Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. .

When domestic abuse and children are involved, divorce and custody can be the epitome of high-stakes conflict and frustration and all too frequently protective parents lose custody of their child to a named abuser. Domestic Abuse, Child Custody, and Visitation helps mental health professionals, attorneys, and lay readers navigate the judicial process so that decisions are truly made in the best interest of children. The text reveals how all the puzzle pieces of the judicial process fit together - judges, attorneys, mental health experts, children, spouses - and how to overcome many of the obstacles they will confront along the way. This runs the gamut, from the selelection of a lawyer and experts, to setting necessary groundwork for an appeal. Domestic Abuse, Child Custody, and Visitation is an essential read for mental health professionals and lay people involved in divorce and custody, family court judges, family law attorneys, and mental health professionals involved in domestic abuse and custody matters.

This open access handbook presents a trustable craniofacial superimposition methodological framework. It includes detailed technical and practical overviews, and discussions about the latest tools and open problems, covering the educational, technical, ethical, and security aspects of this forensic identification technique. The book will be of particular interest to researchers and practitioners in forensic anthropology and forensic ID, and also researchers in computational intelligence. It is the final result of a European project, New Methodologies and Protocols of Forensic Identification by Craniofacial Superimposition (MEPROCS). The project collaborators who contributed to this handbook are: S. Damas, O. Ibanez, M.I. Huete, T. Kahana, C. Wilkinson, E. Ferguson, C. Erolin, C. Cattaneo, P.T. Jayaprakash, R. Jankauskas, F. Cavalli, K. Imaizumi, R. Vicente, D. Navega, E. Cunha, A.H. Ross, E. Veselovskaya, A. Abramov, P. Leston, F. Molinero, E. Ruiz, F. Navarro, J. Cardoso, F. Viegas, D. Humpire, R. Hardiman, J. Clement, A. Valsecchi, B.R. Campomanes-Alvarez, C. Campomanes-Alvarez, A.S. Cagdir, T. Briers, M. Steyn, M. Viniero, D.N. Vieira, and O. Cordon.

Death Investigation: Systems and Procedures is the first book dedicated to the topic of death investigation from a legal standpoint as well as the administrative and operational procedures that pertain to the medical examiner and the coroner system in the United States. Unique in its perspective, this book is the only one not concerned with instructing on investigatory conduct, autopsy procedure, pathology, or the solving of crimes. Instead, it explains the concepts and principles of death investigation established by governments, and outlines the legal and administrative steps that must be taken throughout the case. Beginning with an introduction to the basic types of death investigation, the text explains the circumstances and statutory basis for death investigation systems. The author provides specific details about the role of coroners, medical examiners, and other forensic scientists and personnel who may officially be a part of the investigation. The overall goals of the investigations are included along with case studies and examples illustrating the procedures used in each type. The author also adds a brief summary of the specific system employed by each state. A considerable portion of the book is devoted to practical considerations such as the contents of the autopsy report, the death certificate, principles and issues related to evidence and expert witnesses, as well as a description of a typical day at a medical examiner's or coroner's office. Well referenced with websites and sources of further information, Death Investigation: Systems and Procedures provides a comprehensive, concise procedural reference to students and professionals including lawyers, crime scene technicians, and anyone who works with death investigation data, or within the death investigation systems in the United States.

There is a dramatic rise of novel drug use due to the increased popularity of so-called designer drugs. These synthetic drugs can be illegal in some countries, but legal in others and novel compounds unknown to drug chemistry emerge monthly. This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials. The methods are based on molecular characteristics of the drugs belonging to each individual class of compounds, so it will be clear how the current methods are adaptable to future new drugs that appear in the market.

Key topics and basic laboratory training for beginning students This versatile laboratory manual is designed to support introductory undergraduate courses in forensic anthropology. Usable for both in-person and online classes and suitable to accompany any textbook or for use on its own as a text-lab manual hybrid, it provides basic training for beginner students in relevant methods of biological profile estimation and trauma assessment for use in medico-legal death investigations. Structured in a standard format for classes and existing texts, this manual offers a unique emphasis on lab exercises that align with general studies requirements and basic science competency. Each chapter begins with learning goals and an introductory section that outlines the topics to be covered. The discussion then leads students through the material, including periodic learning checks built into the structure of the chapter, followed by end-of-chapter exercises. Through clear explanations of fundamental principles, the complete medico-legal context is covered with respect to forensic anthropology. Basic information on bone biology, human osteology, and rules of evidence are also presented. Alongside its substantive text discussion of key topics, this manual's exercises can be used in in-person laboratory classes while its learning checks can be completed by online students without access to skeletal material or casts. This book offers the necessary content to teach forensic anthropology regardless of the experience or location of students or the resources of specific colleges and universities.

