The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU's REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics. The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches. Developmental and Reproductive Toxicology, Third Edition: Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies. Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity. Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference. Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment. This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

*takes a patient centred approach * reflects contemporary multi-disciplinary team approach * assesses breast cancer in specialist circumstances eg very young, pregnant, very old * clearly illustrated to highlight key issues

A concise, essential guide to living with bipolar disorder by an internationally known expert. When a diagnosis of bipolar disorder enters your life, you may not be sure where to turn for accurate information about this potentially devastating but treatable illness. Whether you yourself have been diagnosed, or a spouse, parent, child, friend, or employee has developed the illness, the need for information and advice is acute. Presenting the essentials of diagnosis and treatment clearly and succinctly, leading psychiatrist Dr. Francis Mark Mondimore distills everything you need to know about bipolar disorder in this new indispensable guide. In down-to-earth language, Dr. Mondimore explains what bipolar disorder is and how you (or your loved one) can live your best life with the help of medications, therapy, the support of family and friends, and medical care. An extensive list of references is included, along with additional suggested reading materials and online resources. Realistic clinical descriptions and anecdotes reflecting on fascinating historical details associated with this condition provide further information. The Concise Guide to Bipolar Disorder is an excellent up-to-date resource for the newly diagnosed or those seeking rapid answers to the most common questions about bipolar disorder. Past Praise for Books by Francis Mark Mondimore, MD "Offers advice on how to live with bipolar disorder, and how not to become its victim."-Large Print Reviews "An enlightened, pragmatic, and empathic resource for this very complex and challenging illness."-Journal of Clinical Psychiatry "An absolute gold mine for those with the disorder and their families: thorough, candid, and up-to-date advice, full of new possibilities for help."-Kirkus Reviews

With chapters from globally recognized academics, General Radiography shows the multifaceted approach to general radiography and how it enhances healthcare delivery. Potentially influential to how healthcare delivery is offered, it begins with the pertinent chapters examining image acquisition and dose optimization in diagnostic radiography. Next, chapters reflect and critically discuss aspects central to patient care, and imaging within trauma, critical care and pediatric situations. The final section of this book then explores the learning, teaching and education in the field of diagnostic radiography, with novel strategies illustrated.

The book utilises the Five Ways to Well-being as a model: Connect, Be Active, Keep Learning, Give, Take Notice. Each of these Ways are explored through a specific museum object illustrating the important role collections can play in museum well-being. The book considers how museum well-being, and the austerity project became entwined, and how the COVID-19 pandemic supercharged growth in this field. The book explores such diverse topics as walking, slow art, social capital, Virginia Woolf, body positivity, collective joy, identity, art therapy, yoga, Squid Game, Effective Altruism, mindfulness, gift exchange, the Preston model, the limits of data, sketching, photography, inclusive spaces, and workplace well-being. The book signposts a vast array of existing information, and offers a critical engagement with current practices. Museums and Well-being is aimed initially to students of museum studies programmes, it is also an ideal book for a museum staff who needs to add a well-being component to their existing programming; or to reconsider existing programming from the perspective of well-being.

An overview of the wide variety of medical devices that are an integral part of clinical practice, this practical book includes descriptions of medical devices by both clinical specialty and purpose, thus ensuring that a wide variety of devices are included. Covering important elements such as body contact, duration of contact, the mechanism of each device, its intended use, single and/or multiple use, benefits and any side/adverse/toxicological effects to the patient, and how to avoid user error, and authored by clinicians, researchers and educators who are experienced in medical device use, regulation and research, the content will be of benefit to postgraduate clinicians and employees of medical device companies.

A Story of a Marriage Through Dementia and Beyond is the extraordinary, unflinching account from sociologist Laurel Richardson of her love and caregiving through the last period of her husband Ernest Lockridge's life - from his transient amnesia to his death from Lewy Body Dementia. Focusing on the lived experience of the caregiver through the loved one's journey from mild cognitive impairment to death, the book gives the reader the experience of what the medical diagnoses mean and what has led up to the loss. It shows the complex, nuanced lives of a couple both living with the worst effects of a disease like Lewy Body Dementia, while maintaining, sometimes with hope and laughter, their loving connection nourished through a 40-year marriage. Dementia is a 'silver tsunami' - the third leading cause of death amongst senior populations. Richardson's beautifully written book gives on-the-ground emotional support to those already in service as caregivers and helps prepare others for such service. Hospices, book clubs, and medical and allied professionals will find this book extraordinarily valuable. Weaving in autoethnographic and sociological methods and scholarship, as well as a list of reading and further resources for caregivers and scholars, this book will also appeal to courses in a wide range of disciplines and fields, including health communication, nursing and allied health, courses covering death and dying, end-of-life, and illness care, and, of course, scholars pursuing autoethnography, creative non-fiction, and qualitative methods.

