This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.

In Quest of Justice provides the first full account of the establishment and workings of a new kind of state in Egypt in the modern period. Drawing on groundbreaking research in the Egyptian archives, this highly original book shows how the state affected those subject to it and their response. Illustrating how shari'a was actually implemented, how criminal justice functioned, and how scientific-medical knowledges and practices were introduced, Khaled Fahmy offers exciting new interpretations that are neither colonial nor nationalist. Moreover he shows how lower-class Egyptians did not see modern practices that fused medical and legal purposes in new ways as contrary to Islam. This is a major contribution to our understanding of Islam and modernity.

The Forensic Aspects of Hypoglycaemia succinctly covers the medicolegal considerations of hypoglycaemia in a variety of scenarios including driving fatalities, petty crime, homicide and suicide. Covering the definitions and diagnosis of hypoglycaemia to its bearing on criminal behavior, this book draws on the author's extensive experience and contains a wealth of information for physicians and lawyers, including cases from the author's past and notable cases in the public domain.

In an effort to modernize criminal and civil investigations, early Bolsheviks gave forensic doctors-most of whom had been trained under the tsarist regime-new authority over issues of sexuality. Revolutionaries believed that forensic medicine could provide scientific and objective solutions to sexual disorder in the new society. Bolshevik Sexual Forensics explores the institutional history of Russian and Soviet forensic medicine and examines the effects of its authority when confronting sexual disorder. Healey compares sex crime investigations from Petrograd and Sverdlovsk in the 1920s to the numerous publications by forensic doctors and psychiatrists of the prerevolutionary and early Soviet periods to illustrate the role that these specialists played. In addition, Healey presents a fascinating look at how doctors diagnosed and treated hermaphroditism, showing how Soviet physicians revolutionized the standard scientific view in these cases by taking into account individual desire. This study sheds light on unexplored radical and reactionary forces that shaped the Bolshevik "sexual revolution" as lawmakers defined new ways of seeing sexual crime and disorder. Forensic doctors struggled to interpret the replacement of the age of consent with a standard of "sexual maturity," a designation that made female sexuality a collective "resource," not part of an individual's personality. "Innocence," "experience," and virginity played a major role in the expertise doctors furnished in rape and abuse trials. Psychiatrists recoiled from the language of sexual psychology in their investigations of sex criminals. Yet in the clinic, Soviet physicians probed the desires of the two-sexed citizen, whose psychology served as the basis for a distinctly modern approach to the "erasure" of the hermaphrodite. Healey concludes that the vision of men and women as equals after a "sexual revolution" was undermined from the outset of the Soviet experiment. Law and medicine failed to protect women and girls from violence, and Soviet medicine's physiological and biological model of sexual citizenship erased the vision of sexual self-expression, especially for women. This groundbreaking study will appeal to Soviet historians and those interested in gender studies, sexuality, medicine, and forensics.

This volume recognizes and addresses the health care issues of prisoners, to establish best practices and to learn about approaches to these challenges from around the world. It presents new evidence on several emerging and classical prison health issues. The first goal of this volume is to address emerging issues related to health in prison. Second, it presents the most recent research-based evidence and translates it to the practice. The third goal, is that it allows for sufficient diversity while also incorporating updates of some important already recognized prison health. The volume discusses prisons and the life and well-being of prisoners and staff, after growing problems as drug misuse (incl. tobacco smoking), infectious diseases (HIV/AIDS, hepatitis, STIs and TB), psychiatric problems, inadequate and unhealthy living conditions (incl. nutrition), overcrowding of prisons. These are addressed adequately in order to meet the international requirements of equivalence of health care. The scope of this volume is at the same type specific and diverse enough to cover the interests of a large audience that includes many types of practitioners involved in health-related issues in the field of prison health care, such as psychologists, nurses and prison administration officers responsible for health care, legal professionals and social workers.

This volume will describe both growth-inhibitory and mucin-depleting effects of bromelain and N-acetylcysteine, on their own or in combination, in cancer. It will coherently review the pathophysiological aspects of the mucin glycoproteins in malignancies and provide an updated account of the status of bromelain and N-acetylcysteine in cancer therapy. The volume will develop the idea of using these two drugs as a combination formulation for mucin-depleting effects.

