This book makes a case for a multidisciplinary and transdisciplinary approach to energy research-one that brings more of the social sciences to bear. Featuring eight studies from across the spectrum of the social sciences, each applying multiple disciplines to one or more energy-related problems, the book demonstrates the strong analytical and policy-making potential of such a broadened perspective. Case studies include: energy transitions of households in developing countries, the 'curse of oil', politics and visions for renewables, economics and ethics in emissions trading, and carbon capture and storage.

The goals of the science of photobiology can be divided into four categories: to develop (I) ways to optimize the beneficial effects of light on man and his environment, (2) methods to protect organisms, including man, from the detrimental effects of light, (3) photochemical tools for use in studies of life processes, and (4) photochemical therapies in medicine. To achieve these goals will require the knowledgeable collaboration of biologists, chemists, engineers, mathematicians, physicians, and physicists; because photobiology is a truly multidisciplinary science. While a multidis ciplinary science is more intellectually demanding, it also has a greater potential for unexpected breakthroughs that can occur when data from several areas of science are integrated into new concepts for theoretical or practical use. Photochemical and Photobiological Reviews continues to provide in depth coverage of the many specialty areas of photobiology. It is hoped that these reviews will provide an important service to the younger scientists in the field and to senior scientists in related fields, because they provide a ready access to the recent literature in the field, and more importantly, they frequently offer a critical evaluation of the direction that the field is taking, or suggest a redirection when appropriate. Since it is important that this review series remain responsive to the needs of photochemists and photobiologists, the Editor would value com ments and suggestions from its readers."

The Corrosion Resistant Metals Committee and the Nuclear Metallurgy Committee of the Institute of Metals Division of The Metallurgical Society of AlME sponsored a 2-1/2 day symposium on "Corrosion by Liquid Metals." The symposium was held in Philadelphia, October 13-15, 1969, during the 1969 Fall Meeting of the Metallurgical Society and the Materials Engineering Con gress of the American Society for Metals. Cosponsors included the American Society for Metals and the American Nuclear Society. The purpose of the symposium was to bring together the several aspects of the subject of corrosion by liquid metals, so that perspective could be provided on the entire subject, to help in dividuals dealing with liquid metal corrosion problems acquire a sound basis of understanding, and to provide an opportunity for discussion between those doing research in this field. An exposition of the subject is timely, in view of the in creasing development of liquid metal heat and power sources for special purposes, including heat-pipe systems, NASA's SNAP power systems, and the AEC's liquid metal fast breeder reactor system. This book contains the proceedings of the symposium divided into four separate topics: I. Corrosion of Steels by Sodium, II. Alkali-Refractory Metal Interactions, III. Corrosion by Non-Alkali Metals, and IV. Analysis of Solid-Liquid Metal Inter actions (two sessions)."

The workshop entitled "The Role of Cell Interactions in Early Neurogenesis" was held at the Institut d'Etudes Scientifiques in Cargese, Corsica on May 29th to June 3rd, 1983. The setting was ideal for a small meeting whose purpose was to generate as much discussion as possible between the various participants. One of the major topics of this conference was neural induction, that is, the first step in neurogenesis. Neural induction remains poorly understood at the molecular level as compared to the sub- sequent steps of neuronal migration and differentiation. It thus appeared important to unite different researchers working on this fundamental process of neural induction with scientists studying later steps of neurogenesis in order to exchange ideas and suggestions. We would like to acknowledge the invaluable assistance of Marie- France Hanseler, the administrative assistant of CNRS who is respon- sible for the Institute. The workshop was primarily sponsored by CNRS (Centre National de la Recherche Scientifique, France), NATO and EMBO (European Molecular Biology Organization). Additional financial support was generously provided by the International Society of Developmental Biologists, the European Developmental Biology Organiz- ation, the European Council, the Universite Paul Sabatier (Toulouse), la Societe Francaise de Biologie du Developpement, les Etablisse- ments Fabre (Fr~nce) et les Etablissements Sarget (France). The proceedings from this workshop comprise the present volume and there are five general chapters. In addition to the principal lectures given at the Institute, many participants presented short reports and all of these are included in this volume.