Experten geben erstmals einen Uberblick uber die biowissenschaftlichen Grundlagen spurenkundlicher Arbeit sowie ihrer hauptsachlichen Tatigkeitsfelder. In Ubersichtsaufsatzen werden die jeweiligen Fragestellungen und die verwendeten Methoden dieser Arbeitsbereiche vorgestellt."

This book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.

T'zu's The Washing Away of Wrongs (Hsi yuan chi lu), printed in 1247, is the oldest extant book on forensic medicine in the world. Written as a guide for magistrates in conducting inquests, the book is a major source on early Chinese knowledge of pathology and morbid anatomy. Includes a lengthy introductory essay by the translator.

The first book of its kind, Forensic Medicine in Western Society: A History draws on the most recent developments in the historiography, to provide an overview of the history of forensic medicine in the West from the medieval period to the present day. Taking an international, comparative perspective on the changing nature of the relationship between medicine, law and society, it examines the growth of medico-legal ideas, institutions and practices in Britain, Europe (principally France, Italy and Germany) and the United States. Following a thematic structure within a broad chronological framework, the book focuses on practitioners, the development of notions of 'expertise' and the rise of the expert, the main areas of the criminal law to which forensic medicine contributed, medical attitudes towards the victims and perpetrators of crime, and the wider influences such attitudes had. It thus develops an understanding of how medicine has played an active part in shaping legal, political and social change. Including case studies which provide a narrative context to tie forensic medicine to the societies in which it was practiced, and a further reading section at the end of each chapter, Katherine D. Watson creates a vivid portrait of a topic of relevance to social historians and students of the history of medicine, law and crime.

The benchmark first edition of Forensic Radiology, published in 1998, was a milestone in the forensic community -- a bestseller throughout the world and a standard reference for practitioners and educators alike. Like its predecessor, Brogdon's Forensic Radiology, Second Edition covers the entire scope of radiological applications in the forensic sciences, profiling current and anticipated uses of new modalities and techniques. Features: * Provides an introduction to forensic radiology, including historical perspectives and definitions used in the field * Offers instruction on trial preparation and effective courtroom testimony * Demonstrates the use of forensic radiology in identification of the dead * Explores the use of radiology to help in gunshot and abuse cases and in nonviolent crimes * Contains an entirely new section on virtual imaging and virtopsy * Examines technological and safety issues For radiologists, forensic scientists, forensic dentists, medical examiners, investigators, and attorneys Over the past twelve years, the fields of forensic science and radiology have developed considerably, necessitating a revision of this critical work. New Topics in this Edition include: * The radiologist as an expert witness * Modern cross-sectional imaging in anthropology * New approaches to radiology in mass casualty situations * The use of virtual imaging and virtopsy -- new modalities developed and advanced since the publication of the last edition * Forensic and clinical usage of x-rays in body packing for drug smuggling * Imaging in the medical examiner's facility and in the field * Radiology of special objects, antiquities, and mummies

Forensic Medical Investigation of Motor Vehicle Incidents provides an in-depth study of the circumstances underlying motor vehicle incidents and allows for a reasoned analysis of a crash victim's injuries. It also gives law enforcement the tools to communicate relevant information to the forensic pathologists and trains pathologists to infer crucial clues to the scenario that they may then relate to the investigating officers. Beginning with the design of the vehicle, its safety features and other mechanisms for avoiding collision or injury, the book then addresses the myriad behavioral and mitigating medical factors that impair human abilities and cause vehicular incidents. It details the correct forensic classification of injuries and reviews the direction, force, and nature of injury. Organized into incidents involving car-on-car and car-on-pedestrian, as well as bicycles, motorcycles, and heavy machinery, the book delves into extensive accounts of the various insults sustained by the body in the event of impact. This information gives trauma care practitioners the ability to quickly determine the nature and extent of the injuries sustained and allows them to provide faster more effective care to the survivors of the crash. To aid the pathologist in fulfilling the important task of finding a reasonable cause of death, the second portion of the book focuses on the postmortem examination, toxicology, and documented cause of death. Written for all members of the investigative team, including forensic pathologists, police officers, safety engineers, and medical personnel in trauma care, Forensic Investigations of Motor Vehicle Incidents is a preliminary resource that facilitatescommunication among all those concerned with the causes and effects of vehicular incidents.

