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Books > Reference & Interdisciplinary > Interdisciplinary studies > General

Manifest Day by Day - How to Get the Life You Want, Starting Now (Paperback): Alanis Cooper Manifest Day by Day - How to Get the Life You Want, Starting Now (Paperback)
Alanis Cooper
R373 R339 Discovery Miles 3 390 Save R34 (9%) Ships in 9 - 17 working days

If you are feeling stuck, need help achieving your goals or want to make positive changes in any area of your life, this is the book for you. Alanis Cooper has been using manifesting to change her life since 2020, and in this book, she shares her secrets, and gives you the tools to manifest whatever it is you are looking for. From the rule of attraction, to scripting, visualisation, meditation and more, this book will help you begin a daily practice that will change your life forever. Divided into sections covering all the big topics, month by month (friends, family, romance, personal development and more), this book will make manifesting work for you to get the life you want, starting now.

Comparing Political Regimes - A Thematic Introduction to Comparative Politics (Paperback, 4th ed.): Alan Siaroff Comparing Political Regimes - A Thematic Introduction to Comparative Politics (Paperback, 4th ed.)
Alan Siaroff
R1,093 Discovery Miles 10 930 Ships in 10 - 15 working days

Comparing Political Regimes provides a current and comprehensive empirical assessment of the world's 195 sovereign states. Alan Siaroff analyses and classifies countries in terms of economic development, political evolution, and state strength, ultimately outlining and contrasting the aspects of four regime types: liberal democracies, electoral democracies, semi-open autocracies, and closed autocracies. The fourth edition explains institutional differences within democracies and autocracies respectively, including how regimes evolve in key countries and how this change is incremental. An invaluable reference for students to refer to, this book provides a thorough foundational introduction to the comparative politics of countries and contains several unique figures and tables on the world's sovereign states. This new edition modifies the conceptual focus regarding some features of democracy and democratic party systems, expands on variations in autocracies, and adds a new chapter on the historical evolution of democracy, including key thresholds of representative democracy and levels of participation and competition at various historical junctures for all countries.

Where Strangers Become Neighbours - Integrating Immigrants in Vancouver, Canada (Paperback, Softcover reprint of the original... Where Strangers Become Neighbours - Integrating Immigrants in Vancouver, Canada (Paperback, Softcover reprint of the original 1st ed. 2009)
Leonie Sandercock, Giovanni Attili
R2,660 Discovery Miles 26 600 Ships in 18 - 22 working days

In the present age of migration, the influx of immigrants from distant lands leads inevitably to the spatial and social restructuring of cities and regions. It is often accompanied by fears of and hostility towards the newcomers. Nevertheless, in Europe, North America and Japan this influx of immigrants is essential to economic growth. How can immigrants become accepted members of the society of their adopted country? How can strangers become neighbours? What alchemies of political and social imagination are required to achieve peaceful coexistence in the mongrel cities of the 21st century? What philosophies and policies have made integration successful in Canada and how can it be translated into European context? The book tackles an important contemporary issue – the social integration of immigrants in a large metropolis – by way of the detailed case study of one Canadian city. The book provides a large political and legal context which makes this case study comprehensible and inspiring to readers outside Canada.

The Microdistillers' Handbook (Paperback, 3rd New edition): Gavin D. Smith The Microdistillers' Handbook (Paperback, 3rd New edition)
Gavin D. Smith
R370 R336 Discovery Miles 3 360 Save R34 (9%) Ships in 9 - 17 working days
ICT Diffusion in Developing Countries - Towards a New Concept of Technological Takeoff (Paperback, Softcover reprint of the... ICT Diffusion in Developing Countries - Towards a New Concept of Technological Takeoff (Paperback, Softcover reprint of the original 1st ed. 2015)
Ewa Lechman
R2,206 Discovery Miles 22 060 Ships in 18 - 22 working days

This book provides an extensive overview of the diffusion of Information and Communication Technologies (ICTs) in developing countries between 2000 and 2012. It covers issues such as country-specific ICT diffusion patterns, technological substitution and technological convergence. By identifying social, economic and institutional prerequisites and analyzing critical country-specific conditions, the author develops a new approach to explaining the emergence of their technological takeoff. Readers will discover how developing countries are now adopting ICTs, rapidly catching up with the developed world in terms of ICT access and use.    