The Cargese Summer Institute 1B75 on Weak and Electromagnetic Interactions at High Energies was organized by the Universite Pierre et Marie Curie (M. LEVY et J. L. BASDEVANT), the Katholieke Universiteit te Leuven (R. GASTMANS) and the Universite Catholique de Louvain (D. SPEISER et J. WEYERS) who made in 1973 the first contacts with some lecturers, who, on the advice of NATO, joined th their efforts and worked in common. It was the 16 Summer Insti- rd tute held at Cargese and the 3 one organized by the two depart- ments of Theoretical Physics at Leuven and Louvain-Ia-Neuve. When the two groups decided (independently) on the subject of the school, they could not know how lucky their choice eventually would turn out to be : rarely has it been possible ~o present an audience with such a great number of new and decisive discoveries who are likely to stimulate the imagination of theoreticians and the research projects of experimentalists alike. Such were the decisive confirmation of the neutral currents, the di-muon events, the slowly decaying new particles, etc. The organizers were grate- ful indeed that they could find physicists from almost all great centers of high energy physics who had themselves participated in these discoveries. Although the theorists could not match during the last two years the spectacular success of their experimental colleagues, there has been enough important programs, especially in field theory : renormalization of gauge theories, the Brout- Englert-Higgs mechanism, etc...

Recently there have been major developments in the experimental techniques available for the study of the primary events following the absorption of ultra-violet and visible radiation by biological systems. These techniques, which include absorption, emission, resonance Raman, electron spin resonance, nuclear magnetic resonance and photoacoustic spectroscopies, can be used to study the fate of transient species with lifetimes ranging from seconds to nanoseconds and extending in some cases, such as laser flash photolysis, to pico 12 15 (10- S)- and even femtoseconds (10- s). In parallel with these developments there has been a dramatic increase in the use of light in medicine via the direct photochemical alteration of endogenous molecules (phototherapy) or via the photoactivation of drugs in the skin or other tissue (photochemotherapy). Thus neonatal hyperbili rubinaemia can be routinely treated by phototherapy and psoriasis is frequently treated by PUVA photochemotherapy. A promising new photo chemotherapy used the phototoxicity of porphyrin drugs activated by red light to destroy solid malignant tumors. While some of the overall qualitative effects of such treatments are known, only recently have we begun to understand the associated molecular mechanisms. The primary molecular processes involve short-lived species. The pur pose of this Advanced Study Institute was to review some newer experi mental techniques for the study of such species, the application of these techniques to biological and medical systems and to examine the value of such information in phototherapeutic situations."

In today's complex world, we have come to rely increasingly on those who have expertise in specific areas and can bring their knowledge to bear on crucial social, political and scientific questions. Taking the viewpoint that experts are consulted when there is something important at stake for an individual, a group, or society at large, Experts in Science and Society explores expertise as a relational concept. How do experts balance their commitment to science with that to society? How does a society actually determine that a person has expertise? What personal traits are valued in an expert? From where does the expert derive authority? What makes new forms of expertise emerge? These and related questions are addressed from a wide range of areas in order to be inclusive, as well as to demonstrate similarities across areas. Likewise, in order to be culturally comparative, this volume includes examples and discussions of experts in different countries and even in different time periods. The topics include the roles of political experts, scientific experts, medical experts, legal experts, and more.

- The first book that collects an international range of accomplished practitioners and academics together to share their innovative photography practices - Written in a clear and accessible style, ideal for students and practitioners - Uses tangible examples and relatable practices that can inspire or be extrapolated into the reader's own practice - Visually rich with 150 full colour images demonstrating a diverse set of practices.