The use of Compound-specific Stable Isotope Analysis (CSIA) is increasing in many areas of science and technology for source allocation, authentication, and characterization of transformation reactions. Until now, there have been no textbooks available for students with an analytical chemical background or basic introductory books emphasising the instrumentation and theory. This book is the first to focus solely on stable isotope analysis of individual compounds in sometimes complex mixtures. It acts as both a lecture companion for students and a consultant for advanced scientists in fields including forensic and environmental science. The book starts with a brief history of the field before going on to explain stable isotopes from scratch. The different ways to express isotope abundances are introduced together with isotope effects and isotopic fractionation. A detailed account of the required technical equipment and general procedures for CSIA is provided. This includes sections on derivatization and the use of microextraction techniques in GC-IRMS. The very important topic of referencing and calibration in CSIA is clearly described. This differs from approaches used in quantitative analysis and is often difficult for the newcomer to comprehend. Examples of successful applications of CSIA in food authenticity, forensics, archaeology, doping control, environmental science, and extraterrestrial materials are included. Applications in isotope data treatment and presentation are also discussed and emphasis is placed on the general conclusions that can be drawn from the uses of CSIA. Further instrumental developments in the field are highlighted and selected experiments are introduced that may act as a basis for a short practical course at graduate level.

The field of psychology-law is extremely broad, encompassing a strikingly large range of topic areas in both applied psychology and experimental psychology. Importantly, both applied and experimental psychologists have made meaningful contributions to the psychology-law field, and each of these domains includes a range of well-developed topic areas with robust empirical support. Despite the continued and rapid growth of the field, there is no current and comprehensive resource that provides coverage of the major topic areas in the psychology-law field. The Oxford Handbook of Psychology and Law fills this gap and offers an up-to-date, scholarly, and broad overview of psychology-law topics. David DeMatteo and Kyle C. Scherr have brought together a diverse group of highly esteemed applied and experimental researchers and scholars to discuss key topics in the field from both national and international perspectives. The volume is broadly divided into three sections: foundational psychology-law, applied psychology-law, and experimental-psychology-law. The Foundational Psychology-Law section includes chapters that are relevant to both applied psychology and experimental psychology, making a unique contribution that ties together the applied and experimental aspects of the field. The Applied Psychology-Law section provides coverage of topics related to the provision of forensic services (broadly defined) in criminal and civil legal contexts. Lastly, the Experimental Psychology-Law section covers empirically examined legal system issues and outcomes related to victims, offenders, witnesses, attorneys, and triers of fact. With comprehensive coverage of both applied and experimental topic areas and chapters written by a diverse group of well-established psychology-law scholars and emerging future leaders, this Handbook presents emerging, cutting-edge topics in psychology-law that will continue to grow and meaningfully shape future research programs and policy reform.

This book is an ideal introduction to the specialty of post mortem computed tomography (PMCT). It will serve as a comprehensive yet accessible guide to the understanding and interpretation of whole-body studies for both hospital and community settings. Both normal post mortem appearances and findings associated with a wide range of diagnoses encountered in real cases from the coronial service are presented with the aid of numerous images. The coverage encompasses not only findings in all anatomic regions but also the imaging appearances in cases following targeted coronary angiography, attempted cardiopulmonary resuscitation and various special circumstances such as suicide. The inclusion of many practical tips and possible pitfalls will support the radiologist to become more confident when reporting PMCT, while for the more experienced practitioner the wealth of examples will serve as a useful resource. In addition to radiologists, the book will be of value for pathologists at all levels of experience and anyone needing to understand the role and limitations of PMCT.