Microbial Diversity and Biotechnology in Food Security (Paperback, Softcover reprint of the original 1st ed. 2014): R.N.... Microbial Diversity and Biotechnology in Food Security (Paperback, Softcover reprint of the original 1st ed. 2014)
R.N. Kharwar, R. S. Upadhyay, N.K. Dubey, Richa Raghuwanshi
R5,353 Discovery Miles 53 530 Ships in 18 - 22 working days

The roles of microbes in agriculture, industry and environment have been the point of interest since long time for their potential exploitation. Although only a fraction of microbial diversity was accessed by microbiologists earlier for harnessing them owing to limited techniques available. The molecular techniques have opened new vistas to access the wide field of the unexplored microbes and their exploitation for useful genes and novel metabolites. Sincere efforts have been made in biotechnology using microbes leading to improve our life with respect to agriculture and people health. This comprehensive volume covers different aspects of microbial biotechnology and its management in sustainable agriculture for food security and improved human health. The book comprises four sections: Endophytes and Mycorrhizae, Microbial Diversity and Plant Protection, Microbial Functions and Biotechnology, and Microbes and the Environment, which contain 53 chapters. The book examines the aspects on endophytes and mycorrhizae, bioactive compounds, growth promoting microorganisms, disease management with emphasis on biocontrol, genetics of disease resistance, microbial enzymes, advances in potential of microbes and their industrial as well as pharmaceutical applications. In addition, the use of botanicals, and the etiology and management of medicinal and aromatic plants in the post harvest management have been reviewed in greater depth for the benefit of teaching and research community.   The biotechnological developments using microbe potential have enabled us combat the environment and human health problems worldwide in ecofriendly manner. We are sure that this volume will be highly useful to all those concerned with fungi, bacteria, viruses and their biology, including environmental and public health officers and professionals in the field of interest. The volume is an exhaustive coverage of almost all the aspects of microbial biology and biotechnology.

Transdisciplinary Research and Practice for Sustainability Outcomes (Paperback): Dena Fam, Jane Palmer, Chris Riedy, Cynthia... Transdisciplinary Research and Practice for Sustainability Outcomes (Paperback)
Dena Fam, Jane Palmer, Chris Riedy, Cynthia Mitchell
R1,410 Discovery Miles 14 100 Ships in 10 - 15 working days

'Transdisciplinarity' is a form of research and practice that synthesises knowledge from a range of academic disciplines and from the community. There is now global interest and a significant body of work on transdisciplinarity and its potential to address the apparently intractable problems of society. This creates the opportunity for a specific focus on its practical application to sustainability issues. Transdisciplinary Research and Practice for Sustainability Outcomes examines the role of transdisciplinarity in the transformations needed for a sustainable world. After an historical overview of transdisciplinarity, Part I focuses on tools and frameworks to achieve sustainability outcomes in practice and Part II consolidates work by a number of scholars on supporting transdisciplinary researchers and practitioners. Part III is a series of case studies including several international examples that demonstrate the challenges and rewards of transdisciplinary work. The concluding chapter proposes a future research pathway for understanding the human factors that underpin successful transdisciplinary research. As Emeritus Professor Valerie Brown AO notes in her Preface, this book moves transdisciplinary inquiry into the academic and social mainstream. It will be of great interest to researchers and practitioners in the fields of sustainability, qualitative research methods, environmental impact assessment and development studies.

Swarm Planning - The Development of a Planning Methodology to Deal with Climate Adaptation (Paperback, Softcover reprint of the... Swarm Planning - The Development of a Planning Methodology to Deal with Climate Adaptation (Paperback, Softcover reprint of the original 1st ed. 2014)
Rob Roggema
R3,441 Discovery Miles 34 410 Ships in 18 - 22 working days