The goals of the science of photobiology can be divided into four categories: to develop (I) ways to optimize the beneficial effects of light on man and his environment, (2) methods to protect organisms, including man, from the detrimental effects of light, (3) photochemical tools for use in studies of life processes, and (4) photochemical therapies in medicine. To achieve these goals will require the knowledgeable collaboration of biologists, chemists, engineers, mathematicians, physicians, and physicists; because photobiology is a truly multidisciplinary science. While a multidis ciplinary science is more intellectually demanding, it also has a greater potential for unexpected breakthroughs that can occur when data from several areas of science are integrated into new concepts for theoretical or practical use. Photochemical and Photobiological Reviews continues to provide in depth coverage of the many specialty areas of photobiology. It is hoped that these reviews will provide an important service to the younger scientists in the field and to senior scientists in related fields, because they provide a ready access to the recent literature in the field, and more importantly, they frequently offer a critical evaluation of the direction that the field is taking, or suggest a redirection when appropriate. Since it is important that this review series remain responsive to the needs of photochemists and photobiologists, the Editor would value com ments and suggestions from its readers."

Why another textbook on the design of wood sets this book apart is its inclusion of "struc structures? In many years of teaching structural tural planning. " Most textbooks show only the design in wood, the authors have used virtually selection of member proportions or number of every textbook available, as well as using only connectors in a joint to satisfy a given, com a code and no textbook at all. The textbooks pletely defined situation. This book, on the used have included both the old and the rela other hand, shows the thinking process needed tively modem; some have been fairly good, but to determine whether or not the member is re in our opinion each has deficiencies. Some quired in the first place. Following this, the books have too few solved examples. Others spacing and continuity of the member are de omit important material or have an arrange cided, its loads are determined, and finally its ment making them difficult to use as formal shape and size are selected. teaching tools. By writing this book, we intend We believe that illustrating structural plan to correct such deficiencies. ning as well as detailed member and connec The prime purpose of this book is to serve as tion design is of considerable value in helping a classroom text for the engineering or archi the student make the transition from the often tecture student."

This, the ninth volume in the series, appears some 13 years after the first. Like most of its predecessors, Volume 9 is deliberately eclectic, covering a range of topics that the editors think worthy of inclusion. Some of the chapters, such as the review of the literature on benzodiazepines, represent areas that have received relatively little attention in previous volumes-largely because the literature has not previously been "ripe" for review. Others represent literatures that have been reviewed in the past but which continue to advance in sufficient measure that their ripening never ceases. Shepard Siegel's contribution represents a relative rarity in previous volumes: a chapter not laden with a consideration of current empirical work, but a reflective essay designed to stir thought with some pro vocative ideas. The editors trust that readers will continue to find Research Advances to be an important repository of knowledge in the alcohol and drug fields. The Editors Toronto IX Contents 1. THE HUMAN PHARMACOLOGY OF NICOTINE Neal L. Benowitz 1. Introduction 2. Nicotine in Tobacco Products 2 3. Phannacokinetics of Nicotine 4 4. Nicotine and Cotinine Blood Levels during Tobacco Use 14 5. Intake of Nicotine during Cigarette Smoking 18 6. Biochemical Markers of Nicotine Intake 18 7. Regulation of Nicotine Intake during Cigarette Smoking 23 8. Phannacology of Nicotine 28 9. Importance of Nicotine in Human Disease 41 References 45 2. BENZODIAZEPINES AS DRUGS OF ABUSE AND DEPENDENCE 53 Howard D. Cappell, Edward M. Sellers, and Usoa Busto 1."

MOLECULAR ENZYMOLOGY, BECAUSE OF ITS CHEMICAL AND MATHEMATICAL content, is often regarded as a formidable and forbidding topic by undergraduates on a biology or biochemistry course, As a result of teaching enzymology to undergraduates for a number of years, we recognize the areas which appear to cause the most common difficulties in conceptual understanding. We feel that a book treating those areas by means of a logical approach carefully developed from basic principles fills a gap in the multiplicity of enzymology texts currently available. In writing this book we h; lVe had in mind the needs of Honours Biochemistry students, in particular those who may take a special interest in enzymology. The text covers the main bulk of the material required in the second and third years of such courses. In addition, those taking courses in Biological Chemistry may well find the book to be of central interest. The book begins with a description of the fundamentals of catalysis, illustrating these with simple chemical reactions which may be supposed to serve as models of catalytic processes. Protein structure is discussed in terms of the fundamental forces which determine the shape and dynamic behaviour of protein molecules. The approach emphasizes those features thought to be most intimately involved in the catalytic function of enzyme molecules, and is illustrated with specific examples.