A classic in its field, "Human Osteology "has been used by students and professionals through nearly two decades. Now revised and updated for a third edition, the book continues to build on its foundation of detailed photographs and practical real-world application of science. New information, expanded coverage of existing chapters, and additional supportive photographs keep this book current and valuable for both classroom and field work.
Osteologists, archaeologists, anatomists, forensic scientists and paleontologists will all find practical information on accurately identifying, recovering, and analyzing and reporting on human skeletal remains and on making correct deductions from those remains.
KEY FEATURES:
* From the world renowned and bestselling team of osteologist Tim D. White, Michael T. Black and photographer Pieter A. Folkens
* Includes hundreds of exceptional photographs in exquisite detail showing the maximum amount of anatomical information
* Features updated and expanded coverage including forensic damage to bone and updated case study examples
* Presents life sized images of skeletal parts for ease of study and reference

The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner's offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.

Increasing quantities of information about our health, bodies, and biological relationships are being generated by health technologies, research, and surveillance. This escalation presents challenges to us all when it comes to deciding how to manage this information and what should be disclosed to the very people it describes. This book establishes the ethical imperative to take seriously the potential impacts on our identities of encountering bioinformation about ourselves. Emily Postan argues that identity interests in accessing personal bioinformation are currently under-protected in law and often linked to problematic bio-essentialist assumptions. Drawing on a picture of identity constructed through embodied self-narratives, and examples of people's encounters with diverse kinds of information, Postan addresses these gaps. This book provides a robust account of the source, scope, and ethical significance of our identity-related interests in accessing - and not accessing - bioinformation about ourselves, and the need for disclosure practices to respond appropriately. This title is also available as Open Access on Cambridge Core.

Health research around the world relies on access to data, and much of the most valuable, reliable, and comprehensive data collections are held by governments. These collections, which contain data on whole populations, are a powerful tool in the hands of researchers, especially when they are linked and analyzed, and can help to address "wicked problems" in health and emerging global threats such as COVID-19. At the same time, these data collections contain sensitive information that must only be used in ways that respect the values, interests, and rights of individuals and their communities. Sharing Linked Data for Health Research provides a template for allowing research access to government data collections in a regulatory environment designed to build social license while supporting the research enterprise.

Providing a concise and accessible overview of the design, implementation and management of medical software, this textbook will equip students with a solid understanding of critical considerations for both standalone medical software (software as a medical device/SaMD) and software that is integrated into hardware devices. It includes: practical discussion of key regulatory documents and industry standards, and how these translate into concrete considerations for medical software design; detailed coverage of the medical software lifecycle process ; accessible introduction to quality and risk management systems in the context of medical software; succinct coverage of essential topics in data science, machine learning, statistics, cybersecurity, software engineering and healthcare bring readers up-to-speed; six cautionary real-world case studies illustrate the dangers of improper or careless software processes. Accompanied by online resources for instructors, this is the ideal introduction for undergraduate students in biomedical engineering, electrical engineering and computer science, junior software engineers, and digital health entrepreneurs.

Regulators have been more permissive for medical devices compared to their drug and biologic counterparts. While innovative products can thereby reach consumers more quickly, this approach raises serious public health and safety concerns. Additionally, the nature of medical devices is rapidly changing, as software has become as important as hardware. Regulation must keep pace with the current developments and controversies of this technology. This volume provides a multidisciplinary evaluation of the ethical, legal, and regulatory concerns surrounding medical devices in the US and EU. For medical providers, policymakers, and other stakeholders, the book offers a framework for the opportunities and challenges on the horizon for medical device regulation. Readers will gain a nuanced overview of the latest developments in patient privacy and safety, innovation, and new regulatory laws. This book is also available as Open Access on Cambridge Core.

Regulators have been more permissive for medical devices compared to their drug and biologic counterparts. While innovative products can thereby reach consumers more quickly, this approach raises serious public health and safety concerns. Additionally, the nature of medical devices is rapidly changing, as software has become as important as hardware. Regulation must keep pace with the current developments and controversies of this technology. This volume provides a multidisciplinary evaluation of the ethical, legal, and regulatory concerns surrounding medical devices in the US and EU. For medical providers, policymakers, and other stakeholders, the book offers a framework for the opportunities and challenges on the horizon for medical device regulation. Readers will gain a nuanced overview of the latest developments in patient privacy and safety, innovation, and new regulatory laws. This book is also available as Open Access on Cambridge Core.