This book shows that the problem of climate adaptation, which is described in social planning terms as 'wicked,' is at odds with the contemporary practice of spatial planning. The author proposes a new adjusted framework which is more adaptable to unpredictable, wicked, dynamic and non-linear processes. The inspiration for this new method is the behaviour of swarms: bees, ants, birds and fish are capable of self-organization, which enables the system to become less vulnerable to sudden environmental changes. The framework proposed in Swarm Planning consists of these four elements: Two levels of complexity, the first being the whole system and the second its individual components. Each of these has different attributes for adapting to change. Five layers, consisting of networks, focal points, unplanned space, natural resources and emerging occupation patterns. Each layer has its own spatial dynamic, and each is connected to a spatial scale. Non-linear processes, which emerge in different parts of the framework and include emerging patterns, connectedness and tipping points among others. Two planning processes; the first, 'from small to large' works upward from the slowest changing elements to more rapidly-changing ones. The second, 'on the list of partners' addresses each layer from networks through emerging occupation patterns. Swarm Planning applies this framework to a series of pilot studies, and appraises its performance using criteria for an adaptive landscape. The results show that the use of the Swarm Planning Framework reduces the vulnerability of landscapes as well as the impact of climate hazards and disasters, improves response to unexpected hazards and contains adaptation strategies. "This book is a must for planners in government and the private sector as it outlines the concept, strategies and techniques for swarm planning. It is also an important guide for policymakers looking to engage communities in a dialogue about the adaptation planning process." Professor John Martin, La Trobe University "The ultimate value of the book lies in encouraging the planning community to consider options that go far beyond those offered by business-as-usual planning methodologies developed for a set of operating conditions that are fast becoming obsolete. As such it makes an important and much needed contribution to the field." Assistant Professor Dr. Chrisna du Plessis, University of Pretoria

Biocommunication of Animals (Paperback, Softcover reprint of the original 1st ed. 2014): Guenther Witzany Biocommunication of Animals (Paperback, Softcover reprint of the original 1st ed. 2014)
Guenther Witzany
R5,116 Discovery Miles 51 160 Ships in 18 - 22 working days

Every coordination within or between animals depends on communication processes. Although the signaling molecules, vocal and tactile signs, gestures and its combinations differ throughout all species according their evolutionary origins and variety of adaptation processes, certain levels of biocommunication can be found in all animal species:  (a) Abiotic environmental indices such as temperature, light, water, etc. that affect the local ecosphere of an organism and are sensed, interpreted. (b) Trans-specific communication with non-related organisms. (c) Species-specific communication between same or related species. (d) Intraorganismic communication, i.e., sign-mediated coordination within the body of the organism. This book gives an overview of the manifold levels of animal communication exemplified by a variety of species and thereby broadens the understanding of these organisms.

Digital Orientations - Non-Media-Centric Media Studies and Non-Representational Theories of Practice (Paperback, New edition):... Digital Orientations - Non-Media-Centric Media Studies and Non-Representational Theories of Practice (Paperback, New edition)
Shaun Moores
R1,054 Discovery Miles 10 540 Ships in 10 - 15 working days

Might it be possible to rearticulate the term digital in digital media, so that it refers at least as much to the deft movements or orientations of hands and fingers (of digits) as it does to the new media technologies themselves? What if digital media are understood as manual media? Has the academic field of media studies tended to focus too much on media, and not enough on the practices and experiences of daily living that help to give media their meaningfulness? What if media researchers were to pay more attention to knowledge-in-movement or to matters of orientation and habitation, and rather less to those of symbolic representation and cognitive interpretation? Digital Orientations is a bold call for non-media-centric media studies (and ultimately for everyday-life studies) with a non-representational theoretical emphasis. The author engages here with a broad range of work from across the humanities and social sciences, drawing on Merleau-Ponty's phenomenological philosophy, Ingold's anthropology, the geographies of Massey, Seamon and Thrift, and the sociologies of Bourdieu, Sudnow and Urry.

Digital Orientations - Non-Media-Centric Media Studies and Non-Representational Theories of Practice (Hardcover, New edition):... Digital Orientations - Non-Media-Centric Media Studies and Non-Representational Theories of Practice (Hardcover, New edition)
Shaun Moores
R2,719 Discovery Miles 27 190 Ships in 10 - 15 working days

Might it be possible to rearticulate the term digital in digital media, so that it refers at least as much to the deft movements or orientations of hands and fingers (of digits) as it does to the new media technologies themselves? What if digital media are understood as manual media? Has the academic field of media studies tended to focus too much on media, and not enough on the practices and experiences of daily living that help to give media their meaningfulness? What if media researchers were to pay more attention to knowledge-in-movement or to matters of orientation and habitation, and rather less to those of symbolic representation and cognitive interpretation? Digital Orientations is a bold call for non-media-centric media studies (and ultimately for everyday-life studies) with a non-representational theoretical emphasis. The author engages here with a broad range of work from across the humanities and social sciences, drawing on Merleau-Ponty's phenomenological philosophy, Ingold's anthropology, the geographies of Massey, Seamon and Thrift, and the sociologies of Bourdieu, Sudnow and Urry.