This new edition provides both theoretical and practical background of security and forensics for mobile phones. The author discusses confidentiality, integrity, and availability threats in mobile telephones to provide background for the rest of the book. Security and secrets of mobile phones are discussed including software and hardware interception, fraud and other malicious techniques used "against" users. The purpose of this book is to raise user awareness in regards to security and privacy threats present in the use of mobile phones while readers will also learn where forensics data reside in the mobile phone and the network and how to conduct a relevant analysis. The information on denial of service attacks has been thoroughly updated for the new edition. Also, a major addition to this edition is a section discussing software defined radio and open source tools for mobile phones.

This volume will introduce new terminology to the field of oncology, subdividing it into oncokinetics-the mechanics of the tumor cells as they arise and spread throughout the body-and oncodynamics-the impact of abnormal cues generated by tumors on the physiological functioning of the body. The volume will outline the importance of oncodynamics from both a cancer patient's and a caregiver's perspectives, stressing its significant impact on cancer patient functionality and the opportunity that cancer researchers will have to develop cross-disciplinary interactions and predict potential consequences of tumors and/or treatment.

Most professional forensic literature addresses the assessment of adults yet neglects the necessary differences that arise when working with minors. Forensic Mental Health Assessment of Children presents the reader with essential knowledge and practical suggestions regarding the forensic assessment of minors involved in a variety of legal applications. Methods of evaluation are described by leading experts regarding topics frequently encountered and of great importance to the courts including:
-Physical and sexual child abuse
-Domestic violence
-Child custody in divorce proceedings
-Risk assesment for violence
-Potential for rehabilitation in juvenile court cases
-Special education
-Childhood development and trauma as mitigating circumstances in death penalty cases
In addition to reviewing a broad spectrum of topics, methods of evaluation, and the application of specific tests, chapters also address forensic assessment matters such as ethical issues, professional liability, and cultural considerations. This comprehensive resource will be indispensable to mental health practitioners and legal professionals, and of great interest to researchers and students.

This book examines technical aspects of industrial espionage and its impact in modern companies, organizations, and individuals while emphasizing the importance of intellectual property in the information era. The authors discuss the problem itself and then provide statistics and real world cases. The main contribution provides a detailed discussion of the actual equipment, tools and techniques concerning technical surveillance in the framework of espionage. Moreover, they present the best practices and methods of detection (technical surveillance counter measures) as well as means of intellectual property protection.

This reference, now in its second edition, is a comprehensive guide that focuses on the practical aspects of excavating and recovering human remains, as well as any associated evidence, from crime scenes. It highlights the protocols and techniques that are used to successfully survey, map, recover, document, collect, and transport evidence. New additions to the reference include discussion questions and suggested readings, updated mapping and measuring techniques, including a section on GIS and backpack differential GPS systems, expanded information on botany, DNA, and soil, and non-forensic burial contexts. Almost 200 illustrations are included to help clarify concepts.

This book challenges the assumptions of modern criminal law that insanity is a natural, legally and medically defined phenomenon (covering a range of medical disorders). By doing so, it paves the way for a new perspective on insanity and can serve as the basis for a new approach to insanity in modern criminal law. The book covers the following aspects: the structure of the principle of fault in modern criminal law, the development of the insanity defense in criminal law, tangential in personam defenses in criminal law and their implications for insanity and the legal mechanism of reproduction of fault. The focus is on the Anglo-American and European-Continental legal systems. Given the attention consistently drawn by international and domestic events in this context, the book will be of interest to a broad and growing international audience.