As new faculty members in the Section of Psychiatry and Human Behavior at Brown University, we began collaborating on research into assessment and treatment of sexual problems in the fall of 1975. Although each of us arrived with clinical and research in terests in the broad field of sexual problems, the idea for this book grew out of our early discussions and a consensus on the future direction of research. We noted that there had been an extremely rapid increase in knowledge of human sexual behavior as well as sexual disorders and their treatment over the last few decades. It has also become increasingly apparent that sexual problems, broadly conceived, comprise a sizable fraction of the problems for which people seek treatment, and that, although the treatment of sexual problems was achieving some success, treatment was for the most part slow, costly, and without any guarantee of successful outcome. Furthermore, there were many people with sexual prob lems for whom treatment was not available. With these ideas in mind, it seemed timely for investigators in the field of human sex uality and its disorders to turn their attention to the problem of prevention. Organizing a symposium on the topic enabled us to invite leading investigators in the study of sexual behavior to address this area. The chapters in this volume are an outgrowth and refinement of the formal papers delivered at the symposium, which was held in the spring of 1976."

Electronic funds transfer (EFT) systems include a wide range of computer-based payment systems and sources that substitute electronic and digital transfers for movements of cash and paper checks. A few years ago some people were predict ing that EFT would replace paper money and coins entirely and that we would soon be a "checkless" and' 'cashless" society. Such sweeping changes have not occurred, but a slower evolution is clearly underway. Although checks, cur rency, and coin are likely to be here for many years to come, EFT is becoming an established part of our worldwide payment transfer system, and the implications and consequences of this technology are real. They include: * Alterations in personal finance and in the process of purchasing and paying for consumer goods and services. * Changes in the structure of financial and retail organizations and their mode of interaction in the marketplace. * Modifications in the flow of funds in our society and in the interactions among economic institutions. * Alterations in the prospects for invasion of personal privacy, perpetration of fraud and theft, and violation of antitrust regulations. * Changes in the regulatory and competitive balance among the numerous financial institutions in the United States. Such alterations foretell important impacts on people and society. Benefits are forthcoming, but the costs will also be real.

SOIL: beneath our feet / food and fiber / ashes to ashes, dust to dust / dirt!Soil has been called the final frontier of environmental research. The critical role of soil in biogeochemical processes is tied to its properties and place-porous, structured, and spatially variable, it serves as a conduit, buffer, and transformer of water, solutes and gases. Yet what is complex, life-giving, and sacred to some, is ordinary, even ugly, to others. This is the enigma that is soil. Soil and Culture explores the perception of soil in ancient, traditional, and modern societies. It looks at the visual arts (painting, textiles, sculpture, architecture, film, comics and stamps), prose & poetry, religion, philosophy, anthropology, archaeology, wine production, health & diet, and disease & warfare. Soil and Culture explores high culture and popular culture-from the paintings of Hieronymus Bosch to the films of Steve McQueen. It looks at ancient societies and contemporary artists. Contributors from a variety of disciplines delve into the mind of Carl Jung and the bellies of soil eaters, and explore Chinese paintings, African mud cloths, Mayan rituals, Japanese films, French comic strips, and Russian poetry.

The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A."