Taiping Theology - The Localization of Christianity in China, 1843-64 (Hardcover, 1st ed. 2016): Carl S. Kilcourse Taiping Theology - The Localization of Christianity in China, 1843-64 (Hardcover, 1st ed. 2016)
Carl S. Kilcourse
R3,663 Discovery Miles 36 630 Ships in 10 - 15 working days

This book examines the theological worldview of the Taiping Rebellion (1850-64), a Chinese revolutionary movement whose leader, Hong Xiuquan (1814-64), claimed to be the second son of God and younger brother of Jesus. Despite the profound impact of Christian books on Hong's religious thinking, previous scholarship has neglected the localized form of Christianity that he and his closest followers created. Filling that gap in the existing literature, this book analyzes the localization of Christianity in the theology, ethics, and ritual practices of the Taipings. Carl S. Kilcourse not only reveals how Confucianism and popular religion acted as instruments of localization, but also suggests that several key aspects of the Taipings' localized religion were inspired by terms and themes from translated Christian texts. Emphasizing this link between vernacularization and localization, Kilcourse demonstrates both the religious identity of the Taipings and their wider significance in the history of world Christianity.

Publizistikwissenschaft erneuern - Was wir über öffentliche Kommunikation wissen und was wir wissen können (Paperback, 1.... Publizistikwissenschaft erneuern - Was wir über öffentliche Kommunikation wissen und was wir wissen können (Paperback, 1. Aufl. 2016)
Manfred Rühl
R501 Discovery Miles 5 010 Ships in 18 - 22 working days

Manfred Rühl rekonstruiert öffentliche Kommunikation anhand von Kommunikation/Gesellschafts-Konzeptionen bei Christian Thomasius und Kaspar Stieler, Albert Schäffle und Karl Bücher, Jürgen Habermas und Niklas Luhmann. Das essential erläutert die Prinzipien, wonach sich jedes Publizistiksystem mit Politik, Wirtschaft, Technik, Ethik, Recht, Religion, Kunst, Sport und weiteren Funktionssystemen auseinandersetzen kann. Seit dem 19. Jahrhundert wird Publizistik weltweit als Journalismus, Public Relations, Werbung und in Form von weiteren Persuasionssystemen ausdifferenziert. Diese werden auf der Gesellschaftsebene, auf der Marktebene und auf der Organisationsebene voneinander abgegrenzt. Als übergreifende Funktion der Publizistik wird vorgeschlagen: Die Welt für die Weltgesellschaft transparenter, lesbarer und verstehbarer zu machen.

Rethinking Globalization(S) - From Corporate Transnationalism to Local Interventions (Hardcover, 2000 ed.): Nana Rethinking Globalization(S) - From Corporate Transnationalism to Local Interventions (Hardcover, 2000 ed.)
Nana
R1,422 Discovery Miles 14 220 Ships in 18 - 22 working days

Contributors from diverse disciplinary, ideological, and theoretical perspectives examine the multiple aspects and dimensions of globalization in this impressive collection. By employing a variety of methodological approaches, the authors provide insights into the role of numerous agents in furthering the process and project or present and future globalization(s), as manifested in economic, political and cultural domains.

Blogosphere and its Exploration (Paperback, Softcover reprint of the original 1st ed. 2015): Christoph Meinel, Justus Broß,... Blogosphere and its Exploration (Paperback, Softcover reprint of the original 1st ed. 2015)
Christoph Meinel, Justus Broß, Philipp Berger, Patrick Hennig
R2,111 Discovery Miles 21 110 Ships in 18 - 22 working days

This book represents an attempt to fully review the phenomenon of the blogosphere. The intention is to provide a reliable guide to understanding and analyzing the world of the unimaginable number of diverse blogs, each consisting of innumerable posts, which in their entirety form the blogosphere. We go on to answer the questions of how to grasp the complexity of the blogosphere and extract useful knowledge from it. In setting out to write this book, our central aim was to increase the reader’s awareness and understanding of the blogosphere phenomenon, including its structure and characteristics. This can be achieved through a better understanding of individual blogs and their particular technical characteristics, as well as a deeper knowledge of how a single blog is embedded and interconnected within the entire blogosphere. The shape and form of the blogosphere can be described using the analogy of different continents. In our description the defining features and characteristics of the continents are illustrated by paradigmatic example blogs. Following on from the structural analysis we provide details of the available methods and describe the complex challenge of automatically retrieving information from the abundance of data contained in the blogosphere. Finally, we present our blog search platform, called BLOGINTELLIGENCE and describe all the tools and features we have developed during the last couple of years to explore the blogosphere.  