Adverse drug reactions and interactions are still a major headache for healthcare professionals around the world. The US Food and Drug Administration's database recorded almost 300,000 serious adverse events in 2009 alone, of which 45,000 instances proved fatal. This updated new edition of the indispensable guide to drug interactions incorporates fresh research completed since the book's original publication by Humana Press in 2004. Additions include a new section on pharmacogenomics, a rapidly growing field that explores the genetic basis for the variability of responses to drugs. This new material reviews important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation, using case studies involving opiates as exemplars. Existing chapters from the first edition have in most cases been updated and reworked to reflect new data or incorporate better tables and diagrams, as well as to include recent drugs and formulations. Recent references have been inserted too. The handbook features extra material on illicit drug use, with a new chapter tackling the subject that covers cocaine, amphetamines and cannabis, among others. The section on the central nervous system also deals with a number of drugs that are abused illicitly, such as benzodiazepines, opiates flunitrazepam and GHB, while so-called 'social' drugs such as alcohol and nicotine are still discussed in the book's section on environmental and social pharmacology. Focusing as before on detailed explanation and incorporating both pharmacokinetic and pharmacodynamic drug interactions, this book will continue to be a lodestar for health and forensic professionals as well as students.

A host of neurotransmitters and neuroactive substances underlies respiratory regulation in health and disease. The centerpiece of investigations regarding adaptation to hypoxia and sensorial perception has been the dopaminergic system. It is now clear that a complex interaction among various neuroactive substances, rather than a single one, forms the basis of respiratory changes. The research on neurotransmitter interactions provides the knowledge of how the brain functions and a new level of understanding of mind-to-body connection, which opens up avenues for novel therapeutic interventions.

This book both explains in detail diverse aspects of the law as it relates to dentistry and examines key issues in forensic odontostomatology. A central aim is to enable the dentist to achieve a realistic assessment of the legal situation and to reduce uncertainties and liability risk. To this end, experts from across the world discuss the dental law in their own countries, covering both civil and criminal law and highlighting key aspects such as patient rights, insurance, and compensation. In the section on forensic odontostomatology, extensive guidance is provided on development of the dentition, clinical findings and documentation, personal identification, age estimation, and the nature and significance of bite, tooth, and lip marks. This book will be an invaluable source of information for all who practice in the field of dentistry as well as forensic scientists, lawyers, investigative and identification authorities, criminologists, prosecutors, insurance agents, and students.

For the 4th edition of Trauma Biomechanics all existing chapters referring to traffic and sports have been revised and updated. New scientific knowledge and changes in legal defaults (such as norms and standards of crash tests) have been integrated. Additionally one chapter has been added where biomechanical aspects of injuries affected by high energies are communicated in a new way. The mechanical basics for ballistics and explosions are described and the respective impacts on human bodies are discussed. The new edition with the additional chapter therefore is addressed to a broader audience than the previous one.

After 17 years of private practice as a cardiovascular surgeon, my partners qu- tionedtherationalityofmydecisiontoleavetheclinicalpracticebehindandbecome acardiovascular pathologist. Infact,theirdisbeliefofmyintentiontomakethe"leap of faith" was understandable. For a surgeon, the operating room is where the action is. It is as simple as that. And when a cardiac surgeon can hold in his hand a beating heart, now off-bypass and improved by an operation just completed, satisfaction is real and profound. However, life is complex. Throughout my surgical career, questions regarding the pathogenesis of atherosclerotic cardiovascular disease arose; curiosities of va- ous phenotypes of the disease piqued my interest. I became aware of the power of investigative techniques that might address these questions. I then began to realize that my career in the operating room left me little time to address them. I needed to study the disease full time in order to contribute to my understanding of it. Ironically, my ?rst autopsy as a pathology resident was on an individual with a past history of coronary artery bypass surgery. When it came to examining the heart, the dissection, as all pathologists know, was complex. However, I found it to be straightforward and enjoyable. But I subsequently learned that my fellow re- dents and mentors did not share my intrigue and comfort in de?ning the nuances of the operated heart.

