf Coyote Domestic dog Mountain lion Bobcat Raccoon Badger Skunk River Otter Beaver Porcupine Marmot Prairie dog Rabbit Norway rat Squirrel Armadillo Opossum Vampire bat Seal Written by Diane L. France, one of the most respected forensic anthropologists in the world, this supremely organized atlas helps those tasked with bone identification to quickly and efficiently determine the origin of discovered remains and plan the appropriate course of action.

In this timely book, Ruud ter Meulen argues that the current trend towards individual financial responsibility for health and social care should not be at the expense of the welfare of vulnerable and dependent individuals. Written with a multidisciplinary perspective, the book presents a new view of solidarity as a distinct concept from justice with respect to health and social care. It explains the importance of collective responsibility and takes the debate on access to healthcare beyond the usual framework of justice and rights. Academics from a range of backgrounds, including sociology, ethics, philosophy and policy studies will find new perspectives on solidarity and fresh ideas from other disciplines. Policymakers will better appreciate the contribution of family carers to the well-being of dependent and vulnerable people, and the importance of the support of solidarity in these types of care.

Constantin Blanke-Roeser fuhrt zunachst in die Grundlagen der Hirnaneurysmen ein und wertet sodann ein grosses, einschlagiges Untersuchungskollektiv aus dem Hamburger Raum aus. Der Autor interpretiert die Ergebnisse, verknupft sie mit dem aktuellen Forschungsstand und gibt Empfehlungen fur die Differentialdiagnose. Den Abschlussteil der Studie bilden eine Untersuchung der Histologie blutender Hirnaneurysmen sowie Vorschlage fur die Differenzierung von Aneurysma- und Trauma-bedingten Subarachnoidalblutungen (SAB) anhand der Computertomographie. Etwa 4-5 Prozent der Bevoelkerung weltweit sind von Hirnaneurysmen betroffen. Diese koennen ploetzlich zu einer spontanen SAB fuhren. Die Falle sind von traumatisch bedingten SAB zu unterscheiden. Deren Differentialdiagnose ist unter forensischen und versicherungsrechtlichen Aspekten entscheidend.

This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. Written by experts in the field, each section addresses patient selection, pre-operative considerations, technical conduct of the most common operations with open or endovascular options, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease.

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

This book presents recent applications and approaches as well as challenges in digital forensic science. One of the evolving challenges that is covered in the book is the cloud forensic analysis which applies the digital forensic science over the cloud computing paradigm for conducting either live or static investigations within the cloud environment. The book also covers the theme of multimedia forensics and watermarking in the area of information security. That includes highlights on intelligence techniques designed for detecting significant changes in image and video sequences. Moreover, the theme proposes recent robust and computationally efficient digital watermarking techniques. The last part of the book provides several digital forensics related applications, including areas such as evidence acquisition enhancement, evidence evaluation, cryptography, and finally, live investigation through the importance of reconstructing the botnet attack scenario to show the malicious activities and files as evidences to be presented in a court.

Vascular surgery has experienced remarkable growth and diversification in the last decade, especially with its embracing the disruptive endovascular technological revolution. Vascular surgeons remain the only group of specialists capable of total treatment of patients with vascular disease, providing medical, minimally invasive, and surgical therapy. Although vascular surgeons practice in all areas of the world, practice patterns in different areas naturally have both similarities and differences that reflect both regional patterns of disease, genetic characteristics of local peoples, cultural preferences for treatment, local political and economic situations, different access to resources and devices, as well as different training paradigms. Thus, the practice of vascular surgery has diversified and evolved in parallel in many areas, converging and diverging in many ways. Vascular Surgery: A Global Perspective provides the first review and comparison of the diversity of vascular surgery practice around the world. The book is grouped according to common vascular diseases such as aneurysmal and occlusive arterial disease, as well as venous and lymphatic disease and dialysis access. Each major disease topic includes multiple chapters written by expert specialists from around the world, each discussing their local approach to the disease and its treatment. Similarly, the status of vascular surgery practice is addressed, including discussion of the influence of payment systems on practice, patient access to the internet for information, training paradigms, and the legal system including malpractice. This textbook provides the first worldwide summary of the care of patients with vascular disease and will be of interest to a wide audience including vascular surgeons, vascular medical specialists, cardiologists, radiologists, internists, and family practice physicians.

This book examines core issues related to legal insanity, integrating perspectives from psychiatry, law, and ethics. Various criteria for insanity are analyzed and recommendations for forensic psychiatric and legal practice are offered. Many legal systems have an insanity defense, in one form or another. Still, it remains unclear exactly when and why mental disorders affect a person's moral or criminal responsibility. Questions addressed in this book include: Why should insanity be a component of our legal system? What should be the criteria for an insanity defense? What would be the reasons for abolishing it? Who should bear the burden of proof? Furthermore, the book discusses the impact neurosciences may have on psychiatric and psychological evaluations of defendants as well as on legal decisions about insanity.