The Variation Theory of Comparative Literature (Paperback, Softcover reprint of the original 1st ed. 2013): Shunqing Cao The Variation Theory of Comparative Literature (Paperback, Softcover reprint of the original 1st ed. 2013)
Shunqing Cao
R2,132 Discovery Miles 21 320 Ships in 18 - 22 working days

Seeing the restrictions of former studies in Comparative Literature and aiming to amend these deficiencies, the author of this book mainly discusses the major theoretical significance and academic value of the Variation Theory in the whole process of the development of Comparative Literature in the world. In China the seminal comparative study of literature among different cultures can be dated back to ancient China, while the founding of comparative literature as a distinct academic discipline has to be largely owing to the influence of the West. The modern Chinese study of comparative literature formed its uniqueness under Western influence. The direct influence of the translation of western theories into China is remarkable. However, in the course of translation and reception of Western theories, Chinese comparatists and intellectuals have been encountering various problems, and solving them with an alternative method accordingly different from the traditional methods proposed by the French School and the American School. Therefore, in this book, modern Chinese study of comparative literature is put in a historical context with regard to the theoretical issue of the discipline in China through the entire 20th century. At present, many scholars in China and in other countries agree that, with the influence study proposed by the French School and the study of analogy advocated by the American School, the entire theoretical system of Comparative Literature is well built. However, when the comparative study of literature between East and West is concerned, the theory of Comparative Literature is far from perfect. It is not only because many problems still exist, but there are significant defects in their theoretical bases respectively. Many researches have proven that even with the influence study and the study of analogy, we still can not solve many problems in the practice of studies in comparative literature. This does not mean that we have no respect for the contributions of the French School and the American School; we just want to attach importance to literary variations, which is a phenomenon that has long been neglected. The purpose of putting forward the Variation Theory in Comparative Literature is to provide new perspectives, new methods and new theory to the study of comparative literature, which may be a major breakthrough in the international arena of Comparative Literature. The neglect of literary variation is mainly because all the previous theories about comparative literature start off in search of similarities but not differences. Accordingly, in 1990s heterogeneity as a premise of comparability was put forward. And later, the variation theory was further advanced. It is not only the important phenomenon in literary communication, but also the most valuable research object in Comparative Literature. Still, it will be an important path to cultural innovation. The Variation Theory may make up the major flaws of theories by both French school and the American School since it focus on heterogeneity and variability in cross-cultural literary events, especially the ones of inter-civilization which will be a new course for comparative literature. Throughout the history of literature and the history of literary communication, collisions between different civilizations have always been producing new literary events which make the heterogeneity of different civilizations and variability traceable. The higher stage of literary communication may mean dialogue and blend between different cultures. The overarching concerns of this book include different levels of variation in literary communication and the studies of different objects. The introduction begins with a literature review of major achievements made by the French School and the American School with pointing out what they have neglected. The body of the book is divided into three parts. In the first part, Chapter 1 deals with the major contributions of influence study and its weaknesses. The origination of comparative literature in most of European countries is reviewed first, and then the major contributions of the French School are listed to point out its merits and weaknesses. The author discusses the relation between Influence Study and the Variation Theory and the importance of the French school in theoretical development of comparative literature is stressed too. Chapter 2 offers a critical introduction and reflection on the study of analogy . Both its major contributions and weaknesses are made clear to further illustrate the relationship between interpretation and the Variation Theory. And the discursive variation is discussed. Part II is a transitional part with only one chapter that gives a clear account of phenomenon of variation from international perspective. Part III consists of four chapters. Chapter 4 offers a detailed description of The Variation Theory in cross-languages context. Chapter 5 deals with cross-cultural variation in homogeneous circle of civilization. Chapter 6 discusses the variation among heterogeneous civilization. For a long period of time the theoretical study of comparative literature in China has largely been confined to the Chinese academic arena, thus has long been neglected. On one hand western comparatists have gradually realized the importance of a non-western perspective in the study of the discipline; on the other hand, few books are available to introduce the recent development of comparative literature study in China. Compared with the enthusiastic reception of the theories of the French School and the American School, the theories of Chinese comparatists receives relatively little attention in western countries. In this sense, the proposed book attempts to challenge the myth of monolithic theories of comparative literature, trying to construct an alternative theory of the discipline.