This volume consists of lectures delivered at the Sixth Inter national Nathiagali Summer College on Physics and Contemporary Needs held at Islamabad from June 15 to July 2, 1981. The College used to be held at one of the scenic hill resorts of Pakistan, Nathiagali, hence the name of the College. The College was organized by the Pakistan Atomic Energy Commission (PAEC), under the patronage of the International Centre for Theoretical Physics (ICTP), Trieste, with a view to providing an opportunity for local physicists and physicists from developing countries for learning of the latest developments in various branches of physics. The University Grants Commission provided a financial grant for the participation of physicists from the universities of Pakistan. The College had 18 lecturers from 7 countries. The total participation in the College was by over 200 people from 18 different countries. There were 15 days of concentrated lecturing during the day followed by seminars and discussion sessions in the evenings. From its inception the College has had a broad-based, multi disciplinary emphasis. The purpose of the College has been to provide physicists in the developing countries with enough information in various branches of physics so that they can shift, or broaden, their field of research. In the poor countries, like Pakistan, physicists cannot always get facilities and opportunities to continue research in their original field of specialisation at a reasonable level."

Considerable worldwide interest has arisen in recent years in the controlled use of enzymes as catalysts in industrial processing, analytical chemistry and medical therapy. This interest has genera ted the new interdisciplinary field of Enzyme Engineering, which includes both the scientific and technologic aspects of the produc tion, purification, immobilization, and application of enzymes in a variety of situations and reactor configurations. A series of Engineering Foundation conferences on Enzyme Engineering was initia ted to provide an international forum for the exchange of ideas and information over the entire range of this new field. The outstanding success of the first two conferences attests to the vigor and poten tial of this field to contribute significantly to a better under standing and resolution of some of the major problems faced by man kind. The first conference, which was held August 9-13, 1971, at Henniker, New Hampshire, U. S. A., aided significantly in molding the several traditional disciplines that interact to form the field of Enzyme Engineering. The conference was highly successful mainly because many of the key scientists and engineers from the several facets of Enzyme Engineering were brought together for the first time at a single residential meeting. The result was an exchange of ideas and "education" of one another in the pertinent principles of the diverse disciplines which contribute to this field. The second conference, held August 5-10, 1973, at Henniker, New Hampshire, U. S. A."

This book deals with the organic chemistry of polymers which find technological use as adhesives, fibres, paints, plastics and rubbers. For the most part, only polymers which are of commercial significance are considered and the primary aim of the book is to relate theoretical aspects to industrial practice. The book is mainly intended for use by students in technical institutions and universities who are specializing in polymer science and by graduates who require an introduction to this field. Several excellent books have recently appeared dealing with the physical chemistry of polymers but the organic chemistry of polymers has not received so much attention. In recognition of this situation and because the two aspects of polymer chemistry are often taught separately, this book deals specifically with organic chemistry and topics of physical chemistry have been omitted. Also, in this way the book has been kept to a reasonable size. This is not to say that integration of the two areas of polymer science is undesirable; on the contrary, it is of the utmost importance that the inter-relationship should b~ appreciated. I wish to record my thanks to my colleagues with whom I have had many helpful discussions, particularly Mrs S. L. Radchenko. I also thank Miss E. Friesen for obtaining many books and articles on my behalf and Mr H. Harms for encouragement and assistance. I am also grateful to Mrs M. Stevens who skilfully prepared the manuscript. Department of Chemical and Metallurgical Technology, Ryerson Polytechnical Institute, K. J. S.

Other books in this series focus on behavior at the individual level, approached from the viewpoints of biochemistry, anatomy, physiology, and psychology. In this volume we show how the functioning nervous systems of interacting individuals are coordinated, with the ultimate creation of complex social structures. The intri cacies of an individual's nervous system have been subject to intense inquiry, and research at the chemical, cellular, and organ levels has made remarkable progress. Work at the social level has been conducted somewhat independently, by way of behavioral phenomena and communicative interactions. With the emergence of a large body of information from neurobiology, the beginnings of an integrated approach are possible. New data on social functions are presented in the chapters to follow, and the forward-looking reader may wish to reflect on how they clarify understanding of interactions between two or more independent nervous systems. The outcome is harmonious social structure and improvement in the inclusive fitness of group-living individuals. We believe that there is in prospect a new way of looking at social function that will ultimately increase our understanding of the highest and most complex levels of neurobiology. The modern approach to the study of social behavior involves more than the recording of interactions between animals. Each individual brings to the process of social interaction the implications of its prior genetic and experiential history."