Rabies is the deadliest zoonotic disease that threatens humans and animals on all continents except Antarctica. Asia and Africa are worst affected as more than 95 per cent of rabies associated human deaths occur in these regions. India alone bears about 36 per cent of the global human rabies burden. Dogs are the main transmitters of rabies that potentially threaten over 3 billion people in Asia and Africa. Many developed nations have been able to successfully control dog rabies but continue to face the risk from wildlife including bats. Bat rabies is responsible for most human rabies deaths in the United States of America and Canada but has emerged as a public health threat in Australia, Latin America and Western Europe as well. Despite being vaccine preventable, rabies continues to haunt the mankind. Poor resources is a major constraint but the factors like low priority attributed to rabies, misconceptions in the community about the disease and unsystematic approach for its prevention and control are also responsible for the grim situation. Targets have been set for elimination of human and dog rabies in all Latin American countries by 2015 and of human rabies transmitted by dogs in South-East Asia by 2020. However, the myths prevailing among the people together with inadequate knowledge of the health professionals, veterinarians, and the civic body staff about the rabies prevention and control strategies might make the task very difficult. This book comprising eight chapters elaborates the causation of rabies in man and animals, its global epidemiology, risk analysis and effective strategies for the management of exposures. Proven methods of rabies prevention and control have been discussed in length along with the challenges and ways to overcome the constraints through intersectoral coordination. The inclusion of 200 frequently asked questions is a unique feature of the book which may help not only the common people and pet lovers in clearing their doubts about rabies in man and animals also be equally instrumental in updating the knowledge and skills of the public health personnel, veterinarians and other professionals. Apt illustrations and simple language make the contents of the book easily comprehensible and a reading pleasure.

This handbook is unique in its comprehensive coverage of the subject and focus on practical applications in diverse fields. It includes methods for sample preparation, the role of certified reference materials, calibration methods and statistical evaluation of the results. Problems concerning inorganic and bioinorganic speciation analysis, as well as special aspects such as trace analysis of noble metals, radionuclides and volatile organic compounds are also discussed. A significant part of the content presents applications of methods and procedures in medicine (metabolomics and therapeutic drug monitoring); pharmacy (the analysis of contaminants in drugs); studies of environmental samples; food samples and forensic analytics - essential examples that will also facilitate problem solving in related areas.

Introducing the basic concepts of clinical forensic medicine and death investigation, this book covers the main areas of forensic investigation . It provides an introduction to forensic science and coverage of injury patterns, natural disease, accidental trauma, child injury and fatalities, and domestic violence. Anyone who has direct contact with death, crime, and the medicolegal system, including nurses, physicians, attorneys, death investigators, forensic pathologists, and police detectives, will find this an invaluable reference.

This book explores the response of forensic psychiatry and psychology to changes over the last several decades. It presents the disciplines themselves as change agents that have shaped forensic work, public policy, and law. Topics include selected developments in forensic practice, the management and treatment of individuals who have had involvement with law enforcement systems, and the application of administrative principles to the management of forensic entities.

As globalization causes profound changes in business, industry, and trade,it can also have significant effects on populations, environments, and individuals.These effects may be harmful, resulting in injury or illness, prompting the critical question: How best to correct wrongs caused to individuals, communities, and/or the environment of one country by the actions of individuals or corporations of another? Possible answers lie in an emerging discipline. Forensic Epidemiology in the Global Context opens meaningful windows onto the processes of forensic epidemiology, the roles of the epidemiologist in civil disputes, and the potential contribution of the field to legal and justice efforts worldwide. Case examples from the U.K., Nigeria, Ecuador, Romania, and Australia illustrate commonly used methodologies and the challenges involved in their use in U.S. and international courts of law. A chapter on expert testimony takes readers through qualification and admissibility issues, report requirements, and working with attorneys. Included in the coverage: Forensic epidemiology in the international legal arena. The epidemiologist as an expert in litigation. Epidemiological evidence in tort law: dispatches from the U.K. Liability for occupational exposure: the role of epidemiology. Forensic epidemiology and environmental justice. Forensic epidemiology, pathology, ethnics, and human rights. By emphasizing both the scientific and legal components of the equation, Forensic Epidemiology in the Global Context gives researchers and graduate students in epidemiology a unique and timely guide to the present and future of an increasingly salient field.

Multiauthored book dealing comprehensively with the various aspects of imaging of pediatric musculoskeletal trauma. The work is subdivided in three main sections: Overview of lesions; Imaging of traumatic injuries according to body region; typical traumatic injuries of early infancy. The third section includes also legal aspects of child abuse (battered child) and will indicate current international medical-legal guidelines. The didactical approach and the wide-ranging account of the subject makes the book particularly valuable to practitioners from various disciplines, involved in diagnosis and management of trauma of pediatric bone and joint