The Speaking Self: Language Lore and English Usage - Second Edition (Paperback, 1st Ed. 2017): Michael Shapiro The Speaking Self: Language Lore and English Usage - Second Edition (Paperback, 1st Ed. 2017)
Michael Shapiro
R3,174 Discovery Miles 31 740 Ships in 18 - 22 working days

This book aims to explain social variation in language, otherwise the meaning and motivation of language change in its social aspect. It is the expanded and improved 2nd edition of the author's self-published volume with the same title, based on revised and adapted posts on the author's Languagelore blog. Each vignette calls attention to points of grammar and style in contemporary American English, especially cases where language is changing due to innovative usage. In every case where an analysis contains technical or recondite vocabulary, a Glossary precedes the body of the essay, and readers can also consult the Master Glossary which contains all items glossed in the text. The unique form of the book's presentation is aimed at readers who are alert to the peculiarities of present-day American English as they pertain to pronunciation, grammar, and style, without "dumbing down" or compromising the language in which the explanations are couched. Praise for the First Edition "Michael Shapiro is one of the great thinkers in the realm of linguistics and language use, and his integrated understanding of language and speech in its semantic and pragmatic structure, grammatical and historical grounding, and colloquial to literary stylistic variants is perhaps unmatched today. This book is a treasure to be shared." Robert S. Hatten, The University of Texas at Austin "Jewel of a book...a gift to us all from Michael Shapiro. Like a Medieval Chapbook it can be a kind of companion whose vignettes on language use can be randomly and profitably consulted at any moment. Some may consider these vignettes opinionated. That would be to ignore how deeply anchored each vignette is in Shapiro's long and rare polyglot experience with language. It could well serve as a night table book, taken up each night to read and reflect upon --to ponder--both in the twilight mind and in the deeper reaches of associative somnolence. There is nothing else like it that I know of." James W. Fernandez, The University of Chicago

Homeostasis - Tumor - Metastasis (Paperback, Softcover reprint of the original 1st ed. 2014): Gaspar Banfalvi Homeostasis - Tumor - Metastasis (Paperback, Softcover reprint of the original 1st ed. 2014)
Gaspar Banfalvi
R4,736 Discovery Miles 47 360 Ships in 18 - 22 working days

Homeostasis. The health of an organism is influenced by external and internal changes that may lead to the loss of homeostasis. Under healthy conditions organisms compensate these changes. If compensation fails disease ensues. Attention will be paid to lifestyle, environmental changes, genetic makeup and health system. It will be answered how lifestyle, environment, genetic makeup and social conditions help to maintain or upset the biological balance and lead to cancer. Tumor formation. To understand this process the transfer of intracellular and the pathways of extracellular information (signal transduction) will be reviewed briefly. Loss of cellular balance may lead to cell death (.e.g. apoptosis) or to rapid cell growth of cells leading to tumor formation. Metastasis. Animal tumor models serve to understand the spread of the primary tumor cells to distant locations of the organism. Different types of tumors and metastases will be reviewed.

The Growth and Development of National Thought in India (Hardcover, Reprint 2021): Ishwar Nath Topa The Growth and Development of National Thought in India (Hardcover, Reprint 2021)
Ishwar Nath Topa
R3,196 Discovery Miles 31 960 Ships in 18 - 22 working days
Epigenetics and Cancer (Paperback, Softcover reprint of the original 1st ed. 2013): Fazlul H Sarkar Epigenetics and Cancer (Paperback, Softcover reprint of the original 1st ed. 2013)
Fazlul H Sarkar
R4,757 Discovery Miles 47 570 Ships in 18 - 22 working days

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Benefit Sharing - From Biodiversity to Human Genetics (Paperback, Softcover reprint of the original 1st ed. 2013): Doris... Benefit Sharing - From Biodiversity to Human Genetics (Paperback, Softcover reprint of the original 1st ed. 2013)
Doris Schroeder, Julie Cook Lucas
R3,303 Discovery Miles 33 030 Ships in 18 - 22 working days

Biomedical research is increasingly carried out in low- and middle-income countries. International consensus has largely been achieved around the importance of valid consent and protecting research participants from harm. But what are the responsibilities of researchers and funders to share the benefits of their research with research participants and their communities? After setting out the legal, ethical and conceptual frameworks for benefit sharing, this collection analyses seven historical cases to identify the ethical and policy challenges that arise in relation to benefit sharing. A series of recommendations address possible ways forward to achieve justice for research participants in low- and middle-income countries.