This book presents a comprehensive account of the COVID-19 pandemic, also known as the novel coronavirus pandemic, as it happened. This volume examines the first responses to the COVID-19 pandemic, the contexts of earlier epidemics and the epidemiological basics of infectious diseases. Further, it discusses patterns in the spread of the disease; the management and containment of infections at the personal, national, and global level; effects on trade and commerce; the social and psychological impact on people; the disruption and postponement of international events; the role of various international organizations like the WHO in the search for solutions; and the race for a vaccine or a cure. Based on new data and latest developments, the second edition of this volume explores the global spread of COVID-19 since 2019 and examines the emergence of the evolving coronavirus variants (Alpha, Beta, Gamma, Delta and Omicron). Further, it extensively discusses what we have since discovered on the disease, along with recent progress on treatments and vaccines. Authored by a medical professional and an economist working on the frontlines, this book gives a nuanced, verified and fact-checked analysis of the COVID-19 pandemic and its global response. A one-stop resource on the COVID-19 outbreak, it is indispensable for every reader and a holistic work for scholars and researchers of medical sociology, public health, political economy, public policy and governance, sociology of health and medicine, and paramedical and medical practitioners. It will also be a great resource for policymakers, government departments and civil society organizations working in the area.

This book documents the journey of the survivors of sexual violence as they navigate the gruelling criminal justice and health care systems and the stigma and hostility in their communities in the aftermath of the incident. Through personal narratives of survivors and their family members, the book examines critical gaps in the existing networks of criminal procedure, health, and rehabilitation for survivors of sexual violence and rape. Using qualitative research, it distills the narratives gathered through interviews with survivors and their family members to understand their experiences and offers. The book contributes to the corpus of literature on different forms of violence against women in India with an emphasis on understanding the effectiveness of institutions, both formal and informal, in responding to sexual violence, and offering suggestions for changes in the health and support systems available to them. It documents post-incident interactions of survivors with family, community, the police, courts, lawyers, and hospitals and highlights the impact of rape on physical and mental health, work, relationships, education and housing for survivors and their families. This book will be of interest to those engaged in providing support to survivors of sexual violence as well as students and researchers of social work and social policy, health and social care, law, gender studies, human rights and civil liberties, gender and sexuality, social welfare, and mental health.

The Voice of Clinical Reason Harrison's Principles of Internal Medicine is the world's most trusted clinical medicine text-and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine. Harrison's Principles of Internal Medicine stands as the benchmark for authoritative, practical information on patient care and the pathogenesis and clinical management of symptoms and signs and specific diseases. Written and edited by the world's top experts in their respective fields, this landmark guide provides the comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease. Harrison's is world-renowned as the most authoritative source for: * Descriptions of disease mechanisms and how the clinician can apply that knowledge for the best patient care and optimal diagnosis and treatment of specific diseases * Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases * The physiologic and epidemiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow * Updated clinical trial results and recommended guidelines * Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings * Coverage of both therapeutic approaches and specific treatment regimens * Practical clinical decision trees and algorithms * Organ-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, general and specific approaches to therapy Harrison's remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world's top experts are featured in the 21st edition: * Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer * Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries * More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes * More than a dozen atlases featuring curated collections of visual aspects of diagnosis and management * Complete, updated curation and synthesis of primary medical literature which incorporates current data from major studies and clinical trials * Clinical reasoning resources and helpful disease/presentation schemas * Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

* The Recovery Cycle is the positive mirror image of the Addiction Cycle, and the first and only simple and relatable model for positive change in recovery * Written with both therapists and clients in mind - by a clinician in recovery herself - the easy, pragmatic, and conversational style plays to the resistance known to addicted people while gently encouraging sober relationships and spiritual connection * It speaks to all addiction disorders and discusses what every addicted person must go through to fall in love with their sober life, no matter what program they choose, no matter what addiction

--Riveting accounts of difficult expeditions-some historically famous-offer a unique window onto polar ventures. --Exemplifies historical and social science methods for student readers. --Draws valuable findings that apply to many forms of modern disasters and challenges.

Cinema and medicine have been inextricably linked since the earliest days of film, with doctors appearing in fictional films before criminals, the clergy or even cowboys. But why have healthcare professionals - often played by major stars - featured so prominently in film history, and what does this have to tell us now? Responding to Alexander, Lenahan and Pavlov's Cinemeducation (Radcliffe, 2005) which focused on the uses of cinema in medical teaching, this book instead examines what film has to say about medicine, its practitioners, and their cultural meaning. Drawing on a miscellany of films from the dawn of cinema to the 2000s, from horror and westerns to war films and art cinema, and informed by a film and cultural studies-based approach, this will be a valuable text for students of medical or film history, researchers in the medical humanities, and medical practitioners with an interest in the portrayal and cultural representation of their profession.