Hardly a decade ago, membrane receptors were an attractive but largely unproven concept. Since that time enormous progress has been made, and we are now able to consider receptors much more concretely. Their existence has been established, their binding properties have been determined, and in some cases, they have been highly purified and their physical-chemical properties studied. It is now even possible to visualize microscopically some receptors. This progress has resulted largely from the development of highly powerful methods. These methods are the subject of this volume. Although considerably diverse, different receptors share certain common pro perties, and common problems are encountered in their study. Consequently, a small number of techniques are particularly useful in studying different types of receptors. Thus, it makes sense to speak about membrane receptor methodology. A very apparent problem in the study of membrane receptors is their presence in exceedingly small quantities and in a highly impure state. Therefore, very sensitive and specific techniques are required for their detection, characterization and purification. Such sensitivity and specificity is provided by the ability of receptors to bind certain ligands with very high affmity, and it is not surprising that most of the methods described in this volume depend upon this high affinity binding. The antigen-antibody interaction is of comparable sensitivity and speci ficity. Recently, a number of anti-receptor antibodies have been produced or found to occur spontaneously in auto-immune diseases. Undoubtedly, more will be produced in the future."

Since the discovery that neuronal transmission can be chemically mediated, a large number of compounds have been found in the mammalian central nervous system which appear to function as neurotransmitter agents. Recently, electrophysiological and biochemical methods have been developed which have enabled neuroscientists to classify better the myriad of neurotransmitter receptor sites in brain and to study their properties in finer detail. As a result of these investigations, a significant number of new discoveries have been made about the mechanisms involved in neurotransmitter receptor interactions, the role neurotransmitters play in the actions of pharmacological agents and in the pathogenesis of various neuropsychiatric disorders. The present two volume text was compiled to summarize the information relating to the physiological, biochemical, pharmacological and functional characteristics of neurotransmitter receptor sites. While emphasis is placed on neurotransmitter receptors in the mammalian central nervous system, the characteristics of these receptors in other species, both vertebrate and invertebrate, are also discussed where appropriate. While these books cover the major classes of putative neurotransmitters - amino acids, peptides and biogenic amines - and are therefore broad in scope, each is discussed in a concise fashion to highlight the major points of historical and contemporary interest. In addition to outlining data, each chapter addresses current theories relating to the various aspects of receptor properties and function in an attempt to reveal the directions of future research and as a stimulus for other workers in the field.

Assembly of 'difficult' components onto printed circuit boards is emerging as an important application area for small, fast industrial robots. For other robot tasks - for example paint spraying or arc welding - the applications engineer can rely on a body of published information representing decades of accumulated knowledge about the actual process being automated. But for the process of assembly relatively little systematically presented knowledge exists, mainly because so much manual assembly depends on extremely subtle co-ordination of hand, eye and brain which is hard to represent directly in engineering terms. As for the particular processes of electronic assembly, they have hardly been covered at all in the literature. Yet the design of a good PCB automation system depends crucially on the responsible engineer fully understanding every aspect of the process he or she is automating, whether working for the electronics manufacturer, an automation company, a research laboratory or a machine builder. The author of this book has had extensive practical experience in all these roles: as a source of great detail on most aspects of the electronic assembly process it will be of unique value not only to the robot specialist but well beyond that to anyone needing to understand how printed circuit boards are manufactured. P. G. Davey Acknowledgements The author is indebted to many companies and individuals from within the pcb assembly industry.

Masters Theses in the Pure and Applied Sciences was first conceived, published, and disseminated by TPRC at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemina tion phases of the activity was transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we have concluded that it will be in the interest of all concerned if the printing and distribution of the volume were handled by a well-known publishing house to assure improved service and better communication. Hence, effective with this Volume 18, Masters Theses in the Pure and Applied Sciences will be disseminated on a worldwide basis by Plenum Publishing Corporation of New York. All back issues can also be ordered from Plenum. As we embark on this new partnership with Plenum, we also initiate a new venture in that this important annual reference work now covers Canadian universities as well as those in the United States. We are sure that this broader base will greatly enhance the value of these volumes."