This volume presents a series of protocols and methods, some of which are not widely used by researchers/practitioners, and will aid in the execution of different laboratory techniques. Forensic DNA Typing Protocols, Second Edition is arranged into a series of related chapters. Chapter 1-3 examines two different aspects of RNA analysis for body fluid identification. Chapters 4-7 focuses on the storage of biological materials and the extraction of DNA from hard tissues. Chapters 8-10 present methods for monitoring the quality of DNA extracts, and steps to aid in the purification of DNA. Chapters 11-16 talk about methods on non-standard markers, such as INDELs, Y chromosome STRs, and mitochondrial DNA. Detailed procedures and data analysis for phenotypes and ancestry are explored in Chapter 17-19. The last chapter (20) looks at the application of DNA typing to the identification of non-human material to species level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Forensic DNA Typing Protocols, Second Edition, is a valuable resource for forensic specialists, researchers, and anyone interested in the field of forensic science.

This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.

This detailed volume gathers a comprehensive collection of methods, protocols, and procedures used for the identification, characterization, and selection of cancer stem cells. These include surface marker expression, side population, spheres formation, ALDH activity, and numerous others. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and expert tips and troubleshooting advice to avoid potential pitfalls. Comprehensive and practical, Cancer Stem Cells: Methods and Protocols provides researchers with the techniques they will need in order to pursue vital research into this complex field of study.

This volume serves to provide an international overview of personal injury compensation in different geographical areas (15 countries already included), with a special focus on the methods used to ascertain the injury and the related damages. It also goes on to clarify the logical and methodological steps required for a sequential, in-depth ascertainment of any traumatic event and the related personal damage, both pecuniary and non-pecuniary. Personal injury is a legal term for an injury to the body, mind or emotions suffered by the plaintiff under tort and/or civil law regulations. Damages related to the injury can be pecuniary or non-pecuniary in nature. Although several comparative studies and research projects on tort and civil law and personal injury claims aimed at developing new tools for promoting harmonization of private law have been performed at an international level, heterogeneity and divergences still exist in the definition and compensation of personal injury and damage across different national legislative systems. The starting point for any awarding procedure should be a medical, or rather a medico-legal, assessment to gain evidence on the trauma or event causing the injury, the mechanism of injury, the pre-existing health status of the injured party, and the health consequences of the injury (temporary and permanent impairment, work incapacity, etc.). In order to pursue the ultimate goal of an international harmonization of personal injury compensation, it is of upmost importance to define the quality requirements for the medico-legal ascertainment methodology, which are essential for guaranteeing the objectivity, rigor, and reproducibility of the data and the evidence collection procedure. Currently, there are no supra-national medico-legal guidelines dealing with the ascertainment methodology of personal injury and damage under tort and civil law.

This volume recognizes and addresses the health care issues of prisoners, to establish best practices and to learn about approaches to these challenges from around the world. It presents new evidence on several emerging and classical prison health issues. The first goal of this volume is to address emerging issues related to health in prison. Second, it presents the most recent research-based evidence and translates it to the practice. The third goal, is that it allows for sufficient diversity while also incorporating updates of some important already recognized prison health. The volume discusses prisons and the life and well-being of prisoners and staff, after growing problems as drug misuse (incl. tobacco smoking), infectious diseases (HIV/AIDS, hepatitis, STIs and TB), psychiatric problems, inadequate and unhealthy living conditions (incl. nutrition), overcrowding of prisons. These are addressed adequately in order to meet the international requirements of equivalence of health care. The scope of this volume is at the same type specific and diverse enough to cover the interests of a large audience that includes many types of practitioners involved in health-related issues in the field of prison health care, such as psychologists, nurses and prison administration officers responsible for health care, legal professionals and social workers.

Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.

Michael Sand gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin. This book is a postdoctoral thesis on miRNAs in cutaneous malignant melanoma and non-melanoma skin cancer with a focus on the miRNA processing machinery and miRNA expression profiling. The research presented in this book was performed in the Dermatologic Surgery Section at the Department of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin.

This volume will describe both growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine, on their own or in combination, in cancer. It will coherently review the pathophysiological aspects of the mucin glycoproteins in malignancies and provide an updated account of the status of bromelain and N-acetylcysteine in cancer therapy. The volume will develop the idea of using these two drugs as a combination formulation for mucin-depleting effects.

This new edition provides both theoretical and practical background of security and forensics for mobile phones. The author discusses confidentiality, integrity, and availability threats in mobile telephones to provide background for the rest of the book. Security and secrets of mobile phones are discussed including software and hardware interception, fraud and other malicious techniques used "against" users. The purpose of this book is to raise user awareness in regards to security and privacy threats present in the use of mobile phones while readers will also learn where forensics data reside in the mobile phone and the network and how to conduct a relevant analysis. The information on denial of service attacks has been thoroughly updated for the new edition. Also, a major addition to this edition is a section discussing software defined radio and open source tools for mobile phones.