The Routledge Handbook of Clinical Supervision provides a global 'state of the art' overview of clinical supervision, presenting and examining the most comprehensive, robust empirical evidence upon which to base practice. This authoritative volume builds on a previous volume, Fundamental Themes in Clinical Supervision, whilst greatly expanding its coverage. It contains nine updated and 25 entirely new chapters, focusing on both areas of contemporary interest and hitherto under-examined issues. Divided into five parts, it discusses: Education and training Implementation and development Experiences and practice Research activity International perspectives. Containing chapters on Europe, the US, Canada, and Australasia, the Routledge Handbook of Clinical Supervision has a multi-disciplinary approach to clinical supervision and includes chapters relevant to nurses, doctors, psychologists, psychiatrists and counsellors. It will be of interest to students, researchers and practitioners of clinical supervision in a range of health professions.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

Key Features: * Provides a comprehensive and complete resource on Leishmaniasis on various aspects of the disease, distilling credible information from available literature coupled with historical references. * Follows a model approach for handling emerging infectious diseases for the benefit of clinicians and front-line workers. * Discusses the unique problem of skin localizing visceral parasites and provides basic principles of management for other infectious diseases and vector-borne infections.

The overturning of Roe v Wade makes the ethical consideration of abortion more important than ever. Appealing to reason rather than religious belief, this book is the most comprehensive case against the choice of abortion yet published. This third edition of The Ethics of Abortion critically evaluates all the major grounds for denying basic rights to fetal human beings, including the views of those who defend not only abortion but also post-birth abortion. It also provides several (non-theological) justifications for the conclusion that all human beings, including those in utero, should be respected as persons. This book also critiques the view that abortion is not wrong even if the human fetus is a person. The Ethics of Abortion examines hard cases for those who are prolife, such as abortion in cases of rape or in order to save the woman's life, as well as hard cases for defenders of abortion, such as sex selection abortion and the rationale for being "personally opposed" but publicly supportive of abortion. It concludes with a discussion of whether artificial wombs might end the abortion debate. Answering the arguments of defenders of abortion, this book provides reasoned justification for the view that all intentional abortions are ethically wrong and that doctors and nurses who object to abortion should not be forced to act against their consciences. Updates and Revisions to the Third Edition Include: Discusses Achas Burin's 2014 essay, "Beyond Pragmatism: Defending the 'Bright Line' of Birth" in chapter 3 Incorporates into chapter 8 David Boonin's cogently argued 2019 book, Beyond Roe: Why Abortion Should be Legal - Even if the Fetus is a Person Expands chapter 9 to examine tragic cases in which prenatal diagnosis determines with certainty that a fetus will die shortly after birth Includes an updated and expanded section in chapter 11 on recent debates about conscience protections Considers in chapter 12 recent arguments that parents have a right to kill if the product of conception is in an artificial womb Updates statistics on numbers of abortions in the United States, including corrections to statistics that were once thought true but are now known as erroneous Updated bibliography

Presents general and specific examination procedures and tests for joints and articulations Has original photographs of limb examinations contributed by selective surgeons Has ample line diagrams to simplify understanding of limb examinations

This book examines the drug dealer in contemporary society from an interdisciplinary perspective and considers the increasingly blurred demarcation between illegitimate and legitimate drug markets. It explores the motives and drivers of those involved in drug supply and dispels common and stereotypical myths and misconceptions surrounding illegal drug markets and those who operate within them. The drug dealer has become one of our foremost contemporary ‘folk devils’. Those who trade in substances prohibited by law are the subject of array of inaccurate myths and urban legends. Criminology has tended either to shoehorn drug dealers into neat typologies or portray them as ‘victims’ of an uncaring, predatory post-modern society. In reality, we know relatively little about the complex and diverse world of drug markets and our concentration inevitably falls on low-end ‘retail’ dealers who operate in the most visible sectors of the illegal economy. Bringing together an international group of experts, this book considers perspectives from around the world, including UK, USA, South America, Spain, India and Australia. This book will be of interest to students and researchers across criminology, law, sociology, criminal justice and public health, and will be essential reading for those taking courses on drugs, drug markets and substance misuse.

This book is a key edition to the Working With... series. It contains practical information in an accessible format for speech and language therapists to draw on in this subject area. It draws on evidence based models/approaches well recognised in the field of Speech and Language therapy and specialist teaching, in a comprehensive way.

This book acts as a primer for radiographers upon performing computed tomography (CT) examinations. The focus resides in radiation physics, radiobiology, anatomy, imaging protocols and image evaluation. It seeks to provide readers insight into the practical and innovative approaches within CT, backed up with key literature and examples in practice. Recent innovations and the importance of new technology to acquire enhanced quality remain a focal point. These are essential in understanding the importance of dose optimization, patient anatomy and common pathology observed. Patient care will remain central in this book, supported with a dedicated chapter discussing effective communication, patient education, informed consent, coupled with the assessment of laboratory results and vital signs. The editors draw from recent publications and clinical expertise, supported with the growing trend of technological advances utilized within the CT environment. Critically, this volume focuses on the role of CT for an array of audiences but, more specifically, undergraduate and postgraduate radiographers worldwide.