Heat Shock Protein-Based Therapies (Paperback, Softcover reprint of the original 1st ed. 2015): Alexzander A.A. Asea, Naif N.... Heat Shock Protein-Based Therapies (Paperback, Softcover reprint of the original 1st ed. 2015)
Alexzander A.A. Asea, Naif N. Almasoud, Sunil Krishnan, Punit Kaur
R5,032 Discovery Miles 50 320 Ships in 18 - 22 working days

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

The Hidden Rules of Successful Negotiation and Communication - Getting to Yes! (Paperback, Softcover reprint of the original... The Hidden Rules of Successful Negotiation and Communication - Getting to Yes! (Paperback, Softcover reprint of the original 1st ed. 2014)
Marc O. Opresnik
R1,762 Discovery Miles 17 620 Ships in 18 - 22 working days

Negotiations in professional or private life often take an unsatisfactory course due to stress, confrontation with aggressive or unfair behavior, or because of overwhelming situations. Negotiations generally require a thorough preparation, strategy and a sophisticated tactic to make us feel safe in the presentation of our goals and arrive at a mutually satisfactory outcome. Conventional books about negotiations are usually limited to strategies and techniques, but leave out elements of psychological communication and emotional intelligence, which include non-verbal communication and empathy, which in turn are essential for successful negotiation. Therefore, this book on the one hand constitutes the essential techniques and strategies in the context of negotiation, but also considers "soft skills" without which negotiations cannot be successful. This book presents practical examples in dealing with situations such as salary, contract and sales negotiations. In particular on context and time appropriate negotiation techniques; analyzing negotiation partners and their motives; interpret group processes, and how to successfully implement negotiation psychology.

Opening Science - The Evolving Guide on How the Internet is Changing Research, Collaboration and Scholarly Publishing... Opening Science - The Evolving Guide on How the Internet is Changing Research, Collaboration and Scholarly Publishing (Paperback, Softcover reprint of the original 1st ed. 2014)
Sönke Bartling, Sascha Friesike
R2,404 Discovery Miles 24 040 Ships in 18 - 22 working days

Modern information and communication technologies, together with a cultural upheaval within the research community, have profoundly changed research in nearly every aspect. Ranging from sharing and discussing ideas in social networks for scientists to new collaborative environments and novel publication formats, knowledge creation and dissemination as we know it is experiencing a vigorous shift towards increased transparency, collaboration and accessibility. Many assume that research workflows will change more in the next 20 years than they have in the last 200. This book provides researchers, decision makers, and other scientific stakeholders with a snapshot of the basics, the tools, and the underlying visions that drive the current scientific (r)evolution, often called ‘Open Science.’

Cyberspace and International Relations - Theory, Prospects and Challenges (Paperback, Softcover reprint of the original 1st ed.... Cyberspace and International Relations - Theory, Prospects and Challenges (Paperback, Softcover reprint of the original 1st ed. 2014)
Jan-Frederik Kremer, Benedikt Müller
R4,099 Discovery Miles 40 990 Ships in 18 - 22 working days

Cyberspace is everywhere in today’s world and has significant implications not only for global economic activity, but also for international politics and transnational social relations. This compilation addresses for the first time the “cyberization” of international relations - the growing dependence of actors in IR on the infrastructure and instruments of the internet, and the penetration of cyberspace into all fields of their activities. The volume approaches this topical issue in a comprehensive and interdisciplinary fashion, bringing together scholars from disciplines such as IR, security studies, ICT studies and philosophy as well as experts from everyday cyber-practice. In the first part, concepts and theories are presented to shed light on the relationship between cyberspace and international relations, discussing implications for the discipline and presenting fresh and innovative theoretical approaches. Contributions in the second part focus on specific empirical fields of activity (security, economy, diplomacy, cultural activity, transnational communication, critical infrastructure, cyber espionage, social media, and more) and address emerging challenges and prospects for international politics and relations.

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